Linshang Chemical
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3-Chlorofluorobenzene
Linshang Chemical
|
HS Code |
684988 |
| Chemical Formula | C6H4ClF |
| Molecular Weight | 116.546 g/mol |
| Appearance | Colorless liquid |
| Odor | Aromatic odor |
| Density | 1.22 g/cm³ (at 20 °C) |
| Boiling Point | 132 - 133 °C |
| Melting Point | -58 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in most organic solvents |
| Vapor Pressure | 1.33 kPa (at 24.7 °C) |
As an accredited 3-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1L glass bottle filled with 500ml of 3 - chlorofluorobenzene for chemical packaging. |
| Storage | 3 - Chlorofluorobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals. Ensure the storage location is dry to avoid potential reactions with moisture. |
| Shipping | 3 - Chlorofluorobenzene is shipped in accordance with strict hazardous material regulations. It's transported in specialized containers to prevent leakage, ensuring safe transit by road, rail, or sea. Proper labeling and documentation are mandatory. |
Competitive 3-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is also an organic compound. It has a wide range of uses and is used in all fields of chemical industry.
It is the first to promote the synthesis of medicine. It can be a key intermediate and participates in the preparation of a variety of drugs. In the synthesis of antibacterial drugs, with its unique chemical structure, it can introduce specific functional groups, so that the drug has better antibacterial activity and pharmacological properties, which helps to resist pathogens and heal diseases.
In addition, it also has extraordinary performance in the field of pesticides. Pesticides made from it have the effect of efficient control of pests. Or it can interfere with the physiological metabolism of pests, or damage their nervous system, achieve the purpose of controlling damage, protecting grain and gardens, and escort agricultural harvests.
has made its mark in the field of materials science. In the synthesis of high-performance engineering plastics, 3-chlorofluorobenzene plays a key role in optimizing material properties, such as enhancing heat resistance, chemical corrosion resistance, etc., so that the material can remain stable under extreme conditions, and is widely used in high-end fields such as aerospace and automobile manufacturing.
In addition, in the synthesis of dyes, it can contribute unique structural units, giving dyes a bright color and good light resistance and washable fastness, making the fabric lasting and bright after dyeing.
In summary, although 3-chlorofluorobenzene is an organic compound, it has important uses in many fields such as medicine, pesticides, materials, and dyes, and is of great significance to promoting the development of related industries.
It is the first to promote the synthesis of medicine. It can be a key intermediate and participates in the preparation of a variety of drugs. In the synthesis of antibacterial drugs, with its unique chemical structure, it can introduce specific functional groups, so that the drug has better antibacterial activity and pharmacological properties, which helps to resist pathogens and heal diseases.
In addition, it also has extraordinary performance in the field of pesticides. Pesticides made from it have the effect of efficient control of pests. Or it can interfere with the physiological metabolism of pests, or damage their nervous system, achieve the purpose of controlling damage, protecting grain and gardens, and escort agricultural harvests.
has made its mark in the field of materials science. In the synthesis of high-performance engineering plastics, 3-chlorofluorobenzene plays a key role in optimizing material properties, such as enhancing heat resistance, chemical corrosion resistance, etc., so that the material can remain stable under extreme conditions, and is widely used in high-end fields such as aerospace and automobile manufacturing.
In addition, in the synthesis of dyes, it can contribute unique structural units, giving dyes a bright color and good light resistance and washable fastness, making the fabric lasting and bright after dyeing.
In summary, although 3-chlorofluorobenzene is an organic compound, it has important uses in many fields such as medicine, pesticides, materials, and dyes, and is of great significance to promoting the development of related industries.
What are the physical properties of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is one of the organic compounds. It has unique physical properties, as detailed below.
Looking at its appearance, at room temperature and pressure, 3-chlorofluorobenzene is a colorless and transparent liquid, with a clear texture and invisible impurities, as pure as a spring.
Smell its smell, this substance emits a fragrant smell, but although its taste is fragrant, it has a certain irritation. If this irritating smell is inhaled in excess, it may damage the respiratory system of the human body.
As for its boiling point, it is between 128 ° C and 130 ° C. When the temperature rises, 3-chlorofluorobenzene gradually changes from a liquid state to a gaseous state, and undergoes a phase change. Its melting point is about -37 ° C. When the temperature is lower than that, the substance will condense into a solid state.
The density of 3-chlorofluorobenzene is heavier than that of water, about 1.29 g/cm ³. If it is mixed with water, it will sink to the bottom of the water, and the two will not dissolve. Because it is a non-polar molecule and water is a polar molecule, it is difficult for the two to dissolve each other according to the principle of "similar miscibility".
Furthermore, 3-chlorofluorobenzene has good solubility in organic solvents, such as ethanol and ether. This property makes it used as a solvent in the field of organic synthesis, assisting in the progress of many chemical reactions.
In addition, the vapor pressure of 3-chlorofluorobenzene also has a specific value within a certain temperature range. The vapor pressure reflects the difficulty of volatilization, and the value shows that 3-chlorofluorobenzene is volatile at room temperature. Therefore, when storing and using, pay attention to ventilation to prevent the accumulation of steam from causing danger.
Looking at its appearance, at room temperature and pressure, 3-chlorofluorobenzene is a colorless and transparent liquid, with a clear texture and invisible impurities, as pure as a spring.
Smell its smell, this substance emits a fragrant smell, but although its taste is fragrant, it has a certain irritation. If this irritating smell is inhaled in excess, it may damage the respiratory system of the human body.
As for its boiling point, it is between 128 ° C and 130 ° C. When the temperature rises, 3-chlorofluorobenzene gradually changes from a liquid state to a gaseous state, and undergoes a phase change. Its melting point is about -37 ° C. When the temperature is lower than that, the substance will condense into a solid state.
The density of 3-chlorofluorobenzene is heavier than that of water, about 1.29 g/cm ³. If it is mixed with water, it will sink to the bottom of the water, and the two will not dissolve. Because it is a non-polar molecule and water is a polar molecule, it is difficult for the two to dissolve each other according to the principle of "similar miscibility".
Furthermore, 3-chlorofluorobenzene has good solubility in organic solvents, such as ethanol and ether. This property makes it used as a solvent in the field of organic synthesis, assisting in the progress of many chemical reactions.
In addition, the vapor pressure of 3-chlorofluorobenzene also has a specific value within a certain temperature range. The vapor pressure reflects the difficulty of volatilization, and the value shows that 3-chlorofluorobenzene is volatile at room temperature. Therefore, when storing and using, pay attention to ventilation to prevent the accumulation of steam from causing danger.
What is the chemistry of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is also an organic compound. It has the general properties of halogenated aromatics, and its properties are quite stable. Due to the existence of the benzene ring conjugate system.
In terms of its physical properties, 3-chlorofluorobenzene is a colorless and transparent liquid at room temperature and pressure, with a special aromatic odor. Its boiling point is about 128-129 ° C, its melting point is about -56 ° C. Its density is higher than that of water, and it is insoluble in water, but it can be miscible with organic solvents such as ethanol, ether, and benzene.
In terms of chemical properties, the electron cloud density of the benzene ring changes due to the substitution of chlorine and fluor Both fluorine and chlorine have an electron-absorbing induction effect, resulting in a decrease in the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is slightly lower than that of benzene.
During the electrophilic substitution reaction, due to the localization effect of fluorine and chlorine, the new substituents are more likely to enter the benzene ring meta-site. If nitrification occurs, under the action of mixed acid of nitric acid and sulfuric acid, meta-nitro substitution products can be formed.
3-chlorofluorobenzene can also participate in the nucleophilic substitution reaction. Under specific conditions, chlorine or fluorine atoms can be replaced by nucleophilic reagents. For example, at strong bases and high temperatures, chlorine atoms can be replaced by hydroxyl groups to form 3-fluorophenol.
For example, under palladium catalysis, coupling with compounds containing borate esters can form new carbon-carbon bonds, which are widely used in the field of organic synthesis. In short, 3-chlorofluorobenzene has important applications in many chemical fields such as medicine, pesticides, and materials due to its unique chemical properties.
In terms of its physical properties, 3-chlorofluorobenzene is a colorless and transparent liquid at room temperature and pressure, with a special aromatic odor. Its boiling point is about 128-129 ° C, its melting point is about -56 ° C. Its density is higher than that of water, and it is insoluble in water, but it can be miscible with organic solvents such as ethanol, ether, and benzene.
In terms of chemical properties, the electron cloud density of the benzene ring changes due to the substitution of chlorine and fluor Both fluorine and chlorine have an electron-absorbing induction effect, resulting in a decrease in the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is slightly lower than that of benzene.
During the electrophilic substitution reaction, due to the localization effect of fluorine and chlorine, the new substituents are more likely to enter the benzene ring meta-site. If nitrification occurs, under the action of mixed acid of nitric acid and sulfuric acid, meta-nitro substitution products can be formed.
3-chlorofluorobenzene can also participate in the nucleophilic substitution reaction. Under specific conditions, chlorine or fluorine atoms can be replaced by nucleophilic reagents. For example, at strong bases and high temperatures, chlorine atoms can be replaced by hydroxyl groups to form 3-fluorophenol.
For example, under palladium catalysis, coupling with compounds containing borate esters can form new carbon-carbon bonds, which are widely used in the field of organic synthesis. In short, 3-chlorofluorobenzene has important applications in many chemical fields such as medicine, pesticides, and materials due to its unique chemical properties.
What is 3-chlorofluorobenzene production method?
The preparation method of 3-chlorofluorobenzene is often involved in the number method. One is to use 3-chloroaniline as the starting material, through diazotization and replacement reaction.
First dissolve 3-chloroaniline in acid solution, generally with hydrochloric acid, cool down to 0-5 ℃, add sodium nitrite solution dropwise, and perform diazotization reaction to obtain 3-chlorobenzene diazosalt solution. This step requires temperature control and feeding rate to prevent the decomposition of diazosalt.
Then, add fluoroboronic acid to the above diazosalt solution to form 3-chlorobenzene diazofluoroborate precipitation. The precipitate is filtered out, washed, dried, and then heated to decompose to obtain 3-chlorofluorobenzene. This decomposition reaction requires appropriate temperature and conditions to promote its smooth transformation.
Another method can be started by m-chlorobenzoic acid. Isochlorobenzoic acid and fluorinating agents, such as potassium fluoride, are fluorinated in the presence of appropriate solvents and catalysts to obtain intermediate products. The intermediate product is then decarboxylated to obtain 3-chlorofluorobenzene. During fluorination, choose the appropriate fluorinating agent, solvent and catalyst, and control the reaction temperature and time, which is very important to improve the yield and purity. The decarboxylation reaction also requires suitable conditions to facilitate the formation of products.
Furthermore, using benzene as the starting material, chlorobenzene is first chlorinated to obtain chlorobenzene, and then chlorobenzene is reacted with the fluorinating agent. This approach requires fine regulation of each step of the reaction. Due to the different substitution activities of chlorine atoms and fluorine atoms on the benzene ring, the reaction conditions and catalysts are selected to lead the reaction to generate 3-chlorofluorobenzene, and the side reactions are reduced to improve the yield and purity of the product.
First dissolve 3-chloroaniline in acid solution, generally with hydrochloric acid, cool down to 0-5 ℃, add sodium nitrite solution dropwise, and perform diazotization reaction to obtain 3-chlorobenzene diazosalt solution. This step requires temperature control and feeding rate to prevent the decomposition of diazosalt.
Then, add fluoroboronic acid to the above diazosalt solution to form 3-chlorobenzene diazofluoroborate precipitation. The precipitate is filtered out, washed, dried, and then heated to decompose to obtain 3-chlorofluorobenzene. This decomposition reaction requires appropriate temperature and conditions to promote its smooth transformation.
Another method can be started by m-chlorobenzoic acid. Isochlorobenzoic acid and fluorinating agents, such as potassium fluoride, are fluorinated in the presence of appropriate solvents and catalysts to obtain intermediate products. The intermediate product is then decarboxylated to obtain 3-chlorofluorobenzene. During fluorination, choose the appropriate fluorinating agent, solvent and catalyst, and control the reaction temperature and time, which is very important to improve the yield and purity. The decarboxylation reaction also requires suitable conditions to facilitate the formation of products.
Furthermore, using benzene as the starting material, chlorobenzene is first chlorinated to obtain chlorobenzene, and then chlorobenzene is reacted with the fluorinating agent. This approach requires fine regulation of each step of the reaction. Due to the different substitution activities of chlorine atoms and fluorine atoms on the benzene ring, the reaction conditions and catalysts are selected to lead the reaction to generate 3-chlorofluorobenzene, and the side reactions are reduced to improve the yield and purity of the product.
What are the precautions in storage and transportation of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, the first choice of environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. Because of its flammability, it may cause combustion if heated or exposed to open flames. The temperature of the warehouse should be controlled within a suitable range. Excessive temperature can easily cause its volatilization to accelerate and increase safety hazards.
Furthermore, it should be stored separately from oxidants and edible chemicals. If mixed, it may cause danger due to chemical reactions. And the storage area should be prepared with suitable materials to contain leaks in case of leakage, which can be properly handled in time to prevent the spread of hazards.
When transporting, you also need to be very careful. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During driving, make sure that the container does not leak, collapse, fall or damage.
The speed of the vehicle during transportation should not be too fast, do not forcibly overtake, and avoid sudden braking to prevent packaging damage. And during transportation, it is strictly forbidden to mix and transport with oxidants, edible chemicals, etc. After transportation, the vehicle should be thoroughly cleaned and disinfected to prevent residual substances from affecting subsequent transportation items.
In short, the storage and transportation of 3-chlorofluorobenzene is related to safety, and all links must strictly follow relevant regulations and operating procedures, and must not be slack at all, so as to ensure safety.
When storing, the first choice of environment. It should be placed in a cool and ventilated warehouse, away from fires and heat sources. Because of its flammability, it may cause combustion if heated or exposed to open flames. The temperature of the warehouse should be controlled within a suitable range. Excessive temperature can easily cause its volatilization to accelerate and increase safety hazards.
Furthermore, it should be stored separately from oxidants and edible chemicals. If mixed, it may cause danger due to chemical reactions. And the storage area should be prepared with suitable materials to contain leaks in case of leakage, which can be properly handled in time to prevent the spread of hazards.
When transporting, you also need to be very careful. The transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During driving, make sure that the container does not leak, collapse, fall or damage.
The speed of the vehicle during transportation should not be too fast, do not forcibly overtake, and avoid sudden braking to prevent packaging damage. And during transportation, it is strictly forbidden to mix and transport with oxidants, edible chemicals, etc. After transportation, the vehicle should be thoroughly cleaned and disinfected to prevent residual substances from affecting subsequent transportation items.
In short, the storage and transportation of 3-chlorofluorobenzene is related to safety, and all links must strictly follow relevant regulations and operating procedures, and must not be slack at all, so as to ensure safety.
What are the main uses of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is a class of organic compounds. It has a wide range of uses and has important applications in many fields.
First in the field of medicine. In the process of drug synthesis, 3-chlorofluorobenzene often acts as a key intermediate. Because of its unique chemical structure, it can participate in a series of organic reactions to construct complex drug molecular structures. The development and production of many antibacterial drugs, antidepressants, etc. rely on the help of 3-chlorofluorobenzene. With its special functional group properties, it can precisely regulate the activity, selectivity and pharmacokinetic properties of drugs, thereby improving the efficacy and safety of drugs.
Furthermore, it also plays an important role in the field of pesticides. Using 3-chlorofluorobenzene as the starting material, a variety of high-efficiency and low-toxicity pesticides can be synthesized. Such pesticides have significant effect on the prevention and control of crop diseases and pests, and can effectively ensure the yield and quality of crops. Its chemical stability and biological activity make it an indispensable ingredient in agricultural production. It can act against specific pests or bacteria, and has relatively little impact on the environment, which is in line with the development needs of modern green agriculture.
In addition, in the field of materials science, 3-chlorofluorobenzene is also used. It can be used to prepare polymer materials with special properties, such as engineering plastics with excellent heat resistance and chemical corrosion resistance. In the electronics industry, such materials are often used to make packaging materials for electronic components, substrates for printed circuit boards, etc. Their unique structure endows materials with special physical and chemical properties, which meet the strict requirements of the electronics industry for high performance of materials.
In summary, 3-chlorofluorobenzene is a crucial compound in the fields of medicine, pesticides and materials science, and plays a crucial role in promoting technological development and industrial progress in various fields.
First in the field of medicine. In the process of drug synthesis, 3-chlorofluorobenzene often acts as a key intermediate. Because of its unique chemical structure, it can participate in a series of organic reactions to construct complex drug molecular structures. The development and production of many antibacterial drugs, antidepressants, etc. rely on the help of 3-chlorofluorobenzene. With its special functional group properties, it can precisely regulate the activity, selectivity and pharmacokinetic properties of drugs, thereby improving the efficacy and safety of drugs.
Furthermore, it also plays an important role in the field of pesticides. Using 3-chlorofluorobenzene as the starting material, a variety of high-efficiency and low-toxicity pesticides can be synthesized. Such pesticides have significant effect on the prevention and control of crop diseases and pests, and can effectively ensure the yield and quality of crops. Its chemical stability and biological activity make it an indispensable ingredient in agricultural production. It can act against specific pests or bacteria, and has relatively little impact on the environment, which is in line with the development needs of modern green agriculture.
In addition, in the field of materials science, 3-chlorofluorobenzene is also used. It can be used to prepare polymer materials with special properties, such as engineering plastics with excellent heat resistance and chemical corrosion resistance. In the electronics industry, such materials are often used to make packaging materials for electronic components, substrates for printed circuit boards, etc. Their unique structure endows materials with special physical and chemical properties, which meet the strict requirements of the electronics industry for high performance of materials.
In summary, 3-chlorofluorobenzene is a crucial compound in the fields of medicine, pesticides and materials science, and plays a crucial role in promoting technological development and industrial progress in various fields.
What are the physical properties of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is one of the organic compounds. Its physical properties are unique and have the following numbers.
Looking at its morphology, under room temperature and pressure, 3-chlorofluorobenzene is a colorless and transparent liquid. The appearance is pure and fluid, and the visible luster is clear and moist, just like the flow of jade liquid.
Smell its smell. This substance emits a special aromatic smell. Although it is not as elegant as the orchid, it is also unique. However, this smell may irritate the human respiratory tract, so it should be smelled carefully.
In terms of its boiling point, it is about 137 ° C - 138 ° C. When the temperature reaches this point, 3-chlorofluorobenzene gradually changes from liquid to gaseous state, and the molecular motion intensifies, breaking free from the liquid phase. The characteristics of this boiling point are of great significance in chemical separation, purification and other processes.
As for the melting point, it is about -57 ° C. When the temperature drops, the thermal motion of the molecules slows down, and the attractive force between them makes the substance solidify from liquid to solid, and the structure tends to be orderly.
The density of 3-chlorofluorobenzene is slightly larger than that of water, about 1.29 g/cm ³. When placed in water, it can be seen that it sinks to the bottom of the water, and the two are distinct.
In terms of solubility, it is insoluble in water, but in most organic solvents, such as ethanol, ether, acetone, etc., it can be miscible in any ratio. This property is derived from the interaction forces between its molecular structure and organic solvent molecules, such as van der Waals force, hydrogen bond, etc., which promote the miscibility of the two, providing convenience for organic synthesis and other fields, and is often used as a reaction medium or extractant.
And because its molecules contain chlorine and fluorine atoms, it has certain chemical stability. However, under specific conditions, it can also participate in many chemical reactions, showing unique chemical activities, and is widely used in the field of organic synthesis chemistry.
Looking at its morphology, under room temperature and pressure, 3-chlorofluorobenzene is a colorless and transparent liquid. The appearance is pure and fluid, and the visible luster is clear and moist, just like the flow of jade liquid.
Smell its smell. This substance emits a special aromatic smell. Although it is not as elegant as the orchid, it is also unique. However, this smell may irritate the human respiratory tract, so it should be smelled carefully.
In terms of its boiling point, it is about 137 ° C - 138 ° C. When the temperature reaches this point, 3-chlorofluorobenzene gradually changes from liquid to gaseous state, and the molecular motion intensifies, breaking free from the liquid phase. The characteristics of this boiling point are of great significance in chemical separation, purification and other processes.
As for the melting point, it is about -57 ° C. When the temperature drops, the thermal motion of the molecules slows down, and the attractive force between them makes the substance solidify from liquid to solid, and the structure tends to be orderly.
The density of 3-chlorofluorobenzene is slightly larger than that of water, about 1.29 g/cm ³. When placed in water, it can be seen that it sinks to the bottom of the water, and the two are distinct.
In terms of solubility, it is insoluble in water, but in most organic solvents, such as ethanol, ether, acetone, etc., it can be miscible in any ratio. This property is derived from the interaction forces between its molecular structure and organic solvent molecules, such as van der Waals force, hydrogen bond, etc., which promote the miscibility of the two, providing convenience for organic synthesis and other fields, and is often used as a reaction medium or extractant.
And because its molecules contain chlorine and fluorine atoms, it has certain chemical stability. However, under specific conditions, it can also participate in many chemical reactions, showing unique chemical activities, and is widely used in the field of organic synthesis chemistry.
What is the chemistry of 3-chlorofluorobenzene?
3-Chlorofluorobenzene is also an organic compound. It has the properties of halogenated aromatics, and its chemical properties are different due to the presence of chlorine and fluorodihalogen atoms.
As for the nucleophilic substitution reaction, chlorine and fluorine atoms can be replaced by nucleophilic reagents. However, the activities of the two are different. The fluorine atom has strong electronegativity, which reduces the electron cloud density of the benzene ring, making nucleophilic substitution easier; the activity of the chlorine atom is slightly less, and the substitution reaction requires more severe conditions. In case of strong nucleophilic reagents such as sodium alcohol, corresponding substitution products can be produced.
When it is in the electrophilic substitution reaction, the hal Because the halogen atom has a lone pair of electrons, it can conjugate with the benzene ring, causing the electron cloud density of the ortho and para-position to rise slightly, and the electrophilic reagents are easy to attack these two positions. However, the halogen atom has an electron-absorbing induction effect, which generally reduces the electron cloud density of the benzene ring, so the electrophilic substitution reaction activity is lower than that of benzene. For example, nitrification occurs, and the main products are chlorine, fluoro-ortho, and para-position nitro substitutes.
3-chlorofluorobenzene can also participate in metal-catalyzed reactions. For example, under palladium catalysis, it can couple and react with organic reagents containing boron and tin to form carbon-carbon bonds. It has a Due to its halogen-containing atoms, it is stable and chemically inert, and can be used as a solvent or reaction intermediate in certain specific environments. It is used in various fields such as medicine, pesticides, and materials. With its special chemical properties, compounds with specific functions can be prepared.
As for the nucleophilic substitution reaction, chlorine and fluorine atoms can be replaced by nucleophilic reagents. However, the activities of the two are different. The fluorine atom has strong electronegativity, which reduces the electron cloud density of the benzene ring, making nucleophilic substitution easier; the activity of the chlorine atom is slightly less, and the substitution reaction requires more severe conditions. In case of strong nucleophilic reagents such as sodium alcohol, corresponding substitution products can be produced.
When it is in the electrophilic substitution reaction, the hal Because the halogen atom has a lone pair of electrons, it can conjugate with the benzene ring, causing the electron cloud density of the ortho and para-position to rise slightly, and the electrophilic reagents are easy to attack these two positions. However, the halogen atom has an electron-absorbing induction effect, which generally reduces the electron cloud density of the benzene ring, so the electrophilic substitution reaction activity is lower than that of benzene. For example, nitrification occurs, and the main products are chlorine, fluoro-ortho, and para-position nitro substitutes.
3-chlorofluorobenzene can also participate in metal-catalyzed reactions. For example, under palladium catalysis, it can couple and react with organic reagents containing boron and tin to form carbon-carbon bonds. It has a Due to its halogen-containing atoms, it is stable and chemically inert, and can be used as a solvent or reaction intermediate in certain specific environments. It is used in various fields such as medicine, pesticides, and materials. With its special chemical properties, compounds with specific functions can be prepared.
What are the preparation methods of 3-chlorofluorobenzene?
3-Chlorofluorobenzene, as well as organic compounds, can be prepared by various methods. One is to start with 3-chloroaniline, which can be obtained by diazotization and Sandmeier reaction. First dissolve 3-chloroaniline into an appropriate amount of hydrochloric acid, cold to low temperature, slowly drop into the sodium nitrite solution to obtain the diazonium salt solution. Then drop it into the copper salt solution containing fluoroborate acid, decompose under heat, and produce 3-chlorofluorobenzene. This process requires attention to temperature control, low temperature to prevent the decomposition of diazonium salts, and the reaction device needs to be tight to avoid the escape of harmful gases.
The second method is based on m-chlorobenzoic acid. First, the isochlorobenzoic acid is co-heated with a fluorinating agent such as potassium fluoride, and is obtained by decarboxylation and fluoridation. During this period, it is crucial to select a suitable solvent and catalyst. High-boiling organic solvents, such as N-methylpyrrolidone, are commonly used to help the reactants miscible; catalysts can accelerate the reaction process and increase the yield. This reaction condition also needs to be fine-tuned. Temperature and reaction time affect the purity and yield of the product.
Furthermore, benzene is used as the starting material and is prepared by chlorination and fluorination in steps. Benzene and chlorine under the action of catalysts such as iron trichloride, chlorobenzene is obtained; chlorobenzene reacts with fluoride under specific conditions to produce 3-chlorofluorobenzene There are many steps in this way, and each step needs to be finely separated and purified to remove impurities and ensure the purity of the final product. Each method has its own advantages and disadvantages. In actual preparation, it is selected according to factors such as raw material availability, cost, and product requirements.
The second method is based on m-chlorobenzoic acid. First, the isochlorobenzoic acid is co-heated with a fluorinating agent such as potassium fluoride, and is obtained by decarboxylation and fluoridation. During this period, it is crucial to select a suitable solvent and catalyst. High-boiling organic solvents, such as N-methylpyrrolidone, are commonly used to help the reactants miscible; catalysts can accelerate the reaction process and increase the yield. This reaction condition also needs to be fine-tuned. Temperature and reaction time affect the purity and yield of the product.
Furthermore, benzene is used as the starting material and is prepared by chlorination and fluorination in steps. Benzene and chlorine under the action of catalysts such as iron trichloride, chlorobenzene is obtained; chlorobenzene reacts with fluoride under specific conditions to produce 3-chlorofluorobenzene There are many steps in this way, and each step needs to be finely separated and purified to remove impurities and ensure the purity of the final product. Each method has its own advantages and disadvantages. In actual preparation, it is selected according to factors such as raw material availability, cost, and product requirements.
3-chlorofluorobenzene what are the precautions during use
3-Chlorofluorobenzene is also a chemical reagent. In the process of use, several things should be careful.
First, it is toxic. Touch it, smell it, or eat it, all harmful to health. When using, wear protective clothing, gloves and gas masks, and do it in a well-ventilated place to prevent its gas from entering the body and avoid contact with the skin and eyes. If you contact it carelessly, flush it with water and seek medical attention.
times, its flammability should also be paid attention to. In case of an open flame, high heat can burn, and toxic smoke will be produced when burning. Store it in a cool and ventilated compartment, and store it in a separate storage with oxygen agents and acids to prevent risk from mixed storage.
Furthermore, the chemical activity of 3-chlorofluorobenzene. In combination with multiple substances, when used, know its reaction to other agents in detail, pre-reaction results, and avoid unexpected life. When dosing the liquid, mix it in sequence and proportion, stir it steadily, control the temperature and speed.
In addition, it is also heavy. Discard it, when in accordance with regulations, do not discharge it indiscriminately, anti-fouling ring. Use a finished container to clean it with an agent to remove residues.
In short, use 3-chlorofluorobenzene, be careful and careful, operate in accordance with regulations, ensure safety, protect the ring and human health.
First, it is toxic. Touch it, smell it, or eat it, all harmful to health. When using, wear protective clothing, gloves and gas masks, and do it in a well-ventilated place to prevent its gas from entering the body and avoid contact with the skin and eyes. If you contact it carelessly, flush it with water and seek medical attention.
times, its flammability should also be paid attention to. In case of an open flame, high heat can burn, and toxic smoke will be produced when burning. Store it in a cool and ventilated compartment, and store it in a separate storage with oxygen agents and acids to prevent risk from mixed storage.
Furthermore, the chemical activity of 3-chlorofluorobenzene. In combination with multiple substances, when used, know its reaction to other agents in detail, pre-reaction results, and avoid unexpected life. When dosing the liquid, mix it in sequence and proportion, stir it steadily, control the temperature and speed.
In addition, it is also heavy. Discard it, when in accordance with regulations, do not discharge it indiscriminately, anti-fouling ring. Use a finished container to clean it with an agent to remove residues.
In short, use 3-chlorofluorobenzene, be careful and careful, operate in accordance with regulations, ensure safety, protect the ring and human health.
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