Linshang Chemical
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3-Chlorobenzeneboronic Acid / 3-Chlorophenylboronic Acid
Linshang Chemical
|
HS Code |
430701 |
| Chemical Formula | C6H6BClO2 |
| Molecular Weight | 156.38 |
| Appearance | White to off - white solid |
| Melting Point | 143 - 148 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Pka Value | ~8.8 |
| Density | 1.35 g/cm³ |
| Cas Number | 1073-06-9 |
As an accredited 3-Chlorobenzeneboronic Acid / 3-Chlorophenylboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chlorobenzeneboronic acid packaged in a sealed, chemical - resistant bottle. |
| Storage | 3 - Chlorobenzeneboronic Acid/3 - Chlorophenylboronic Acid should be stored in a cool, dry place. Keep it in a tightly - sealed container to prevent moisture absorption, as boronic acids can react with water. Store away from heat sources and incompatible substances like strong oxidizing agents. Ensure the storage area has good ventilation to minimize exposure risks. |
| Shipping | 3 - Chlorobenzeneboronic Acid/3 - Chlorophenylboronic Acid is shipped in well - sealed containers. They are carefully packed to prevent breakage and leakage, following strict chemical transportation regulations to ensure safety during transit. |
Competitive 3-Chlorobenzeneboronic Acid / 3-Chlorophenylboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chlorobenzeneboronic Acid / 3-Chlorophenylboronic Acid in China?
As a trusted 3-Chlorobenzeneboronic Acid / 3-Chlorophenylboronic Acid manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chlorobenzeneboronic Acid / 3-Chlorophenylboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chlorophenylboronic acid (3-chlorobenzeneboronic Acid/3-chlorophenylboronic Acid)?
3-Chlorophenylboronic acid, in the shape of crystalline powder, is often nearly white in color. This substance has a wide range of uses and is a key reagent in the field of organic synthesis.
First, it plays a significant role in the formation of carbon-carbon bonds. For example, in the Suzuki-Miyaura coupling reaction, 3-chlorophenylboronic acid can efficiently form carbon-carbon bonds with halogenated aromatics or olefins under palladium catalysis. This reaction condition is mild and the selectivity is very good. It is often used to build complex molecular structures in drug synthesis and material preparation. With this method, organic molecules with specific structures and functions can be precisely synthesized, paving the way for the creation of new drugs and high-performance materials.
Second, in the field of materials science, 3-chlorophenylboronic acid is also useful. It can be used to prepare optoelectronic materials. Due to its structural properties, it can endow materials with unique optical and electrical properties. For example, by specific chemical modifications, it can be used as a component of an organic Light Emitting Diode (OLED) or an organic photovoltaic cell to improve the absorption and emission efficiency of the material to light, or to improve the charge transport ability, thereby optimizing the device performance.
Furthermore, in terms of chemical sensors, 3-chlorophenylboronic acid can be used as a recognition element. Because of its specific interaction with specific molecules, sensors that respond sensitively to substances such as sugars and amino acids can be designed with this property. When the target molecule is present, it triggers detectable signal changes, such as changes in color and fluorescence intensity, to achieve rapid and accurate detection of specific substances, with great potential for applications in biomedical detection, environmental monitoring, and other scenarios.
First, it plays a significant role in the formation of carbon-carbon bonds. For example, in the Suzuki-Miyaura coupling reaction, 3-chlorophenylboronic acid can efficiently form carbon-carbon bonds with halogenated aromatics or olefins under palladium catalysis. This reaction condition is mild and the selectivity is very good. It is often used to build complex molecular structures in drug synthesis and material preparation. With this method, organic molecules with specific structures and functions can be precisely synthesized, paving the way for the creation of new drugs and high-performance materials.
Second, in the field of materials science, 3-chlorophenylboronic acid is also useful. It can be used to prepare optoelectronic materials. Due to its structural properties, it can endow materials with unique optical and electrical properties. For example, by specific chemical modifications, it can be used as a component of an organic Light Emitting Diode (OLED) or an organic photovoltaic cell to improve the absorption and emission efficiency of the material to light, or to improve the charge transport ability, thereby optimizing the device performance.
Furthermore, in terms of chemical sensors, 3-chlorophenylboronic acid can be used as a recognition element. Because of its specific interaction with specific molecules, sensors that respond sensitively to substances such as sugars and amino acids can be designed with this property. When the target molecule is present, it triggers detectable signal changes, such as changes in color and fluorescence intensity, to achieve rapid and accurate detection of specific substances, with great potential for applications in biomedical detection, environmental monitoring, and other scenarios.
What are the synthesis methods of 3-chlorophenylboronic acid (3-chlorobenzeneboronic Acid/3-chlorophenylboronic Acid)
There are several common methods for the synthesis of 3-chlorobenzeneboronic Acid/3-chlorophenylboronic Acid as follows.
One is the Grignard reagent method. The Grignard reagent 3-chlorophenyl magnesium bromide is prepared by reacting 3-chlorobenzene with magnesium chips in an anhydrous ether or tetrahydrofuran and other organic solvents. This process needs to be carried out in an anhydrous and anaerobic environment. Because the Grignard reagent is extremely active, it is easy to react with water or oxygen and fails. Then the Grignard reagent is reacted with trimethyl borate at low temperature, the reaction is completed, and the hydrolysis treatment is carried out with dilute acid such as hydrochloric acid or dilute sulfuric acid to obtain 3-chlorophenylboronic acid. Although this method is classic, the preparation conditions of Grignard reagent are strict and the operation requirements are quite high.
The second is the palladium catalytic coupling method. Using 3-chlorohalobenzene (such as 3-chlorobromobenzene or 3-chloroiodobenzene) and diphenol borate as raw materials, in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as tri-tert-butylphosphine, etc.), in suitable organic solvents (such as toluene, dioxane, etc.), the reaction usually requires the participation of bases (such as potassium carbonate, sodium carbonate, etc.) to promote the reaction. This method has relatively mild reaction conditions and good selectivity, but the palladium catalyst is expensive and costly.
The third is the lithium reagent method. 3-Chlorohalobenzene reacts with butyl lithium at low temperature to form 3-chlorophenyl lithium reagent. The lithium reagent is then reacted with borate ester, and the target product 3-chlorophenylboronic acid can be obtained by subsequent hydrolysis steps. This method also requires low temperature and anhydrous and anaerobic conditions. The lithium reagent has high activity, and extra caution is required during operation.
Synthesis of 3-chlorophenylboronic acid has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, cost, and product purity to choose an appropriate method.
One is the Grignard reagent method. The Grignard reagent 3-chlorophenyl magnesium bromide is prepared by reacting 3-chlorobenzene with magnesium chips in an anhydrous ether or tetrahydrofuran and other organic solvents. This process needs to be carried out in an anhydrous and anaerobic environment. Because the Grignard reagent is extremely active, it is easy to react with water or oxygen and fails. Then the Grignard reagent is reacted with trimethyl borate at low temperature, the reaction is completed, and the hydrolysis treatment is carried out with dilute acid such as hydrochloric acid or dilute sulfuric acid to obtain 3-chlorophenylboronic acid. Although this method is classic, the preparation conditions of Grignard reagent are strict and the operation requirements are quite high.
The second is the palladium catalytic coupling method. Using 3-chlorohalobenzene (such as 3-chlorobromobenzene or 3-chloroiodobenzene) and diphenol borate as raw materials, in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as tri-tert-butylphosphine, etc.), in suitable organic solvents (such as toluene, dioxane, etc.), the reaction usually requires the participation of bases (such as potassium carbonate, sodium carbonate, etc.) to promote the reaction. This method has relatively mild reaction conditions and good selectivity, but the palladium catalyst is expensive and costly.
The third is the lithium reagent method. 3-Chlorohalobenzene reacts with butyl lithium at low temperature to form 3-chlorophenyl lithium reagent. The lithium reagent is then reacted with borate ester, and the target product 3-chlorophenylboronic acid can be obtained by subsequent hydrolysis steps. This method also requires low temperature and anhydrous and anaerobic conditions. The lithium reagent has high activity, and extra caution is required during operation.
Synthesis of 3-chlorophenylboronic acid has its own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, cost, and product purity to choose an appropriate method.
What are the physical properties of 3-chlorophenylboronic acid (3-chlorobenzeneboronic Acid/3-chlorophenylboronic Acid)
3-Chlorophenylboronic acid, also known as 3-chlorobenzeneboronic Acid or 3-chlorophenylboronic Acid, is a commonly used reagent in organic synthesis. Its physical properties are crucial and closely related to many chemical processes.
Looking at its properties, under normal temperature and pressure, 3-chlorophenylboronic acid is mostly white to white solid crystals. This solid state property makes it easy to store and use, and it has good stability in conventional laboratory and industrial operating environments.
The melting point is about 235-239 ° C. As an important physical constant of a substance, the melting point reflects its lattice structure and the strength of intermolecular forces. Such a range of melting points indicates that moderate heating is required to convert it from solid to liquid. Within this temperature range, the structure and properties of the substance are relatively stable.
Solubility is also one of the key physical properties. 3-chlorophenylboronic acid is slightly soluble in common organic solvents such as ether and petroleum ether, but can be better dissolved in polar solvents such as methanol, ethanol and dichloromethane. This solubility property provides convenience for its application in organic synthesis reactions. Good solubility in polar solvents allows it to fully contact and mix with reactants that are also soluble in such solvents, and then react effectively.
In addition, 3-chlorophenylboronic acid has a certain solubility in water, but its solubility is relatively limited. This property is particularly important when it comes to aqueous or two-phase reaction systems, and determines whether they can function in a specific reaction environment.
Although the density is not precise and widely reported, the density of 3-chlorophenylboronic acid may also be in this range based on the density of similar boron-containing aromatic compounds, which is usually estimated in the range of 1.3-1.5 g/cm ³. Density, as the mass per unit volume of a substance, has guiding significance for the setting of its measurement and mixing ratio in practical operation.
Looking at its properties, under normal temperature and pressure, 3-chlorophenylboronic acid is mostly white to white solid crystals. This solid state property makes it easy to store and use, and it has good stability in conventional laboratory and industrial operating environments.
The melting point is about 235-239 ° C. As an important physical constant of a substance, the melting point reflects its lattice structure and the strength of intermolecular forces. Such a range of melting points indicates that moderate heating is required to convert it from solid to liquid. Within this temperature range, the structure and properties of the substance are relatively stable.
Solubility is also one of the key physical properties. 3-chlorophenylboronic acid is slightly soluble in common organic solvents such as ether and petroleum ether, but can be better dissolved in polar solvents such as methanol, ethanol and dichloromethane. This solubility property provides convenience for its application in organic synthesis reactions. Good solubility in polar solvents allows it to fully contact and mix with reactants that are also soluble in such solvents, and then react effectively.
In addition, 3-chlorophenylboronic acid has a certain solubility in water, but its solubility is relatively limited. This property is particularly important when it comes to aqueous or two-phase reaction systems, and determines whether they can function in a specific reaction environment.
Although the density is not precise and widely reported, the density of 3-chlorophenylboronic acid may also be in this range based on the density of similar boron-containing aromatic compounds, which is usually estimated in the range of 1.3-1.5 g/cm ³. Density, as the mass per unit volume of a substance, has guiding significance for the setting of its measurement and mixing ratio in practical operation.
3-Chlorophenylboronic acid (3-chlorobenzeneboronic Acid/3-chlorophenylboronic Acid) in storage and transportation
When storing and transporting 3 - chlorobenzeneboronic Acid/3 - chlorophenylboronic Acid, it is necessary to pay more attention to many matters. This is an organoboron compound with certain chemical activity, so proper disposal is extremely critical.
When storing, the first environment is dry. Because it is prone to hydrolysis in contact with water, the quality is damaged and the efficiency is reduced. It should be placed in a dry and well-ventilated place, away from water sources and moisture. If the warehouse should be kept dry, the humidity should be controlled within a specific range.
Secondly, the temperature should not be ignored. It should be stored in a cool environment, protected from high temperature and direct sunlight. High temperature can easily cause it to decompose or accelerate chemical reactions, affecting stability. In general, the storage temperature should be maintained within a suitable range and do not exceed a specific upper limit.
Furthermore, the packaging must be tight. Use sealed packaging to prevent contact with air. Oxygen, water vapor and other components in the air may interact with 3-chlorophenylboronic acid to cause deterioration. Appropriate packaging materials, such as glass bottles, plastic bottles, etc., can be selected, and ensure that the seal is good.
When transporting, the relevant rules must also be followed. Shockproof is an important part. Because it is a chemical product, it is vibrated or the package is broken, causing leakage. Transportation vehicles should run smoothly to reduce bumps.
At the same time, transportation should be classified according to regulations. 3-chlorophenylboronic acid is classified as a specific category of chemicals and needs to be operated according to the corresponding transportation requirements. Transport personnel should be familiar with its characteristics and emergency handling methods, and can respond quickly in the event of an accident.
In addition, avoid mixing with incompatible substances. Certain chemicals come into contact with it or cause dangerous reactions, endangering transportation safety. Therefore, it is necessary to identify the items that cannot be mixed to ensure the safety of the transportation process.
When storing, the first environment is dry. Because it is prone to hydrolysis in contact with water, the quality is damaged and the efficiency is reduced. It should be placed in a dry and well-ventilated place, away from water sources and moisture. If the warehouse should be kept dry, the humidity should be controlled within a specific range.
Secondly, the temperature should not be ignored. It should be stored in a cool environment, protected from high temperature and direct sunlight. High temperature can easily cause it to decompose or accelerate chemical reactions, affecting stability. In general, the storage temperature should be maintained within a suitable range and do not exceed a specific upper limit.
Furthermore, the packaging must be tight. Use sealed packaging to prevent contact with air. Oxygen, water vapor and other components in the air may interact with 3-chlorophenylboronic acid to cause deterioration. Appropriate packaging materials, such as glass bottles, plastic bottles, etc., can be selected, and ensure that the seal is good.
When transporting, the relevant rules must also be followed. Shockproof is an important part. Because it is a chemical product, it is vibrated or the package is broken, causing leakage. Transportation vehicles should run smoothly to reduce bumps.
At the same time, transportation should be classified according to regulations. 3-chlorophenylboronic acid is classified as a specific category of chemicals and needs to be operated according to the corresponding transportation requirements. Transport personnel should be familiar with its characteristics and emergency handling methods, and can respond quickly in the event of an accident.
In addition, avoid mixing with incompatible substances. Certain chemicals come into contact with it or cause dangerous reactions, endangering transportation safety. Therefore, it is necessary to identify the items that cannot be mixed to ensure the safety of the transportation process.
What is the market price range for 3-chlorophenylboronic acid (3-chlorobenzeneboronic Acid/3-chlorophenylboronic Acid)?
3-Chlorophenylboronic acid, the market price varies depending on the quantity and purity. Common industrial grade, the content is about 98%, the batch size is 1-5 kg, and the price per kg is about 200-300 yuan. If the quantity rises to 5-10 kg, it will be reduced to 180-250 yuan per kg due to economies of scale. More than 10 kg, the price may be as low as 150-200 yuan.
High purity products for scientific research, more than 99% purity, small packages such as 1 gram, about 30-50 yuan per gram; 5 grams, about 25-40 yuan per gram; 10 grams, about 20-35 yuan per gram.
The market fluctuates, and the impact of raw materials, supply and demand is considerable. High prices of raw materials such as chlorobenzene may cause the price of 3-chlorophenylboronic acid to rise; oversupply and demand lead to falling prices. For real-time prices, it is advisable to consult chemical manufacturers, reagent suppliers or relevant e-commerce platforms.
High purity products for scientific research, more than 99% purity, small packages such as 1 gram, about 30-50 yuan per gram; 5 grams, about 25-40 yuan per gram; 10 grams, about 20-35 yuan per gram.
The market fluctuates, and the impact of raw materials, supply and demand is considerable. High prices of raw materials such as chlorobenzene may cause the price of 3-chlorophenylboronic acid to rise; oversupply and demand lead to falling prices. For real-time prices, it is advisable to consult chemical manufacturers, reagent suppliers or relevant e-commerce platforms.
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