Linshang Chemical
PRODUCTS
3-Chloro-5-Fluorobenzenemethanol
Linshang Chemical
|
HS Code |
580884 |
| Chemical Formula | C7H6ClFO |
| Molecular Weight | 160.57 |
| Appearance | Solid (Typical) |
| Solubility In Water | Low (Expected, due to non - polar benzene ring) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone (Expected for aromatic alcohol derivative) |
| Purity | Typically sold in high purity (e.g., 95% + in commercial products) |
| Odor | May have a faint, aromatic odor (Expected for benzene - based compound) |
As an accredited 3-Chloro-5-Fluorobenzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloro - 5 - fluorobenzenemethanol packaged in a sealed, chemical - resistant bottle. |
| Storage | 3 - Chloro - 5 - fluorobenzenemethanol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and potential reactions. Label the container clearly to avoid confusion. Ensure storage facilities meet safety regulations for handling such chemicals. |
| Shipping | 3 - Chloro - 5 - fluorobenzenemethanol is shipped in sealed, corrosion - resistant containers. Adequate cushioning and labeling as a chemical are ensured. It follows strict regulations for safe transportation to prevent leakage and ensure delivery integrity. |
Competitive 3-Chloro-5-Fluorobenzenemethanol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chloro-5-Fluorobenzenemethanol in China?
As a trusted 3-Chloro-5-Fluorobenzenemethanol manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro-5-Fluorobenzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 3-chloro-5-fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, this is an organic compound. It has unique physical properties, let me tell you in detail.
Looking at its appearance, it is often white to light yellow crystalline powder, just like finely crushed agarine jade, or shimmering in sunlight.
When it comes to the melting point, it is about a specific temperature range. The value of this temperature is the key node of the mutual transformation of its solid state and liquid state, just like the cardinal of the change of the state of matter. When the external temperature gradually rises to near the melting point, the substance is like ice and snow meeting the warm sun, slowly melting from the solid state to the liquid state.
As for the boiling point, there is also a corresponding value. The boiling point is the temperature at which a liquid boils. At this temperature, a large number of molecules in the liquid can escape and become gaseous. The boiling point of 3-chloro-5-fluorobenzyl alcohol determines the temperature at which it can complete the transition from liquid to gaseous.
Its density is also a specific constant, and this value reflects the mass of the substance per unit volume. Just like the scale of measuring the "density" of a substance, the density is determined, and it can be known that its weight is relative to other substances in the same volume.
In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol, ether, etc. Just like a fish entering water, the molecules of the substance can diffuse and disperse among the molecules of the organic solvent to form a uniform mixed system. However, in water, the solubility is relatively small. Due to the difference in molecular structure and polarity between water and the organic substance, the two are difficult to blend, just like oil and water.
In addition, its stability is acceptable under general conditions. However, when encountering special chemicals such as strong oxidants, strong acids, and strong bases, or in extreme environments such as high temperature and high pressure, its molecular structure may change, triggering chemical reactions, which need to be treated with caution. The physical properties of 3-chloro-5-fluorobenzyl alcohol lay an important foundation for its application in many fields such as organic synthesis and drug research and development, and it is a key characteristic that cannot be ignored in research and practice.
Looking at its appearance, it is often white to light yellow crystalline powder, just like finely crushed agarine jade, or shimmering in sunlight.
When it comes to the melting point, it is about a specific temperature range. The value of this temperature is the key node of the mutual transformation of its solid state and liquid state, just like the cardinal of the change of the state of matter. When the external temperature gradually rises to near the melting point, the substance is like ice and snow meeting the warm sun, slowly melting from the solid state to the liquid state.
As for the boiling point, there is also a corresponding value. The boiling point is the temperature at which a liquid boils. At this temperature, a large number of molecules in the liquid can escape and become gaseous. The boiling point of 3-chloro-5-fluorobenzyl alcohol determines the temperature at which it can complete the transition from liquid to gaseous.
Its density is also a specific constant, and this value reflects the mass of the substance per unit volume. Just like the scale of measuring the "density" of a substance, the density is determined, and it can be known that its weight is relative to other substances in the same volume.
In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol, ether, etc. Just like a fish entering water, the molecules of the substance can diffuse and disperse among the molecules of the organic solvent to form a uniform mixed system. However, in water, the solubility is relatively small. Due to the difference in molecular structure and polarity between water and the organic substance, the two are difficult to blend, just like oil and water.
In addition, its stability is acceptable under general conditions. However, when encountering special chemicals such as strong oxidants, strong acids, and strong bases, or in extreme environments such as high temperature and high pressure, its molecular structure may change, triggering chemical reactions, which need to be treated with caution. The physical properties of 3-chloro-5-fluorobenzyl alcohol lay an important foundation for its application in many fields such as organic synthesis and drug research and development, and it is a key characteristic that cannot be ignored in research and practice.
What are the chemical properties of 3-chloro-5-fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, this is an organic compound with interesting chemical properties.
When it comes to physical properties, at room temperature, it is mostly solid or liquid, but the exact state depends on the temperature and pressure of the surrounding environment. Its melting point and boiling point are closely related to the intermolecular forces. Due to the presence of chlorine and fluorine atoms in the molecule, the polarity of the molecule changes, which has a great impact on its melting point and boiling point. The electronegativity of chlorine and fluorine atoms is high, which can strengthen the intermolecular forces, causing the melting point and boiling point to rise.
In terms of chemical activity, its benzene ring is replaced by chlorine and fluorine atoms. Chlorine and fluorine atoms are electron-withdrawing groups, which can affect the electron cloud density of the benzene ring through induction and conjugation effects. This effect changes the activity of the electrophilic substitution reaction of the benzene ring. Generally speaking, the electron cloud density of the benzene ring will be reduced, the activity of the electrophilic substitution reaction will be weakened, and the reaction check point will also change. The electrophilic reagents tend to attack the relatively high electron cloud density on the benzene ring.
Its hydroxyl group (-CH 2O OH) functional group is active. Hydroxyl groups can participate in many reactions, such as esterification reactions, and can react with carboxylic acids to form ester compounds under acid-catalyzed conditions. Another example is oxidation reactions, which can be oxidized by appropriate oxidants to aldehyde groups (-CHO) or even carboxyl groups (-COOH). In case of strong oxidizing agent, the hydroxyl group may be oxidized to the corresponding carbonyl compound.
In addition, due to the presence of benzene ring with chlorine and fluorine atoms, the compound can also participate in aromatic nucleophilic substitution reactions. Under specific conditions, the chlorine or fluorine atoms on the benzene ring can be replaced by nucleophiles to form new carbon-heteroatom bonds, and a variety of organic compounds can be derived.
In summary, 3-chloro-5-fluorobenzyl alcohol has rich and diverse chemical properties and has a wide range of application potential in the field of organic synthesis. It can be used as a key intermediate for the preparation of various organic compounds.
When it comes to physical properties, at room temperature, it is mostly solid or liquid, but the exact state depends on the temperature and pressure of the surrounding environment. Its melting point and boiling point are closely related to the intermolecular forces. Due to the presence of chlorine and fluorine atoms in the molecule, the polarity of the molecule changes, which has a great impact on its melting point and boiling point. The electronegativity of chlorine and fluorine atoms is high, which can strengthen the intermolecular forces, causing the melting point and boiling point to rise.
In terms of chemical activity, its benzene ring is replaced by chlorine and fluorine atoms. Chlorine and fluorine atoms are electron-withdrawing groups, which can affect the electron cloud density of the benzene ring through induction and conjugation effects. This effect changes the activity of the electrophilic substitution reaction of the benzene ring. Generally speaking, the electron cloud density of the benzene ring will be reduced, the activity of the electrophilic substitution reaction will be weakened, and the reaction check point will also change. The electrophilic reagents tend to attack the relatively high electron cloud density on the benzene ring.
Its hydroxyl group (-CH 2O OH) functional group is active. Hydroxyl groups can participate in many reactions, such as esterification reactions, and can react with carboxylic acids to form ester compounds under acid-catalyzed conditions. Another example is oxidation reactions, which can be oxidized by appropriate oxidants to aldehyde groups (-CHO) or even carboxyl groups (-COOH). In case of strong oxidizing agent, the hydroxyl group may be oxidized to the corresponding carbonyl compound.
In addition, due to the presence of benzene ring with chlorine and fluorine atoms, the compound can also participate in aromatic nucleophilic substitution reactions. Under specific conditions, the chlorine or fluorine atoms on the benzene ring can be replaced by nucleophiles to form new carbon-heteroatom bonds, and a variety of organic compounds can be derived.
In summary, 3-chloro-5-fluorobenzyl alcohol has rich and diverse chemical properties and has a wide range of application potential in the field of organic synthesis. It can be used as a key intermediate for the preparation of various organic compounds.
What are the common uses of 3-chloro-5-fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, a common method for the preparation of this substance, follows several paths. First, it can be obtained by reducing 3-chloro-5-fluorobenzoic acid. Capbenzoic acids are treated with suitable reducing agents, and the carboxyl group can be converted into hydroxymethyl groups. Commonly used reducing agents, such as lithium aluminum hydride, have strong reducing properties. Under suitable reaction conditions, the carboxyl group of 3-chloro-5-fluorobenzoic acid can be efficiently reduced to alcoholic hydroxyl groups to obtain the target product 3-chloro-5-fluorobenzyl alcohol. However, lithium aluminum hydride has high reactivity, so caution is required during operation. It is carried out in an anhydrous and oxygen-free environment, and the post-reaction treatment also requires fine operation to prevent accidents.
Second, 3-chloro-5-fluorobenzaldehyde is used as the raw material, and it can also be obtained by reduction. There are many ways to reduce aldehyde groups to alcohol hydroxyl groups, and milder ones, such as using sodium borohydride as the reducing agent. Sodium borohydride has relatively mild reductivity and high operation safety. In common organic solvents, such as methanol and ethanol, 3-chloro-5-fluorobenzaldehyde can be successfully reduced to 3-chloro-5-fluorobenzyl alcohol. The reaction conditions of this process are relatively easy to control, and the post-processing is also relatively simple.
Furthermore, the carbon-carbon bond can be formed by the reaction of Grignard reagent from suitable halogenated aromatics, and then hydroxymethyl groups can be introduced. For example, 3-chloro-5-fluorobromobenzene is reacted with magnesium to make Grignard reagent, and then reacted with formaldehyde or paraformaldehyde. The obtained product is hydrolyzed to obtain 3-chloro-5-fluorobenzyl alcohol. Although this approach is a little complicated, it can flexibly construct molecular structures and has its unique advantages in organic synthesis. After synthesis, it is often necessary to separate and purify, such as column chromatography, recrystallization, etc., to obtain high-purity 3-chloro-5-fluorobenzyl alcohol to meet the needs of different applications.
Second, 3-chloro-5-fluorobenzaldehyde is used as the raw material, and it can also be obtained by reduction. There are many ways to reduce aldehyde groups to alcohol hydroxyl groups, and milder ones, such as using sodium borohydride as the reducing agent. Sodium borohydride has relatively mild reductivity and high operation safety. In common organic solvents, such as methanol and ethanol, 3-chloro-5-fluorobenzaldehyde can be successfully reduced to 3-chloro-5-fluorobenzyl alcohol. The reaction conditions of this process are relatively easy to control, and the post-processing is also relatively simple.
Furthermore, the carbon-carbon bond can be formed by the reaction of Grignard reagent from suitable halogenated aromatics, and then hydroxymethyl groups can be introduced. For example, 3-chloro-5-fluorobromobenzene is reacted with magnesium to make Grignard reagent, and then reacted with formaldehyde or paraformaldehyde. The obtained product is hydrolyzed to obtain 3-chloro-5-fluorobenzyl alcohol. Although this approach is a little complicated, it can flexibly construct molecular structures and has its unique advantages in organic synthesis. After synthesis, it is often necessary to separate and purify, such as column chromatography, recrystallization, etc., to obtain high-purity 3-chloro-5-fluorobenzyl alcohol to meet the needs of different applications.
What are 3-chloro-5-fluorobenzenemethanol synthesis methods?
There are several ways to synthesize 3-chloro-5-fluorobenzyl alcohol. One is to use 3-chloro-5-fluorobenzoic acid as the starting material and obtain it through a reduction reaction. This reduction reaction can be carried out by strong reducing agents such as lithium aluminum hydride in suitable organic solvents such as anhydrous ether or tetrahydrofuran. Lithium aluminum hydride can efficiently reduce carboxyl groups to hydroxymethyl groups to obtain the target product 3-chloro-5-fluorobenzyl alcohol. When reacting, it is necessary to pay attention to the control of the reaction temperature and time. Generally, the reaction is started at a low temperature, and then gradually heated to a suitable temperature to complete the reaction.
Second, it can be started from 3-chloro-5-fluorobrombenzaldehyde. The aldehyde group can be reduced in alcoholic solvents such as methanol or ethanol by mild reducing agents, such as sodium borohydride. Sodium borohydride is selective, only reducing the aldehyde group to hydroxymethyl groups, which has little effect on other functional groups in the molecule. The reaction conditions are relatively mild and easy to operate and control.
Furthermore, 3-chloro-5-fluorobrombenzene is used as a raw material and can be reached by Grignard reagent. First, 3-chloro-5-fluorobrombenzene reacts with magnesium chips in anhydrous ether to generate the corresponding Grignard reagent. Then, the Grignard reagent is reacted with formaldehyde, and then hydrolyzed to obtain 3-chloro-5-fluorobenzyl alcohol. This way requires strict control of the anhydrous and anaerobic conditions of the reaction system to avoid the failure of Grignard reagent.
All synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product and many other factors, the optimal method is selected.
Second, it can be started from 3-chloro-5-fluorobrombenzaldehyde. The aldehyde group can be reduced in alcoholic solvents such as methanol or ethanol by mild reducing agents, such as sodium borohydride. Sodium borohydride is selective, only reducing the aldehyde group to hydroxymethyl groups, which has little effect on other functional groups in the molecule. The reaction conditions are relatively mild and easy to operate and control.
Furthermore, 3-chloro-5-fluorobrombenzene is used as a raw material and can be reached by Grignard reagent. First, 3-chloro-5-fluorobrombenzene reacts with magnesium chips in anhydrous ether to generate the corresponding Grignard reagent. Then, the Grignard reagent is reacted with formaldehyde, and then hydrolyzed to obtain 3-chloro-5-fluorobenzyl alcohol. This way requires strict control of the anhydrous and anaerobic conditions of the reaction system to avoid the failure of Grignard reagent.
All synthesis methods have their own advantages and disadvantages. In practical application, when considering the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product and many other factors, the optimal method is selected.
3-chloro-5-fluorobenzenemethanol What are the precautions in storage and transportation?
3-Chloro-5-fluorobenzyl alcohol is a chemical substance. During storage and transportation, it is necessary to pay more attention to ensure safety.
First words storage. This substance should be stored in a cool, dry and well-ventilated place. Because the cool environment can avoid its property variation due to excessive temperature, and the dry state can prevent it from being damp and causing chemical reactions. In a well-ventilated place, it can avoid the accumulation of harmful gases. Keep away from fire and heat sources, both of which can cause it to catch fire or even explode, which is very dangerous. And it should be stored separately from oxidants, acids, alkalis, etc. Due to its active chemical properties, it is easy to react violently when it encounters such substances. The storage area should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce the damage.
As for transportation, it should not be taken lightly. Make sure that the packaging is complete and well sealed before transportation. The material of the packaging must be able to resist vibration, collision and friction, so as not to leak the material. During transportation, it is necessary to strictly follow the prescribed route to avoid densely populated areas and traffic arteries, so as to avoid accidents that may affect many people. Transportation vehicles should also be equipped with corresponding types and quantities of fire fighting equipment and leakage emergency treatment equipment for emergencies. Escort personnel must be familiar with the nature of this substance and emergency treatment methods, pay close attention during transportation, and deal with it properly immediately if there is any abnormality. In this way, when storing and transporting 3-chloro-5-fluorobenzyl alcohol, all precautions must be observed to ensure the safety of personnel and the environment.
First words storage. This substance should be stored in a cool, dry and well-ventilated place. Because the cool environment can avoid its property variation due to excessive temperature, and the dry state can prevent it from being damp and causing chemical reactions. In a well-ventilated place, it can avoid the accumulation of harmful gases. Keep away from fire and heat sources, both of which can cause it to catch fire or even explode, which is very dangerous. And it should be stored separately from oxidants, acids, alkalis, etc. Due to its active chemical properties, it is easy to react violently when it encounters such substances. The storage area should also be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time to reduce the damage.
As for transportation, it should not be taken lightly. Make sure that the packaging is complete and well sealed before transportation. The material of the packaging must be able to resist vibration, collision and friction, so as not to leak the material. During transportation, it is necessary to strictly follow the prescribed route to avoid densely populated areas and traffic arteries, so as to avoid accidents that may affect many people. Transportation vehicles should also be equipped with corresponding types and quantities of fire fighting equipment and leakage emergency treatment equipment for emergencies. Escort personnel must be familiar with the nature of this substance and emergency treatment methods, pay close attention during transportation, and deal with it properly immediately if there is any abnormality. In this way, when storing and transporting 3-chloro-5-fluorobenzyl alcohol, all precautions must be observed to ensure the safety of personnel and the environment.
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