Linshang Chemical
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3-Chloroisocyanatobenzene
Linshang Chemical
|
HS Code |
185634 |
| Chemical Formula | C7H4ClNO |
| Molecular Weight | 153.565 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 220 - 222 °C |
| Melting Point | 18 - 20 °C |
| Density | 1.325 g/cm³ at 25 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | Low |
| Flash Point | 92 °C |
| Odor | Pungent |
As an accredited 3-Chloroisocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - chloroisocyanatobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | 3 - Chloroisocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from incompatible substances like acids, bases, and reactive chemicals to avoid potential reactions. |
| Shipping | 3 - Chloroisocyanatobenzene is a chemical that requires careful shipping. It should be packaged in corrosion - resistant containers, kept away from heat and ignition sources. Shipments must comply with relevant chemical transportation regulations for safe transit. |
Competitive 3-Chloroisocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
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What are the chemical properties of 3-chloroisocyanatobenzene?
3-Phenyl chloroisocyanate is an organic compound with unique chemical properties. Its chemical activity is quite high and it is easy to react with many nucleophilic reagents.
In contact with water, 3-chloroisocyanate phenyl ester will hydrolyze rapidly, and the isocyanate group interacts with water to generate corresponding amines and carbon dioxide. The reaction is violent, or the system pressure increases, so it should be stored and used with caution.
The chlorine atom in 3-chloroisocyanate phenyl ester shows a certain activity due to the influence of benzene ring and isocyanate group. It can be substituted with nucleophilic reagents such as alcohols and amines. When reacting with alcohols, chlorine atoms are replaced by alkoxy groups to form ether derivatives; when reacting with amines, substituted amine products are formed. This property makes it a key intermediate in the construction of complex compounds in the field of organic synthesis.
Furthermore, the carbon and nitrogen double bond in the isocyanate group is chemically active. It can react with compounds containing active hydrogen, such as alcohols, phenols, amines, carboxylic acids, etc., according to a specific mechanism. React with alcohols to form carbamates, and react with amines to form urea compounds. These reactions are widely used in the synthesis of polyurethane materials, and 3-chlorophenyl isocyanate can be used as a raw material or an intermediate to participate in them.
In addition, the benzene ring in the 3-chloroisocyanate molecule confers certain aromatic properties and conjugation stability. Although the benzene ring is slightly less reactive than the isocyanate group and the chlorine atom, under certain conditions, such as the presence of strong oxidants or electrophilic reagents, benzene rings will also react, such as oxidation reactions, electrophilic substitution reactions, etc.
Due to its active chemical properties, 3-chloroisocyanate phenyl ester has a wide range of uses in organic synthesis, materials science and other fields. However, due to its potential danger, strict safety procedures must be followed when operating.
In contact with water, 3-chloroisocyanate phenyl ester will hydrolyze rapidly, and the isocyanate group interacts with water to generate corresponding amines and carbon dioxide. The reaction is violent, or the system pressure increases, so it should be stored and used with caution.
The chlorine atom in 3-chloroisocyanate phenyl ester shows a certain activity due to the influence of benzene ring and isocyanate group. It can be substituted with nucleophilic reagents such as alcohols and amines. When reacting with alcohols, chlorine atoms are replaced by alkoxy groups to form ether derivatives; when reacting with amines, substituted amine products are formed. This property makes it a key intermediate in the construction of complex compounds in the field of organic synthesis.
Furthermore, the carbon and nitrogen double bond in the isocyanate group is chemically active. It can react with compounds containing active hydrogen, such as alcohols, phenols, amines, carboxylic acids, etc., according to a specific mechanism. React with alcohols to form carbamates, and react with amines to form urea compounds. These reactions are widely used in the synthesis of polyurethane materials, and 3-chlorophenyl isocyanate can be used as a raw material or an intermediate to participate in them.
In addition, the benzene ring in the 3-chloroisocyanate molecule confers certain aromatic properties and conjugation stability. Although the benzene ring is slightly less reactive than the isocyanate group and the chlorine atom, under certain conditions, such as the presence of strong oxidants or electrophilic reagents, benzene rings will also react, such as oxidation reactions, electrophilic substitution reactions, etc.
Due to its active chemical properties, 3-chloroisocyanate phenyl ester has a wide range of uses in organic synthesis, materials science and other fields. However, due to its potential danger, strict safety procedures must be followed when operating.
What are the main uses of 3-chloroisocyanatobenzene?
Phenyl 3-chloroisocyanate is an important compound in organic chemistry. It has a wide range of main uses and is a key intermediate in the field of organic synthesis.
First, it plays a significant role in the synthesis of medicine. The preparation of many drugs depends on its participation in the reaction. By undergoing specific chemical reactions with other compounds, molecular structures with specific pharmacological activities can be constructed. For example, in the synthesis of certain anti-infective drugs, 3-chloroisocyanate phenyl ester can be combined with compounds containing specific functional groups, and through carefully designed reaction steps, pharmaceutical ingredients with good antibacterial and antiviral effects are finally generated.
Second, it also plays an important role in the field of pesticide synthesis. It can be used as a key raw material for the synthesis of high-efficiency pesticides. By reacting with various organic reagents, pesticide products that can effectively control crop diseases and pests can be generated. Such pesticides can precisely act on the specific physiological processes of pests or pathogens, inhibit their growth and reproduction, thereby ensuring the healthy growth of crops and improving the yield and quality of crops.
Third, in the field of materials science, 3-chlorophenyl isocyanate also has outstanding performance. It can be used to prepare polymer materials with special properties. It can react with polymer monomers containing active hydrogen, thereby changing the chemical structure and properties of polymer materials. For example, to make it have better heat resistance, corrosion resistance or mechanical properties, etc., it is widely used in aerospace, automobile manufacturing and other industries that require strict material properties. In conclusion, phenyl 3-chloroisocyanate, with its unique chemical structure and reactivity, plays an indispensable role in many fields such as medicine, pesticides, and materials science, and is of great significance to the development of various related industries.
First, it plays a significant role in the synthesis of medicine. The preparation of many drugs depends on its participation in the reaction. By undergoing specific chemical reactions with other compounds, molecular structures with specific pharmacological activities can be constructed. For example, in the synthesis of certain anti-infective drugs, 3-chloroisocyanate phenyl ester can be combined with compounds containing specific functional groups, and through carefully designed reaction steps, pharmaceutical ingredients with good antibacterial and antiviral effects are finally generated.
Second, it also plays an important role in the field of pesticide synthesis. It can be used as a key raw material for the synthesis of high-efficiency pesticides. By reacting with various organic reagents, pesticide products that can effectively control crop diseases and pests can be generated. Such pesticides can precisely act on the specific physiological processes of pests or pathogens, inhibit their growth and reproduction, thereby ensuring the healthy growth of crops and improving the yield and quality of crops.
Third, in the field of materials science, 3-chlorophenyl isocyanate also has outstanding performance. It can be used to prepare polymer materials with special properties. It can react with polymer monomers containing active hydrogen, thereby changing the chemical structure and properties of polymer materials. For example, to make it have better heat resistance, corrosion resistance or mechanical properties, etc., it is widely used in aerospace, automobile manufacturing and other industries that require strict material properties. In conclusion, phenyl 3-chloroisocyanate, with its unique chemical structure and reactivity, plays an indispensable role in many fields such as medicine, pesticides, and materials science, and is of great significance to the development of various related industries.
What are 3-chloroisocyanatobenzene synthesis methods?
The synthesis method of phenyl 3-chloroisocyanate, although the ancient book "Tiangong Kaiwu" does not contain this substance, it can be deduced according to the principles of ancient chemical synthesis.
First, m-chloroaniline is used as the starting material and first reacts with phosgene. M-chloroaniline needs to be finely purified to remove impurities to ensure the purity of the reaction. Phosgene also needs to be well prepared, and its reaction conditions are very critical. In a low temperature and inert gas protected environment, phosgene is slowly introduced into the solution of m-chloroaniline. This process requires strict control of temperature and inlet rate to prevent side reactions from occurring. Phosgene reacts with m-chloroaniline, the amino group reacts with the carbonyl group in phosgene to form an intermediate product, and then further dehydrochlorination to obtain 3-chloroisocyanate phenyl ester.
Second, start with m-chlorobenzoic acid. First convert m-chlorobenzoic acid to m-chlorobenzoyl chloride, and commonly used chlorinating reagents such as dichlorosulfoxide. When the two react, add an appropriate amount of catalyst and heat to promote the complete reaction. After obtaining m-chlorobenzoyl chloride, react with sodium azide. In this step, the reaction is carried out in a suitable solvent, and the temperature is controlled to fully react the m-chlorobenzoyl chloride with sodium azide to form an acyl azide. Then, through the Curtius rearrangement reaction, the acyl azide is converted into an isocyanate, that is, 3-chloroisocyanate.
Third, m-chlorobrombenzene can also be used as a raw material. First, the Grignard reagent is prepared. The m-chlorobrombenzene is reacted with magnesium chips in a solvent such as anhydrous ethyl ether. After the Grignard reagent is prepared, it is then reacted with cyanate. During the reaction, attention should be paid to the dryness of the solvent and the anhydrous and oxygen-free reaction system of the reaction system, so that the Grignard reagent can effectively react with the cyan
First, m-chloroaniline is used as the starting material and first reacts with phosgene. M-chloroaniline needs to be finely purified to remove impurities to ensure the purity of the reaction. Phosgene also needs to be well prepared, and its reaction conditions are very critical. In a low temperature and inert gas protected environment, phosgene is slowly introduced into the solution of m-chloroaniline. This process requires strict control of temperature and inlet rate to prevent side reactions from occurring. Phosgene reacts with m-chloroaniline, the amino group reacts with the carbonyl group in phosgene to form an intermediate product, and then further dehydrochlorination to obtain 3-chloroisocyanate phenyl ester.
Second, start with m-chlorobenzoic acid. First convert m-chlorobenzoic acid to m-chlorobenzoyl chloride, and commonly used chlorinating reagents such as dichlorosulfoxide. When the two react, add an appropriate amount of catalyst and heat to promote the complete reaction. After obtaining m-chlorobenzoyl chloride, react with sodium azide. In this step, the reaction is carried out in a suitable solvent, and the temperature is controlled to fully react the m-chlorobenzoyl chloride with sodium azide to form an acyl azide. Then, through the Curtius rearrangement reaction, the acyl azide is converted into an isocyanate, that is, 3-chloroisocyanate.
Third, m-chlorobrombenzene can also be used as a raw material. First, the Grignard reagent is prepared. The m-chlorobrombenzene is reacted with magnesium chips in a solvent such as anhydrous ethyl ether. After the Grignard reagent is prepared, it is then reacted with cyanate. During the reaction, attention should be paid to the dryness of the solvent and the anhydrous and oxygen-free reaction system of the reaction system, so that the Grignard reagent can effectively react with the cyan
3-chloroisocyanatobenzene What are the precautions during storage and transportation?
3-Phenyl chloroisocyanate is a commonly used raw material in organic synthesis. When storing and transporting, the following things should be paid attention to:
First, the storage environment is the most critical. This substance must be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is sensitive to heat, it is easy to decompose when heated, which can cause danger. The temperature of the warehouse should be controlled between -15 ° C and 30 ° C, and the humidity should also be maintained at 40% - 70% to prevent moisture from dissolving.
Second, the packaging must be tight. Usually, a sealed packaging container should be used to avoid contact with air and moisture. Because it is easy to react with water, it generates toxic hydrogen chloride gas and carbon dioxide, which not only endangers the environment, but also poses a threat to human health. The packaging material should be selected to withstand its corrosion, such as special plastic drums or iron drums lined with special coatings.
Third, when transporting, relevant laws and standards must be followed. Enterprises and vehicles with hazardous chemical transportation qualifications should be selected, and the transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, ensure that the vehicle runs smoothly and avoids violent vibration and collision to prevent package damage.
Fourth, careful operation and handling are required. Operators must wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing. During the handling process, it should be handled lightly, and it must not be dropped or dragged to avoid leakage.
Fifth, the storage area must be set up with obvious warning signs, indicating the words "toxic" and "flammable", and should be equipped with professional emergency rescue equipment and equipment, such as eye washers, showers and fire extinguishers, so as to facilitate quick response measures in emergency situations.
First, the storage environment is the most critical. This substance must be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is sensitive to heat, it is easy to decompose when heated, which can cause danger. The temperature of the warehouse should be controlled between -15 ° C and 30 ° C, and the humidity should also be maintained at 40% - 70% to prevent moisture from dissolving.
Second, the packaging must be tight. Usually, a sealed packaging container should be used to avoid contact with air and moisture. Because it is easy to react with water, it generates toxic hydrogen chloride gas and carbon dioxide, which not only endangers the environment, but also poses a threat to human health. The packaging material should be selected to withstand its corrosion, such as special plastic drums or iron drums lined with special coatings.
Third, when transporting, relevant laws and standards must be followed. Enterprises and vehicles with hazardous chemical transportation qualifications should be selected, and the transportation vehicles must be equipped with corresponding fire equipment and leakage emergency treatment equipment. During driving, ensure that the vehicle runs smoothly and avoids violent vibration and collision to prevent package damage.
Fourth, careful operation and handling are required. Operators must wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing. During the handling process, it should be handled lightly, and it must not be dropped or dragged to avoid leakage.
Fifth, the storage area must be set up with obvious warning signs, indicating the words "toxic" and "flammable", and should be equipped with professional emergency rescue equipment and equipment, such as eye washers, showers and fire extinguishers, so as to facilitate quick response measures in emergency situations.
3-chloroisocyanatobenzene impact on the environment and human health
3-Phenyl chloroisocyanate, which has a great impact on the environment and human health.
At the environmental end, it is volatile, escapes into the atmosphere, or reacts with other chemicals to generate new pollutants, causing air quality to decline and endangering the ecology. And if it is initialized into the water body by rain, it will pollute the water source, be highly toxic to aquatic organisms, interfere with the balance of aquatic ecosystems, and cause damage to biodiversity. If it penetrates into the soil, it will change the soil chemistry, hinder plant growth, and affect soil ecological functions.
As far as human health is concerned, it is highly irritating to the eyes, skin, respiratory tract, etc. If inhaled, it can cause coughing, asthma, breathing difficulties and other respiratory diseases, and even cause pulmonary edema in severe cases, which is life-threatening. Skin contact can cause redness, swelling, pain, and burns. If not treated in time, it may cause complications such as infection. Eye contact, mild tingling, tears, and severe cases can cause vision impairment. Long-term exposure to the environment containing this substance may increase the risk of cancer, because it may be a carcinogen and threaten human health.
In short, 3-chlorophenyl isocyanate poses significant hazards to the environment and human health, and needs to be treated with caution and proper handling.
At the environmental end, it is volatile, escapes into the atmosphere, or reacts with other chemicals to generate new pollutants, causing air quality to decline and endangering the ecology. And if it is initialized into the water body by rain, it will pollute the water source, be highly toxic to aquatic organisms, interfere with the balance of aquatic ecosystems, and cause damage to biodiversity. If it penetrates into the soil, it will change the soil chemistry, hinder plant growth, and affect soil ecological functions.
As far as human health is concerned, it is highly irritating to the eyes, skin, respiratory tract, etc. If inhaled, it can cause coughing, asthma, breathing difficulties and other respiratory diseases, and even cause pulmonary edema in severe cases, which is life-threatening. Skin contact can cause redness, swelling, pain, and burns. If not treated in time, it may cause complications such as infection. Eye contact, mild tingling, tears, and severe cases can cause vision impairment. Long-term exposure to the environment containing this substance may increase the risk of cancer, because it may be a carcinogen and threaten human health.
In short, 3-chlorophenyl isocyanate poses significant hazards to the environment and human health, and needs to be treated with caution and proper handling.
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