Linshang Chemical
PRODUCTS
3-Fluoro-4-Chloro-1-Bromobenzene
Linshang Chemical
|
HS Code |
311736 |
| Chemical Formula | C6H3BrClF |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 197 - 199 °C |
| Melting Point | N/A |
| Density | 1.759 g/mL at 25 °C |
| Flash Point | 82.2 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ether, chloroform |
| Stability | Stable under normal conditions, but avoid heat, flames and strong oxidizing agents |
As an accredited 3-Fluoro-4-Chloro-1-Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram vial of 3 - fluoro - 4 - chloro - 1 - bromobenzene, tightly sealed. |
| Storage | 3 - fluoro - 4 - chloro - 1 - bromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames to prevent ignition. Keep it in a tightly sealed container to avoid vapor leakage. Store it separately from oxidizing agents and reactive chemicals to prevent potentially hazardous reactions. |
| Shipping | 3 - fluoro - 4 - chloro - 1 - bromobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to strict chemical transportation regulations, ensuring proper handling to prevent leakage and environmental or safety hazards during transit. |
Competitive 3-Fluoro-4-Chloro-1-Bromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Fluoro-4-Chloro-1-Bromobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Fluoro-4-Chloro-1-Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 3-fluoro-4-chloro-1-bromobenzene?
3-Fluoro-4-chloro-1-bromobenzene is one of the organic compounds. Among its molecules, above the benzene ring, the fluorine atom occupies the third position, the chlorine atom is at the fourth position, and the bromine atom is at the first position. The chemical properties of this compound are quite unique, due to the existence of halogen atoms, it has many special reaction properties.
Let's talk about the nucleophilic substitution reaction first. Because fluorine, chlorine, and bromine atoms are all electron-absorbing, the electron cloud density of the benzene ring decreases, especially at the adjacent position of the halogen atom, the electron cloud density decreases even more. Therefore, nucleophilic reagents are easy to attack the benzene ring and replace the halogen atom. However, different halogen atoms have different Usually, the bromine atom has the strongest leaving ability, followed by the chlorine atom, and the fluorine atom is the weakest. Therefore, during the nucleophilic substitution reaction, the bromine atom is most easily replaced, while the fluorine atom is more difficult.
Let's talk about the electrophilic substitution reaction again. Although the halogen atom is an electron-withdrawing group, it belongs to an ortho-para-position group. The solitary pair electrons of the halogen atom can be conjugated with the benzene ring, so that the electron cloud density of the ortho-para-position is relatively increased. Therefore, when the electrophilic reagent attacks the benzene ring, it mostly replaces in the ortho-para-position of the halogen atom. However, due to In general, fluorine atoms have strong electron-absorbing ability, which greatly reduces the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is slightly lower than that of chlorine and bromine substitutes.
In addition, 3-fluoro-4-chloro-1-bromobenzene is often used as an intermediate in organic synthesis. Because halogen atoms can be converted into other functional groups through various reactions to construct complex organic molecular structures, it has important applications in drug synthesis, materials science and other fields. By selecting suitable reaction conditions, different halogen atoms can selectively react to achieve the synthesis of specific target products.
Let's talk about the nucleophilic substitution reaction first. Because fluorine, chlorine, and bromine atoms are all electron-absorbing, the electron cloud density of the benzene ring decreases, especially at the adjacent position of the halogen atom, the electron cloud density decreases even more. Therefore, nucleophilic reagents are easy to attack the benzene ring and replace the halogen atom. However, different halogen atoms have different Usually, the bromine atom has the strongest leaving ability, followed by the chlorine atom, and the fluorine atom is the weakest. Therefore, during the nucleophilic substitution reaction, the bromine atom is most easily replaced, while the fluorine atom is more difficult.
Let's talk about the electrophilic substitution reaction again. Although the halogen atom is an electron-withdrawing group, it belongs to an ortho-para-position group. The solitary pair electrons of the halogen atom can be conjugated with the benzene ring, so that the electron cloud density of the ortho-para-position is relatively increased. Therefore, when the electrophilic reagent attacks the benzene ring, it mostly replaces in the ortho-para-position of the halogen atom. However, due to In general, fluorine atoms have strong electron-absorbing ability, which greatly reduces the electron cloud density of the benzene ring, and the electrophilic substitution reaction activity is slightly lower than that of chlorine and bromine substitutes.
In addition, 3-fluoro-4-chloro-1-bromobenzene is often used as an intermediate in organic synthesis. Because halogen atoms can be converted into other functional groups through various reactions to construct complex organic molecular structures, it has important applications in drug synthesis, materials science and other fields. By selecting suitable reaction conditions, different halogen atoms can selectively react to achieve the synthesis of specific target products.
What are 3-fluoro-4-chloro-1-bromobenzene synthesis methods?
There are several common ways to make 3-fluoro-4-chloro-1-bromobenzene.
One is to use benzene as the starting material. First, benzene is brominated to obtain bromobenzene. Under the action of a specific catalyst, bromobenzene reacts with chlorine reagents to introduce chlorine atoms to generate 4-chloro-1-bromobenzene. After fluorination, fluorine atoms are introduced at specific positions on the benzene ring, resulting in 3-fluoro-4-chloro-1-bromobenzene. In this process, when brominating, suitable catalysts and reaction conditions need to be selected to control the substitution check point of bromine atoms in the benzene ring. The reaction between chlorination and fluorination also requires precise regulation of reaction conditions, such as temperature, pressure, reagent ratio, etc., in order to obtain higher yield and selectivity.
Second, it can start from halogenated benzoic acid. For example, using benzoic acid containing a specific halogen atom as a raw material, the carboxyl group is first converted into a suitable leaving group, and then the desired halogen atom is gradually introduced through a decarboxylation and halogenation reaction. Specifically, the benzene ring of benzoic acid can be halogenated first, bromine and chlorine atoms can be introduced, and then the carboxyl group can be converted into a leaving group through a specific reaction. Under appropriate conditions, decarboxylation and fluorine atoms can be This path requires a detailed understanding of the properties and reactivity of the intermediates in each step of the reaction, and proper planning of the reaction sequence and conditions to make the reaction proceed smoothly.
Furthermore, halogenated benzonitrile is also feasible as the starting material. First halogenate the benzene ring of benzonitrile, introduce bromine and chlorine atoms, and then convert the cyanyl group into other functional groups or directly remove the cyanyl group through a specific method, and introduce fluorine atoms at the same time. In this process, the cyanyl group conversion reaction requires careful selection of reagents and conditions to avoid adverse effects on the existing halogen atoms on the benzene ring.
All these production methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively weigh many factors such as raw material availability, cost, reaction difficulty, yield and purity requirements, and choose the most suitable method.
One is to use benzene as the starting material. First, benzene is brominated to obtain bromobenzene. Under the action of a specific catalyst, bromobenzene reacts with chlorine reagents to introduce chlorine atoms to generate 4-chloro-1-bromobenzene. After fluorination, fluorine atoms are introduced at specific positions on the benzene ring, resulting in 3-fluoro-4-chloro-1-bromobenzene. In this process, when brominating, suitable catalysts and reaction conditions need to be selected to control the substitution check point of bromine atoms in the benzene ring. The reaction between chlorination and fluorination also requires precise regulation of reaction conditions, such as temperature, pressure, reagent ratio, etc., in order to obtain higher yield and selectivity.
Second, it can start from halogenated benzoic acid. For example, using benzoic acid containing a specific halogen atom as a raw material, the carboxyl group is first converted into a suitable leaving group, and then the desired halogen atom is gradually introduced through a decarboxylation and halogenation reaction. Specifically, the benzene ring of benzoic acid can be halogenated first, bromine and chlorine atoms can be introduced, and then the carboxyl group can be converted into a leaving group through a specific reaction. Under appropriate conditions, decarboxylation and fluorine atoms can be This path requires a detailed understanding of the properties and reactivity of the intermediates in each step of the reaction, and proper planning of the reaction sequence and conditions to make the reaction proceed smoothly.
Furthermore, halogenated benzonitrile is also feasible as the starting material. First halogenate the benzene ring of benzonitrile, introduce bromine and chlorine atoms, and then convert the cyanyl group into other functional groups or directly remove the cyanyl group through a specific method, and introduce fluorine atoms at the same time. In this process, the cyanyl group conversion reaction requires careful selection of reagents and conditions to avoid adverse effects on the existing halogen atoms on the benzene ring.
All these production methods have their own advantages and disadvantages. In actual preparation, it is necessary to comprehensively weigh many factors such as raw material availability, cost, reaction difficulty, yield and purity requirements, and choose the most suitable method.
3-fluoro-4-chloro-1-bromobenzene in what areas?
3-Fluoro-4-chloro-1-bromobenzene, this compound is used in the fields of medicine, pesticides, and materials.
In the field of medicine, due to its unique chemical structure, it can be used as a key intermediate to synthesize characteristic drugs. For example, when developing specific antifungal drugs, the halogen atoms in its structure can precisely bind to specific targets in the fungus, so as to interfere with the normal physiological metabolism of the fungus and achieve the effect of inhibiting or killing the fungus. In the process of creating new anti-tumor drugs, 3-fluoro-4-chloro-1-bromobenzene can be connected to the drug molecular backbone through a series of chemical reactions, giving the drug better targeting and biological activity, helping the drug to accurately act on tumor cells, while reducing damage to normal cells.
In the field of pesticides, 3-fluoro-4-chloro-1-bromobenzene also plays an important role. Taking the research and development of herbicides as an example, its structural characteristics make the synthetic herbicide highly selective and highly herbicidal for specific weeds. It can precisely inhibit weed photosynthesis or interfere with its hormone balance, causing weed growth to be inhibited or even killed, with little impact on crops. In the creation of insecticides, it can be used as a raw material to synthesize new insecticides. The halogen atom properties can enhance the effect of insecticides on the nervous system or respiratory system of pests, improve the insecticidal effect, and because of the special structure, it helps to reduce the residue of insecticides in the environment and reduce the harm to the ecological environment.
In the field of materials, 3-fluoro-4-chloro-1-bromobenzene can participate in the synthesis of high-performance materials. For example, when synthesizing special engineering plastics, introducing them into the polymer backbone can change the force and arrangement of plastic molecules, thereby improving the heat resistance, chemical resistance and mechanical properties of plastics. In the preparation of optoelectronic materials, it can be used as a functional monomer to form materials with unique optoelectronic properties through polymerization, which can be used to manufacture organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, giving the devices better luminous efficiency and carrier transport performance.
In the field of medicine, due to its unique chemical structure, it can be used as a key intermediate to synthesize characteristic drugs. For example, when developing specific antifungal drugs, the halogen atoms in its structure can precisely bind to specific targets in the fungus, so as to interfere with the normal physiological metabolism of the fungus and achieve the effect of inhibiting or killing the fungus. In the process of creating new anti-tumor drugs, 3-fluoro-4-chloro-1-bromobenzene can be connected to the drug molecular backbone through a series of chemical reactions, giving the drug better targeting and biological activity, helping the drug to accurately act on tumor cells, while reducing damage to normal cells.
In the field of pesticides, 3-fluoro-4-chloro-1-bromobenzene also plays an important role. Taking the research and development of herbicides as an example, its structural characteristics make the synthetic herbicide highly selective and highly herbicidal for specific weeds. It can precisely inhibit weed photosynthesis or interfere with its hormone balance, causing weed growth to be inhibited or even killed, with little impact on crops. In the creation of insecticides, it can be used as a raw material to synthesize new insecticides. The halogen atom properties can enhance the effect of insecticides on the nervous system or respiratory system of pests, improve the insecticidal effect, and because of the special structure, it helps to reduce the residue of insecticides in the environment and reduce the harm to the ecological environment.
In the field of materials, 3-fluoro-4-chloro-1-bromobenzene can participate in the synthesis of high-performance materials. For example, when synthesizing special engineering plastics, introducing them into the polymer backbone can change the force and arrangement of plastic molecules, thereby improving the heat resistance, chemical resistance and mechanical properties of plastics. In the preparation of optoelectronic materials, it can be used as a functional monomer to form materials with unique optoelectronic properties through polymerization, which can be used to manufacture organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, giving the devices better luminous efficiency and carrier transport performance.
What are the physical properties of 3-fluoro-4-chloro-1-bromobenzene?
3-Fluoro-4-chloro-1-bromobenzene is one of the organic compounds. Its physical properties are unique.
First of all, its appearance is mostly colorless to light yellow liquid under normal conditions, clear and has a special smell. Looking at its color and shape, it is due to the action of halogen atoms in the molecular structure, which causes the distribution of electron clouds to be different, and it shows this shape.
As for the boiling point, it is about a certain temperature range. Due to the existence of van der Waals forces between molecules, and the electronegativity of halogen atoms makes the molecules polarized and increases the intermolecular force, the boiling point is higher than that of general benzene series. The specific value will vary slightly due to experimental conditions, but it is roughly within a specific range. The melting point of
also has a corresponding value. In its crystal structure, the arrangement of molecules and the interaction between molecules determine the melting point. The position and type of halogen atoms on the benzene ring affect the degree of molecular packing, so that the melting point presents a specific value, which is the key temperature for the transformation of substances in solid and liquid states.
In terms of solubility, this compound is slightly soluble in water. Due to the large difference between its molecular polarity and that of water molecules, it is difficult for the hydrogen bond of water to effectively bind to this compound. However, in organic solvents such as ethanol, ether, etc., the solubility is quite good. The molecules of organic solvents and 3-fluoro-4-chloro-1-bromobenzene are compatible with each other.
The density is higher than that of water, which is due to the large relative atomic mass of the halogen atoms in the molecule, which increases the mass per unit volume and causes the density to be higher than that of water.
In summary, the physical properties of 3-fluoro-4-chloro-1-bromobenzene, such as appearance, boiling point, melting point, solubility and density, are determined by its unique molecular structure, which is an important consideration in the research and application of organic chemistry.
First of all, its appearance is mostly colorless to light yellow liquid under normal conditions, clear and has a special smell. Looking at its color and shape, it is due to the action of halogen atoms in the molecular structure, which causes the distribution of electron clouds to be different, and it shows this shape.
As for the boiling point, it is about a certain temperature range. Due to the existence of van der Waals forces between molecules, and the electronegativity of halogen atoms makes the molecules polarized and increases the intermolecular force, the boiling point is higher than that of general benzene series. The specific value will vary slightly due to experimental conditions, but it is roughly within a specific range. The melting point of
also has a corresponding value. In its crystal structure, the arrangement of molecules and the interaction between molecules determine the melting point. The position and type of halogen atoms on the benzene ring affect the degree of molecular packing, so that the melting point presents a specific value, which is the key temperature for the transformation of substances in solid and liquid states.
In terms of solubility, this compound is slightly soluble in water. Due to the large difference between its molecular polarity and that of water molecules, it is difficult for the hydrogen bond of water to effectively bind to this compound. However, in organic solvents such as ethanol, ether, etc., the solubility is quite good. The molecules of organic solvents and 3-fluoro-4-chloro-1-bromobenzene are compatible with each other.
The density is higher than that of water, which is due to the large relative atomic mass of the halogen atoms in the molecule, which increases the mass per unit volume and causes the density to be higher than that of water.
In summary, the physical properties of 3-fluoro-4-chloro-1-bromobenzene, such as appearance, boiling point, melting point, solubility and density, are determined by its unique molecular structure, which is an important consideration in the research and application of organic chemistry.
What are 3-fluoro-4-chloro-1-bromobenzene storage conditions?
3-Fluoro-4-chloro-1-bromobenzene is also an organic compound. Its storage conditions are related to its stability and safety, which cannot be ignored.
Cover this compound, it is more active, and it is prone to changes when exposed to light, heat, oxidants, etc. Therefore, when storing, it is best to choose a cool place. In a cool place, the temperature is always low, which can reduce the activity of its molecules and slow down the rate of its chemical reaction. If it is in a high temperature place, the thermal movement of the molecule will intensify, or it will cause reactions such as decomposition and polymerization, which will damage its quality.
For the second time, avoid direct light. Light, the source of energy, can also supply energy for chemical reactions. When this compound is irradiated by light, its chemical bonds may break due to energy gain, causing many side reactions. Therefore, it should be stored in a container protected from light, such as a brown glass bottle, which can block light from entering and keep it stable.
Furthermore, keep away from oxidants. Oxidants are highly oxidizing, and 3-fluoro-4-chloro-1-bromobenzene encounters, or severe oxidation reactions may occur, resulting in dangerous combustion and explosion. Therefore, the storage place should be isolated from the oxidant, placed in separate shelves, and kept at a certain distance.
In addition, the humidity of the storage environment should also be paid attention to. Excessive moisture may cause hydrolysis of compounds, which affects their purity and properties. Therefore, it should be placed in a dry place, which can be stored in the desiccant to absorb water vapor in the air.
As for the choice of container, it is also crucial. A well-sealed container must be used to prevent the compound from evaporating and escaping, polluting the environment, and preventing it from contacting with air components and causing adverse reactions. Common glass containers have good sealing performance and stable chemical properties, and are mostly the choice for storing such compounds.
In summary, the storage of 3-fluoro-4-chloro-1-bromobenzene should be stored in a cool, dark, dry place away from oxidants, in a sealed container, so that its properties can be kept stable for later use.
Cover this compound, it is more active, and it is prone to changes when exposed to light, heat, oxidants, etc. Therefore, when storing, it is best to choose a cool place. In a cool place, the temperature is always low, which can reduce the activity of its molecules and slow down the rate of its chemical reaction. If it is in a high temperature place, the thermal movement of the molecule will intensify, or it will cause reactions such as decomposition and polymerization, which will damage its quality.
For the second time, avoid direct light. Light, the source of energy, can also supply energy for chemical reactions. When this compound is irradiated by light, its chemical bonds may break due to energy gain, causing many side reactions. Therefore, it should be stored in a container protected from light, such as a brown glass bottle, which can block light from entering and keep it stable.
Furthermore, keep away from oxidants. Oxidants are highly oxidizing, and 3-fluoro-4-chloro-1-bromobenzene encounters, or severe oxidation reactions may occur, resulting in dangerous combustion and explosion. Therefore, the storage place should be isolated from the oxidant, placed in separate shelves, and kept at a certain distance.
In addition, the humidity of the storage environment should also be paid attention to. Excessive moisture may cause hydrolysis of compounds, which affects their purity and properties. Therefore, it should be placed in a dry place, which can be stored in the desiccant to absorb water vapor in the air.
As for the choice of container, it is also crucial. A well-sealed container must be used to prevent the compound from evaporating and escaping, polluting the environment, and preventing it from contacting with air components and causing adverse reactions. Common glass containers have good sealing performance and stable chemical properties, and are mostly the choice for storing such compounds.
In summary, the storage of 3-fluoro-4-chloro-1-bromobenzene should be stored in a cool, dark, dry place away from oxidants, in a sealed container, so that its properties can be kept stable for later use.
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