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3-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
192988 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.06 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 277 - 278 °C |
| Melting Point | −16 °C |
| Density | 1.483 g/cm³ |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 113 °C |
| Vapor Pressure | Low at room temperature |
| Acidity | Reacts as an acid chloride |
As an accredited 3-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chlorobenzenesulfonyl chloride packaged in a sealed, corrosion - resistant bottle. |
| Storage | 3 - Chlorobenzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and reactive substances. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. Due to its potential hazards, it should be separated from incompatible chemicals and stored in accordance with safety regulations to prevent leakage and chemical reactions. |
| Shipping | 3 - Chlorobenzenesulfonyl chloride is a hazardous chemical. Shipping requires compliance with strict regulations. It must be packaged in appropriate containers, labeled clearly, and transported by carriers licensed for hazardous materials to ensure safety during transit. |
Competitive 3-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 3-Chlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chlorobenzenesulfonyl Chloride?
3-Chlorobenzenesulfonyl chloride is a crucial raw material in organic synthesis and has a wide range of uses in many fields.
First, in the field of pharmaceutical synthesis, it can be used as a key intermediate. For example, when synthesizing some antibacterial drugs, 3-chlorobenzenesulfonyl chloride can participate in the reaction to build the specific structure of the drug molecule. By substituting with compounds containing heteroatoms such as nitrogen and oxygen, sulfonyl functional groups can be introduced, thereby endowing the drug with specific pharmacological activity and stability, so as to improve the efficacy of the drug.
Second, in the field of pesticides, it also plays an important role. The preparation of many efficient pesticides is inseparable from 3-chlorobenzenesulfonyl chloride. It can react with different organic compounds to generate substances with insecticidal, bactericidal or herbicidal activities. By rationally designing the reaction route and using the activity of its sulfonyl chloride group, the desired pesticide structure can be precisely synthesized, the control effect of pesticides on specific pests and diseases can be enhanced, and the environmental friendliness and biological activity of pesticides can be optimized.
Furthermore, in terms of materials science, 3-chlorobenzenesulfonyl chloride can be used to prepare polymer materials with special properties. For example, by reacting with polymer monomers containing active groups such as hydroxyl groups and amino groups, the sulfonyl chloride group can be introduced into the polymer chain, thereby improving the solubility, thermal stability, and mechanical properties of the polymer material. The modified polymer materials can be used in coatings, plastics and other fields to improve the comprehensive properties of the materials and meet the needs of different industrial scenarios.
In addition, in the field of dye synthesis, 3-chlorobenzenesulfonyl chloride can be used as an important starting material for the synthesis of specific structural dyes. By reacting with various aromatic amines, phenolic compounds, etc., dye molecules with specific colors and dyeing properties can be constructed to meet the needs of different colors and fastness dyes in textile, printing and dyeing industries.
First, in the field of pharmaceutical synthesis, it can be used as a key intermediate. For example, when synthesizing some antibacterial drugs, 3-chlorobenzenesulfonyl chloride can participate in the reaction to build the specific structure of the drug molecule. By substituting with compounds containing heteroatoms such as nitrogen and oxygen, sulfonyl functional groups can be introduced, thereby endowing the drug with specific pharmacological activity and stability, so as to improve the efficacy of the drug.
Second, in the field of pesticides, it also plays an important role. The preparation of many efficient pesticides is inseparable from 3-chlorobenzenesulfonyl chloride. It can react with different organic compounds to generate substances with insecticidal, bactericidal or herbicidal activities. By rationally designing the reaction route and using the activity of its sulfonyl chloride group, the desired pesticide structure can be precisely synthesized, the control effect of pesticides on specific pests and diseases can be enhanced, and the environmental friendliness and biological activity of pesticides can be optimized.
Furthermore, in terms of materials science, 3-chlorobenzenesulfonyl chloride can be used to prepare polymer materials with special properties. For example, by reacting with polymer monomers containing active groups such as hydroxyl groups and amino groups, the sulfonyl chloride group can be introduced into the polymer chain, thereby improving the solubility, thermal stability, and mechanical properties of the polymer material. The modified polymer materials can be used in coatings, plastics and other fields to improve the comprehensive properties of the materials and meet the needs of different industrial scenarios.
In addition, in the field of dye synthesis, 3-chlorobenzenesulfonyl chloride can be used as an important starting material for the synthesis of specific structural dyes. By reacting with various aromatic amines, phenolic compounds, etc., dye molecules with specific colors and dyeing properties can be constructed to meet the needs of different colors and fastness dyes in textile, printing and dyeing industries.
What are the physical properties of 3-chlorobenzenesulfonyl Chloride?
3-Chlorobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are quite unique, and I will describe them in detail today.
Looking at its properties, under room temperature and pressure, 3-chlorobenzenesulfonyl chloride is a colorless to light yellow liquid with a clear appearance and a flowing state. Its odor is pungent and corrosive, and it is uncomfortable to smell. This is due to its chemical activity.
When it comes to the boiling point, it is about 275-277 ° C, which means that it needs to provide considerable heat to change from liquid to gas. Such a high boiling point is due to the strong interaction force between molecules. The melting point is about -16 ° C, that is, when the temperature drops to this value, 3-chlorobenzenesulfonyl chloride solidifies from liquid to solid.
In terms of density, it is about 1.49 g/cm ³, which is heavier than water. If it is placed in one place with water, it will sink underwater. Its solubility is also an important property. In most organic solvents, such as ether, benzene, chloroform, etc., 3-chlorobenzenesulfonyl chloride can be well dissolved. This property makes it possible to use these organic solvents as the reaction medium to promote the reaction in organic synthesis reactions. However, its solubility in water is not good, and it is prone to hydrolysis in water. This hydrolysis reaction or system produces acidic substances, which also reflects the activity of its chemical properties.
In addition, the vapor pressure of 3-chlorobenzenesulfonyl chloride also has a corresponding value at a specific temperature, which is related to its existence and volatilization in the gas phase, and has important reference significance for setting the operation or storage conditions of the gas phase. Its refractive index is also a specific value, reflecting the refractive characteristics of light when passing through the substance, and may have applications in optical analysis and related research.
In summary, the many physical properties of 3-chlorobenzenesulfonyl chloride, such as appearance, odor, melting point, density, solubility, etc., all affect its application in organic synthesis, chemical production, and other fields. Users need to be familiar with and make good use of these properties to achieve the intended purpose.
Looking at its properties, under room temperature and pressure, 3-chlorobenzenesulfonyl chloride is a colorless to light yellow liquid with a clear appearance and a flowing state. Its odor is pungent and corrosive, and it is uncomfortable to smell. This is due to its chemical activity.
When it comes to the boiling point, it is about 275-277 ° C, which means that it needs to provide considerable heat to change from liquid to gas. Such a high boiling point is due to the strong interaction force between molecules. The melting point is about -16 ° C, that is, when the temperature drops to this value, 3-chlorobenzenesulfonyl chloride solidifies from liquid to solid.
In terms of density, it is about 1.49 g/cm ³, which is heavier than water. If it is placed in one place with water, it will sink underwater. Its solubility is also an important property. In most organic solvents, such as ether, benzene, chloroform, etc., 3-chlorobenzenesulfonyl chloride can be well dissolved. This property makes it possible to use these organic solvents as the reaction medium to promote the reaction in organic synthesis reactions. However, its solubility in water is not good, and it is prone to hydrolysis in water. This hydrolysis reaction or system produces acidic substances, which also reflects the activity of its chemical properties.
In addition, the vapor pressure of 3-chlorobenzenesulfonyl chloride also has a corresponding value at a specific temperature, which is related to its existence and volatilization in the gas phase, and has important reference significance for setting the operation or storage conditions of the gas phase. Its refractive index is also a specific value, reflecting the refractive characteristics of light when passing through the substance, and may have applications in optical analysis and related research.
In summary, the many physical properties of 3-chlorobenzenesulfonyl chloride, such as appearance, odor, melting point, density, solubility, etc., all affect its application in organic synthesis, chemical production, and other fields. Users need to be familiar with and make good use of these properties to achieve the intended purpose.
What are the chemical properties of 3-chlorobenzenesulfonyl Chloride?
3-Chlorobenzenesulfonyl chloride is a key chemical reagent in organic synthesis. Its chemical properties are unique, showing the following numbers.
First, it has strong acylation ability. The sulfonyl chloride group in this molecule is very active, and it is easy to acylate with compounds containing active hydrogen, such as alcohols and amines. When met with alcohols, sulfonates can be formed. This reaction usually proceeds smoothly under mild alkaline conditions. Organic bases such as pyridine are often used as acid binding agents. For example, when reacted with ethanol, ethyl 3-chlorobenzenesulfonate is formed. During this process, the chlorine atom of the sulfonyl chloride is replaced by an ethoxy group, and the resulting hydrogen chloride is absorbed by the base.
Second, it can react positively with nucleophiles. Amino substances can react rapidly with 3-chlorobenzenesulfonyl chloride to form sulfonamides as nucleophiles. This reaction is widely used in the field of drug synthesis, and the construction of many drug molecules depends on it. For example, when reacting with aniline, 3-chlorobenzenesulfonyl aniline will be formed. During the reaction, the amine nitrogen atom launches a nucleophilic attack on the carbon atom of the sulfonyl chloride, and the chlorine atom leaves, thereby forming a new carbon-nitrogen bond.
Third, a hydrolysis reaction can occur. Under water and alkaline conditions, 3-chlorobenzenesulfonyl chloride is easily hydrolyzed, and the sulfonyl chloride group will be converted into a sulfonic acid group. If this reaction is properly controlled, it can be used to prepare 3-chlorobenzenesulfonic acid. However, if the reaction conditions are severe, further side reactions may be caused, such as hydrolysis of the chlorine atoms on the benzene ring.
Fourth, participate in the substitution reaction of aromatic rings. Although the benzene ring is relatively stable, the benzene ring of 3-chlorobenzenesulfonyl chloride can undergo electrophilic substitution reaction under certain conditions, such as when there is a catalyst and high temperature. Because the sulfonyl chloride group is an electron-withdrawing group, the electron cloud density of the benzene ring will be reduced, so the newly introduced substituents enter the meso, which is related to the localization effect of the original substituents on the benzene ring. In conclusion, 3-chlorobenzenesulfonyl chloride plays an important role in many fields of organic synthesis due to its unique chemical properties. However, it is necessary to carefully control the reaction conditions according to its reaction characteristics in order to achieve the desired synthesis purpose.
First, it has strong acylation ability. The sulfonyl chloride group in this molecule is very active, and it is easy to acylate with compounds containing active hydrogen, such as alcohols and amines. When met with alcohols, sulfonates can be formed. This reaction usually proceeds smoothly under mild alkaline conditions. Organic bases such as pyridine are often used as acid binding agents. For example, when reacted with ethanol, ethyl 3-chlorobenzenesulfonate is formed. During this process, the chlorine atom of the sulfonyl chloride is replaced by an ethoxy group, and the resulting hydrogen chloride is absorbed by the base.
Second, it can react positively with nucleophiles. Amino substances can react rapidly with 3-chlorobenzenesulfonyl chloride to form sulfonamides as nucleophiles. This reaction is widely used in the field of drug synthesis, and the construction of many drug molecules depends on it. For example, when reacting with aniline, 3-chlorobenzenesulfonyl aniline will be formed. During the reaction, the amine nitrogen atom launches a nucleophilic attack on the carbon atom of the sulfonyl chloride, and the chlorine atom leaves, thereby forming a new carbon-nitrogen bond.
Third, a hydrolysis reaction can occur. Under water and alkaline conditions, 3-chlorobenzenesulfonyl chloride is easily hydrolyzed, and the sulfonyl chloride group will be converted into a sulfonic acid group. If this reaction is properly controlled, it can be used to prepare 3-chlorobenzenesulfonic acid. However, if the reaction conditions are severe, further side reactions may be caused, such as hydrolysis of the chlorine atoms on the benzene ring.
Fourth, participate in the substitution reaction of aromatic rings. Although the benzene ring is relatively stable, the benzene ring of 3-chlorobenzenesulfonyl chloride can undergo electrophilic substitution reaction under certain conditions, such as when there is a catalyst and high temperature. Because the sulfonyl chloride group is an electron-withdrawing group, the electron cloud density of the benzene ring will be reduced, so the newly introduced substituents enter the meso, which is related to the localization effect of the original substituents on the benzene ring. In conclusion, 3-chlorobenzenesulfonyl chloride plays an important role in many fields of organic synthesis due to its unique chemical properties. However, it is necessary to carefully control the reaction conditions according to its reaction characteristics in order to achieve the desired synthesis purpose.
What are the synthesis methods of 3-chlorobenzenesulfonyl Chloride?
There are two ways to synthesize 3-chlorobenzenesulfonyl chloride. One is to use 3-chlorobenzenesulfonic acid to react with a chlorinating agent. Usually phosphorus pentachloride, phosphorus trichloride or thionyl chloride are used as chlorination agents. Taking phosphorus pentachloride as an example, 3-chlorobenzenesulfonic acid is placed in a reaction kettle, and phosphorus pentachloride is slowly added, and the two react at a suitable temperature. The reaction mechanism is that the phosphorus atoms in phosphorus pentachloride have strong electrophilicity and can attack the sulfur atoms in the sulfonic acid group, and then through a series of group transfer and elimination steps, 3-chlorobenzenesulfonyl chloride is generated. After the reaction, the purified product can be obtained by distillation
The second method is to use benzene as the starting material and first chlorinate to obtain 3-chlorobenzene. In this process, benzene can react with chlorine in the presence of catalysts such as ferric chloride, and the reaction conditions can be controlled. 3-chlorobenzene then interacts with fuming sulfuric acid to introduce a sulfonic acid group to obtain 3-chlorobenzenesulfonic acid. Finally, as mentioned above, 3-chlorobenzenesulfonic acid is treated with a chlorinating agent to obtain 3-chlorobenzenesulfonic acid chloride. Although this route is slightly complicated, the raw material is easy to obtain, and it is also a common method. In actual synthesis, the appropriate synthesis route needs to be selected according to many factors such as raw material availability, cost, product purity, etc.
The second method is to use benzene as the starting material and first chlorinate to obtain 3-chlorobenzene. In this process, benzene can react with chlorine in the presence of catalysts such as ferric chloride, and the reaction conditions can be controlled. 3-chlorobenzene then interacts with fuming sulfuric acid to introduce a sulfonic acid group to obtain 3-chlorobenzenesulfonic acid. Finally, as mentioned above, 3-chlorobenzenesulfonic acid is treated with a chlorinating agent to obtain 3-chlorobenzenesulfonic acid chloride. Although this route is slightly complicated, the raw material is easy to obtain, and it is also a common method. In actual synthesis, the appropriate synthesis route needs to be selected according to many factors such as raw material availability, cost, product purity, etc.
What are the precautions for 3-chlorobenzenesulfonyl Chloride in storage and transportation?
3-Chlorobenzenesulfonyl chloride is a chemical substance. During storage and transportation, many matters must be observed.
It is active in nature, and it is easy to react in contact with water, generating acid mist. Therefore, the storage place must be dry, away from water sources and humid places. In the warehouse, the air should be circulated, and the temperature should be appropriate. It should not be too high to prevent it from deteriorating or causing danger.
In addition, 3-chlorobenzenesulfonyl chloride is corrosive and will cause burns in contact with the skin and eyes. When transporting, the packaging must be tight to prevent leakage. The containers used should be resistant to corrosion and marked with obvious warning labels to make everyone aware of its danger.
Transportation personnel also need to undergo professional training to be familiar with the characteristics of this object and emergency response methods. If there is a risk of leakage on the way, take measures quickly, evacuate the crowd, and do not approach it. When cleaning up leaks, protective equipment is essential, and collect and handle them in the correct way to avoid polluting the environment.
In addition, the storage place should also be separated from oxidants, alkalis and other substances, because it encounters them, or reacts violently, endangering safety. During daily management, regularly check to see if the packaging is damaged to ensure the safety of storage and transportation. In this way, it is necessary to be comprehensive.
It is active in nature, and it is easy to react in contact with water, generating acid mist. Therefore, the storage place must be dry, away from water sources and humid places. In the warehouse, the air should be circulated, and the temperature should be appropriate. It should not be too high to prevent it from deteriorating or causing danger.
In addition, 3-chlorobenzenesulfonyl chloride is corrosive and will cause burns in contact with the skin and eyes. When transporting, the packaging must be tight to prevent leakage. The containers used should be resistant to corrosion and marked with obvious warning labels to make everyone aware of its danger.
Transportation personnel also need to undergo professional training to be familiar with the characteristics of this object and emergency response methods. If there is a risk of leakage on the way, take measures quickly, evacuate the crowd, and do not approach it. When cleaning up leaks, protective equipment is essential, and collect and handle them in the correct way to avoid polluting the environment.
In addition, the storage place should also be separated from oxidants, alkalis and other substances, because it encounters them, or reacts violently, endangering safety. During daily management, regularly check to see if the packaging is damaged to ensure the safety of storage and transportation. In this way, it is necessary to be comprehensive.
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