Linshang Chemical
PRODUCTS
(3-Chloropropyl)Benzene
Linshang Chemical
|
HS Code |
838546 |
| Chemical Formula | C9H11Cl |
| Molar Mass | 154.64 g/mol |
| Appearance | Colorless to light yellow liquid |
| Odor | Characteristic aromatic odor |
| Density | 1.065 g/cm³ (approximate) |
| Boiling Point | 218 - 220 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 86 °C (closed cup, approximate) |
As an accredited (3-Chloropropyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of (3 - chloropropyl)benzene packaged in a sealed, corrosion - resistant drum. |
| Storage | (3 - chloropropyl)benzene should be stored in a cool, well - ventilated area away from heat sources, open flames, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances to prevent chemical reactions. Ensure proper labeling for easy identification and safety compliance. |
| Shipping | (3 - chloropropyl)benzene is shipped in well - sealed, corrosion - resistant containers. Compliance with international chemical transportation regulations is ensured to prevent leakage and ensure safe transit during road, rail, or sea shipments. |
Competitive (3-Chloropropyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading (3-Chloropropyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of (3-chloropropyl) benzene?
(3-Chloropropyl) benzene is also an organic compound. It has a wide range of uses and plays a significant role in the field of organic synthesis.
First, it is often an important intermediate for the synthesis of many drugs. The preparation of drugs requires delicate construction of molecular structures. The specific chemical structure of (3-chloropropyl) benzene can be introduced into the target drug molecule through various chemical reactions to achieve the required pharmacological activity. For example, in the synthesis path of some nervous system drugs, (3-chloropropyl) benzene can be gradually converted into key structural fragments through halogenation reactions, nucleophilic substitution reactions, etc., and then synthesized into drugs with specific therapeutic effects.
Second, it is also indispensable in the field of materials science. It can be used as a monomer or modifier to participate in the synthesis of polymer materials. By polymerizing with other monomers, polymer materials are endowed with unique properties. For example, when preparing plastics with certain special properties, the introduction of (3-chloropropyl) benzene can improve the solubility, processability and mechanical properties of plastics, making the prepared plastic products more practical in specific environments.
Third, it is also used in the fragrance industry. Due to its unique chemical structure, through appropriate chemical modification and preparation, fragrance components with special aroma can be prepared, adding unique flavors and layers to the preparation of fragrances, enriching the types and qualities of fragrances.
In conclusion, (3-chloropropyl) benzene, with its unique chemical structure, plays an important role in drug synthesis, materials science, fragrance industry, and many other fields, promoting the development and progress of various fields.
First, it is often an important intermediate for the synthesis of many drugs. The preparation of drugs requires delicate construction of molecular structures. The specific chemical structure of (3-chloropropyl) benzene can be introduced into the target drug molecule through various chemical reactions to achieve the required pharmacological activity. For example, in the synthesis path of some nervous system drugs, (3-chloropropyl) benzene can be gradually converted into key structural fragments through halogenation reactions, nucleophilic substitution reactions, etc., and then synthesized into drugs with specific therapeutic effects.
Second, it is also indispensable in the field of materials science. It can be used as a monomer or modifier to participate in the synthesis of polymer materials. By polymerizing with other monomers, polymer materials are endowed with unique properties. For example, when preparing plastics with certain special properties, the introduction of (3-chloropropyl) benzene can improve the solubility, processability and mechanical properties of plastics, making the prepared plastic products more practical in specific environments.
Third, it is also used in the fragrance industry. Due to its unique chemical structure, through appropriate chemical modification and preparation, fragrance components with special aroma can be prepared, adding unique flavors and layers to the preparation of fragrances, enriching the types and qualities of fragrances.
In conclusion, (3-chloropropyl) benzene, with its unique chemical structure, plays an important role in drug synthesis, materials science, fragrance industry, and many other fields, promoting the development and progress of various fields.
What are the physical properties of (3-chloropropyl) benzene
(3-Chloropropyl) benzene has several physical properties. Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow transparent liquid, like a flowing glass, with a clear texture. Its smell is slightly aromatic, but it also has a slightly different taste. It is not pungent, but it can also attract attention.
On its boiling point, it is about 205 to 208 degrees Celsius. This value is quite high, which shows that the attractive force between molecules is quite strong, and it needs more energy to convert it from liquid to gas. The melting point is about minus 54 degrees Celsius, so it is stable in liquid state at room temperature.
In terms of density, it is about 1.06 grams per cubic centimeter, which is heavier than water. If placed in water, it is like sinking gold into water, slowly sinking, and layering with water.
Solubility is also an important physical property. (3-chloropropyl) benzene is insoluble in water, and the two are like Jingwei, making it difficult to blend. However, in organic solvents, such as ethanol, ether, acetone, etc., it can well dissolve with each other, just like a duck in water, and dissolves seamlessly, showing affinity with organic solvents.
In addition, its refractive index also has a specific value, about 1.520 - 1.524, which makes it a unique state of light deflection when light passes through, which is of concern to optical research and other fields. Such physical properties are the key to understanding (3-chloropropyl) benzene, and are important in many matters such as chemical industry and scientific research.
On its boiling point, it is about 205 to 208 degrees Celsius. This value is quite high, which shows that the attractive force between molecules is quite strong, and it needs more energy to convert it from liquid to gas. The melting point is about minus 54 degrees Celsius, so it is stable in liquid state at room temperature.
In terms of density, it is about 1.06 grams per cubic centimeter, which is heavier than water. If placed in water, it is like sinking gold into water, slowly sinking, and layering with water.
Solubility is also an important physical property. (3-chloropropyl) benzene is insoluble in water, and the two are like Jingwei, making it difficult to blend. However, in organic solvents, such as ethanol, ether, acetone, etc., it can well dissolve with each other, just like a duck in water, and dissolves seamlessly, showing affinity with organic solvents.
In addition, its refractive index also has a specific value, about 1.520 - 1.524, which makes it a unique state of light deflection when light passes through, which is of concern to optical research and other fields. Such physical properties are the key to understanding (3-chloropropyl) benzene, and are important in many matters such as chemical industry and scientific research.
What are the chemical properties of (3-chloropropyl) benzene
(3-Chloropropyl) benzene is one of the organic compounds. Its chemical properties are unique, with the dual characteristics of aromatics and halogenated alkanes.
As far as its aromatic hydrocarbon part is concerned, the benzene ring has a conjugated system and is stable, but it also gives it a specific reactivity. Electrophilic substitution reactions can occur. If bromination is taken as an example, under the catalysis of suitable catalysts such as iron filings, bromine can replace hydrogen atoms on the benzene ring to form halogenated aromatics. This is because the electron cloud density of the benzene ring is high, which is attractive to electrophilics.
As for the halogenated alkane part, that is, 3-chloropropyl, the chlorine atom has strong electronegativity, which makes the C-Cl bond polar. This polar bond is susceptible to attack by nucleophiles and triggers nucleophilic substitution reactions. For example, when co-heated with an aqueous solution of sodium hydroxide, the chlorine atom can be replaced by a hydroxyl group to form (3-hydroxypropyl) benzene; if reacted with sodium cyanide in an alcoholic solution, the chlorine atom is replaced by a cyano group, and the product is (3-cyanopropyl) benzene. This cyano group can be later converted into other functional groups such as carboxyl groups through reactions such as hydrolysis.
In addition, the C-Cl bond in (3-chloropropyl) benzene can be eliminated under certain conditions. If heated in a strong alkali alcohol solution, hydrogen chloride can be removed to form allyl benzene. This reaction follows the E2 elimination mechanism and is completed in one step, involving the breaking of old bonds and the formation of new bonds.
In short, (3-chloropropyl) benzene is rich in chemical properties, and its aromatics and halogenated alkanes interact with each other. It has important application value in the field of organic synthesis and can be converted into various organic compounds through various reaction paths.
As far as its aromatic hydrocarbon part is concerned, the benzene ring has a conjugated system and is stable, but it also gives it a specific reactivity. Electrophilic substitution reactions can occur. If bromination is taken as an example, under the catalysis of suitable catalysts such as iron filings, bromine can replace hydrogen atoms on the benzene ring to form halogenated aromatics. This is because the electron cloud density of the benzene ring is high, which is attractive to electrophilics.
As for the halogenated alkane part, that is, 3-chloropropyl, the chlorine atom has strong electronegativity, which makes the C-Cl bond polar. This polar bond is susceptible to attack by nucleophiles and triggers nucleophilic substitution reactions. For example, when co-heated with an aqueous solution of sodium hydroxide, the chlorine atom can be replaced by a hydroxyl group to form (3-hydroxypropyl) benzene; if reacted with sodium cyanide in an alcoholic solution, the chlorine atom is replaced by a cyano group, and the product is (3-cyanopropyl) benzene. This cyano group can be later converted into other functional groups such as carboxyl groups through reactions such as hydrolysis.
In addition, the C-Cl bond in (3-chloropropyl) benzene can be eliminated under certain conditions. If heated in a strong alkali alcohol solution, hydrogen chloride can be removed to form allyl benzene. This reaction follows the E2 elimination mechanism and is completed in one step, involving the breaking of old bonds and the formation of new bonds.
In short, (3-chloropropyl) benzene is rich in chemical properties, and its aromatics and halogenated alkanes interact with each other. It has important application value in the field of organic synthesis and can be converted into various organic compounds through various reaction paths.
What are the synthesis methods of (3-chloropropyl) benzene
The method of preparing (3-chloropropyl) benzene has been around for a long time. There are several common methods:
First, benzene and 3-chloropropylene are used as raw materials and prepared by Fu-gram alkylation reaction. This reaction requires Lewis acid such as anhydrous aluminum trichloride as a catalyst. In the reactor, benzene and 3-chloropropylene are mixed in a certain proportion, slowly add a catalyst, and stir the reaction at a suitable temperature. In this process, the catalyst activity is very critical, and the temperature needs to be precisely controlled. If the temperature is too low, the reaction rate is slow; if the temperature is too high, side reactions will easily occur, resulting in a decrease in the purity of the product. After the reaction is completed, (3-chloropropyl) benzene can be obtained through neutralization, liquid separation, distillation and other steps.
Second, benzyl chloride and ethylene are used as raw materials. First, benzyl chloride is reacted with magnesium to make Grignard's reagent, and then added with ethylene, and then the target product is prepared by hydrolysis and chlorination. When preparing Grignard's reagent, the reaction system must be anhydrous and oxygen-free, otherwise Grignard's reagent is easy to decompose. When adding the reaction, suitable reaction conditions need to be selected to improve the reaction yield. The hydrolysis step also needs to be carefully operated to control the degree of reaction, so as not to affect the subsequent chlorination reaction.
Third, benzene and 1,3-dichloropropane are used as raw materials to react under alkaline conditions Factors such as the type and amount of alkali, reaction temperature and time all have a significant impact on the reaction result. If the amount of alkali is insufficient, the reaction is difficult to proceed fully; if the reaction time is too long, the product may be further chlorinated or other side reactions may occur. After the reaction is completed, pure (3-chloropropyl) benzene is obtained through separation, purification and other operations.
All methods have advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider factors such as raw material availability, cost, and product purity requirements to choose the best method.
First, benzene and 3-chloropropylene are used as raw materials and prepared by Fu-gram alkylation reaction. This reaction requires Lewis acid such as anhydrous aluminum trichloride as a catalyst. In the reactor, benzene and 3-chloropropylene are mixed in a certain proportion, slowly add a catalyst, and stir the reaction at a suitable temperature. In this process, the catalyst activity is very critical, and the temperature needs to be precisely controlled. If the temperature is too low, the reaction rate is slow; if the temperature is too high, side reactions will easily occur, resulting in a decrease in the purity of the product. After the reaction is completed, (3-chloropropyl) benzene can be obtained through neutralization, liquid separation, distillation and other steps.
Second, benzyl chloride and ethylene are used as raw materials. First, benzyl chloride is reacted with magnesium to make Grignard's reagent, and then added with ethylene, and then the target product is prepared by hydrolysis and chlorination. When preparing Grignard's reagent, the reaction system must be anhydrous and oxygen-free, otherwise Grignard's reagent is easy to decompose. When adding the reaction, suitable reaction conditions need to be selected to improve the reaction yield. The hydrolysis step also needs to be carefully operated to control the degree of reaction, so as not to affect the subsequent chlorination reaction.
Third, benzene and 1,3-dichloropropane are used as raw materials to react under alkaline conditions Factors such as the type and amount of alkali, reaction temperature and time all have a significant impact on the reaction result. If the amount of alkali is insufficient, the reaction is difficult to proceed fully; if the reaction time is too long, the product may be further chlorinated or other side reactions may occur. After the reaction is completed, pure (3-chloropropyl) benzene is obtained through separation, purification and other operations.
All methods have advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider factors such as raw material availability, cost, and product purity requirements to choose the best method.
What are the precautions for (3-chloropropyl) benzene during storage and transportation?
For (3-chloropropyl) benzene, many things need to be paid attention to when storing and transporting.
The first to bear the brunt is the choice of storage environment. This substance should be placed in a cool and ventilated place, away from fires and heat sources. Because of its flammability, high temperatures or open flames are highly flammable, causing unexpected disasters. The temperature of the warehouse should be controlled within a suitable range to prevent excessive temperature from causing its volatilization to increase and increase the risk.
Furthermore, storage containers should not be underestimated. Choose suitable containers and ensure that they are tightly sealed. To prevent it from coming into contact with air, chemical reactions such as oxidation, which can affect quality or even generate dangerous products. At the same time, the material of the container must be able to withstand the corrosion of (3-chloropropyl) benzene to avoid leakage due to damage to the container.
When transporting, there are also many precautions. The transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment for emergencies. On the way, be sure to drive slowly to avoid sudden brakes and bumps to prevent damage and leakage of the container. Transportation personnel should also be familiar with the characteristics of (3-chloropropyl) benzene, and in the event of an emergency, they can respond quickly and appropriately.
In addition, whether it is storage or transportation, it needs to be stored or transported separately from oxidants, acids, alkalis and other substances. Because (3-chloropropyl) benzene and these substances are prone to violent reactions, resulting in serious consequences. Clear warning signs should be set up in storage areas and transportation vehicles to remind everyone to take precautions. In this way, the safety of (3-chloropropyl) benzene during storage and transportation must be ensured.
The first to bear the brunt is the choice of storage environment. This substance should be placed in a cool and ventilated place, away from fires and heat sources. Because of its flammability, high temperatures or open flames are highly flammable, causing unexpected disasters. The temperature of the warehouse should be controlled within a suitable range to prevent excessive temperature from causing its volatilization to increase and increase the risk.
Furthermore, storage containers should not be underestimated. Choose suitable containers and ensure that they are tightly sealed. To prevent it from coming into contact with air, chemical reactions such as oxidation, which can affect quality or even generate dangerous products. At the same time, the material of the container must be able to withstand the corrosion of (3-chloropropyl) benzene to avoid leakage due to damage to the container.
When transporting, there are also many precautions. The transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment for emergencies. On the way, be sure to drive slowly to avoid sudden brakes and bumps to prevent damage and leakage of the container. Transportation personnel should also be familiar with the characteristics of (3-chloropropyl) benzene, and in the event of an emergency, they can respond quickly and appropriately.
In addition, whether it is storage or transportation, it needs to be stored or transported separately from oxidants, acids, alkalis and other substances. Because (3-chloropropyl) benzene and these substances are prone to violent reactions, resulting in serious consequences. Clear warning signs should be set up in storage areas and transportation vehicles to remind everyone to take precautions. In this way, the safety of (3-chloropropyl) benzene during storage and transportation must be ensured.
What are the main uses of (3-chloropropyl) benzene?
(3-Chloropropyl) benzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
First, it can be used as a raw material for organic synthesis. The art of organic synthesis requires many basic raw materials as the cornerstone. (3-chloropropyl) benzene can be converted into other organic compounds through various reactions, such as substitution and addition. With its active chlorine atom, it can interact with a variety of nucleophiles and introduce other functional groups, so as to obtain products with complex structures and different functions, which are crucial in the synthesis of drugs, fragrances, dyes, etc.
Second, it also contributes to the field of materials science. It can be used as a monomer or modifier to participate in the preparation of polymer materials. Through polymerization, it is integrated into the polymer skeleton to impart specific properties to the material, such as improving the solubility, thermal stability, and mechanical properties of the material.
Third, in the field of pharmaceutical chemistry, (3-chloropropyl) benzene may be an important intermediate for the synthesis of drugs. When drugs are developed, chemists use their unique chemical structure to modify and transform to construct biologically active molecular structures, laying the foundation for the creation of new drugs.
Fourth, in the fragrance industry, compounds with special aromas can be synthesized through reaction, adding a unique flavor to fragrance formulations and enriching fragrance categories.
In summary, (3-chloropropyl) benzene plays an important role in many fields such as organic synthesis, materials science, medicinal chemistry, and fragrance industry due to its unique chemical properties. It has a wide range of uses and far-reaching influence.
First, it can be used as a raw material for organic synthesis. The art of organic synthesis requires many basic raw materials as the cornerstone. (3-chloropropyl) benzene can be converted into other organic compounds through various reactions, such as substitution and addition. With its active chlorine atom, it can interact with a variety of nucleophiles and introduce other functional groups, so as to obtain products with complex structures and different functions, which are crucial in the synthesis of drugs, fragrances, dyes, etc.
Second, it also contributes to the field of materials science. It can be used as a monomer or modifier to participate in the preparation of polymer materials. Through polymerization, it is integrated into the polymer skeleton to impart specific properties to the material, such as improving the solubility, thermal stability, and mechanical properties of the material.
Third, in the field of pharmaceutical chemistry, (3-chloropropyl) benzene may be an important intermediate for the synthesis of drugs. When drugs are developed, chemists use their unique chemical structure to modify and transform to construct biologically active molecular structures, laying the foundation for the creation of new drugs.
Fourth, in the fragrance industry, compounds with special aromas can be synthesized through reaction, adding a unique flavor to fragrance formulations and enriching fragrance categories.
In summary, (3-chloropropyl) benzene plays an important role in many fields such as organic synthesis, materials science, medicinal chemistry, and fragrance industry due to its unique chemical properties. It has a wide range of uses and far-reaching influence.
What are the physical properties of (3-chloropropyl) benzene
The physical properties of (3-chloropropyl) benzene are as follows: Looking at it, it is a colorless to light yellow transparent liquid at room temperature, resembling a clear oil, with a uniform texture and no precipitation and suspended solids. Smell it, there is an aromatic gas, but its taste is not as rich and pungent as the common aromatic hydrocarbons, slightly softer.
In terms of its melting point, the melting point is quite low, about -50 ° C below, so it is liquid at room temperature and pressure. The boiling point is between 210-215 ° C, which is higher than that of ordinary small molecule organic matter. This is due to the slightly stronger intermolecular force.
As for the density, it is slightly higher than that of water, about 1.06 - 1.08 g/cm ³, so it can sink to the bottom when poured into water. In terms of solubility, it is almost insoluble in water, because it is a non-polar organic matter, while water is a polar solvent, the polarity difference between the two is large, and it is difficult to dissolve. However, in organic solvents such as ethanol, ether, benzene, etc., it is very easy to dissolve, which follows the principle of "similar miscibility".
Furthermore, (3-chloropropyl) benzene is volatile and can slowly escape into the air in an open environment. Its vapor is heavier than air and easy to accumulate in low places. And it is flammable, in case of open flame, hot topic can be burned, the flame is bright when burning, accompanied by black smoke.
In terms of its melting point, the melting point is quite low, about -50 ° C below, so it is liquid at room temperature and pressure. The boiling point is between 210-215 ° C, which is higher than that of ordinary small molecule organic matter. This is due to the slightly stronger intermolecular force.
As for the density, it is slightly higher than that of water, about 1.06 - 1.08 g/cm ³, so it can sink to the bottom when poured into water. In terms of solubility, it is almost insoluble in water, because it is a non-polar organic matter, while water is a polar solvent, the polarity difference between the two is large, and it is difficult to dissolve. However, in organic solvents such as ethanol, ether, benzene, etc., it is very easy to dissolve, which follows the principle of "similar miscibility".
Furthermore, (3-chloropropyl) benzene is volatile and can slowly escape into the air in an open environment. Its vapor is heavier than air and easy to accumulate in low places. And it is flammable, in case of open flame, hot topic can be burned, the flame is bright when burning, accompanied by black smoke.
What are the chemical properties of (3-chloropropyl) benzene
(3-Chloropropyl) benzene is one of the organic compounds. It has specific chemical properties, which are described below.
In terms of reactivity, the presence of benzene rings gives it unique properties. Benzene rings are rich in electrons, nucleophilic, and easily react with electrophilic reagents. For example, electrophilic substitution reactions can occur with halogenating agents under appropriate conditions, introducing other groups at specific positions in the benzene ring. This reaction occurs because the conjugated system of the benzene ring provides an electron cloud that attracts electrophilic reagents to attack.
Furthermore, the chlorine atoms in the side chains also affect their chemical behavior. Chlorine atoms have an electron-absorbing induction effect, which reduces the electron cloud density of the carbon atoms connected to them. This makes the carbon atom vulnerable to attack by nucleophiles, thereby initiating nucleophilic substitution reactions. If reacted with nucleophiles such as sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
In addition, (3-chloropropyl) benzene can participate in free radical reactions. Under specific conditions, the propyl group of the side chain can generate free radicals, which can then participate in the addition and substitution reactions initiated by free radicals. For example, under the action of light or initiators, free radical addition reactions can occur with compounds containing double bonds to form new carbon-carbon bonds.
In addition, its chemical stability is also worthy of attention. Due to the conjugation stability of the benzene ring, (3-chloropropyl) benzene is relatively stable under normal conditions. When encountering extreme conditions such as strong oxidants or high temperatures, the benzene ring or side chain may also undergo reactions such as oxidation, destroying its original structure.
In summary, the existence of (3-chloropropyl) benzene ring and side chain chlorine atoms presents diverse chemical properties and has important application value in organic synthesis and other fields.
In terms of reactivity, the presence of benzene rings gives it unique properties. Benzene rings are rich in electrons, nucleophilic, and easily react with electrophilic reagents. For example, electrophilic substitution reactions can occur with halogenating agents under appropriate conditions, introducing other groups at specific positions in the benzene ring. This reaction occurs because the conjugated system of the benzene ring provides an electron cloud that attracts electrophilic reagents to attack.
Furthermore, the chlorine atoms in the side chains also affect their chemical behavior. Chlorine atoms have an electron-absorbing induction effect, which reduces the electron cloud density of the carbon atoms connected to them. This makes the carbon atom vulnerable to attack by nucleophiles, thereby initiating nucleophilic substitution reactions. If reacted with nucleophiles such as sodium alcohol, chlorine atoms can be replaced by alkoxy groups to form corresponding ether compounds.
In addition, (3-chloropropyl) benzene can participate in free radical reactions. Under specific conditions, the propyl group of the side chain can generate free radicals, which can then participate in the addition and substitution reactions initiated by free radicals. For example, under the action of light or initiators, free radical addition reactions can occur with compounds containing double bonds to form new carbon-carbon bonds.
In addition, its chemical stability is also worthy of attention. Due to the conjugation stability of the benzene ring, (3-chloropropyl) benzene is relatively stable under normal conditions. When encountering extreme conditions such as strong oxidants or high temperatures, the benzene ring or side chain may also undergo reactions such as oxidation, destroying its original structure.
In summary, the existence of (3-chloropropyl) benzene ring and side chain chlorine atoms presents diverse chemical properties and has important application value in organic synthesis and other fields.
What are the synthesis methods of (3-chloropropyl) benzene
There are several common methods for preparing (3-chloropropyl) benzene.
First, benzene and 3-chloropropylene are used as raw materials, and under the action of a suitable catalyst, the Fu-gram alkylation reaction occurs. This reaction requires the right catalyst, such as anhydrous aluminum trichloride, etc., to make the reaction proceed smoothly. In the process, the double bond of 3-chloropropylene is affected by the catalyst, and the electron cloud is rearranged, which is then connected to the benzene ring to form (3-chloropropyl) benzene.
Second, the radical substitution reaction between propylene and chlorine under light conditions can first generate 3-chloropropylene. Then 3-chloropropene reacts with benzene under the action of Lewis acid catalyst. In this two-step reaction, the lighting conditions of the former need to be precisely controlled, so that chlorine only replaces propylene α-hydrogen atoms to obtain the target intermediate 3-chloropropene; the activity and dosage of the latter catalyst are related to the yield and purity of the product.
Third, benzene is used as the starting material to make Grignard reagents, such as phenyl magnesium bromide. Then it undergoes a nucleophilic addition reaction with 3-chloropropanal. The obtained product is dehydrated and reduced, and finally (3-chloropropenyl) benzene can be obtained. This method step is slightly complicated, but the reaction conditions of each step are relatively mild, and the equipment requirements are not very high. Each method has its advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider the availability of raw materials, cost, product purity requirements and other factors to choose the appropriate one.
First, benzene and 3-chloropropylene are used as raw materials, and under the action of a suitable catalyst, the Fu-gram alkylation reaction occurs. This reaction requires the right catalyst, such as anhydrous aluminum trichloride, etc., to make the reaction proceed smoothly. In the process, the double bond of 3-chloropropylene is affected by the catalyst, and the electron cloud is rearranged, which is then connected to the benzene ring to form (3-chloropropyl) benzene.
Second, the radical substitution reaction between propylene and chlorine under light conditions can first generate 3-chloropropylene. Then 3-chloropropene reacts with benzene under the action of Lewis acid catalyst. In this two-step reaction, the lighting conditions of the former need to be precisely controlled, so that chlorine only replaces propylene α-hydrogen atoms to obtain the target intermediate 3-chloropropene; the activity and dosage of the latter catalyst are related to the yield and purity of the product.
Third, benzene is used as the starting material to make Grignard reagents, such as phenyl magnesium bromide. Then it undergoes a nucleophilic addition reaction with 3-chloropropanal. The obtained product is dehydrated and reduced, and finally (3-chloropropenyl) benzene can be obtained. This method step is slightly complicated, but the reaction conditions of each step are relatively mild, and the equipment requirements are not very high. Each method has its advantages and disadvantages. In actual preparation, it is necessary to comprehensively consider the availability of raw materials, cost, product purity requirements and other factors to choose the appropriate one.
What to pay attention to when storing and transporting (3-chloropropyl) benzene
For (3-chloropropyl) benzene, many matters must be paid attention to during storage and transportation.
The first word of storage should be placed in a cool and ventilated warehouse. This is because (3-chloropropyl) benzene is volatile to a certain extent and may be flammable. A cool and ventilated place can reduce its volatilization rate and reduce fire risks. The temperature of the warehouse should be controlled within a reasonable range, and it must not be too high to prevent it from increasing volatilization due to rising temperature, increasing pressure, and causing danger such as container rupture.
Furthermore, it should be stored separately from oxidants and edible chemicals. Oxidants have strong oxidizing properties. (3-chloropropyl) benzene can come into contact with it or cause violent chemical reactions, causing accidents. When stored separately from edible chemicals, it is necessary to avoid its contamination of food and ensure the safety of people's diet.
Where it is stored, the packaging must be tightly sealed. This can prevent it from evaporating and escaping, and can also prevent external moisture, air, etc. from contacting it to prevent it from deteriorating.
As for transportation, transportation vehicles should have corresponding qualifications. Drivers and escorts must be professionally trained and familiar with the dangerous characteristics of (3-chloropropyl) benzene and emergency measures. During transportation, make sure that the container does not leak, collapse, fall, or damage.
The choice of driving route is also crucial. It should avoid densely populated areas and important places, such as schools, hospitals, shopping malls, etc., to reduce the harm to the public in the event of accidents. And transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to prepare for emergencies. In this way, the stability of (3-chloropropyl) benzene storage and transportation can be guaranteed.
The first word of storage should be placed in a cool and ventilated warehouse. This is because (3-chloropropyl) benzene is volatile to a certain extent and may be flammable. A cool and ventilated place can reduce its volatilization rate and reduce fire risks. The temperature of the warehouse should be controlled within a reasonable range, and it must not be too high to prevent it from increasing volatilization due to rising temperature, increasing pressure, and causing danger such as container rupture.
Furthermore, it should be stored separately from oxidants and edible chemicals. Oxidants have strong oxidizing properties. (3-chloropropyl) benzene can come into contact with it or cause violent chemical reactions, causing accidents. When stored separately from edible chemicals, it is necessary to avoid its contamination of food and ensure the safety of people's diet.
Where it is stored, the packaging must be tightly sealed. This can prevent it from evaporating and escaping, and can also prevent external moisture, air, etc. from contacting it to prevent it from deteriorating.
As for transportation, transportation vehicles should have corresponding qualifications. Drivers and escorts must be professionally trained and familiar with the dangerous characteristics of (3-chloropropyl) benzene and emergency measures. During transportation, make sure that the container does not leak, collapse, fall, or damage.
The choice of driving route is also crucial. It should avoid densely populated areas and important places, such as schools, hospitals, shopping malls, etc., to reduce the harm to the public in the event of accidents. And transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment to prepare for emergencies. In this way, the stability of (3-chloropropyl) benzene storage and transportation can be guaranteed.
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