Linshang Chemical
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3-Fluoro-4-Chloro Iodo Benzene
Linshang Chemical
|
HS Code |
161205 |
| Chemical Formula | C6H3ClF I |
| Molecular Weight | 256.44 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 210 - 215°C |
| Density | Approx. 2.04 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Vapor Pressure | Low at room temperature |
| Purity | Typically available in high purity, e.g., 95%+ |
| Cas Number | 55799 - 32 - 7 |
As an accredited 3-Fluoro-4-Chloro Iodo Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - fluoro - 4 - chloro iodo benzene in a sealed, chemical - resistant bottle. |
| Storage | 3 - Fluoro - 4 - chloro iodo benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. It should be kept in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. |
| Shipping | 3 - fluoro - 4 - chloro Iodo Benzene is a chemical. Shipping requires proper packaging in corrosion - resistant containers. It must comply with hazardous material regulations, with clear labeling for safe transportation to prevent any risks during transit. |
Competitive 3-Fluoro-4-Chloro Iodo Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Fluoro-4-Chloro Iodo Benzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Fluoro-4-Chloro Iodo Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-fluoro-4-chloro Iodo Benzene?
3-Fluoro-4-chloroiodobenzene is also an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the field of medicinal chemistry, this compound can be used to create new drugs. Due to its unique structure, the introduction of fluorine, chlorine and iodine atoms endows the molecule with specific physicochemical properties and biological activities. Through the method of organic synthesis, it can be used as a starting material. After many chemical reactions, complex molecular structures with specific pharmacological activities can be constructed for the development of drugs for the treatment of various diseases, such as anti-cancer drugs, anti-infective drugs, etc.
Second, in the field of materials science, 3-fluoro-4-chloroiodobenzene also has important uses. It can be integrated into polymer materials by polymerization or other chemical modification methods, thereby changing the electrical, optical or thermal properties of the materials. For example, materials with special photoelectric properties are prepared for use in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve the performance and efficiency of the devices.
Furthermore, in the field of fine chemicals, it is often used as a raw material for the synthesis of special chemicals. Fine chemicals with specific functions, such as special fragrances, pigments, catalyst ligands, etc. are prepared by substitution and addition reactions with other organic reagents to meet the needs of different industries and scientific research.
3-Fluoro-4-chloroiodobenzene plays an important role in many fields such as drugs, materials and fine chemicals due to its unique chemical structure, providing a key material basis and synthetic building block for the development of related fields.
First, in the field of medicinal chemistry, this compound can be used to create new drugs. Due to its unique structure, the introduction of fluorine, chlorine and iodine atoms endows the molecule with specific physicochemical properties and biological activities. Through the method of organic synthesis, it can be used as a starting material. After many chemical reactions, complex molecular structures with specific pharmacological activities can be constructed for the development of drugs for the treatment of various diseases, such as anti-cancer drugs, anti-infective drugs, etc.
Second, in the field of materials science, 3-fluoro-4-chloroiodobenzene also has important uses. It can be integrated into polymer materials by polymerization or other chemical modification methods, thereby changing the electrical, optical or thermal properties of the materials. For example, materials with special photoelectric properties are prepared for use in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells to improve the performance and efficiency of the devices.
Furthermore, in the field of fine chemicals, it is often used as a raw material for the synthesis of special chemicals. Fine chemicals with specific functions, such as special fragrances, pigments, catalyst ligands, etc. are prepared by substitution and addition reactions with other organic reagents to meet the needs of different industries and scientific research.
3-Fluoro-4-chloroiodobenzene plays an important role in many fields such as drugs, materials and fine chemicals due to its unique chemical structure, providing a key material basis and synthetic building block for the development of related fields.
What are the physical properties of 3-fluoro-4-chloro Iodo Benzene?
3-Fluoro-4-chloroiodobenzene is a genus of organohalogenated aromatic hydrocarbons. It has unique physical properties and has attracted much attention in the field of organic synthesis.
In terms of appearance, under room temperature and pressure, 3-fluoro-4-chloroiodobenzene is often colorless to light yellow liquid, which is clear and has a certain fluidity. This property is easy to miscible with other reagents in many reaction systems, which is conducive to the reaction.
In terms of boiling point, due to the presence of halogen atoms such as fluorine, chlorine, and iodine in the molecule, the strong electronegativity of the halogen atom enhances the intermolecular force, resulting in a relatively high boiling point. At a certain temperature range (the specific value varies slightly due to differences in experimental conditions), this temperature allows the molecule to obtain enough energy to overcome the intermolecular forces, and then transform from liquid to gaseous.
The melting point is also characterized by the influence of halogen atoms. The relative positions of fluorine, chlorine, and iodine atoms and the electronic effect make the molecular lattice arranged in a specific way, giving the substance a specific melting point. This melting point characteristic is crucial in the separation and purification process, and its purity can be determined by the melting point.
In terms of solubility, 3-fluoro-4-chloroiodobenzene is insoluble in water. Water is a polar solvent, and the molecular polarity of this organic substance is relatively weak. According to the principle of "similar miscibility", its solubility in water is very small. However, in organic solvents such as dichloromethane, chloroform, ether, etc., it exhibits good solubility. These organic solvents and 3-fluoro-4-chloroiodobenzene molecules can form similar intermolecular forces, such as van der Waals forces, to achieve mutual solubility. This solubility characteristic provides a basis for the selection of reaction solvents in organic synthesis. Suitable organic solvents can often be selected to construct homogeneous reaction systems and improve reaction efficiency.
In terms of density, 3-fluoro-4-chloroiodobenzene has a higher density than water. This property is important for experimental operations involving liquid-liquid separation. In stratification phenomena, it is in the lower layer, which is convenient for separation from the aqueous phase by means of liquid separation.
In terms of appearance, under room temperature and pressure, 3-fluoro-4-chloroiodobenzene is often colorless to light yellow liquid, which is clear and has a certain fluidity. This property is easy to miscible with other reagents in many reaction systems, which is conducive to the reaction.
In terms of boiling point, due to the presence of halogen atoms such as fluorine, chlorine, and iodine in the molecule, the strong electronegativity of the halogen atom enhances the intermolecular force, resulting in a relatively high boiling point. At a certain temperature range (the specific value varies slightly due to differences in experimental conditions), this temperature allows the molecule to obtain enough energy to overcome the intermolecular forces, and then transform from liquid to gaseous.
The melting point is also characterized by the influence of halogen atoms. The relative positions of fluorine, chlorine, and iodine atoms and the electronic effect make the molecular lattice arranged in a specific way, giving the substance a specific melting point. This melting point characteristic is crucial in the separation and purification process, and its purity can be determined by the melting point.
In terms of solubility, 3-fluoro-4-chloroiodobenzene is insoluble in water. Water is a polar solvent, and the molecular polarity of this organic substance is relatively weak. According to the principle of "similar miscibility", its solubility in water is very small. However, in organic solvents such as dichloromethane, chloroform, ether, etc., it exhibits good solubility. These organic solvents and 3-fluoro-4-chloroiodobenzene molecules can form similar intermolecular forces, such as van der Waals forces, to achieve mutual solubility. This solubility characteristic provides a basis for the selection of reaction solvents in organic synthesis. Suitable organic solvents can often be selected to construct homogeneous reaction systems and improve reaction efficiency.
In terms of density, 3-fluoro-4-chloroiodobenzene has a higher density than water. This property is important for experimental operations involving liquid-liquid separation. In stratification phenomena, it is in the lower layer, which is convenient for separation from the aqueous phase by means of liquid separation.
What are the chemical properties of 3-fluoro-4-chloro Iodo Benzene?
3-Fluoro-4-chloroiodobenzene, this is an organic halogenated aromatic hydrocarbon. Its chemical properties are unique and related to many reaction characteristics.
As far as nucleophilic substitution is concerned, the activity of iodine atoms is quite high. Because of its relatively small carbon-iodine bond energy, iodine atoms are easy to leave, just like the old weak journey and easy to collapse. Therefore, when many nucleophiles attack, iodine atoms are easily replaced. In case of hydroxyl negative ions, nucleophilic substitution can occur, forming derivatives containing hydroxyl groups, just like replacing the old with a new soldier. In this process, the nucleophilicity of nucleophilic reagents and reaction conditions (such as temperature and solvent) are all affected. Strong nucleophiles, suitable temperatures, and polar aprotic solvents are all conducive to the reaction.
In the field of metal catalytic coupling reactions, 3-fluoro-4-chloroiodobenzene is also active. Taking palladium catalytic coupling as an example, iodine atoms can be coupled with other organic halides, alkenes, alkynes, etc. under the action of palladium catalysts. This reaction is like building a pavilion, with palladium as a guide to connect different organic fragments. It can build complex organic structures and is of great significance in drug synthesis, material chemistry, etc.
However, fluorine and chlorine atoms are difficult to replace under normal conditions due to their high electronegativity and stable carbon-halogen bonds. However, under certain conditions, such as strong nucleophilic reagents and high temperatures, fluorine and chlorine atoms can also be replaced, but compared with iodine atoms, it is quite difficult, like a solid barrier, which is not easy to overcome.
In addition, the chemical properties of 3-fluoro-4-chloroiodobenzene are affected by the electron effect of the benzene ring. Fluorine and chlorine atoms have electron-absorbing effects, which reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction; however, due to the existence of conjugation effects, electrophilic substitution can still occur at specific positions. The localization effect follows the rules of aromatic hydrocarbon substitution, and the ortho and para-position substitution are complex and changeable due to different groups.
As far as nucleophilic substitution is concerned, the activity of iodine atoms is quite high. Because of its relatively small carbon-iodine bond energy, iodine atoms are easy to leave, just like the old weak journey and easy to collapse. Therefore, when many nucleophiles attack, iodine atoms are easily replaced. In case of hydroxyl negative ions, nucleophilic substitution can occur, forming derivatives containing hydroxyl groups, just like replacing the old with a new soldier. In this process, the nucleophilicity of nucleophilic reagents and reaction conditions (such as temperature and solvent) are all affected. Strong nucleophiles, suitable temperatures, and polar aprotic solvents are all conducive to the reaction.
In the field of metal catalytic coupling reactions, 3-fluoro-4-chloroiodobenzene is also active. Taking palladium catalytic coupling as an example, iodine atoms can be coupled with other organic halides, alkenes, alkynes, etc. under the action of palladium catalysts. This reaction is like building a pavilion, with palladium as a guide to connect different organic fragments. It can build complex organic structures and is of great significance in drug synthesis, material chemistry, etc.
However, fluorine and chlorine atoms are difficult to replace under normal conditions due to their high electronegativity and stable carbon-halogen bonds. However, under certain conditions, such as strong nucleophilic reagents and high temperatures, fluorine and chlorine atoms can also be replaced, but compared with iodine atoms, it is quite difficult, like a solid barrier, which is not easy to overcome.
In addition, the chemical properties of 3-fluoro-4-chloroiodobenzene are affected by the electron effect of the benzene ring. Fluorine and chlorine atoms have electron-absorbing effects, which reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction; however, due to the existence of conjugation effects, electrophilic substitution can still occur at specific positions. The localization effect follows the rules of aromatic hydrocarbon substitution, and the ortho and para-position substitution are complex and changeable due to different groups.
What are the synthesis methods of 3-fluoro-4-chloro Iodo Benzene?
The synthesis method of 3-fluoro-4-chloroiodobenzene has existed in ancient times, and with the changes of the world, the method has also become more and more abundant. The following are all common methods:
First, halogenated aromatic hydrocarbons are used as starting materials. First, halogenated benzene containing fluorine and chlorine is taken and interacted with iodizing reagents. In the past, potassium iodide and copper salt were used as catalysts to exchange halogens in a specific temperature and solvent. For example, in a suitable organic solvent, such as N, N-dimethylformamide, halogenated benzene, potassium iodide and cuprous chloride containing fluorochlorine are co-placed, heated to an appropriate temperature, and stirred continuously. After a while, 3-fluoro-4-chloroiodobenzene is formed. In this process, the difference in the activity of halogen atoms is extremely critical, and the position of fluorine and chlorine on the benzene ring also affects the difficulty and yield of the reaction.
Second, metal-organic reagents are used as the diameter. First prepare an aromatic reagent containing fluorochlorine, such as Grignard reagent or lithium reagent. Magnesium chips and halogenated benzene containing fluorochlorine are used in anhydrous ether to initiate a reaction to obtain Grignard reagent. Then react slowly with an iodine source, such as iodine elemental substance, at low temperature. The temperature is controlled in an appropriate range to avoid the growth of side reactions. This approach requires water and oxygen exclusion, which requires strict reaction environment. However, its selectivity is quite good, and 3-fluoro-4-chloroiodobenzene can be accurately obtained.
Third, the coupling reaction with the help of transition metal catalysis. The halogenated benzene containing fluorochlorine is used as a substrate, and the iodine substitution reagent is coupled in the presence of a transition metal catalyst, such as a palladium catalyst. It is often matched with ligands, such as tri-tert-butylphosphine, to improve the activity and selectivity of the catalyst. Heat the reaction in a suitable base and solvent. This method can be achieved under mild conditions, and has good compatibility with functional groups. It can introduce iodine atoms into complex molecular systems to construct the structure of 3-fluoro-4-chloroiodobenzene.
The above synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, such as the availability of raw materials, cost considerations, yield and purity requirements, etc., to achieve the best environment.
First, halogenated aromatic hydrocarbons are used as starting materials. First, halogenated benzene containing fluorine and chlorine is taken and interacted with iodizing reagents. In the past, potassium iodide and copper salt were used as catalysts to exchange halogens in a specific temperature and solvent. For example, in a suitable organic solvent, such as N, N-dimethylformamide, halogenated benzene, potassium iodide and cuprous chloride containing fluorochlorine are co-placed, heated to an appropriate temperature, and stirred continuously. After a while, 3-fluoro-4-chloroiodobenzene is formed. In this process, the difference in the activity of halogen atoms is extremely critical, and the position of fluorine and chlorine on the benzene ring also affects the difficulty and yield of the reaction.
Second, metal-organic reagents are used as the diameter. First prepare an aromatic reagent containing fluorochlorine, such as Grignard reagent or lithium reagent. Magnesium chips and halogenated benzene containing fluorochlorine are used in anhydrous ether to initiate a reaction to obtain Grignard reagent. Then react slowly with an iodine source, such as iodine elemental substance, at low temperature. The temperature is controlled in an appropriate range to avoid the growth of side reactions. This approach requires water and oxygen exclusion, which requires strict reaction environment. However, its selectivity is quite good, and 3-fluoro-4-chloroiodobenzene can be accurately obtained.
Third, the coupling reaction with the help of transition metal catalysis. The halogenated benzene containing fluorochlorine is used as a substrate, and the iodine substitution reagent is coupled in the presence of a transition metal catalyst, such as a palladium catalyst. It is often matched with ligands, such as tri-tert-butylphosphine, to improve the activity and selectivity of the catalyst. Heat the reaction in a suitable base and solvent. This method can be achieved under mild conditions, and has good compatibility with functional groups. It can introduce iodine atoms into complex molecular systems to construct the structure of 3-fluoro-4-chloroiodobenzene.
The above synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to actual needs, such as the availability of raw materials, cost considerations, yield and purity requirements, etc., to achieve the best environment.
What are the precautions for storing and transporting 3-fluoro-4-chloro Iodo Benzene?
3-Fluoro-4-chloroiodobenzene is an organic compound. When storing and transporting, the following matters must be paid attention to.
First storage conditions. Because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. Avoid direct sunlight, which can cause photochemical reactions and damage material stability. Warehouse temperature should be carefully controlled, usually not exceeding 30 ° C, to prevent excessive temperature from causing reactions or accelerating decomposition. Humidity is also critical. Excessive humidity may cause it to absorb moisture, which in turn affects quality. Relative humidity should be maintained below 65%.
Second discussion on packaging requirements. It must be packed with suitable packaging materials. It is common to use glass bottles or plastic bottles of specific materials to ensure a tight seal and prevent air and water vapor from invading. Information such as the name of the substance, its nature, and hazard warnings should be clearly marked on the outside of the package for identification and management.
Furthermore, transportation safety. During transportation, impact, vibration, and friction should be prevented, which may cause damage to the package and cause leakage. According to its chemical properties, it should be isolated and transported from oxidants, reducing agents, strong acids and alkalis, etc., to avoid dangerous reactions caused by mixing. Transportation vehicles should also be equipped with necessary emergency treatment equipment, such as fire extinguishers, adsorption materials, etc., for emergencies.
Operational specifications should not be ignored. Personnel exposed to this compound should be professionally trained to know its properties and safe operation procedures. Handling should be handled with care, and brutal operation is strictly prohibited. Workplaces should be equipped with effective ventilation facilities to reduce the concentration of harmful substances in the air and protect the health of workers.
In conclusion, the storage and transportation of 3-fluoro-4-chloroiodobenzene requires all-round attention to environmental conditions, packaging conditions, transportation safety and operating specifications to ensure its safety and stability and avoid latent risks.
First storage conditions. Because of its certain chemical activity, it should be stored in a cool, dry and well-ventilated place. Avoid direct sunlight, which can cause photochemical reactions and damage material stability. Warehouse temperature should be carefully controlled, usually not exceeding 30 ° C, to prevent excessive temperature from causing reactions or accelerating decomposition. Humidity is also critical. Excessive humidity may cause it to absorb moisture, which in turn affects quality. Relative humidity should be maintained below 65%.
Second discussion on packaging requirements. It must be packed with suitable packaging materials. It is common to use glass bottles or plastic bottles of specific materials to ensure a tight seal and prevent air and water vapor from invading. Information such as the name of the substance, its nature, and hazard warnings should be clearly marked on the outside of the package for identification and management.
Furthermore, transportation safety. During transportation, impact, vibration, and friction should be prevented, which may cause damage to the package and cause leakage. According to its chemical properties, it should be isolated and transported from oxidants, reducing agents, strong acids and alkalis, etc., to avoid dangerous reactions caused by mixing. Transportation vehicles should also be equipped with necessary emergency treatment equipment, such as fire extinguishers, adsorption materials, etc., for emergencies.
Operational specifications should not be ignored. Personnel exposed to this compound should be professionally trained to know its properties and safe operation procedures. Handling should be handled with care, and brutal operation is strictly prohibited. Workplaces should be equipped with effective ventilation facilities to reduce the concentration of harmful substances in the air and protect the health of workers.
In conclusion, the storage and transportation of 3-fluoro-4-chloroiodobenzene requires all-round attention to environmental conditions, packaging conditions, transportation safety and operating specifications to ensure its safety and stability and avoid latent risks.
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