3-Chlorobenzenethiolate
Linshang Chemical
HS Code |
948598 |
Chemical Formula | C6H4ClS- |
Molar Mass | 144.61 g/mol (approximate for the anion) |
Appearance | Typically exists as a salt, appearance depends on the cation; often solid |
Odor | Thiolates usually have a strong, unpleasant odor |
Solubility In Water | Solubility depends on the cation; some metal salts may have limited solubility |
Solubility In Organic Solvents | Soluble in some polar organic solvents like ethanol, DMSO |
Acidity Basicity | As an anion, it can act as a base in appropriate chemical environments |
Stability | Stable under normal conditions, but can react with oxidizing agents |
Reactivity | Reactive towards electrophiles, can participate in substitution reactions |
Toxicity | Potentially toxic; thiolates can be harmful if ingested or absorbed through skin |
As an accredited 3-Chlorobenzenethiolate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100g of 3 - chlorobenzenethiolate packaged in a sealed, chemical - resistant container. |
Storage | 3 - Chlorobenzenethiolate should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture and air exposure, which could potentially lead to decomposition or reaction. Label the storage container clearly to ensure proper handling and to avoid any mix - ups. |
Shipping | 3 - Chlorobenzenethiolate, a chemical, must be shipped in accordance with strict hazardous materials regulations. It should be in well - sealed, appropriate containers to prevent leakage, and transported by carriers licensed for such chemicals. |
Competitive 3-Chlorobenzenethiolate prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 3-Chlorobenzenethiolate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
Above this benzene, there is a chlorine atom in the third position (according to the carbon atom of benzene). The chlorine atom, a group of benzene elements, has strong properties, and the benzene phase is different. Because of its effectiveness, it can affect the sub-cloud of benzene.
And the thiol group (-SH) of benzene is deuterated to form a thiol (-S -), that is, to form a special part of 3-chlorobenzenethiolate. This thiol has a certain degree of nucleation due to the existence of unformed molecules on sulfur atoms.
In addition, the 3-chlorobenzenethiolate process, with benzene groups, both have the characteristics of chlorine atoms and thiols. This makes it exhibit special properties in the synthesis and reaction.
First of all, under normal temperature and pressure, 3-chlorothiophenol salt is often white to light yellow solid powder, fine texture, and good uniformity can be seen. This appearance feature is quite helpful for the preliminary identification and determination of the substance. Looking at its color state, it can be seen.
Second word solubility, it shows unique properties in organic solvents. In polar organic solvents such as ethanol and acetone, 3-chlorothiophenol salt has a certain solubility. Ethanol is a common organic solvent with polar molecules. It can interact with 3-chlorothiophenol salt molecules through intermolecular forces, so that 3-chlorothiophenol salt partially dissolves. However, in water, its solubility is very small. Although water is also a polar solvent, the molecular structure of 3-chlorothiophenol salt makes it weak to interact with water molecules, making it difficult to overcome its own intermolecular forces and dissolve in water.
Furthermore, the melting point is also a key physical property. The melting point of 3-chlorothiophenol salt is relatively high, and specific temperature conditions are required to convert it from solid to liquid. This melting point characteristic is crucial for the separation, purification and treatment of the substance at a specific temperature environment. By controlling the temperature, the phase transition can be achieved, and then the purpose of separation or reaction can be achieved.
In addition, in terms of odor, 3-chlorothiophenol salts often emit a special odor, which is slightly irritating and can be distinguished by smell. This odor characteristic is also an important basis for identifying the substance.
In summary, the physical properties, appearance, solubility, melting point and odor of 3-chlorothiophenol salts are all important entry points for the understanding and study of this compound, and are of great significance for chemical experiments, industrial production and related fields.
Another method starts with 3-chloroaniline, reacts with diazotization to obtain diazonium salt, then reacts with potassium thiocyanate, and then hydrolyzes to obtain 3-chlorothiophenol, and then forms a salt. The diazotization reaction needs to be low temperature to maintain the stability of diazonium salt, and the dosage ratio of reagents needs to be accurate, otherwise the yield will be affected.
Furthermore, 3-chlorophenol can be started from 3-chlorophenol, and after thioreaction, with appropriate sulfur reagents, such as sodium hydride, under suitable conditions, 3-chlorothiophenol can be obtained first, and finally its salt. This way is relatively simple, but the selection of thioreagents and the optimization of reaction conditions are the keys to obtaining high yield.
All these methods have their own advantages and disadvantages. In practical application, the availability of raw materials, the difficulty of reaction, and the consideration of cost should be carefully selected to achieve the purpose of efficient preparation of 3-chlorothiophenol.
One of them can be obtained by reacting 3-chlorothiophenol with alkali metal hydroxide. Take an appropriate amount of 3-chlorothiophenol, place it in a clean reaction vessel, and slowly add an aqueous solution of alkali metal hydroxide, such as sodium hydroxide solution. This process requires constant stirring to make the two fully contact the reaction. Because 3-chlorothiophenol is weakly acidic, it can undergo acid-base neutralization with alkali metal hydroxide to generate 3-chlorothiophenol and water. The reaction formula is roughly: 3-chlorothiophenol + alkali metal hydroxide → 3-chlorothiophenol + water. After the reaction is complete, pure 3-chlorobrombenzene thiophenate can be obtained by means of evaporation solvent and crystallization.
Second, 3-chlorobrombenzene and sodium hydrosulfide are used as raw materials. First dissolve 3-chlorobrombenzene in a suitable organic solvent, such as N, N-dimethylformamide (DMF). In a nitrogen-protected atmosphere, add sodium hydrosulfide to it. This reaction needs to be carried out at a certain temperature, usually heated to a moderate temperature, such as 50-80 ° C, and continuously stirred. The bromine atom in 3-chlorobrombenzene has high activity and can be replaced by thiohydrogen ions to generate 3-chlorobrombenzene thiophenol. Then, add an appropriate amount of alkali, such as potassium carbonate, 3-chlorothiophenol reacts with the base, and then converts to 3-chlorothiophenol salt. After the reaction, a series of post-processing steps such as extraction, washing, drying, concentration, etc. can obtain the target product 3-chlorothiophenol salt.
Third, 3-chloronitrobenzene is used as the starting material. First, 3-chloronitrobenzene is reduced to 3-chloroaniline, which is commonly used as a reducing agent such as iron filings and hydrochloric acid system. 3-chloroaniline reacts with potassium thiocyanate under appropriate conditions to generate 3-chlorophenylthiourea. 3-Chlorothiophenol can be obtained by hydrolysis of 3-chlorothiophenol, and finally reacts with alkali to form 3-chlorothiophenol salt. This method is a little complicated, but the raw materials are relatively easy to obtain, and it is also a feasible preparation route under specific conditions. Pay attention to the precise control of the reaction conditions at each step, including temperature, reaction time, proportion of reactants, etc., to improve the yield and purity of the product.
The first person to pay attention, its chemical properties are lively. 3 - Chlorothiophenol salt encounters certain substances, or reacts violently. During operation, it is necessary to carefully review all kinds of reagents and materials in contact with it, so as not to cause accidents by contact. In case of strong oxidizing agents, there is a risk of combustion and explosion. Therefore, when storing and using, it should be separated from dangerous substances such as oxidizing agents according to its characteristics, and be careful to take precautions.
Furthermore, it is toxic. Harmful to the human body, if it is accidentally touched, or penetrated through the skin, or accidentally inhaled its volatile gas, it can damage health. Light or cause skin itching, redness and swelling, respiratory discomfort; severe cases may endanger the viscera. Therefore, when operating, protective gear is indispensable. Wear protective clothing and gloves to ensure that the skin is not exposed; and prepare a gas mask to prevent inhalation of harmful gases. And after the operation, be sure to wash your hands and expose your skin to prevent residual toxins from hurting the body.
Environmental impact should not be ignored. 3 - If chlorothiophenol salts flow into the environment, or pollute soil and water sources, it will harm the ecology. Waste after use should not be discarded at will. It must be properly disposed of in accordance with regulations, or handed over to a professional organization to handle it in an environmentally friendly manner, so as not to cause harm to nature.
Operating skills are also key. When taking it, the accuracy of the quantity is related to the success or failure of the reaction. When using a precise measuring tool, take it according to the square, and do not increase or decrease at will. And in the reaction process, temperature, pH and other conditions, it also needs to be strictly controlled. Minor differences, or the reaction is biased, do not achieve the expected effect.
In terms of recording, the details of the operation process should be recorded in detail. When to take it, the geometry of the dosage, and the reaction phenomenon are all important information. This is very beneficial for subsequent analysis and summary, and it is also convenient to trace the problem and optimize the process.
Its chemical properties are the first to promote nucleophilicity. The anion part of phenylthiophenol has nucleophilic characteristics and is easy to attack electrophilic reagents. Because the sulfur atom has a lone pair electron, it has an affinity for the positive center. In case of halogenated hydrocarbons, it can initiate a nucleophilic substitution reaction, and the sulfur atom replaces the halogen atom to form a new sulfur-containing organic compound. This reaction is commonly used in the field of organic synthesis, which can produce a variety of products with sulfur-containing structures and expand the variety of organic molecules.
Furthermore, chlorine atoms of 3-chlorobenzenethiolate can participate in the reaction. Although the activity of chlorine atoms on the benzene ring is lower than that of alkyl halides, substitution reactions can occur under appropriate conditions, such as strong bases and high temperature environments. Chlorine atoms can be replaced by other nucleophilic groups, enriching the molecular structure. And due to the electronegativity of chlorine atoms, it has an impact on the distribution of electron clouds in the benzene ring, which indirectly affects the reactivity and selectivity of phenylthiophenol anions.
In addition, the stability of 3-chlorobenzenethiolate is also key to its chemical properties. Under different environments, the stability is different. In acidic media, the anion of phenylthiophenol is easily protonated and converted to 3-chlorobenzenethiol, and the structure and reactivity are It is relatively stable in alkaline or neutral environments and can participate in various reactions.
Its solubility also affects its chemical behavior. Generally speaking, such compounds have good solubility in organic solvents such as dichloromethane and tetrahydrofuran, making it easy to carry out reactions in organic phases. However, their solubility in water is limited, which determines the choice of reaction system and affects the separation of the reaction and the product.
First, it is often a key reagent in organic synthesis. It can interact with halogenated hydrocarbons and react with nucleophilic substitution to generate thioether compounds. Such thioethers have important applications in various fields such as medicine, pesticides and materials science. For example, when synthesizing pharmaceutical intermediates with specific structures, 3-chlorothiophenol salts can introduce sulfur-containing groups, endow the compounds with unique biological activity, and pave the way for the development of new drugs.
Second, the method of surface treatment of metals is also useful. It can be combined with the metal surface to form a dense protective film. This film can effectively resist the erosion of the metal by the external environment, such as preventing the metal from rusting and enhancing its corrosion resistance. Taking steel products as an example, after being treated with 3-chlorothiophenol, its service life can be significantly extended, and it has considerable benefits in industrial production and daily life.
Third, in the category of catalytic reactions, 3-chlorothiophenol can sometimes be used as a ligand. In synergy with metal catalysts, the electron cloud density and spatial structure of the catalyst can be changed, thereby regulating the activity and selectivity of the catalytic reaction. In the catalytic process of some organic synthesis, with its unique coordination properties, the reaction can be carried out efficiently and directionally, and the purity and yield of the product can be improved, which is of great significance to the development of fine chemicals.
Furthermore, the choice of solvent is also crucial. Different solvents have an impact on the solubility, stability and reactivity of 3-chlorothiophenol salt. According to the specific reaction mechanism and expected products, the appropriate solvent should be selected to promote the reaction.
And the ratio of the reactants needs to be precisely regulated. If the ratio of 3-chlorothiophenol salt to other reactants is improper, or the reaction is incomplete, or unnecessary by-products are generated. Special attention should be paid to the cleanliness of the reaction system, impurities or interfere with the reaction process, or poison the catalyst. If the reaction requires a catalyst, it is necessary to ensure that its activity and dosage are accurate.
In addition, safety should not be ignored. 3-chlorothiophenol salt may be toxic and irritating. When operating, follow safety procedures and prepare suitable protective measures, such as protective clothing, gloves and goggles. Operate in a well-ventilated place to prevent the accumulation of harmful gases and damage to personal health. It is also necessary to properly dispose of the reaction waste, according to the requirements of environmental protection, do not discard it at will, and avoid polluting the environment. In this way, the synthesis reaction of 3-chlorophenylthiophenol salt can be smooth and the ideal product can be obtained.
First of all, ecology, it enters the nature, or it is very harmful to aquatic organisms. Water is the source of all things, and many aquatic organisms depend on it for survival. If 3-chlorothiophenol salt enters the water body, it may cause poisoning to aquatic organisms. Fish inhale or ingest water containing this substance, or damage their gills, livers and other organs, causing breathing difficulties, metabolic disorders, and even death. And it also affects aquatic plants, or inhibits their photosynthesis, disturbs their growth and development, and disrupts the ecological balance of water bodies.
Furthermore, if the soil contains 3-chlorothiophenol, it may affect the activity of soil microorganisms. Soil microorganisms are crucial to soil fertility and material circulation. This substance may inhibit the growth and reproduction of beneficial microorganisms, such as nitrogen-fixing bacteria, phosphorus-solubilizing bacteria, etc., causing soil nutrient transformation to be blocked, affecting plant nutrient absorption, and then affecting terrestrial ecosystems.
As for the human body, 3-chlorothiophenol may enter the body through the respiratory tract, skin contact, dietary intake, etc. Inhaled through the respiratory tract, this substance may irritate the respiratory mucosa, causing cough, asthma and other symptoms. Long-term exposure may damage lung function and increase the risk of respiratory diseases. Skin contact may cause skin allergies, itching, redness and swelling, etc. If ingested through diet, this substance may accumulate in the body, damage the liver, kidneys and other organs, interfere with the normal metabolism of the human body, and affect physical health.
From this perspective, 3-chlorothiophenol salts have a great impact on the environment, and both the balance of the ecosystem and human health are threatened. Therefore, such substances should be handled with caution to prevent them from entering the environment wantonly, so as to ensure ecological harmony and human health.
In today's market, its demand is maintained at a certain level. In the field of pharmaceutical synthesis, because it can participate in the construction of specific drug molecular structures and help the research and development of new drugs, it is often sought by the pharmaceutical industry. For example, when developing new antibacterial and antiviral drugs, 3-chlorothiophenol salts may be involved, laying the foundation for the active ingredients of finished drugs.
In the field of materials science, it may be used for the creation of special materials. Such as synthesizing materials with special electrical and optical properties to meet the needs of electronic and optical device manufacturing. Therefore, the electronics industry and related scientific research institutions are also the source of their market demand.
However, looking at its supply, it depends on the method of chemical synthesis. Chemical companies that can produce this product must have excellent craftsmanship and compliance processes to ensure product purity and quality. Some large chemical companies have mature technology and considerable production capacity, and are important in market supply.
And in trade circulation, it is often transferred to the demand side through the hands of professional chemical product traders. During the trade process, the conditions of transportation and storage also need to be strictly controlled. Due to its nature or risk to transportation, relevant safety regulations must be followed. Overall, 3-chlorothiophenol salts play an indispensable role in specific chemical, pharmaceutical, and materials markets, where demand and supply are intertwined to create a market.

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