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3-Chloro-5-Fluorobromobenzene
Linshang Chemical
|
HS Code |
314029 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 195 - 197 °C |
| Density | Data may vary, typically around 1.7 - 1.8 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ether, dichloromethane |
| Vapor Pressure | Low at room temperature |
| Flash Point | Data may vary, but potentially flammable, so flash point relevant |
As an accredited 3-Chloro-5-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 5 - fluorobromobenzene packaged in a sealed glass bottle. |
| Storage | 3 - Chloro - 5 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Ensure the storage location is clearly labeled for easy identification and safety compliance. |
| Shipping | 3 - Chloro - 5 - fluorobromobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers, following all hazardous material regulations. Ensure proper labeling for safe and compliant transportation. |
Competitive 3-Chloro-5-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What are the chemical properties of 3-chloro-5-fluorobromobenzene?
3-Chloro-5-fluorobromobenzene is also an organic compound. It has the properties of halogenated aromatics and is chemically active. It has unique reactivity due to the presence of chlorine, fluorine and bromine halogen atoms.
In this compound, chlorine, fluorine and bromine atoms are all electron-absorbing, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, under appropriate conditions, the electrophilic substitution reaction can still occur, and the substitution check point is affected by the localization effect of the halogen atom. Chlorine, fluorine and bromine are all ortho-para-site locators, but their localization capabilities are different, and the reaction check point caused by the
In addition, due to the characteristics of halogen atoms, nucleophilic substitution reactions can occur. Under the action of nucleophilic reagents, halogen atoms can be replaced by nucleophilic groups. This reaction condition often requires specific solvents and bases. If alcohols are used as solvents, the halogen atoms can be replaced by hydroxyl groups, alkoxy groups, etc. in the presence of bases.
In addition, 3-chloro-5-fluorobrobenzene can participate in the coupling reaction of metal catalysis. For example, under the action of metal catalysts such as palladium and nickel, it reacts with coupling reagents such as boric acids or boric acid esters containing alkenyl groups and aryl groups to form carbon-carbon bonds. This is an important method for constructing complex organic molecules.
Its chemical properties are widely used in the field of organic synthesis, and can be used as intermediates to prepare organic compounds such as medicines, pesticides, and materials, assisting chemists in creating a variety of substances with specific functions.
In this compound, chlorine, fluorine and bromine atoms are all electron-absorbing, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, under appropriate conditions, the electrophilic substitution reaction can still occur, and the substitution check point is affected by the localization effect of the halogen atom. Chlorine, fluorine and bromine are all ortho-para-site locators, but their localization capabilities are different, and the reaction check point caused by the
In addition, due to the characteristics of halogen atoms, nucleophilic substitution reactions can occur. Under the action of nucleophilic reagents, halogen atoms can be replaced by nucleophilic groups. This reaction condition often requires specific solvents and bases. If alcohols are used as solvents, the halogen atoms can be replaced by hydroxyl groups, alkoxy groups, etc. in the presence of bases.
In addition, 3-chloro-5-fluorobrobenzene can participate in the coupling reaction of metal catalysis. For example, under the action of metal catalysts such as palladium and nickel, it reacts with coupling reagents such as boric acids or boric acid esters containing alkenyl groups and aryl groups to form carbon-carbon bonds. This is an important method for constructing complex organic molecules.
Its chemical properties are widely used in the field of organic synthesis, and can be used as intermediates to prepare organic compounds such as medicines, pesticides, and materials, assisting chemists in creating a variety of substances with specific functions.
What are 3-chloro-5-fluorobromobenzene synthesis methods?
The synthesis methods of 3-chloro-5-fluorobromobenzene are quite various, and the following are described in detail by you.
First, the method of halogenation reaction. With benzene as the initial raw material, chlorine atoms are first introduced, and chlorine gas can be used to react with benzene in a catalyst such as ferric chloride under appropriate reaction conditions to obtain chlorobenzene. Then, in a specific reaction system, chlorobenzene is reacted with fluoride to introduce fluorine atoms. Suitable nucleophilic substitution reaction conditions can be selected, such as a suitable base and a specific solvent, chlorobenzene is reacted with a fluorination reagent to generate benzene derivatives containing chlorine and fluorine. Finally, a bromination reaction is carried out with a brominating reagent, such as bromine, in the presence of a suitable catalyst, and bromine atoms are introduced at a specific position to obtain 3-chloro-5-fluorobromobenzene.
Second, through the substitution reaction route. If a suitable benzene derivative with a specific substituent is used as the starting material, and its substituent can be selectively substituted. For example, the substituent on a benzene derivative can be gradually replaced with chlorine, fluorine, and bromine atoms through nucleophilic substitution or electrophilic substitution. After carefully designing the reaction sequence and conditions, the synthesis of 3-chloro-5-fluorobromobenzene can also be achieved. For example, a benzene derivative with a leavable group is first reacted with a chlorine source to introduce chlorine atoms, and then reacted with a fluorine source and a bromine source in sequence, following a reasonable reaction plan to complete the preparation of the target product.
Third, with the help of metal catalysis. Metal catalytic coupling reactions are quite important in organic synthesis. Suitable halogenated benzene derivatives can be selected, such as chlorine-containing halogenated benzene. Under the action of metal catalysts such as palladium catalysts, metal catalytic coupling reactions are carried out with fluorine-containing reagents to form chlorine-containing and fluorine-containing benzene intermediates. Subsequently, using the metal-catalyzed bromination reaction, in a suitable reaction system, the intermediate is reacted with the brominating reagent, and bromine atoms are precisely introduced at a specific position to successfully synthesize 3-chloro-5-fluorobromobenzene. In this process, the selection of metal catalysts, the use of ligands, and the optimization of reaction conditions all have a significant impact on the success or failure of the reaction and the selectivity of the product.
First, the method of halogenation reaction. With benzene as the initial raw material, chlorine atoms are first introduced, and chlorine gas can be used to react with benzene in a catalyst such as ferric chloride under appropriate reaction conditions to obtain chlorobenzene. Then, in a specific reaction system, chlorobenzene is reacted with fluoride to introduce fluorine atoms. Suitable nucleophilic substitution reaction conditions can be selected, such as a suitable base and a specific solvent, chlorobenzene is reacted with a fluorination reagent to generate benzene derivatives containing chlorine and fluorine. Finally, a bromination reaction is carried out with a brominating reagent, such as bromine, in the presence of a suitable catalyst, and bromine atoms are introduced at a specific position to obtain 3-chloro-5-fluorobromobenzene.
Second, through the substitution reaction route. If a suitable benzene derivative with a specific substituent is used as the starting material, and its substituent can be selectively substituted. For example, the substituent on a benzene derivative can be gradually replaced with chlorine, fluorine, and bromine atoms through nucleophilic substitution or electrophilic substitution. After carefully designing the reaction sequence and conditions, the synthesis of 3-chloro-5-fluorobromobenzene can also be achieved. For example, a benzene derivative with a leavable group is first reacted with a chlorine source to introduce chlorine atoms, and then reacted with a fluorine source and a bromine source in sequence, following a reasonable reaction plan to complete the preparation of the target product.
Third, with the help of metal catalysis. Metal catalytic coupling reactions are quite important in organic synthesis. Suitable halogenated benzene derivatives can be selected, such as chlorine-containing halogenated benzene. Under the action of metal catalysts such as palladium catalysts, metal catalytic coupling reactions are carried out with fluorine-containing reagents to form chlorine-containing and fluorine-containing benzene intermediates. Subsequently, using the metal-catalyzed bromination reaction, in a suitable reaction system, the intermediate is reacted with the brominating reagent, and bromine atoms are precisely introduced at a specific position to successfully synthesize 3-chloro-5-fluorobromobenzene. In this process, the selection of metal catalysts, the use of ligands, and the optimization of reaction conditions all have a significant impact on the success or failure of the reaction and the selectivity of the product.
In what areas is 3-chloro-5-fluorobromobenzene applied?
3-Chloro-5-fluorobromobenzene is useful in many fields.
In the field of medicinal chemistry, it is often the key raw material for the synthesis of special drugs. With its halogen atom properties, it can be used for organic synthesis to construct complex and delicate drug molecular structures. For example, when developing new antibacterial and antiviral drugs, using this as the starting material, through multi-step reactions, suitable functional groups can be introduced, making the prepared drugs have high affinity and inhibitory activity against specific pathogens, thus contributing greatly to human health and well-being.
In the field of materials science, it is also indispensable. It can be used as a monomer for the preparation of special performance polymer materials. After polymerization, its structural units are integrated into the polymer chain, giving the material unique electrical, optical or thermal properties. For example, the synthesis of organic photovoltaic materials with excellent photoelectric conversion efficiency is used in the field of solar cells to promote the development of new energy.
Furthermore, in the field of pesticide chemistry, it has a wide range of uses. It can be used as an important intermediate for the synthesis of high-efficiency and low-toxicity pesticides. With its chemical activity, it can create pesticides that are highly lethal to pests but have minimal harm to the environment and non-target organisms, so as to ensure a bumper agricultural harvest and maintain the balance of the ecological environment.
In summary, 3-chloro-5-fluorobromobenzene plays a key role in many important fields such as medicine, materials, and pesticides, promoting technological innovation and development in various fields.
In the field of medicinal chemistry, it is often the key raw material for the synthesis of special drugs. With its halogen atom properties, it can be used for organic synthesis to construct complex and delicate drug molecular structures. For example, when developing new antibacterial and antiviral drugs, using this as the starting material, through multi-step reactions, suitable functional groups can be introduced, making the prepared drugs have high affinity and inhibitory activity against specific pathogens, thus contributing greatly to human health and well-being.
In the field of materials science, it is also indispensable. It can be used as a monomer for the preparation of special performance polymer materials. After polymerization, its structural units are integrated into the polymer chain, giving the material unique electrical, optical or thermal properties. For example, the synthesis of organic photovoltaic materials with excellent photoelectric conversion efficiency is used in the field of solar cells to promote the development of new energy.
Furthermore, in the field of pesticide chemistry, it has a wide range of uses. It can be used as an important intermediate for the synthesis of high-efficiency and low-toxicity pesticides. With its chemical activity, it can create pesticides that are highly lethal to pests but have minimal harm to the environment and non-target organisms, so as to ensure a bumper agricultural harvest and maintain the balance of the ecological environment.
In summary, 3-chloro-5-fluorobromobenzene plays a key role in many important fields such as medicine, materials, and pesticides, promoting technological innovation and development in various fields.
What are the physical properties of 3-chloro-5-fluorobromobenzene?
3-Chloro-5-fluorobromobenzene is one of the organic compounds. Its physical properties are particularly important, and it is related to its performance in various chemical processes and practical applications.
First of all, under normal temperature and pressure, 3-chloro-5-fluorobromobenzene is probably in a liquid state. This is determined by the nature of the intermolecular force. The intermolecular force has van der Waals force, in which the dispersion force, the induction force and the orientation force interact to maintain a liquid state in the common temperature range.
times and melting point and boiling point. The temperature at which a substance changes from a solid state to a liquid state. The melting point of 3-chloro-5-fluorobromobenzene is low. Due to the introduction of chlorine, fluorine and bromine atoms in the molecular structure, the intermolecular arrangement is difficult to be closely ordered, and the lattice energy is reduced, so the melting point is not high. As for the boiling point, it is relatively high. Although the molecule is not very polar, the presence of halogen atoms increases the molecular mass and intermolecular force. To make the molecule break free from the liquid phase, the energy required increases, and the boiling point rises.
Furthermore, solubility. In organic solvents such as ethanol, ether, dichloromethane, etc., 3-chloro-5-fluorobromobenzene has good solubility. Because it is an organic compound, it follows the principle of "similar miscibility". The molecules of the organic solvent and the compound can interact with each other by van der Waals force and miscible with each other. In water, the solubility is not good. Water is a highly polar solvent, and the force between the molecules of 3-chloro-5-fluorobrobenzene is weak, making it difficult to form an effective mixture.
In terms of density, the density of 3-chloro-5-fluorobrobenzene is greater than that of water. This is because the relative atomic mass of the halogen atom chlorine, fluorine, and bromine is larger, resulting in an increase in the molecular mass. Under the same volume, the mass is heavier, so the density is
In addition, the color state of 3-chloro-5-fluorobromobenzene is usually a colorless to light yellow transparent liquid, and it has a certain volatility. It can evaporate slowly in the air and emit a special odor. The generation of this odor is due to the chemical properties of its molecular structure, which interact with olfactory receptors to make people perceive its unique odor.
First of all, under normal temperature and pressure, 3-chloro-5-fluorobromobenzene is probably in a liquid state. This is determined by the nature of the intermolecular force. The intermolecular force has van der Waals force, in which the dispersion force, the induction force and the orientation force interact to maintain a liquid state in the common temperature range.
times and melting point and boiling point. The temperature at which a substance changes from a solid state to a liquid state. The melting point of 3-chloro-5-fluorobromobenzene is low. Due to the introduction of chlorine, fluorine and bromine atoms in the molecular structure, the intermolecular arrangement is difficult to be closely ordered, and the lattice energy is reduced, so the melting point is not high. As for the boiling point, it is relatively high. Although the molecule is not very polar, the presence of halogen atoms increases the molecular mass and intermolecular force. To make the molecule break free from the liquid phase, the energy required increases, and the boiling point rises.
Furthermore, solubility. In organic solvents such as ethanol, ether, dichloromethane, etc., 3-chloro-5-fluorobromobenzene has good solubility. Because it is an organic compound, it follows the principle of "similar miscibility". The molecules of the organic solvent and the compound can interact with each other by van der Waals force and miscible with each other. In water, the solubility is not good. Water is a highly polar solvent, and the force between the molecules of 3-chloro-5-fluorobrobenzene is weak, making it difficult to form an effective mixture.
In terms of density, the density of 3-chloro-5-fluorobrobenzene is greater than that of water. This is because the relative atomic mass of the halogen atom chlorine, fluorine, and bromine is larger, resulting in an increase in the molecular mass. Under the same volume, the mass is heavier, so the density is
In addition, the color state of 3-chloro-5-fluorobromobenzene is usually a colorless to light yellow transparent liquid, and it has a certain volatility. It can evaporate slowly in the air and emit a special odor. The generation of this odor is due to the chemical properties of its molecular structure, which interact with olfactory receptors to make people perceive its unique odor.
What are 3-chloro-5-fluorobromobenzene storage conditions?
3-Chloro-5-fluorobromobenzene is also an organic compound. Its storage is essential, related to safety and quality, and cannot be ignored.
This compound has a certain chemical activity. When storing, the first thing to do is to choose a dry place. Moisture is easy to cause chemical reactions and cause it to deteriorate. Therefore, it should be placed in a well-ventilated and dry warehouse when avoiding moisture. The humidity of the warehouse should be controlled below 60% relative humidity.
The temperature is also critical. High temperature can promote its decomposition or accelerate chemical reactions, and low temperature may cause its physical state to change. Therefore, the storage temperature should be maintained in a cool range, preferably not exceeding 30 degrees Celsius.
Furthermore, this compound should be isolated from oxidizing agents, strong alkalis, etc. Because of its active chemical properties, it is easy to react violently when exposed to oxidizing agents, and even cause the risk of fire and explosion; when exposed to strong alkalis, there may be unpredictable chemical reactions. Therefore, it must be stored in categories and must not be mixed.
In addition, the storage place should be equipped with obvious warning signs to indicate its danger, so that anyone who enters or exits can be alerted. And there must be complete fire and leakage emergency treatment equipment in case of emergency. After taking it, be sure to seal the container to prevent it from being deteriorated due to excessive contact with air.
In this way, 3-chloro-5-fluorobromobenzene can be stored under the above conditions to ensure its quality and avoid safety risks.
This compound has a certain chemical activity. When storing, the first thing to do is to choose a dry place. Moisture is easy to cause chemical reactions and cause it to deteriorate. Therefore, it should be placed in a well-ventilated and dry warehouse when avoiding moisture. The humidity of the warehouse should be controlled below 60% relative humidity.
The temperature is also critical. High temperature can promote its decomposition or accelerate chemical reactions, and low temperature may cause its physical state to change. Therefore, the storage temperature should be maintained in a cool range, preferably not exceeding 30 degrees Celsius.
Furthermore, this compound should be isolated from oxidizing agents, strong alkalis, etc. Because of its active chemical properties, it is easy to react violently when exposed to oxidizing agents, and even cause the risk of fire and explosion; when exposed to strong alkalis, there may be unpredictable chemical reactions. Therefore, it must be stored in categories and must not be mixed.
In addition, the storage place should be equipped with obvious warning signs to indicate its danger, so that anyone who enters or exits can be alerted. And there must be complete fire and leakage emergency treatment equipment in case of emergency. After taking it, be sure to seal the container to prevent it from being deteriorated due to excessive contact with air.
In this way, 3-chloro-5-fluorobromobenzene can be stored under the above conditions to ensure its quality and avoid safety risks.
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