Linshang Chemical
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3-Chloroiodobenzene
Linshang Chemical
|
HS Code |
442418 |
| Name | 3-Chloroiodobenzene |
| Chemical Formula | C6H4ClI |
| Molar Mass | 238.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Density | 1.857 g/cm³ at 25 °C |
| Boiling Point | 218 - 220 °C |
| Melting Point | −16 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 92.2 °C |
| Cas Number | 637-87-6 |
| Refractive Index | 1.637 at 20 °C |
As an accredited 3-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - chloroiodobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 3 - Chloroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Due to its potential toxicity, it should be stored separately from food and beverages, and clearly labeled to ensure proper handling and safety. |
| Shipping | 3 - Chloroiodobenzene is shipped in accordance with hazardous chemical regulations. It's packed in sealed, corrosion - resistant containers, safeguarded during transit to prevent leakage and ensure safe delivery. |
Competitive 3-Chloroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-chloroiodobenzene?
3-Chloroiodobenzene, an organic compound, has a wide range of uses. In the field of organic synthesis, it can be called a crucial intermediate.
One of them can be used to construct various complex organic molecular structures. For example, in the palladium-catalyzed cross-coupling reaction, the chlorine atom and the iodine atom of 3-chloroiodobenzene can participate in different reaction paths respectively. The iodine atom is highly active and easily couples with alkenyl and aryl-containing boric acids and other reagents to form carbon-carbon bonds, so that biphenyl derivatives with specific structures can be constructed. This process is like building a delicate building block, each step of the reaction is carefully constructed, laying the foundation for the synthesis of compounds with biological activity or special physical properties.
Second, in the field of medicinal chemistry, 3-chloroiodobenzene also plays a key role. Due to its unique structure, it can become the starting material for the design of new drug molecules. Through subsequent chemical modification, different functional groups are introduced, which in turn regulates the activity, solubility and affinity of drug molecules with targets. For example, it is like finely carving a key so that it can precisely open the lock of disease treatment.
Furthermore, in the field of materials science, 3-chloroiodobenzene can be polymerized or copolymerized with other monomers to prepare materials with special photoelectric properties. Such materials may show excellent application prospects in organic Light Emitting Diode (OLED), solar cells and other fields, just like adding a bright star to the stage of new materials.
In summary, 3-chloroiodobenzene, with its unique chemical structure, occupies an indispensable position in many fields such as organic synthesis, drug development, and material preparation. It is like a shining pearl, guiding the direction of many scientific research and industrial production.
One of them can be used to construct various complex organic molecular structures. For example, in the palladium-catalyzed cross-coupling reaction, the chlorine atom and the iodine atom of 3-chloroiodobenzene can participate in different reaction paths respectively. The iodine atom is highly active and easily couples with alkenyl and aryl-containing boric acids and other reagents to form carbon-carbon bonds, so that biphenyl derivatives with specific structures can be constructed. This process is like building a delicate building block, each step of the reaction is carefully constructed, laying the foundation for the synthesis of compounds with biological activity or special physical properties.
Second, in the field of medicinal chemistry, 3-chloroiodobenzene also plays a key role. Due to its unique structure, it can become the starting material for the design of new drug molecules. Through subsequent chemical modification, different functional groups are introduced, which in turn regulates the activity, solubility and affinity of drug molecules with targets. For example, it is like finely carving a key so that it can precisely open the lock of disease treatment.
Furthermore, in the field of materials science, 3-chloroiodobenzene can be polymerized or copolymerized with other monomers to prepare materials with special photoelectric properties. Such materials may show excellent application prospects in organic Light Emitting Diode (OLED), solar cells and other fields, just like adding a bright star to the stage of new materials.
In summary, 3-chloroiodobenzene, with its unique chemical structure, occupies an indispensable position in many fields such as organic synthesis, drug development, and material preparation. It is like a shining pearl, guiding the direction of many scientific research and industrial production.
What are the physical properties of 3-chloroiodobenzene?
3-Chloroiodobenzene is an organic compound. It has special physical properties and is listed below.
First appearance, 3-chloroiodobenzene is a colorless to light yellow liquid at room temperature. It is clear and has a certain fluidity. It can refract light under sunlight, such as oily things.
When it comes to boiling point, it is about 220-225 ℃. At this temperature, 3-chloroiodobenzene changes from liquid to gaseous state, because the molecule is energized enough to break free from the attractive forces between molecules. The value of the boiling point is related to the phase transition under different temperature environments, and is of great significance in experimental operations such as distillation and separation, as well as in industrial processes.
In addition to the melting point, the melting point of 3-chloroiodobenzene is low, about - 20 ° C. When the ambient temperature drops below the melting point, it solidifies from a liquid state to a solid state, and the molecular arrangement tends to be ordered from disorder, and the lattice structure gradually forms.
The density of 3-chloroiodobenzene is greater than that of water, about 1.99 g/cm ³. If it is placed in a container with water, it will sink to the bottom of the water. This characteristic is due to the close arrangement of molecules and the large atomic weight.
Its solubility also has characteristics, slightly soluble in water, because 3-chloroiodobenzene is a non-polar or weakly polar molecule, while water is a strongly polar molecule, according to the principle of "similar miscibility", the mutual solubility of the two is poor. However, it is soluble in most organic solvents, such as ethanol, ether, benzene, etc. Because organic solvents are weakly polar or non-polar, and are compatible with the intermolecular force of 3-chloroiodobenzene, they can be miscible with each other.
In addition, 3-chloroiodobenzene has a certain volatility and can evaporate slowly in the air. Its vapor has a special smell. Although it is not pungent and intolerable, it should also be noted that because of its vapor or certain toxicity, excessive inhalation or harm to human health.
First appearance, 3-chloroiodobenzene is a colorless to light yellow liquid at room temperature. It is clear and has a certain fluidity. It can refract light under sunlight, such as oily things.
When it comes to boiling point, it is about 220-225 ℃. At this temperature, 3-chloroiodobenzene changes from liquid to gaseous state, because the molecule is energized enough to break free from the attractive forces between molecules. The value of the boiling point is related to the phase transition under different temperature environments, and is of great significance in experimental operations such as distillation and separation, as well as in industrial processes.
In addition to the melting point, the melting point of 3-chloroiodobenzene is low, about - 20 ° C. When the ambient temperature drops below the melting point, it solidifies from a liquid state to a solid state, and the molecular arrangement tends to be ordered from disorder, and the lattice structure gradually forms.
The density of 3-chloroiodobenzene is greater than that of water, about 1.99 g/cm ³. If it is placed in a container with water, it will sink to the bottom of the water. This characteristic is due to the close arrangement of molecules and the large atomic weight.
Its solubility also has characteristics, slightly soluble in water, because 3-chloroiodobenzene is a non-polar or weakly polar molecule, while water is a strongly polar molecule, according to the principle of "similar miscibility", the mutual solubility of the two is poor. However, it is soluble in most organic solvents, such as ethanol, ether, benzene, etc. Because organic solvents are weakly polar or non-polar, and are compatible with the intermolecular force of 3-chloroiodobenzene, they can be miscible with each other.
In addition, 3-chloroiodobenzene has a certain volatility and can evaporate slowly in the air. Its vapor has a special smell. Although it is not pungent and intolerable, it should also be noted that because of its vapor or certain toxicity, excessive inhalation or harm to human health.
Is 3-chloroiodobenzene chemically stable?
3-Chloroiodobenzene is also an organic compound. The stability of its chemical properties needs to be studied carefully.
On its structure, above the benzene ring, chlorine and iodine are in one place each. The benzene ring is inherently stable because of its conjugation system. However, the substitution of chlorine and iodine also affects its properties.
The chlorine atom has an electron-absorbing induction effect. Although the electron cloud density of the iodine atom is large, its atomic radius is also large. The two are on the benzene ring, which changes the electron cloud density distribution of the benzene ring. This change affects the reactivity of 3-chloroiodobenzene.
In the electrophilic substitution reaction, the electron cloud density of benzene ring decreases due to the electron-absorbing action of chlorine and iodine, and the electrophilic substitution reaction activity slightly decreases compared with benzene. However, the selectivity of the reaction check point is complicated due to the localization effect of the two. Chlorine is an ortho-para localization group, and iodine also has a certain ortho-para localization tendency, so the distribution of reaction products has its own unique characteristics.
As for stability, 3-chloroiodobenzene can exist stably at room temperature and pressure without special conditions. However, under extreme conditions such as high temperature, strong oxidant, and strong base, its chemical bonds can be affected and changed. For example, at high temperatures, carbon-chlorine bonds and carbon-iodine bonds may break, causing chemical reactions to form new compounds.
Under conditions such as light, halogen atoms may initiate free radical reactions, which impair the stability of 3-chloroiodobenzene. Therefore, in general, 3-chloroiodobenzene has certain stability in conventional environments, but in special chemical environments, its properties are variable and it participates in various chemical reactions.
On its structure, above the benzene ring, chlorine and iodine are in one place each. The benzene ring is inherently stable because of its conjugation system. However, the substitution of chlorine and iodine also affects its properties.
The chlorine atom has an electron-absorbing induction effect. Although the electron cloud density of the iodine atom is large, its atomic radius is also large. The two are on the benzene ring, which changes the electron cloud density distribution of the benzene ring. This change affects the reactivity of 3-chloroiodobenzene.
In the electrophilic substitution reaction, the electron cloud density of benzene ring decreases due to the electron-absorbing action of chlorine and iodine, and the electrophilic substitution reaction activity slightly decreases compared with benzene. However, the selectivity of the reaction check point is complicated due to the localization effect of the two. Chlorine is an ortho-para localization group, and iodine also has a certain ortho-para localization tendency, so the distribution of reaction products has its own unique characteristics.
As for stability, 3-chloroiodobenzene can exist stably at room temperature and pressure without special conditions. However, under extreme conditions such as high temperature, strong oxidant, and strong base, its chemical bonds can be affected and changed. For example, at high temperatures, carbon-chlorine bonds and carbon-iodine bonds may break, causing chemical reactions to form new compounds.
Under conditions such as light, halogen atoms may initiate free radical reactions, which impair the stability of 3-chloroiodobenzene. Therefore, in general, 3-chloroiodobenzene has certain stability in conventional environments, but in special chemical environments, its properties are variable and it participates in various chemical reactions.
What are the synthesis methods of 3-chloroiodobenzene?
The synthesis method of 3-chloroiodobenzene has existed in ancient times, and is described in detail as follows.
First, it is formed by halogenation reaction. Benzene can be used as the substrate first, and chlorobenzene can be obtained by chlorination. Under specific conditions, chlorobenzene can be obtained by iodination with an appropriate iodine substitution reagent, such as iodine and an appropriate oxidizer, under the action of a catalyst. 3-chloroiodobenzene is obtained. Among them, during the chlorination reaction, a suitable chlorination agent, such as chlorine gas or ferric chloride, needs to be selected to control the reaction temperature, time and ratio of the reactants, so that the chlorine atom precisely replaces the hydrogen atom on To the iodization reaction, the oxidant involved can be nitric acid or hydrogen peroxide, etc., and the catalyst such as copper salts can promote the iodine atom to replace the hydrogen atom at a specific position of chlorobenzene, so as to achieve the purpose of synthesizing 3-chloroiodobenzene.
Second, it is prepared by coupling reaction. It can make chlorine-containing aromatic hydrocarbon derivatives and iodine-containing reagents under the catalysis of transition metal catalysts. For example, chlorophenylboronic acid and iodoaromatic hydrocarbons are used as raw materials. Under the action of palladium catalyst, in an alkaline environment, Suzuki coupling reaction occurs, and a carbon-carbon bond is cleverly constructed to realize the synthesis of 3-chloroiodobenzene. In this reaction, the choice and amount of catalyst, the type and concentration of base, the reaction solvent, etc., all have a great influence on the reaction, and need to be carefully regulated to obtain the ideal yield and selectivity.
Third, it is obtained by the diazonium salt conversion method. First, aniline is reacted by diazotization to obtain diazonium salt. After that, under suitable conditions, the diazonium salt is reacted with cuprous chloride, potassium iodide and other reagents, and the diazonium group is replaced by chlorine atom and iodine atom respectively through Sandmeyer reaction or similar reactions to achieve the synthesis of 3-chloroiodobenzene. In this process, the diazotization reaction needs to strictly control the temperature and pH value to ensure the stability and reactivity of the diazo salt, and the subsequent substitution reaction also needs to be carefully operated to ensure the smooth progress of the reaction.
First, it is formed by halogenation reaction. Benzene can be used as the substrate first, and chlorobenzene can be obtained by chlorination. Under specific conditions, chlorobenzene can be obtained by iodination with an appropriate iodine substitution reagent, such as iodine and an appropriate oxidizer, under the action of a catalyst. 3-chloroiodobenzene is obtained. Among them, during the chlorination reaction, a suitable chlorination agent, such as chlorine gas or ferric chloride, needs to be selected to control the reaction temperature, time and ratio of the reactants, so that the chlorine atom precisely replaces the hydrogen atom on To the iodization reaction, the oxidant involved can be nitric acid or hydrogen peroxide, etc., and the catalyst such as copper salts can promote the iodine atom to replace the hydrogen atom at a specific position of chlorobenzene, so as to achieve the purpose of synthesizing 3-chloroiodobenzene.
Second, it is prepared by coupling reaction. It can make chlorine-containing aromatic hydrocarbon derivatives and iodine-containing reagents under the catalysis of transition metal catalysts. For example, chlorophenylboronic acid and iodoaromatic hydrocarbons are used as raw materials. Under the action of palladium catalyst, in an alkaline environment, Suzuki coupling reaction occurs, and a carbon-carbon bond is cleverly constructed to realize the synthesis of 3-chloroiodobenzene. In this reaction, the choice and amount of catalyst, the type and concentration of base, the reaction solvent, etc., all have a great influence on the reaction, and need to be carefully regulated to obtain the ideal yield and selectivity.
Third, it is obtained by the diazonium salt conversion method. First, aniline is reacted by diazotization to obtain diazonium salt. After that, under suitable conditions, the diazonium salt is reacted with cuprous chloride, potassium iodide and other reagents, and the diazonium group is replaced by chlorine atom and iodine atom respectively through Sandmeyer reaction or similar reactions to achieve the synthesis of 3-chloroiodobenzene. In this process, the diazotization reaction needs to strictly control the temperature and pH value to ensure the stability and reactivity of the diazo salt, and the subsequent substitution reaction also needs to be carefully operated to ensure the smooth progress of the reaction.
What are the precautions for 3-chloroiodobenzene in storage and transportation?
3-Chloroiodobenzene is also an organic compound. When storing and transporting, many matters must be paid attention to.
The first word of storage, because it has a certain chemical activity, should be placed in a cool, dry and well ventilated place. Avoid open fires and hot topics to avoid the risk of explosion. If it is heated or caught in fire, or causes a violent reaction, it is very dangerous. The temperature of the warehouse should be controlled within a suitable range, not too high, so as not to change the properties of the material. It also needs to be separated from oxidants, strong bases and other substances, because it is easy to chemically react with these substances, cause material deterioration, or even cause accidents.
As for transportation, it must be done in accordance with the relevant hazardous chemicals transportation regulations. Transportation vehicles should have corresponding qualifications and complete protective facilities. When loading and unloading, the operation must be gentle, and do not drop or heavy pressure to prevent packaging damage and leakage of 3-chloroiodobenzene. During transportation, drivers and escorts must always pay attention to prevent sun and rain, and ensure a stable transportation environment. In case of leakage, take emergency measures, evacuate the crowd, seal the scene, and clean up and dispose of it by professional means to prevent its spread and endanger the surrounding environment and personal safety.
In short, the storage and transportation of 3-chloroiodobenzene must be strictly handled and followed to ensure safety.
The first word of storage, because it has a certain chemical activity, should be placed in a cool, dry and well ventilated place. Avoid open fires and hot topics to avoid the risk of explosion. If it is heated or caught in fire, or causes a violent reaction, it is very dangerous. The temperature of the warehouse should be controlled within a suitable range, not too high, so as not to change the properties of the material. It also needs to be separated from oxidants, strong bases and other substances, because it is easy to chemically react with these substances, cause material deterioration, or even cause accidents.
As for transportation, it must be done in accordance with the relevant hazardous chemicals transportation regulations. Transportation vehicles should have corresponding qualifications and complete protective facilities. When loading and unloading, the operation must be gentle, and do not drop or heavy pressure to prevent packaging damage and leakage of 3-chloroiodobenzene. During transportation, drivers and escorts must always pay attention to prevent sun and rain, and ensure a stable transportation environment. In case of leakage, take emergency measures, evacuate the crowd, seal the scene, and clean up and dispose of it by professional means to prevent its spread and endanger the surrounding environment and personal safety.
In short, the storage and transportation of 3-chloroiodobenzene must be strictly handled and followed to ensure safety.
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