Linshang Chemical
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3-Chlorobenzenethiol
Linshang Chemical
|
HS Code |
539189 |
| Chemical Formula | C6H5ClS |
| Molecular Weight | 144.62 |
| Appearance | Colorless to pale yellow liquid |
| Odor | Pungent, mercaptan - like odor |
| Boiling Point | 205 - 207 °C |
| Melting Point | -25 °C |
| Density | 1.26 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 77 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 3-Chlorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 3 - chlorobenzenethiol, tightly sealed in chemical - resistant packaging. |
| Storage | 3 - Chlorobenzenethiol should be stored in a cool, well - ventilated area away from heat and ignition sources. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials due to its potentially reactive nature. Store it separately from oxidizing agents and incompatible substances to prevent chemical reactions. Keep it out of reach of children and unauthorized personnel. |
| Shipping | 3 - Chlorobenzenethiol is shipped in accordance with strict hazardous material regulations. It's typically packaged in sealed, corrosion - resistant containers, transported in well - ventilated vehicles, ensuring safety during transit. |
Competitive 3-Chlorobenzenethiol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Chlorobenzenethiol in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chlorobenzenethiol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chlorobenzenethiol?
3-Chlorothiophenol is also an organic compound. It has a wide range of uses and has important applications in various fields.
First, in the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drugs. The creation of many drugs relies on it as a starting material. Through delicate chemical reactions, medicinal molecules with complex structures and unique effects are derived. The properties of chlorine atoms and thiophenol groups in its structure endow molecules with specific activity and reactivity. It can interact with targets in organisms or participate in the conformational shaping of drug molecules, which has a profound impact on the pharmacological activity, absorption, distribution, metabolism and excretion of drugs.
Second, it also has important functions in the field of materials science. It can be used to prepare special polymer materials. Due to its high reactivity, thiophenol groups can chemically react with many monomers or polymers to modify the surface properties or structure of the material. For example, it can improve the properties of polymer materials such as oxidation resistance, corrosion resistance and surface adhesion, making the material more suitable for high-end fields such as aerospace, electronics and electrical appliances.
Third, it is an extremely important reagent in the field of organic synthesis chemistry. It can participate in many organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, it can construct a rich and diverse structure of organic compounds, expand the types and functions of organic molecules, and provide an effective tool for organic synthesis chemists to explore the synthesis path of novel compounds.
Fourth, it also has certain applications in the fragrance industry. Its unique smell can be properly blended and modified to prepare specific fragrances, adding a different flavor to the fragrance formula and meeting the diverse needs of different consumers for aroma.
First, in the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drugs. The creation of many drugs relies on it as a starting material. Through delicate chemical reactions, medicinal molecules with complex structures and unique effects are derived. The properties of chlorine atoms and thiophenol groups in its structure endow molecules with specific activity and reactivity. It can interact with targets in organisms or participate in the conformational shaping of drug molecules, which has a profound impact on the pharmacological activity, absorption, distribution, metabolism and excretion of drugs.
Second, it also has important functions in the field of materials science. It can be used to prepare special polymer materials. Due to its high reactivity, thiophenol groups can chemically react with many monomers or polymers to modify the surface properties or structure of the material. For example, it can improve the properties of polymer materials such as oxidation resistance, corrosion resistance and surface adhesion, making the material more suitable for high-end fields such as aerospace, electronics and electrical appliances.
Third, it is an extremely important reagent in the field of organic synthesis chemistry. It can participate in many organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, it can construct a rich and diverse structure of organic compounds, expand the types and functions of organic molecules, and provide an effective tool for organic synthesis chemists to explore the synthesis path of novel compounds.
Fourth, it also has certain applications in the fragrance industry. Its unique smell can be properly blended and modified to prepare specific fragrances, adding a different flavor to the fragrance formula and meeting the diverse needs of different consumers for aroma.
What are the physical properties of 3-chlorobenzenethiol?
3-Chlorothiophenol, its physical properties are as follows:
This substance is mostly liquid at room temperature, and it has a certain fluidity. In color, it often appears colorless to light yellow, such as clear oil, when pure, there is no obvious turbidity.
Smell it, it has a special and pungent smell. This smell is similar to the typical smell of thiols, which is very strong. As soon as it gets close, it goes straight into the nasal cavity, which is impressive.
Its boiling point is in a certain range, about 220-225 ° C. The characteristics of the boiling point make it possible to change the state of matter from liquid to gaseous under a specific temperature environment. That is, when the ambient temperature reaches near the boiling point, 3-chlorothiophenol molecules gain enough energy to break free from the liquid phase and escape into the air to form a gaseous state.
In terms of melting point, it is roughly around -30 ° C. This temperature is the critical value for the transition between solid and liquid states. When the temperature is lower than the melting point, the substance solidifies into a solid state, and the molecules are arranged in a regular and orderly manner; when it is higher than the melting point, it gradually melts into a liquid state, and the molecular activity range increases, and the arrangement tends to be disordered.
The density is heavier than that of water, which is about 1.27g/cm ³. When mixed with water, it will sink to the bottom because its unit volume mass is greater than that of water
In terms of solubility, it has little solubility in water. Due to the large difference between the molecular structure and the polarity of water molecules, it is difficult to dissolve with water. However, in organic solvents, such as ethanol, ether, benzene, etc., it has good solubility. Due to the appropriate force between organic solvent molecules and 3-chlorothiophenol molecules, they can be interspersed and mixed with each other to achieve mutual solubility.
This substance is mostly liquid at room temperature, and it has a certain fluidity. In color, it often appears colorless to light yellow, such as clear oil, when pure, there is no obvious turbidity.
Smell it, it has a special and pungent smell. This smell is similar to the typical smell of thiols, which is very strong. As soon as it gets close, it goes straight into the nasal cavity, which is impressive.
Its boiling point is in a certain range, about 220-225 ° C. The characteristics of the boiling point make it possible to change the state of matter from liquid to gaseous under a specific temperature environment. That is, when the ambient temperature reaches near the boiling point, 3-chlorothiophenol molecules gain enough energy to break free from the liquid phase and escape into the air to form a gaseous state.
In terms of melting point, it is roughly around -30 ° C. This temperature is the critical value for the transition between solid and liquid states. When the temperature is lower than the melting point, the substance solidifies into a solid state, and the molecules are arranged in a regular and orderly manner; when it is higher than the melting point, it gradually melts into a liquid state, and the molecular activity range increases, and the arrangement tends to be disordered.
The density is heavier than that of water, which is about 1.27g/cm ³. When mixed with water, it will sink to the bottom because its unit volume mass is greater than that of water
In terms of solubility, it has little solubility in water. Due to the large difference between the molecular structure and the polarity of water molecules, it is difficult to dissolve with water. However, in organic solvents, such as ethanol, ether, benzene, etc., it has good solubility. Due to the appropriate force between organic solvent molecules and 3-chlorothiophenol molecules, they can be interspersed and mixed with each other to achieve mutual solubility.
What is the chemistry of 3-chlorobenzenethiol?
3-Chlorothiophenol, an organic compound, has unique chemical properties. In its structure, the chlorine atom above the phenyl ring is connected to the thiol group (-SH), and this special structure gives it a different activity.
From the perspective of physical properties, 3-chlorothiophenol is mostly a liquid at room temperature and has a pungent odor. In terms of solubility, it is soluble in organic solvents such as ethanol and ether, but has poor solubility in water. Because both the phenyl ring and the thiol group are hydrophobic groups.
When it comes to chemical properties, the presence of thiol groups makes 3-chlorothiophenol acidic. The electronegativity of sulfur atoms is larger than that of hydrogen atoms, and the electron cloud of hydrogen-sulfur bonds is biased towards sulfur atoms, causing hydrogen atoms to leave in the form of protons, so they can react with bases to form corresponding salts.
In addition, 3-chlorothiophenol has strong reducing properties. The outer layer of sulfur atoms in sulfhydryl groups has unshared electron pairs and is easily oxidized. In case of strong oxidants, it can be oxidized to sulfoxides or sulfones; in case of weak oxidants, it can also form disulfides.
In the nucleophilic substitution reaction, the sulfhydryl group of 3-chlorothiophenol exhibits nucleophilicity. The chlorine atom on the benzene ring is affected by the electronic effect of the benzene ring and has a certain electrophilicity. The sulfhydryl negative ion can attack the chlorine atom to connect to the carbon atom, and the nucleophilic substitution reaction occurs to generate new sulfur-containing organic compounds.
At the same time, the 3-chlorothiophenol phenyl ring can carry out the electrophilic substitution reaction. Because the sulfhydryl group is the power supply, the electron cloud density of the benzene ring can increase, and it is more vulnerable to the attack of electrophilic reagents, and the reaction mainly occurs
From the perspective of physical properties, 3-chlorothiophenol is mostly a liquid at room temperature and has a pungent odor. In terms of solubility, it is soluble in organic solvents such as ethanol and ether, but has poor solubility in water. Because both the phenyl ring and the thiol group are hydrophobic groups.
When it comes to chemical properties, the presence of thiol groups makes 3-chlorothiophenol acidic. The electronegativity of sulfur atoms is larger than that of hydrogen atoms, and the electron cloud of hydrogen-sulfur bonds is biased towards sulfur atoms, causing hydrogen atoms to leave in the form of protons, so they can react with bases to form corresponding salts.
In addition, 3-chlorothiophenol has strong reducing properties. The outer layer of sulfur atoms in sulfhydryl groups has unshared electron pairs and is easily oxidized. In case of strong oxidants, it can be oxidized to sulfoxides or sulfones; in case of weak oxidants, it can also form disulfides.
In the nucleophilic substitution reaction, the sulfhydryl group of 3-chlorothiophenol exhibits nucleophilicity. The chlorine atom on the benzene ring is affected by the electronic effect of the benzene ring and has a certain electrophilicity. The sulfhydryl negative ion can attack the chlorine atom to connect to the carbon atom, and the nucleophilic substitution reaction occurs to generate new sulfur-containing organic compounds.
At the same time, the 3-chlorothiophenol phenyl ring can carry out the electrophilic substitution reaction. Because the sulfhydryl group is the power supply, the electron cloud density of the benzene ring can increase, and it is more vulnerable to the attack of electrophilic reagents, and the reaction mainly occurs
What are 3-chlorobenzenethiol synthesis methods?
There are several methods for the synthesis of 3-chlorobenzothiophenol.
One of them can be obtained by reacting 3-chlorobromobenzene with thiourea. First take an appropriate amount of 3-chlorobromobenzene and place it in a reaction vessel with thiourea in a certain proportion. Add an appropriate amount of organic solvent, such as ethanol, to help dissolve and promote the reaction. Warm up to an appropriate temperature, usually between 80-100 ° C, and continue to stir. During this reaction, the bromine atom in 3-chlorobromobenzene undergoes nucleophilic substitution with thiourea, and the sulfur atom of thiourea replaces the bromine atom to form an intermediate. After the hydrolysis step, under alkaline conditions, such as treating the intermediate with sodium hydroxide solution, and then acidizing, 3-chlorothiophenol is obtained.
Second, 3-chloroaniline is used as the starting material. First, 3-chloroaniline reacts with sodium nitrite in an acidic environment to form diazonium salts. Generally, this reaction is carried out at a low temperature, 0-5 ° C, and in the presence of hydrochloric acid to form 3-chlorobenzene diazonate. Afterwards, a potassium hydride solution is added to the reaction system, and the diazonium group is replaced by a mercapto group to form 3-chlorothiophenol.
Third, starting from 3-chlorobenzoic acid. First, 3-chlorobenzoic acid is reduced to 3-chlorobenzyl alcohol, and common reducing agents such as lithium aluminum hydride are used. Then 3-chlorobenzyl alcohol is reacted with a halogenating agent to obtain 3-chlorohalobenzene. Then according to the steps of reacting with thiourea in the first method, through nucleophilic substitution, hydrolysis, acidification, etc., 3-chlorothiophenol can also be prepared.
Each method has its own advantages and disadvantages. It is necessary to choose a suitable method to synthesize 3-chlorothiophenol according to the actual situation, such as raw material availability, cost, product purity requirements, etc.
One of them can be obtained by reacting 3-chlorobromobenzene with thiourea. First take an appropriate amount of 3-chlorobromobenzene and place it in a reaction vessel with thiourea in a certain proportion. Add an appropriate amount of organic solvent, such as ethanol, to help dissolve and promote the reaction. Warm up to an appropriate temperature, usually between 80-100 ° C, and continue to stir. During this reaction, the bromine atom in 3-chlorobromobenzene undergoes nucleophilic substitution with thiourea, and the sulfur atom of thiourea replaces the bromine atom to form an intermediate. After the hydrolysis step, under alkaline conditions, such as treating the intermediate with sodium hydroxide solution, and then acidizing, 3-chlorothiophenol is obtained.
Second, 3-chloroaniline is used as the starting material. First, 3-chloroaniline reacts with sodium nitrite in an acidic environment to form diazonium salts. Generally, this reaction is carried out at a low temperature, 0-5 ° C, and in the presence of hydrochloric acid to form 3-chlorobenzene diazonate. Afterwards, a potassium hydride solution is added to the reaction system, and the diazonium group is replaced by a mercapto group to form 3-chlorothiophenol.
Third, starting from 3-chlorobenzoic acid. First, 3-chlorobenzoic acid is reduced to 3-chlorobenzyl alcohol, and common reducing agents such as lithium aluminum hydride are used. Then 3-chlorobenzyl alcohol is reacted with a halogenating agent to obtain 3-chlorohalobenzene. Then according to the steps of reacting with thiourea in the first method, through nucleophilic substitution, hydrolysis, acidification, etc., 3-chlorothiophenol can also be prepared.
Each method has its own advantages and disadvantages. It is necessary to choose a suitable method to synthesize 3-chlorothiophenol according to the actual situation, such as raw material availability, cost, product purity requirements, etc.
What are the precautions in storage and transportation of 3-chlorobenzenethiol?
3-Chlorothiophenol is an organic compound. When storing and transporting, many important items need to be paid attention to.
It is corrosive and harmful to the human body, so when storing, it should be sealed first. It must be placed in a cool and ventilated warehouse, away from fire and heat sources to prevent it from being decomposed or volatilized by heat and causing danger. The temperature of the warehouse should be controlled within an appropriate range, and must not be too high.
In addition, because of its irritation to the skin, eyes and respiratory tract, and even injury, during the handling process, the operator must be fully armed and wear protective equipment, such as gas masks, protective gloves, protective clothing, etc., to protect their own safety.
And because of its certain chemical activity, during storage and transportation, it is necessary to avoid contact with oxidants, strong alkalis and other substances, otherwise it may cause violent chemical reactions, causing disasters such as combustion and explosion.
When transporting, choose a safe and reliable means of transportation to ensure that the container does not leak, collapse, fall, or damage. And during transportation, it should be protected from exposure to the sun, rain, and high temperature.
All of these are important matters that should not be ignored when storing and transporting 3-chlorothiophenol. If you are not careful, it will cause disasters. You must treat it with caution to ensure safety.
It is corrosive and harmful to the human body, so when storing, it should be sealed first. It must be placed in a cool and ventilated warehouse, away from fire and heat sources to prevent it from being decomposed or volatilized by heat and causing danger. The temperature of the warehouse should be controlled within an appropriate range, and must not be too high.
In addition, because of its irritation to the skin, eyes and respiratory tract, and even injury, during the handling process, the operator must be fully armed and wear protective equipment, such as gas masks, protective gloves, protective clothing, etc., to protect their own safety.
And because of its certain chemical activity, during storage and transportation, it is necessary to avoid contact with oxidants, strong alkalis and other substances, otherwise it may cause violent chemical reactions, causing disasters such as combustion and explosion.
When transporting, choose a safe and reliable means of transportation to ensure that the container does not leak, collapse, fall, or damage. And during transportation, it should be protected from exposure to the sun, rain, and high temperature.
All of these are important matters that should not be ignored when storing and transporting 3-chlorothiophenol. If you are not careful, it will cause disasters. You must treat it with caution to ensure safety.
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