Linshang Chemical
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3-Fluoro-4-Chlorobromobenzene
Linshang Chemical
|
HS Code |
641042 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 225.44 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 195 - 197 °C |
| Density | 1.819 g/cm³ |
| Flash Point | 83 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | Low |
| Stability | Stable under normal conditions |
As an accredited 3-Fluoro-4-Chlorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 3 - fluoro - 4 - chlorobromobenzene packaged in a sealed glass bottle. |
| Storage | 3 - fluoro - 4 - chlorobromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, acids, and bases to avoid potential chemical reactions. Use a dedicated storage space to ensure safety and easy identification. |
| Shipping | 3 - Fluoro - 4 - chlorobromobenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent damage during transit. Shipments follow strict chemical transport regulations to ensure safety. |
Competitive 3-Fluoro-4-Chlorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Fluoro-4-Chlorobromobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Fluoro-4-Chlorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3-fluoro-4-chlorobromobenzene?
3-Fluoro-4-chlorobrombenzene is also an organic compound. Its chemical properties are particularly important and are related to many chemical reactions.
This compound has the properties of halogenated aromatics. The atoms of fluorine, chlorine and bromine are on the benzene ring. Due to the large electronegativity of halogen atoms, the electron cloud density of the benzene ring is reduced, resulting in lower electrophilic substitution activity than that of benzene. However, different halogen atoms have different effects on the electron cloud of the benzene ring. Although fluorine atoms have great electronegativity, due to the conjugation effect of the 2p orbital and the large π bond of the benzene ring, the effect on the electron cloud density of the benzene ring is different from that of chlorine
In electrophilic substitution, the halogen atom is an adjacent and para-locator. Because the solitary pair electron can be conjugated with the benzene ring, the density of the adjacent and para-locator electron clouds is relatively high, and the electrophilic reagents are easy to attack these two places. However, due to factors such as steric resistance, the localization effect of each halogen atom is also different.
It can participate in many reactions. Such as nucleophilic substitution reaction, under suitable conditions, the halogen atom on the benzene ring can be replaced by nucleophilic reagents. In the case of strong nucleophilic reagents, the fluorine atom can be replaced. Because of the large bond energy of the C-F bond, the negative ion formed after the fluorine atom leaves has good stability. Chlorine and bromine atoms
It can also react with metal catalysis, such as interacting with metal magnesium, to obtain Grignard reagent. This reagent has a wide range of uses in organic synthesis and can react with a variety of carbonyl compounds to build carbon-carbon bonds and expand the molecular skeleton.
In addition, 3-fluoro-4-chlorobromobenzene contains multiple halogen atoms, which can be used to prepare functional materials. It has potential application value in the fields of medicine, pesticides, materials science, etc. It can be modified by its structure to create new compounds with specific properties.
This compound has the properties of halogenated aromatics. The atoms of fluorine, chlorine and bromine are on the benzene ring. Due to the large electronegativity of halogen atoms, the electron cloud density of the benzene ring is reduced, resulting in lower electrophilic substitution activity than that of benzene. However, different halogen atoms have different effects on the electron cloud of the benzene ring. Although fluorine atoms have great electronegativity, due to the conjugation effect of the 2p orbital and the large π bond of the benzene ring, the effect on the electron cloud density of the benzene ring is different from that of chlorine
In electrophilic substitution, the halogen atom is an adjacent and para-locator. Because the solitary pair electron can be conjugated with the benzene ring, the density of the adjacent and para-locator electron clouds is relatively high, and the electrophilic reagents are easy to attack these two places. However, due to factors such as steric resistance, the localization effect of each halogen atom is also different.
It can participate in many reactions. Such as nucleophilic substitution reaction, under suitable conditions, the halogen atom on the benzene ring can be replaced by nucleophilic reagents. In the case of strong nucleophilic reagents, the fluorine atom can be replaced. Because of the large bond energy of the C-F bond, the negative ion formed after the fluorine atom leaves has good stability. Chlorine and bromine atoms
It can also react with metal catalysis, such as interacting with metal magnesium, to obtain Grignard reagent. This reagent has a wide range of uses in organic synthesis and can react with a variety of carbonyl compounds to build carbon-carbon bonds and expand the molecular skeleton.
In addition, 3-fluoro-4-chlorobromobenzene contains multiple halogen atoms, which can be used to prepare functional materials. It has potential application value in the fields of medicine, pesticides, materials science, etc. It can be modified by its structure to create new compounds with specific properties.
What are the physical properties of 3-fluoro-4-chlorobromobenzene?
3-Fluoro-4-chlorobromobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical uses.
First, its appearance, under normal conditions, is mostly colorless to light yellow liquid, clear and transparent, and it is quite fluid. This color state can be the first sign of discrimination in actual operation and identification.
times and boiling point, about a certain temperature range, this value is generally within a certain range due to specific measurement conditions or slight differences. The boiling point is related to its performance in separation operations such as distillation, which is necessary for chemical process design.
Melting point is also an important physical property. The specific melting point makes solid-liquid transformation possible under a specific temperature environment. Knowing the melting point is of great significance for the purification and crystallization of substances.
Furthermore, its density is also fixed, and the relative density value reflects the comparison with the density of common substances such as water. This characteristic is a key consideration in the operation of stratification and separation of mixed systems.
In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol and ether, but it has a low solubility in water. This solubility characteristic determines its behavior in different solvent systems, and has a profound impact on the choice of reaction medium and the planning of product separation and purification paths.
In addition, its volatility cannot be ignored. Although it is not extremely volatile, it will still be partially volatile under certain temperature and environmental conditions. This property is closely related to the safety of the storage and use environment.
All these physical properties are indispensable basic information in chemical production, scientific research and other fields, and play a decisive role in the application, treatment and related process design of 3-fluoro-4-chlorobromobenzene.
First, its appearance, under normal conditions, is mostly colorless to light yellow liquid, clear and transparent, and it is quite fluid. This color state can be the first sign of discrimination in actual operation and identification.
times and boiling point, about a certain temperature range, this value is generally within a certain range due to specific measurement conditions or slight differences. The boiling point is related to its performance in separation operations such as distillation, which is necessary for chemical process design.
Melting point is also an important physical property. The specific melting point makes solid-liquid transformation possible under a specific temperature environment. Knowing the melting point is of great significance for the purification and crystallization of substances.
Furthermore, its density is also fixed, and the relative density value reflects the comparison with the density of common substances such as water. This characteristic is a key consideration in the operation of stratification and separation of mixed systems.
In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol and ether, but it has a low solubility in water. This solubility characteristic determines its behavior in different solvent systems, and has a profound impact on the choice of reaction medium and the planning of product separation and purification paths.
In addition, its volatility cannot be ignored. Although it is not extremely volatile, it will still be partially volatile under certain temperature and environmental conditions. This property is closely related to the safety of the storage and use environment.
All these physical properties are indispensable basic information in chemical production, scientific research and other fields, and play a decisive role in the application, treatment and related process design of 3-fluoro-4-chlorobromobenzene.
What are the main uses of 3-fluoro-4-chlorobromobenzene?
3-Fluoro-4-chlorobromobenzene, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. In organic synthesis, halogenated aromatics can be converted into other functional groups through many reactions, thus constructing complex drug molecular structures. Taking the preparation of specific anti-cancer drugs as an example, 3-fluoro-4-chlorobromobenzene can form a core structure with anti-cancer activity through nucleophilic substitution reaction with reagents containing specific functional groups, laying the foundation for drug development.
In the field of materials science, it also has important uses. Because it contains halogen atoms, it can participate in polymerization reactions to generate polymer materials with special properties. For example, by polymerizing with suitable monomers, the obtained material may have good thermal stability, flame retardancy and other characteristics, suitable for electronic device insulation materials, etc., to improve material properties and application range.
In pesticide chemistry, it is also indispensable. As an intermediate, it can participate in the synthesis of a variety of high-efficiency pesticides. For example, through a series of reactions, it can be converted into highly toxic and selective pesticides for specific pests, which can help agricultural pest control and ensure crop yield and quality. In short, 3-fluoro-4-chlorobromobenzene has important uses in many fields and is of great significance to the development of related industries.
In the field of materials science, it also has important uses. Because it contains halogen atoms, it can participate in polymerization reactions to generate polymer materials with special properties. For example, by polymerizing with suitable monomers, the obtained material may have good thermal stability, flame retardancy and other characteristics, suitable for electronic device insulation materials, etc., to improve material properties and application range.
In pesticide chemistry, it is also indispensable. As an intermediate, it can participate in the synthesis of a variety of high-efficiency pesticides. For example, through a series of reactions, it can be converted into highly toxic and selective pesticides for specific pests, which can help agricultural pest control and ensure crop yield and quality. In short, 3-fluoro-4-chlorobromobenzene has important uses in many fields and is of great significance to the development of related industries.
What are 3-fluoro-4-chlorobromobenzene synthesis methods?
The method of preparing 3-fluoro-4-chlorobromobenzene depends on the technique of organic synthesis. One method can start from an appropriate aromatic hydrocarbon. If benzene is used as a base, chlorine atoms are introduced first, and chlorine gas and benzene can be used under the catalysis of ferric trichloride to perform an electrophilic substitution reaction to obtain chlorobenzene.
The fluorine atom is introduced at a specific position of chlorobenzene. This can be achieved by nucleophilic substitution reaction. In the presence of a suitable solvent and catalyst, chlorine can be replaced by fluorine to obtain a fluorine atom at a specific position on the benzene ring.
Then bromine atoms are introduced. 3-Fluoro-4-chlorobromobenzene can be obtained by electrophilic substitution reaction at specific positions of chlorofluorobenzene using brominating reagents, such as bromine and suitable catalysts.
There are also other methods, such as using other compounds containing benzene ring as starting materials, and a series of steps such as functional group conversion and substitution reaction can also achieve the purpose of preparation. Each method needs to consider the control of reaction conditions, such as temperature, pressure, type and dosage of catalyst, etc., in order to improve the yield and selectivity, so that the reaction can proceed smoothly to obtain high-purity 3-fluoro-4-chlorobromobenzene.
The fluorine atom is introduced at a specific position of chlorobenzene. This can be achieved by nucleophilic substitution reaction. In the presence of a suitable solvent and catalyst, chlorine can be replaced by fluorine to obtain a fluorine atom at a specific position on the benzene ring.
Then bromine atoms are introduced. 3-Fluoro-4-chlorobromobenzene can be obtained by electrophilic substitution reaction at specific positions of chlorofluorobenzene using brominating reagents, such as bromine and suitable catalysts.
There are also other methods, such as using other compounds containing benzene ring as starting materials, and a series of steps such as functional group conversion and substitution reaction can also achieve the purpose of preparation. Each method needs to consider the control of reaction conditions, such as temperature, pressure, type and dosage of catalyst, etc., in order to improve the yield and selectivity, so that the reaction can proceed smoothly to obtain high-purity 3-fluoro-4-chlorobromobenzene.
3-fluoro-4-chlorobromobenzene what are the precautions during storage and transportation?
For 3-fluoro-4-chlorobromobenzene, many matters should be paid attention to during storage and transportation.
First words storage, this substance should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, if it is exposed to high temperature and humidity, or causes chemical reactions, it will damage its quality. The storage place should be away from fire and heat sources to avoid risks such as fire. In addition, it needs to be stored separately from oxidizing agents, strong alkalis and other substances. Due to its chemical properties, it is easy to react violently when mixed with them. For storage containers, it is also required to ensure that they are well sealed to prevent leakage. Containers made of glass or specific plastics are commonly used because of their relatively good chemical stability.
As for transportation, transportation personnel must be professionally trained and familiar with its characteristics and emergency treatment methods. During transportation, vehicles should avoid high temperature periods, drive slowly and steadily, and prevent violent vibration and collision to avoid package damage and leakage. Packaging must be solid, and warning signs such as toxic, harmful, flammable, etc. should be posted in accordance with relevant regulations to indicate its danger. If there is a leakage during transportation, the surrounding people should be evacuated immediately, the scene should be isolated, and the professionals should dispose of it according to their characteristics. For example, it should be adsorbed with inert materials such as sand. Do not rinse with water at will to avoid polluting the environment or causing more serious consequences. Overall, the storage and transportation of 3-fluoro-4-chlorobromobenzene should be handled with caution and in accordance with regulations to ensure safety.
First words storage, this substance should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, if it is exposed to high temperature and humidity, or causes chemical reactions, it will damage its quality. The storage place should be away from fire and heat sources to avoid risks such as fire. In addition, it needs to be stored separately from oxidizing agents, strong alkalis and other substances. Due to its chemical properties, it is easy to react violently when mixed with them. For storage containers, it is also required to ensure that they are well sealed to prevent leakage. Containers made of glass or specific plastics are commonly used because of their relatively good chemical stability.
As for transportation, transportation personnel must be professionally trained and familiar with its characteristics and emergency treatment methods. During transportation, vehicles should avoid high temperature periods, drive slowly and steadily, and prevent violent vibration and collision to avoid package damage and leakage. Packaging must be solid, and warning signs such as toxic, harmful, flammable, etc. should be posted in accordance with relevant regulations to indicate its danger. If there is a leakage during transportation, the surrounding people should be evacuated immediately, the scene should be isolated, and the professionals should dispose of it according to their characteristics. For example, it should be adsorbed with inert materials such as sand. Do not rinse with water at will to avoid polluting the environment or causing more serious consequences. Overall, the storage and transportation of 3-fluoro-4-chlorobromobenzene should be handled with caution and in accordance with regulations to ensure safety.
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