Linshang Chemical
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3-Chloro-5-Iodo(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
350077 |
| Chemical Formula | C7H3ClF3I |
| Molar Mass | 318.45 g/mol |
| Appearance | liquid (usually) |
| Boiling Point | data needed |
| Melting Point | data needed |
| Density | data needed |
| Solubility In Water | insoluble (estimated, aromatic halide with fluoromethyl group) |
| Solubility In Organic Solvents | soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | data needed |
| Flash Point | data needed |
| Stability | stable under normal conditions, but may react with strong oxidizing/reducing agents |
As an accredited 3-Chloro-5-Iodo(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro - 5 - iodo(trifluoromethyl)benzene packaged in a sealed glass bottle. |
| Storage | Store 3 - chloro - 5 - iodo(trifluoromethyl)benzene in a cool, dry, well - ventilated area away from heat sources, flames, and oxidizing agents. Keep it in a tightly sealed container, preferably made of a material resistant to corrosion. Label the container clearly to prevent misidentification and ensure proper handling and storage to maintain its stability and safety. |
| Shipping | 3 - chloro - 5 - iodo(trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning is used to prevent breakage. Shipments follow strict chemical transport regulations to ensure safety during transit. |
Competitive 3-Chloro-5-Iodo(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 3-chloro-5-iodo (trifluoromethyl) benzene?
3-Chloro-5-iodine (trifluoromethyl) benzene, this is an organic compound with unique chemical properties, which is worth exploring.
From the perspective of substituents, chlorine atoms, iodine atoms and trifluoromethyl groups all endow the compound with specific activities. Chlorine atoms and iodine atoms are halogen atoms, which have certain electronegativity, which can affect the distribution of molecular electron clouds and change their reactivity. Iodine atoms are relatively large, and the steric resistance effect is significant, which may play a key role in many reactions. Trifluoromethyl groups have strong electron absorption due to the extremely high electronegativity of fluorine atoms, which decreases the electron cloud density of benzene rings and increases the difficulty of electrophilic substitution reactions, but may make nucleophilic substitution reactions more likely to occur.
For the electrophilic substitution reaction, the electron cloud density of benzene ring decreases due to the electron-withdrawing action of trifluoromethyl, and its reactivity is lower than that of benzene. The new substituent is more inclined to enter the meso-site with relatively high electron cloud density, and the compound has chlorine and iodine in the meso-relationship. Therefore, the selection of the check point for further electrophilic substitution reactions may be affected by both steric resistance and electronic effects.
In the nucleophilic substitution reaction, the halogen atom can be used as the leaving group. Compared with the iodine atom, the chlorine atom is more active as a leaving group. Because of its large atomic radius and relatively small C-I bond energy, the iodine atom is more prone to heterocleavage, so that the compound can undergo nucleophilic substitution reaction under appropriate nucleophilic reagents and reaction conditions.
In addition, the presence of trifluoromethyl may affect the physical properties of the compound, such as solubility and boiling point. Because of its strong hydrophobicity, or the solubility of the compound in organic solvents is better than that of water.
In summary, the chemical properties of 3-chloro-5-iodine (trifluoromethyl) benzene are determined by the electronic and spatial effects of each substituent. In the field of organic synthesis, specific reactions can be designed according to their characteristics to prepare organic materials or pharmaceutical intermediates with special functions.
From the perspective of substituents, chlorine atoms, iodine atoms and trifluoromethyl groups all endow the compound with specific activities. Chlorine atoms and iodine atoms are halogen atoms, which have certain electronegativity, which can affect the distribution of molecular electron clouds and change their reactivity. Iodine atoms are relatively large, and the steric resistance effect is significant, which may play a key role in many reactions. Trifluoromethyl groups have strong electron absorption due to the extremely high electronegativity of fluorine atoms, which decreases the electron cloud density of benzene rings and increases the difficulty of electrophilic substitution reactions, but may make nucleophilic substitution reactions more likely to occur.
For the electrophilic substitution reaction, the electron cloud density of benzene ring decreases due to the electron-withdrawing action of trifluoromethyl, and its reactivity is lower than that of benzene. The new substituent is more inclined to enter the meso-site with relatively high electron cloud density, and the compound has chlorine and iodine in the meso-relationship. Therefore, the selection of the check point for further electrophilic substitution reactions may be affected by both steric resistance and electronic effects.
In the nucleophilic substitution reaction, the halogen atom can be used as the leaving group. Compared with the iodine atom, the chlorine atom is more active as a leaving group. Because of its large atomic radius and relatively small C-I bond energy, the iodine atom is more prone to heterocleavage, so that the compound can undergo nucleophilic substitution reaction under appropriate nucleophilic reagents and reaction conditions.
In addition, the presence of trifluoromethyl may affect the physical properties of the compound, such as solubility and boiling point. Because of its strong hydrophobicity, or the solubility of the compound in organic solvents is better than that of water.
In summary, the chemical properties of 3-chloro-5-iodine (trifluoromethyl) benzene are determined by the electronic and spatial effects of each substituent. In the field of organic synthesis, specific reactions can be designed according to their characteristics to prepare organic materials or pharmaceutical intermediates with special functions.
What are the physical properties of 3-chloro-5-iodo (trifluoromethyl) benzene?
3-Chloro-5-iodine (trifluoromethyl) benzene, this substance is an organic compound. Its physical properties are quite critical and are related to many chemical applications.
When it comes to appearance, under room temperature and pressure, it usually takes the form of a colorless to light yellow liquid, with a clear appearance and good visibility. It is like a clear spring, pure and free of impurities.
Smell it, the substance emits a specific smell, but the specific smell description is quite difficult to be precise. It seems to have a unique aromatic smell, which is slightly different from the smell of common hydrocarbons, but it is difficult to describe exactly. It is like a mysterious spirit hidden in the field of unique odors. The boiling point of
is related to many factors, and in the standard atmospheric pressure environment, the boiling point is roughly within a certain range. This boiling point characteristic determines the conditions for the transformation of the state of matter during the heating process, just like a door leading to the conversion of gaseous and liquid states.
Melting point is also one of the important physical properties. At a specific temperature, the substance will transform from solid to liquid. The level of melting point reflects the strength of the force between molecules, which is like a quantitative manifestation of the force between molecules pulling each other.
In terms of density, 3-chloro-5-iodine (trifluoromethyl) benzene has a higher density than water, so if mixed with water, it will sink to the bottom of the water like a sunken stone, showing obvious stratification.
Solubility is also a key property. In organic solvents, such as common ether, dichloromethane, etc., the substance has good solubility and can be miscible with these organic solvents, just like the fusion of fish and water, but in water, its solubility is extremely poor, just like water and oil. This difference in solubility has important application value in the process of chemical separation and purification, like a sieve that can accurately screen substances.
When it comes to appearance, under room temperature and pressure, it usually takes the form of a colorless to light yellow liquid, with a clear appearance and good visibility. It is like a clear spring, pure and free of impurities.
Smell it, the substance emits a specific smell, but the specific smell description is quite difficult to be precise. It seems to have a unique aromatic smell, which is slightly different from the smell of common hydrocarbons, but it is difficult to describe exactly. It is like a mysterious spirit hidden in the field of unique odors. The boiling point of
is related to many factors, and in the standard atmospheric pressure environment, the boiling point is roughly within a certain range. This boiling point characteristic determines the conditions for the transformation of the state of matter during the heating process, just like a door leading to the conversion of gaseous and liquid states.
Melting point is also one of the important physical properties. At a specific temperature, the substance will transform from solid to liquid. The level of melting point reflects the strength of the force between molecules, which is like a quantitative manifestation of the force between molecules pulling each other.
In terms of density, 3-chloro-5-iodine (trifluoromethyl) benzene has a higher density than water, so if mixed with water, it will sink to the bottom of the water like a sunken stone, showing obvious stratification.
Solubility is also a key property. In organic solvents, such as common ether, dichloromethane, etc., the substance has good solubility and can be miscible with these organic solvents, just like the fusion of fish and water, but in water, its solubility is extremely poor, just like water and oil. This difference in solubility has important application value in the process of chemical separation and purification, like a sieve that can accurately screen substances.
What are the common uses of 3-chloro-5-iodo (trifluoromethyl) benzene?
3-Chloro-5-iodine (trifluoromethyl) benzene, a common method for the synthesis of this substance, follows the principle of organic synthesis.
First, the benzene derivative containing trifluoromethyl is used as the starting material. The chlorine atom is introduced at a specific position in the benzene ring, which can be achieved by electrophilic substitution reaction. If trifluoromethyl benzene is used as the substrate, under appropriate reaction conditions, such as Lewis acid (such as anhydrous aluminum trichloride), it reacts with chlorinated reagents (such as chlorine gas or sulfoxide chloride, etc.), because trifluoromethyl is the meta-locator, chlorine atoms can be selectively introduced into the meta-site to obtain m-chlorotrifluoromethylbenzene.
Then, the iodine atom is introduced into the specific position of the above-mentioned product. This step can utilize the iodine substitution reaction, usually by adding an appropriate oxidizing agent to facilitate the reaction. If m-chlorotrifluoromethylbenzene is used as a raw material, in the presence of potassium iodide and an appropriate oxidizing agent (such as hydrogen peroxide or periodic acid, etc.), in a suitable solvent (such as acetic acid, etc.), the iodine atom will selectively enter the benzene ring and be at a specific position with the chlorine atom (in this case, meta-position and also meta-position with trifluoromethyl) to obtain 3-chloro-5-iodine (trifluoromethyl) benzene.
Second, halogenated benzene First introduce trifluoromethyl, which can be reacted by nucleophilic substitution and other reactions, such as reacting with suitable halogenated benzene (such as m-chloroiodobenzene) and trifluoromethylation reagents (such as trifluoromethyl copper lithium reagent, etc.) to form halogenated benzene containing trifluoromethyl, and then adjust the position of the halogen atom through subsequent appropriate reactions to achieve the synthesis of the target product.
However, all synthesis paths need to pay attention to the precise control of reaction conditions, such as temperature, reactant ratio, reaction time, etc., which are related to the yield and purity of the product. And the selection of reagents involved in each step also needs to comprehensively consider many factors such as reaction activity, cost and operation difficulty.
First, the benzene derivative containing trifluoromethyl is used as the starting material. The chlorine atom is introduced at a specific position in the benzene ring, which can be achieved by electrophilic substitution reaction. If trifluoromethyl benzene is used as the substrate, under appropriate reaction conditions, such as Lewis acid (such as anhydrous aluminum trichloride), it reacts with chlorinated reagents (such as chlorine gas or sulfoxide chloride, etc.), because trifluoromethyl is the meta-locator, chlorine atoms can be selectively introduced into the meta-site to obtain m-chlorotrifluoromethylbenzene.
Then, the iodine atom is introduced into the specific position of the above-mentioned product. This step can utilize the iodine substitution reaction, usually by adding an appropriate oxidizing agent to facilitate the reaction. If m-chlorotrifluoromethylbenzene is used as a raw material, in the presence of potassium iodide and an appropriate oxidizing agent (such as hydrogen peroxide or periodic acid, etc.), in a suitable solvent (such as acetic acid, etc.), the iodine atom will selectively enter the benzene ring and be at a specific position with the chlorine atom (in this case, meta-position and also meta-position with trifluoromethyl) to obtain 3-chloro-5-iodine (trifluoromethyl) benzene.
Second, halogenated benzene First introduce trifluoromethyl, which can be reacted by nucleophilic substitution and other reactions, such as reacting with suitable halogenated benzene (such as m-chloroiodobenzene) and trifluoromethylation reagents (such as trifluoromethyl copper lithium reagent, etc.) to form halogenated benzene containing trifluoromethyl, and then adjust the position of the halogen atom through subsequent appropriate reactions to achieve the synthesis of the target product.
However, all synthesis paths need to pay attention to the precise control of reaction conditions, such as temperature, reactant ratio, reaction time, etc., which are related to the yield and purity of the product. And the selection of reagents involved in each step also needs to comprehensively consider many factors such as reaction activity, cost and operation difficulty.
What are the synthesis methods of 3-chloro-5-iodo (trifluoromethyl) benzene?
There are several methods for synthesizing 3-chloro-5-iodine (trifluoromethyl) benzene. First, it can be obtained from the electrophilic substitution reaction of aromatic hydrocarbons. First, take the benzene derivative containing trifluoromethyl, use chlorine as the electrophilic reagent, and carry out the chlorination reaction under the action of an appropriate catalyst such as ferric chloride. Introduce chlorine atoms at specific positions in the benzene ring to obtain the benzene intermediate containing chlorine and trifluoromethyl. Then, use this intermediate as the substrate, and then use iodine as the electrophilic reagent. Under suitable conditions, with the help of a catalyst, carry out the iodization reaction, so that the iodine atoms are also connected to the designated positions in the benzene ring, and finally obtain the target product 3-chloro
Second, it can be synthesized by the cross-coupling reaction of halogenated aromatics. First, a benzene derivative containing trifluoromethyl and one end is halogen (such as bromine), and one end containing chlorine and iodine is a metal-organic reagent (such as organozinc reagent, organoboron reagent, etc.). Then, under the catalysis of transition metal catalysts (such as palladium catalysts), the two are cross-coupled. In this reaction, the carbon-metal bond of the metal-organic reagent and the carbon-halogen bond of the halogenated aromatic hydrocarbon are broken and recombined, resulting in the formation of the target product 3-chloro-5-iodine (trifluoromethyl) benzene.
Or, first synthesize benzene derivatives containing trifluoromethyl and iodine, and then introduce chlorine atoms through halogenation reaction. Take a suitable trifluoromethyl benzene substrate, first replace the iodine with an iodine reagent, and under specific reaction conditions, connect the iodine to the benzene ring. Then, the product containing iodine and trifluoromethyl is chlorinated in the presence of a chlorination reagent and a catalyst, and chlorine atoms are successfully introduced to obtain 3-chloro-5-iodine (trifluoromethyl) benzene. These methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.
Second, it can be synthesized by the cross-coupling reaction of halogenated aromatics. First, a benzene derivative containing trifluoromethyl and one end is halogen (such as bromine), and one end containing chlorine and iodine is a metal-organic reagent (such as organozinc reagent, organoboron reagent, etc.). Then, under the catalysis of transition metal catalysts (such as palladium catalysts), the two are cross-coupled. In this reaction, the carbon-metal bond of the metal-organic reagent and the carbon-halogen bond of the halogenated aromatic hydrocarbon are broken and recombined, resulting in the formation of the target product 3-chloro-5-iodine (trifluoromethyl) benzene.
Or, first synthesize benzene derivatives containing trifluoromethyl and iodine, and then introduce chlorine atoms through halogenation reaction. Take a suitable trifluoromethyl benzene substrate, first replace the iodine with an iodine reagent, and under specific reaction conditions, connect the iodine to the benzene ring. Then, the product containing iodine and trifluoromethyl is chlorinated in the presence of a chlorination reagent and a catalyst, and chlorine atoms are successfully introduced to obtain 3-chloro-5-iodine (trifluoromethyl) benzene. These methods have their own advantages and disadvantages, and they need to be used according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.
What should I pay attention to when storing and transporting 3-chloro-5-iodo (trifluoromethyl) benzene?
3-Chloro-5-iodine (trifluoromethyl) benzene is an organic compound. When storing and transporting it, many key matters must be paid attention to.
For the first storage, this compound needs to be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature is easy to decompose or cause other chemical reactions, so the temperature should be maintained at room temperature or lower, generally not exceeding 30 ° C. Air humidity cannot be ignored. High humidity environment may cause moisture deterioration, and the humidity of the storage place should be controlled below 60% relative humidity. And be sure to keep away from fire sources, heat sources and oxidants. Because of its flammability and reactivity, it may cause severe combustion or even explosion when encountering fire sources or oxidants. At the same time, it should be stored in a special chemical storage cabinet, classified according to its nature, to avoid mixing with other chemicals such as acids and alkalis, in order to prevent uncontrollable chemical reactions.
When transporting, packaging is crucial. It is necessary to use packaging materials with good sealing and corrosion resistance, such as special glass or plastic bottles, and supplemented by cushioning materials to prevent damage due to collisions during transportation. Transportation vehicles also need to select professional vehicles with corresponding qualifications to ensure that the vehicle is well ventilated and the temperature and humidity are controllable. Transportation personnel must be professionally trained to be familiar with the dangerous characteristics of this compound and emergency treatment measures. During transportation, vibration, impact and friction should be strictly avoided to prevent chemical leakage due to package damage. In the event of a leak, appropriate measures should be taken immediately according to the emergency plan, evacuate the surrounding personnel, isolate the leakage area, and promptly notify professionals to deal with it.
For the first storage, this compound needs to be stored in a cool, dry and well-ventilated place. Because it is more sensitive to heat, high temperature is easy to decompose or cause other chemical reactions, so the temperature should be maintained at room temperature or lower, generally not exceeding 30 ° C. Air humidity cannot be ignored. High humidity environment may cause moisture deterioration, and the humidity of the storage place should be controlled below 60% relative humidity. And be sure to keep away from fire sources, heat sources and oxidants. Because of its flammability and reactivity, it may cause severe combustion or even explosion when encountering fire sources or oxidants. At the same time, it should be stored in a special chemical storage cabinet, classified according to its nature, to avoid mixing with other chemicals such as acids and alkalis, in order to prevent uncontrollable chemical reactions.
When transporting, packaging is crucial. It is necessary to use packaging materials with good sealing and corrosion resistance, such as special glass or plastic bottles, and supplemented by cushioning materials to prevent damage due to collisions during transportation. Transportation vehicles also need to select professional vehicles with corresponding qualifications to ensure that the vehicle is well ventilated and the temperature and humidity are controllable. Transportation personnel must be professionally trained to be familiar with the dangerous characteristics of this compound and emergency treatment measures. During transportation, vibration, impact and friction should be strictly avoided to prevent chemical leakage due to package damage. In the event of a leak, appropriate measures should be taken immediately according to the emergency plan, evacuate the surrounding personnel, isolate the leakage area, and promptly notify professionals to deal with it.
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