Linshang Chemical
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3-Chloro Benzene Boronic Acid:
Linshang Chemical
|
HS Code |
177327 |
| Chemical Formula | C6H6BClO2 |
| Molar Mass | 156.37 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 155 - 160 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Pka | Around 8.5 |
| Boiling Point | Decomposes before boiling |
| Stability | Stable under normal conditions, but sensitive to strong oxidizing agents |
As an accredited 3-Chloro Benzene Boronic Acid: factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloro Benzene Boronic Acid packaged in a sealed chemical - grade bottle. |
| Storage | 3 - Chloro benzene boronic acid should be stored in a cool, dry place, away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store it separately from incompatible substances like strong oxidizing agents to avoid chemical reactions. Follow all safety regulations during storage. |
| Shipping | 3 - Chloro Benzene Boronic Acid is shipped in well - sealed, corrosion - resistant containers. It follows strict chemical transportation regulations to ensure safety during transit, safeguarding against spills and environmental exposure. |
Competitive 3-Chloro Benzene Boronic Acid: prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Where to Buy 3-Chloro Benzene Boronic Acid: in China?
As a trusted 3-Chloro Benzene Boronic Acid: manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloro Benzene Boronic Acid: supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
3-Chloro Benzene Boronic Acid: What are its main applications?
3-Chlorophenylboronic acid, an important reagent in organic synthesis, is widely used in many fields.
First, in the field of medicinal chemistry, it can be used as a key intermediate. Drug development requires the construction of complex organic molecular structures. 3-chlorophenylboronic acid can be linked to other halogenated aromatics or olefins through coupling reactions to precisely build a drug molecular framework. For example, when developing specific anti-cancer drugs, it is connected to biologically active fragments through such reactions to construct molecules with specific pharmacological activities, which can help develop new anti-cancer drugs with better efficacy and fewer side effects.
Second, in the field of materials science, it is often used to prepare functional materials. For example, when preparing organic optoelectronic materials, by using them to participate in the reaction, specific functional groups can be introduced to change the electronic structure and optical properties of the material, so as to meet the requirements of organic Light Emitting Diode (OLED), organic solar cells and other devices on material properties, and improve the luminous efficiency, stability and photoelectric conversion efficiency of the device.
Third, it plays an important role in the field of total synthesis of natural products. Natural products have complex structures and are difficult to synthesize. The reaction involving 3-chlorophenylboronic acid can realize complex structure construction and modification, and help chemists complete the total synthesis of difficult natural products, laying the foundation for in-depth research on the biological activity and pharmacological effects of natural products.
Fourth, in the study of organic synthesis methodologies, it is a commonly used research object. Scientists develop novel organic synthesis methods and strategies by exploring their reaction mechanisms and selectivity with different reagents and under different reaction conditions, promoting the development of organic synthesis chemistry and providing more efficient and green methods for organic synthesis.
First, in the field of medicinal chemistry, it can be used as a key intermediate. Drug development requires the construction of complex organic molecular structures. 3-chlorophenylboronic acid can be linked to other halogenated aromatics or olefins through coupling reactions to precisely build a drug molecular framework. For example, when developing specific anti-cancer drugs, it is connected to biologically active fragments through such reactions to construct molecules with specific pharmacological activities, which can help develop new anti-cancer drugs with better efficacy and fewer side effects.
Second, in the field of materials science, it is often used to prepare functional materials. For example, when preparing organic optoelectronic materials, by using them to participate in the reaction, specific functional groups can be introduced to change the electronic structure and optical properties of the material, so as to meet the requirements of organic Light Emitting Diode (OLED), organic solar cells and other devices on material properties, and improve the luminous efficiency, stability and photoelectric conversion efficiency of the device.
Third, it plays an important role in the field of total synthesis of natural products. Natural products have complex structures and are difficult to synthesize. The reaction involving 3-chlorophenylboronic acid can realize complex structure construction and modification, and help chemists complete the total synthesis of difficult natural products, laying the foundation for in-depth research on the biological activity and pharmacological effects of natural products.
Fourth, in the study of organic synthesis methodologies, it is a commonly used research object. Scientists develop novel organic synthesis methods and strategies by exploring their reaction mechanisms and selectivity with different reagents and under different reaction conditions, promoting the development of organic synthesis chemistry and providing more efficient and green methods for organic synthesis.
3-Chloro Benzene Boronic Acid: What are the synthesis methods?
There are several common methods for preparing 3-chlorophenylboronic acid. One is the metallization of halogenated aromatics. First, 3-chlorobrombenzene reacts with butyllithium at a low temperature, such as minus 78 degrees Celsius, in an inert solvent such as anhydrous ether or tetrahydrofuran. The butyl of butyllithium captures the hydrogen of 3-chlorobromophenylbromide ortho-position to form an organolithium intermediate, which is very active. Then trimethyl borate is added and hydrolyzed to obtain 3-chlorophenylboronic acid. This process requires strict anhydrous and anaerobic, because organolithium compounds are highly reactive in contact with water and oxygen.
The second is the palladium catalytic coupling method. Using 3-chlorobenzene halide (such as 3-chlorobrombenzene or 3-chloroiodobenzene) and diphenol borate as raw materials, under the action of palladium catalyst, such as tetra (triphenylphosphine) palladium (0), in a suitable solvent, such as 1,4-dioxane or toluene, a base such as potassium carbonate is added to heat the reaction. The palladium catalyst promotes the coupling of halobenzene and borate to form 3-chlorobenzene borate, and then hydrolyzes to obtain the target product 3-chlorobenzene borate. This method has good selectivity and relatively mild conditions, but the cost of palladium catalyst is higher.
The third is the Grignard reagent method. 3-Chlorobromobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to make Grignard's reagent. Grignard's reagent is also highly active, and then reacts with borate esters, and then hydrolyzes to obtain 3-chlorophenylboronic acid. This process also needs to be strictly anhydrous, and the reaction rate and temperature need to be controlled during the preparation of Grignard's reagent. All methods have advantages and disadvantages. In actual preparation, the appropriate method should be selected according to factors such as raw material availability, cost, and product purity.
The second is the palladium catalytic coupling method. Using 3-chlorobenzene halide (such as 3-chlorobrombenzene or 3-chloroiodobenzene) and diphenol borate as raw materials, under the action of palladium catalyst, such as tetra (triphenylphosphine) palladium (0), in a suitable solvent, such as 1,4-dioxane or toluene, a base such as potassium carbonate is added to heat the reaction. The palladium catalyst promotes the coupling of halobenzene and borate to form 3-chlorobenzene borate, and then hydrolyzes to obtain the target product 3-chlorobenzene borate. This method has good selectivity and relatively mild conditions, but the cost of palladium catalyst is higher.
The third is the Grignard reagent method. 3-Chlorobromobenzene is reacted with magnesium chips in anhydrous ether or tetrahydrofuran to make Grignard's reagent. Grignard's reagent is also highly active, and then reacts with borate esters, and then hydrolyzes to obtain 3-chlorophenylboronic acid. This process also needs to be strictly anhydrous, and the reaction rate and temperature need to be controlled during the preparation of Grignard's reagent. All methods have advantages and disadvantages. In actual preparation, the appropriate method should be selected according to factors such as raw material availability, cost, and product purity.
3-Chloro Benzene Boronic Acid: What Are Its Physical Properties?
3-Chlorophenylboronic acid, its physical properties are as follows.
In terms of view, 3-chlorophenylboronic acid is often in the state of white to white solid powder. This form makes it easy to weigh, transfer and mix in many reaction systems, and the powdered substance has a large specific surface area. During chemical reactions, it can be more fully contacted with other reactants and promote the reaction.
When it comes to the melting point, it is generally between 140 ° C and 145 ° C. The melting point is an important physical property. This temperature limit indicates that when the ambient temperature rises to this range, 3-chlorophenylboronic acid will change from a solid state to a liquid state. The determination of melting point is not only helpful for the identification of substances, but also of great significance for the control of conditions in synthesis and purification.
In terms of solubility, 3-chlorophenylboronic acid has certain solubility in common organic solvents such as methanol, ethanol, and dichloromethane. In polar organic solvents such as methanol and ethanol, due to the existence of boron atoms and hydroxyl groups in 3-chlorophenylboronic acid molecules, it can form hydrogen bonds with alcohol solvents, so it is soluble; in weak polar organic solvents such as dichloromethane, although its polarity is different from that of 3-chlorophenylboronic acid molecules, there are still Van der Waals forces between molecules, which make it soluble to a certain extent. However, in water, its solubility is relatively poor. Due to the strong polarity of water molecules, the matching degree of force between 3-chlorophenylboronic acid molecules is not good.
The density is about 1.38 g/cm ³. The density reflects the mass per unit volume of the substance. This value determines the relationship between the space occupied by 3-chlorophenylboronic acid and the mass when participating in the reaction or storage. It has a guiding effect on the quantity of materials and the selection of containers in actual operation.
In summary, the white powder morphology, specific melting point, solubility and density of 3-chlorophenylboronic acid play a key role in its application in organic synthesis, medicinal chemistry and other fields. According to its properties, researchers can rationally design reactions and optimize processes.
In terms of view, 3-chlorophenylboronic acid is often in the state of white to white solid powder. This form makes it easy to weigh, transfer and mix in many reaction systems, and the powdered substance has a large specific surface area. During chemical reactions, it can be more fully contacted with other reactants and promote the reaction.
When it comes to the melting point, it is generally between 140 ° C and 145 ° C. The melting point is an important physical property. This temperature limit indicates that when the ambient temperature rises to this range, 3-chlorophenylboronic acid will change from a solid state to a liquid state. The determination of melting point is not only helpful for the identification of substances, but also of great significance for the control of conditions in synthesis and purification.
In terms of solubility, 3-chlorophenylboronic acid has certain solubility in common organic solvents such as methanol, ethanol, and dichloromethane. In polar organic solvents such as methanol and ethanol, due to the existence of boron atoms and hydroxyl groups in 3-chlorophenylboronic acid molecules, it can form hydrogen bonds with alcohol solvents, so it is soluble; in weak polar organic solvents such as dichloromethane, although its polarity is different from that of 3-chlorophenylboronic acid molecules, there are still Van der Waals forces between molecules, which make it soluble to a certain extent. However, in water, its solubility is relatively poor. Due to the strong polarity of water molecules, the matching degree of force between 3-chlorophenylboronic acid molecules is not good.
The density is about 1.38 g/cm ³. The density reflects the mass per unit volume of the substance. This value determines the relationship between the space occupied by 3-chlorophenylboronic acid and the mass when participating in the reaction or storage. It has a guiding effect on the quantity of materials and the selection of containers in actual operation.
In summary, the white powder morphology, specific melting point, solubility and density of 3-chlorophenylboronic acid play a key role in its application in organic synthesis, medicinal chemistry and other fields. According to its properties, researchers can rationally design reactions and optimize processes.
3-Chloro Benzene Boronic Acid: What is the market price?
3-Chlorophenylboronic acid is in the market, and its price varies according to many conditions. In the past, the price of such materials often depended on supply and demand, difficulty in preparation, and quality.
If the state of supply and demand is stable, the production process is mature and popular, and the supply in the market is abundant, its price may become stable and cheap. Because of the skilled production method, many workshops can produce it, and the supply increases, the price is difficult to be high.
However, if the production is difficult, rare raw materials or difficult skills are required, and the market demand is strong, its price will be high. Rare raw materials are hard to find, resulting in a significant increase in costs; difficult skills require high craftsmanship and sophisticated utensils, which all raise the cost of output, and the price is also high.
And at the end of the quality, high-purity 3-chlorophenylboronic acid, because its preparation requires more exquisite means, can be suitable for high-end uses, and the price is higher than that of ordinary ones. Low purity or only for ordinary work, the price is slightly lower.
Furthermore, the wide and narrow city and the slow transportation also affect its price. Selling far to different places, transportation insurance is difficult and expensive, and the price also increases.
Overall, in order to know the exact market price of 3-chlorophenylboronic acid, we must carefully examine the market conditions at that time, visit various suppliers, and compare all quotations.
If the state of supply and demand is stable, the production process is mature and popular, and the supply in the market is abundant, its price may become stable and cheap. Because of the skilled production method, many workshops can produce it, and the supply increases, the price is difficult to be high.
However, if the production is difficult, rare raw materials or difficult skills are required, and the market demand is strong, its price will be high. Rare raw materials are hard to find, resulting in a significant increase in costs; difficult skills require high craftsmanship and sophisticated utensils, which all raise the cost of output, and the price is also high.
And at the end of the quality, high-purity 3-chlorophenylboronic acid, because its preparation requires more exquisite means, can be suitable for high-end uses, and the price is higher than that of ordinary ones. Low purity or only for ordinary work, the price is slightly lower.
Furthermore, the wide and narrow city and the slow transportation also affect its price. Selling far to different places, transportation insurance is difficult and expensive, and the price also increases.
Overall, in order to know the exact market price of 3-chlorophenylboronic acid, we must carefully examine the market conditions at that time, visit various suppliers, and compare all quotations.
3-Chloro Benzene Boronic Acid: What Are the Quality Standards?
The Quality Standard of 3-chlorophenylboronic acid is crucial to its quality and application efficiency. The Quality Standard of this substance covers the following items:
One is appearance. Normally, 3-chlorophenylboronic acid should be white to off-white crystalline powder. If the appearance color and shape are different, it may suggest purity or impurities.
The second is purity. This is an important indicator and usually needs to be determined by high-performance liquid chromatography (HPLC) and other accurate analytical methods. High-purity 3-chlorophenylboronic acid should generally have a purity of more than 98%. The higher the purity, the more suitable it is for high-end chemical synthesis and pharmaceutical research and development.
The third is the melting point. 3-chlorophenylboronic acid has a specific melting point range. By accurately measuring the melting point, its purity and material characteristics can be preliminarily determined. Its melting point range is roughly within a certain range. If the measured melting point deviates from this range, it may mean that there is impurity interference.
The fourth is the impurity content. Including organic impurities and inorganic impurities, organic impurities can be quantified and qualitative analysis by HPLC and other methods; inorganic impurities such as heavy metal content need to be detected by atomic absorption spectroscopy (AAS) and other technologies. Strict control of impurity content can ensure its stability and reliability in various applications.
The fifth is moisture content. The amount of moisture can affect the stability and reactivity of 3-chlorophenylboronic acid. It is often determined by Karl Fischer method, etc., and the moisture content needs to be controlled within a reasonable range.
Only by strictly following these Quality Standards and carefully controlling various indicators can high-quality 3-chlorophenylboronic acid be produced to meet the needs of chemical, pharmaceutical and other fields.
One is appearance. Normally, 3-chlorophenylboronic acid should be white to off-white crystalline powder. If the appearance color and shape are different, it may suggest purity or impurities.
The second is purity. This is an important indicator and usually needs to be determined by high-performance liquid chromatography (HPLC) and other accurate analytical methods. High-purity 3-chlorophenylboronic acid should generally have a purity of more than 98%. The higher the purity, the more suitable it is for high-end chemical synthesis and pharmaceutical research and development.
The third is the melting point. 3-chlorophenylboronic acid has a specific melting point range. By accurately measuring the melting point, its purity and material characteristics can be preliminarily determined. Its melting point range is roughly within a certain range. If the measured melting point deviates from this range, it may mean that there is impurity interference.
The fourth is the impurity content. Including organic impurities and inorganic impurities, organic impurities can be quantified and qualitative analysis by HPLC and other methods; inorganic impurities such as heavy metal content need to be detected by atomic absorption spectroscopy (AAS) and other technologies. Strict control of impurity content can ensure its stability and reliability in various applications.
The fifth is moisture content. The amount of moisture can affect the stability and reactivity of 3-chlorophenylboronic acid. It is often determined by Karl Fischer method, etc., and the moisture content needs to be controlled within a reasonable range.
Only by strictly following these Quality Standards and carefully controlling various indicators can high-quality 3-chlorophenylboronic acid be produced to meet the needs of chemical, pharmaceutical and other fields.
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