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3-Chlorobenzenesulphonyl Chloride
Linshang Chemical
|
HS Code |
764720 |
| Chemical Formula | C6H4Cl2O2S |
| Molar Mass | 211.06 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Pungent |
| Density | 1.49 g/cm³ |
| Boiling Point | 251 - 253 °C |
| Melting Point | −15 °C |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 110 °C |
| Vapor Pressure | Low |
As an accredited 3-Chlorobenzenesulphonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 3 - chlorobenzenesulphonyl chloride packaged in a sealed, corrosion - resistant container. |
| Storage | 3 - Chlorobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent contact with moisture, as it can react with water. Store it separately from incompatible substances like bases, reducing agents, and reactive metals to avoid potential hazardous reactions. |
| Shipping | 3 - Chlorobenzenesulphonyl chloride is a hazardous chemical. Shipping should be in accordance with strict regulations. It must be properly packaged in corrosion - resistant containers, labeled clearly, and transported by carriers authorized for hazardous goods. |
Competitive 3-Chlorobenzenesulphonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 3-Chlorobenzenesulphonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 3-chlorobenzenesulphonyl Chloride?
3-Chlorobenzenesulfonyl chloride, its physical properties are particularly important, and it is very useful in chemical industry. This substance is usually colorless to slightly yellow liquid at room temperature, and it is clear and transparent when viewed. However, it also has white to light yellow crystals, which vary depending on the conditions.
Its smell is pungent and strong, and it is uncomfortable to smell. It is also highly volatile. The boiling point is quite high, between 275 ° C and 280 ° C. This property makes it easy to transform into a gaseous state in a higher temperature environment. The melting point is between 14 ° C and 16 ° C. If the temperature drops below the melting point, it will change from liquid to solid.
Its density is greater than that of water, about 1.48g/cm ³. When placed in water, it will sink to the bottom of the water. In terms of solubility, 3-chlorobenzenesulfonyl chloride is insoluble in water, but it is easily soluble in many organic solvents, such as ether, benzene, chloroform, etc. Due to the principle of "similar miscibility", its molecular structure is similar to that of organic solvents, so it can be miscible.
In addition, 3-chlorobenzenesulfonyl chloride is sensitive to light. When exposed to light, it is easy to react chemically, resulting in a gradual change in its properties. And because it is volatile, it will gradually dissipate in the air. When operating, be careful not to let it contact the skin and respiratory tract to prevent injury.
Its smell is pungent and strong, and it is uncomfortable to smell. It is also highly volatile. The boiling point is quite high, between 275 ° C and 280 ° C. This property makes it easy to transform into a gaseous state in a higher temperature environment. The melting point is between 14 ° C and 16 ° C. If the temperature drops below the melting point, it will change from liquid to solid.
Its density is greater than that of water, about 1.48g/cm ³. When placed in water, it will sink to the bottom of the water. In terms of solubility, 3-chlorobenzenesulfonyl chloride is insoluble in water, but it is easily soluble in many organic solvents, such as ether, benzene, chloroform, etc. Due to the principle of "similar miscibility", its molecular structure is similar to that of organic solvents, so it can be miscible.
In addition, 3-chlorobenzenesulfonyl chloride is sensitive to light. When exposed to light, it is easy to react chemically, resulting in a gradual change in its properties. And because it is volatile, it will gradually dissipate in the air. When operating, be careful not to let it contact the skin and respiratory tract to prevent injury.
What are the chemical properties of 3-chlorobenzenesulphonyl Chloride?
3-Chlorobenzenesulfonyl chloride is a key reagent in organic synthesis. It has active chemical properties and exhibits unique characteristics in many reactions.
This substance easily interacts with nucleophiles. For example, in case of alcohols, a nucleophilic substitution reaction occurs to form a sulfonate. The mechanism is that the oxygen atom of the alcohol is rich in electrons and acts as a nucleophilic reagent to attack the sulfur atom in 3-chlorobenzenesulfonyl chloride, while the chlorine atom is separated as a leaving group, thus forming a sulfonate compound. This reaction is often used in organic synthesis to prepare sulfonates with specific structures, which may have important uses in materials science and medicinal chemistry. When
meets amines, it also undergoes nucleophilic substitution to form sulfonamides. The nitrogen atom of the amine acts as a nucleophilic reagent, attacking the sulfur atom, and the chlorine leaves to form a sulfonamide structure. Sulfonamide compounds are widely used in the field of medicine. Many drug molecular structures contain this group, so it can give drugs specific physiological activities.
3-chlorobenzenesulfonyl chloride is also unstable in contact with water and will hydrolyze. The hydroxyl group in the water molecule attacks the sulfur atom, and the chlorine atom is replaced by the hydroxyl group to form 3-chlorobenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction is more likely to occur in a humid environment, so it is necessary to pay
In addition, the benzene ring part can undergo electrophilic substitution reaction. Although the sulfonyl chloride group is an electron-withdrawing group, the electron cloud density of the benzene ring is reduced, but under appropriate conditions, such as suitable catalyst and reaction temperature, electrophilic substitution reactions such as nitrification and halogenation can still occur. These reactions can introduce other functional groups on the benzene ring, further enrich the structure of compounds, expand its application range in organic synthesis, and lay the foundation for the synthesis of complex organic molecules. In conclusion, 3-chlorobenzenesulfonyl chloride occupies an important position in the field of organic synthesis chemistry due to its diverse chemical reactivity.
This substance easily interacts with nucleophiles. For example, in case of alcohols, a nucleophilic substitution reaction occurs to form a sulfonate. The mechanism is that the oxygen atom of the alcohol is rich in electrons and acts as a nucleophilic reagent to attack the sulfur atom in 3-chlorobenzenesulfonyl chloride, while the chlorine atom is separated as a leaving group, thus forming a sulfonate compound. This reaction is often used in organic synthesis to prepare sulfonates with specific structures, which may have important uses in materials science and medicinal chemistry. When
meets amines, it also undergoes nucleophilic substitution to form sulfonamides. The nitrogen atom of the amine acts as a nucleophilic reagent, attacking the sulfur atom, and the chlorine leaves to form a sulfonamide structure. Sulfonamide compounds are widely used in the field of medicine. Many drug molecular structures contain this group, so it can give drugs specific physiological activities.
3-chlorobenzenesulfonyl chloride is also unstable in contact with water and will hydrolyze. The hydroxyl group in the water molecule attacks the sulfur atom, and the chlorine atom is replaced by the hydroxyl group to form 3-chlorobenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction is more likely to occur in a humid environment, so it is necessary to pay
In addition, the benzene ring part can undergo electrophilic substitution reaction. Although the sulfonyl chloride group is an electron-withdrawing group, the electron cloud density of the benzene ring is reduced, but under appropriate conditions, such as suitable catalyst and reaction temperature, electrophilic substitution reactions such as nitrification and halogenation can still occur. These reactions can introduce other functional groups on the benzene ring, further enrich the structure of compounds, expand its application range in organic synthesis, and lay the foundation for the synthesis of complex organic molecules. In conclusion, 3-chlorobenzenesulfonyl chloride occupies an important position in the field of organic synthesis chemistry due to its diverse chemical reactivity.
What are the main uses of 3-chlorobenzenesulphonyl Chloride?
3-Chlorobenzenesulfonyl chloride, an important compound in organic chemistry, has a wide range of uses and plays a key role in many fields.
In the field of medicinal chemistry, it is often a key intermediate. With its unique chemical structure, it can participate in many organic synthesis reactions to build complex drug molecular structures. For example, by substituting with nucleophiles such as nitrogen and oxygen, specific functional groups can be introduced to lay the foundation for the synthesis of drugs with specific pharmacological activities. In the synthesis process of many antibiotics, cardiovascular drugs, etc., 3-chlorobenzenesulfonyl chloride can be seen, helping to create novel and efficient drugs.
It also plays an important role in the field of materials science. It can be used to synthesize polymer materials with special properties. By polymerizing with monomers containing reactive groups, polymers are endowed with properties such as good thermal stability, chemical stability and mechanical properties. In the preparation of some high-performance engineering plastics and functional film materials, 3-chlorobenzenesulfonyl chloride is involved as an important raw material to improve the comprehensive properties of materials and meet the needs of different fields for special properties of materials.
In the dye industry, 3-chlorobenzenesulfonyl chloride is an important starting material for the synthesis of various dyes. With the help of its reaction with different aromatic amines, phenols and other compounds, a rich and diverse dye color system can be constructed, giving dyes good color, light resistance and washing resistance. In the preparation of many high-end textile dyes and ink dyes, 3-chlorobenzenesulfonyl chloride is required to provide strong support for the development of the dye industry.
In short, 3-chlorobenzenesulfonyl chloride plays an indispensable role in many fields such as medicine, materials, and dyes, promoting the continuous development and innovation of related industries due to its unique chemical properties.
In the field of medicinal chemistry, it is often a key intermediate. With its unique chemical structure, it can participate in many organic synthesis reactions to build complex drug molecular structures. For example, by substituting with nucleophiles such as nitrogen and oxygen, specific functional groups can be introduced to lay the foundation for the synthesis of drugs with specific pharmacological activities. In the synthesis process of many antibiotics, cardiovascular drugs, etc., 3-chlorobenzenesulfonyl chloride can be seen, helping to create novel and efficient drugs.
It also plays an important role in the field of materials science. It can be used to synthesize polymer materials with special properties. By polymerizing with monomers containing reactive groups, polymers are endowed with properties such as good thermal stability, chemical stability and mechanical properties. In the preparation of some high-performance engineering plastics and functional film materials, 3-chlorobenzenesulfonyl chloride is involved as an important raw material to improve the comprehensive properties of materials and meet the needs of different fields for special properties of materials.
In the dye industry, 3-chlorobenzenesulfonyl chloride is an important starting material for the synthesis of various dyes. With the help of its reaction with different aromatic amines, phenols and other compounds, a rich and diverse dye color system can be constructed, giving dyes good color, light resistance and washing resistance. In the preparation of many high-end textile dyes and ink dyes, 3-chlorobenzenesulfonyl chloride is required to provide strong support for the development of the dye industry.
In short, 3-chlorobenzenesulfonyl chloride plays an indispensable role in many fields such as medicine, materials, and dyes, promoting the continuous development and innovation of related industries due to its unique chemical properties.
What is the preparation method of 3-chlorobenzenesulphonyl Chloride?
The preparation of 3-chlorobenzenesulfonyl chloride is an important technique in the field of organic synthesis. The preparation method is often obtained by the interaction of 3-chlorobenzenesulfonate and chlorination reagents.
In the past, phosphorus pentachloride was commonly used as a chlorination reagent. First take an appropriate amount of 3-chlorobenzenesulfonic acid and place it in a reactor. The kettle needs to be dry and can withstand certain temperatures and pressures. Slowly add phosphorus pentachloride to the kettle. This process must be carried out in a low temperature environment, generally controlled between 0 ° C and 5 ° C to prevent the reaction from being too violent. Phosphorus pentachloride and 3-chlorobenzenesulfonic acid will react as follows: The hydroxyl group in 3-chlorobenzenesulfonic acid is replaced by a chlorine at During the reaction, it is necessary to continuously stir to make the reactants fully contact, so that the reaction can proceed uniformly.
When the reaction is basically completed, heat up to a moderate temperature, such as 40 ° C to 50 ° C, and maintain it for a period of time to promote the complete reaction. After that, the reaction mixture is treated. Because it contains unreacted raw materials, generated 3-chlorobenzenesulfonyl chloride and by-products, it can be first distilled under reduced pressure to separate low-boiling point impurities. Subsequently, it is extracted with an organic solvent, and ethyl ether or dichloromethane is used to dissolve 3-chlorobenzenesulfonyl chloride in it. The organic phase is then washed and dried to remove residual impurities. Finally, by distillation, fractions in a specific boiling point range are collected to obtain pure 3-chlorobenzenesulfonyl chloride
In addition, thionyl chloride can also be used as a chlorination reagent. This reagent is relatively mild and the reaction conditions are slightly easier to control. Similarly, 3-chlorobenzenesulfonic acid is taken from the reaction vessel and an appropriate amount of thionyl chloride is added. In the initial stage of the reaction, it can be slightly heated to initiate the reaction, and then the reaction proceeds spontaneously. The thionyl chloride reacts with 3-chlorobenzenesulfonic acid to generate 3-chlorobenzenesulfonyl chloride, sulfur dioxide and hydrogen chloride gas. After the reaction is completed, the reaction system is heated to a certain temperature to allow excess thionyl chloride and the generated gas to escape. The remaining product can also be obtained with high purity after appropriate treatment, such as distillation and recrystallization.
In the past, phosphorus pentachloride was commonly used as a chlorination reagent. First take an appropriate amount of 3-chlorobenzenesulfonic acid and place it in a reactor. The kettle needs to be dry and can withstand certain temperatures and pressures. Slowly add phosphorus pentachloride to the kettle. This process must be carried out in a low temperature environment, generally controlled between 0 ° C and 5 ° C to prevent the reaction from being too violent. Phosphorus pentachloride and 3-chlorobenzenesulfonic acid will react as follows: The hydroxyl group in 3-chlorobenzenesulfonic acid is replaced by a chlorine at During the reaction, it is necessary to continuously stir to make the reactants fully contact, so that the reaction can proceed uniformly.
When the reaction is basically completed, heat up to a moderate temperature, such as 40 ° C to 50 ° C, and maintain it for a period of time to promote the complete reaction. After that, the reaction mixture is treated. Because it contains unreacted raw materials, generated 3-chlorobenzenesulfonyl chloride and by-products, it can be first distilled under reduced pressure to separate low-boiling point impurities. Subsequently, it is extracted with an organic solvent, and ethyl ether or dichloromethane is used to dissolve 3-chlorobenzenesulfonyl chloride in it. The organic phase is then washed and dried to remove residual impurities. Finally, by distillation, fractions in a specific boiling point range are collected to obtain pure 3-chlorobenzenesulfonyl chloride
In addition, thionyl chloride can also be used as a chlorination reagent. This reagent is relatively mild and the reaction conditions are slightly easier to control. Similarly, 3-chlorobenzenesulfonic acid is taken from the reaction vessel and an appropriate amount of thionyl chloride is added. In the initial stage of the reaction, it can be slightly heated to initiate the reaction, and then the reaction proceeds spontaneously. The thionyl chloride reacts with 3-chlorobenzenesulfonic acid to generate 3-chlorobenzenesulfonyl chloride, sulfur dioxide and hydrogen chloride gas. After the reaction is completed, the reaction system is heated to a certain temperature to allow excess thionyl chloride and the generated gas to escape. The remaining product can also be obtained with high purity after appropriate treatment, such as distillation and recrystallization.
3-chlorobenzenesulphonyl what are the precautions when using Chloride
3-Chlorobenzenesulfonyl chloride is a chemical substance. When using it, many matters must be observed.
First safety protection. This substance is corrosive and will cause burns when it touches the skin and eyes. Therefore, protective equipment is indispensable when used. In front of protective clothing, the material needs to be resistant to the erosion of this chemical to prevent penetration. Hands should also wear anti-corrosive gloves, which are tightly fitted, without gaps, and have comprehensive hand protection. Protective glasses or masks should be worn for the eyes to strictly protect the eyes from the danger of splashing.
Ventilation conditions are also key. Use this substance in a well-ventilated place or in a fume hood. In this way, the volatile harmful gases can be quickly dissipated, do not gather in the air, avoid inhalation and damage to breathing.
Furthermore, the operation needs to be careful. When taking it, the appliance should be clean and dry to prevent impurities from mixing in, damaging its quality, and may cause accidental reactions. Pour or measure, the action should be slow to avoid its splashing. And mixing, reaction and other operations, according to the standard method, add reagents in the correct order, control temperature and speed, to ensure a smooth reaction, and there is no risk of emergencies.
Storage should not be underestimated. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. It must be stored separately from alkalis, alcohols, etc., and must not be mixed to prevent violent reactions, causing fires and explosions.
After use, the remnants should not be disposed of at will. It needs to be properly handled in accordance with relevant regulations, or handed over to professional institutions to make it harmless, free from pollution to the environment, and harmful to the ecology.
In short, use 3-chlorobenzenesulfonyl chloride, safety first, and all details should be paid attention to, so as to ensure smooth operation and human safety.
First safety protection. This substance is corrosive and will cause burns when it touches the skin and eyes. Therefore, protective equipment is indispensable when used. In front of protective clothing, the material needs to be resistant to the erosion of this chemical to prevent penetration. Hands should also wear anti-corrosive gloves, which are tightly fitted, without gaps, and have comprehensive hand protection. Protective glasses or masks should be worn for the eyes to strictly protect the eyes from the danger of splashing.
Ventilation conditions are also key. Use this substance in a well-ventilated place or in a fume hood. In this way, the volatile harmful gases can be quickly dissipated, do not gather in the air, avoid inhalation and damage to breathing.
Furthermore, the operation needs to be careful. When taking it, the appliance should be clean and dry to prevent impurities from mixing in, damaging its quality, and may cause accidental reactions. Pour or measure, the action should be slow to avoid its splashing. And mixing, reaction and other operations, according to the standard method, add reagents in the correct order, control temperature and speed, to ensure a smooth reaction, and there is no risk of emergencies.
Storage should not be underestimated. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. It must be stored separately from alkalis, alcohols, etc., and must not be mixed to prevent violent reactions, causing fires and explosions.
After use, the remnants should not be disposed of at will. It needs to be properly handled in accordance with relevant regulations, or handed over to professional institutions to make it harmless, free from pollution to the environment, and harmful to the ecology.
In short, use 3-chlorobenzenesulfonyl chloride, safety first, and all details should be paid attention to, so as to ensure smooth operation and human safety.
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