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3-Fluoro-5-Bromochlorobenzene
Linshang Chemical
|
HS Code |
544867 |
| Chemical Formula | C6H3BrClF |
| Molecular Weight | 209.44 |
| Appearance | colorless to light yellow liquid |
| Boiling Point | 176 - 178 °C |
| Density | 1.726 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Refractive Index | 1.552 - 1.554 |
As an accredited 3-Fluoro-5-Bromochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 3 - fluoro - 5 - bromochlorobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 3 - fluoro - 5 - bromochlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of corrosion - resistant materials. Label the storage container clearly to avoid misidentification. This helps ensure safety and prevent degradation of the chemical. |
| Shipping | 3 - fluoro - 5 - bromochlorobenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage. Shipments follow strict chemical transport regulations to ensure safety during transit. |
Competitive 3-Fluoro-5-Bromochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Fluoro-5-Bromochlorobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Fluoro-5-Bromochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 3-fluoro-5-bromochlorobenzene?
3-Fluoro-5-bromochlorobenzene is one of the organic compounds. Its chemical properties are particularly important and are related to many chemical reactions and applications.
First of all, its substitution reaction. Due to the electron cloud density distribution of the benzene ring, the presence of halogen atoms (fluorine, bromine, chlorine) changes the electron cloud density of the benzene ring. Although fluorine atoms have high electronegativity, they can slightly increase the electron cloud density of the benzene ring by p-π conjugation effect, but the induction effect results in the overall reduction of the electron cloud density of the benzene ring. The same is true for bromine and chlorine. Therefore, in the electrophilic substitution reaction, the activity of 3-fluoro-5-bromochlorobenzene is lower than Electrophilic reagents are easy to attack positions with relatively high electron cloud density, and fluorine neighbors and para-positions are theoretically easier to be replaced. However, due to the combined influence of the steric resistance and electronic effect of bromine and chlorine, the actual reaction check points and conditions need to be studied in detail.
Furthermore, the metal-catalyzed reaction in which it participates. In the palladium-catalyzed cross-coupling reaction, the halogen atom of 3-fluoro-5-bromochlorobenzene can react with organometallic reagents (such as organoboron reagents, organozinc reagents, etc.) to form carbon-carbon bonds. In this reaction, different halogen atoms have different reactivity. Usually bromine and chlorine are more active than fluorine. Under suitable conditions, specific halogen atoms can be selectively activated to achieve precise synthesis.
And it also has characteristics in nucleophilic substitution reactions. Although it is difficult to nucleophilic substitution of benzene cyclohalides, halogen atoms can be replaced by nucleophilic reagents under strong nucleophilic reagents and specific conditions. If nucleophilic reagents such as sodium alcohol and amines are used, in the presence of high temperature, high pressure or phase transfer catalysts, halogen atoms may be replaced by alkoxy groups, amino groups, etc.
In addition, the physical properties of 3-fluoro-5-bromochlorobenzene are also related to its chemical properties. It is a volatile organic compound, and its melting point and boiling point are affected by intermolecular forces and structures. It has good solubility in organic solvents, which makes it convenient for it to participate in chemical reactions in solutions and provides an environment for its chemical properties to be exhibited.
In summary, 3-fluoro-5-bromochlorobenzene is rich in chemical properties and plays an important role in the field of organic synthesis. Many reaction characteristics need to be further explored by chemists to expand its application in materials and drug synthesis.
First of all, its substitution reaction. Due to the electron cloud density distribution of the benzene ring, the presence of halogen atoms (fluorine, bromine, chlorine) changes the electron cloud density of the benzene ring. Although fluorine atoms have high electronegativity, they can slightly increase the electron cloud density of the benzene ring by p-π conjugation effect, but the induction effect results in the overall reduction of the electron cloud density of the benzene ring. The same is true for bromine and chlorine. Therefore, in the electrophilic substitution reaction, the activity of 3-fluoro-5-bromochlorobenzene is lower than Electrophilic reagents are easy to attack positions with relatively high electron cloud density, and fluorine neighbors and para-positions are theoretically easier to be replaced. However, due to the combined influence of the steric resistance and electronic effect of bromine and chlorine, the actual reaction check points and conditions need to be studied in detail.
Furthermore, the metal-catalyzed reaction in which it participates. In the palladium-catalyzed cross-coupling reaction, the halogen atom of 3-fluoro-5-bromochlorobenzene can react with organometallic reagents (such as organoboron reagents, organozinc reagents, etc.) to form carbon-carbon bonds. In this reaction, different halogen atoms have different reactivity. Usually bromine and chlorine are more active than fluorine. Under suitable conditions, specific halogen atoms can be selectively activated to achieve precise synthesis.
And it also has characteristics in nucleophilic substitution reactions. Although it is difficult to nucleophilic substitution of benzene cyclohalides, halogen atoms can be replaced by nucleophilic reagents under strong nucleophilic reagents and specific conditions. If nucleophilic reagents such as sodium alcohol and amines are used, in the presence of high temperature, high pressure or phase transfer catalysts, halogen atoms may be replaced by alkoxy groups, amino groups, etc.
In addition, the physical properties of 3-fluoro-5-bromochlorobenzene are also related to its chemical properties. It is a volatile organic compound, and its melting point and boiling point are affected by intermolecular forces and structures. It has good solubility in organic solvents, which makes it convenient for it to participate in chemical reactions in solutions and provides an environment for its chemical properties to be exhibited.
In summary, 3-fluoro-5-bromochlorobenzene is rich in chemical properties and plays an important role in the field of organic synthesis. Many reaction characteristics need to be further explored by chemists to expand its application in materials and drug synthesis.
What are the common preparation methods for 3-fluoro-5-bromochlorobenzene?
3-Fluoro-5-bromochlorobenzene is also an organic compound. Its common preparation method follows the path of organic synthesis.
One method is also to take the appropriate aromatic compound as the starting material. If benzene is used as the starting point, bromine atoms are first introduced by halogenation reaction. To introduce bromine into the benzene ring, benzene and bromine can be electrophilic substitution reaction with the help of catalysts such as iron bromide to obtain bromobenzene.
The second rule is to make bromobenzene and chlorine react under the conditions of light or a specific catalyst, and chlorine atoms can be introduced at the appropriate position of the benzene ring. This step requires controlling the reaction conditions so that the chlorine atoms are introduced into the desired position to obtain benzene derivatives containing bromine and chlorine. At the end of
, then use an appropriate fluorination reagent, such as potassium fluoride, etc., in an organic solvent, react with the previous product to replace the halogen atom at a specific position with a fluorine atom. This step requires attention to factors such as reaction temperature, time and reagent ratio in order to accurately replace the fluorine atom to obtain 3-fluoro-5-bromochlorobenzene.
There are other methods, or benzene derivatives containing appropriate substituents can be prepared first, and then fluorine, bromine and chlorine atoms are introduced in turn. However, according to the characteristics and reactivity of each atom, the reaction conditions and reagents should be carefully selected, and the reaction process should be carefully regulated to achieve the purpose of preparation. In short, to prepare 3-fluoro-5-bromochlorobenzene, the reaction mechanism of each step, strict selection of conditions and reagents can be effectively obtained.
One method is also to take the appropriate aromatic compound as the starting material. If benzene is used as the starting point, bromine atoms are first introduced by halogenation reaction. To introduce bromine into the benzene ring, benzene and bromine can be electrophilic substitution reaction with the help of catalysts such as iron bromide to obtain bromobenzene.
The second rule is to make bromobenzene and chlorine react under the conditions of light or a specific catalyst, and chlorine atoms can be introduced at the appropriate position of the benzene ring. This step requires controlling the reaction conditions so that the chlorine atoms are introduced into the desired position to obtain benzene derivatives containing bromine and chlorine. At the end of
, then use an appropriate fluorination reagent, such as potassium fluoride, etc., in an organic solvent, react with the previous product to replace the halogen atom at a specific position with a fluorine atom. This step requires attention to factors such as reaction temperature, time and reagent ratio in order to accurately replace the fluorine atom to obtain 3-fluoro-5-bromochlorobenzene.
There are other methods, or benzene derivatives containing appropriate substituents can be prepared first, and then fluorine, bromine and chlorine atoms are introduced in turn. However, according to the characteristics and reactivity of each atom, the reaction conditions and reagents should be carefully selected, and the reaction process should be carefully regulated to achieve the purpose of preparation. In short, to prepare 3-fluoro-5-bromochlorobenzene, the reaction mechanism of each step, strict selection of conditions and reagents can be effectively obtained.
In what areas is 3-fluoro-5-bromochlorobenzene applied?
3-Fluoro-5-bromochlorobenzene, this compound has applications in many fields.
plays a key role in the field of pharmaceutical synthesis. The properties of halogen atoms can be introduced into the molecular structure of drugs through specific chemical reactions. The electronic and spatial effects of halogen atoms can significantly affect the interaction between drugs and targets. For example, it can change the lipophilicity of drug molecules, thereby enhancing their ability to penetrate biofilms and enhancing the bioavailability of drugs. And it can improve the activity and selectivity of drugs through special interactions such as halogen bonds with protein targets.
It is also of great value in the field of materials science. In the field of organic optoelectronic materials, 3-fluoro-5-bromochlorobenzene can be used as a building block for the synthesis of conjugated polymers or small molecules with specific optoelectronic properties. The presence of halogen atoms can adjust the electron cloud distribution of the material, affect its energy level structure, and then change the material's luminescence, conductivity and other properties. For example, in organic Light Emitting Diode (OLED) materials, the luminous efficiency and color purity can be optimized by rationally designing the structure containing this compound.
has also many applications in pesticide chemistry. Halogenated aromatics often exhibit good biological activity and can be used as lead compounds for structural modification and optimization. 3-Fluoro-5-bromochlorobenzene may be introduced into pesticide molecules to endow pesticides with biological activities such as insecticidal and bactericidal. Due to its unique chemical structure, it may be able to act against specific pests or pathogens, and the stability of halogen atoms may make pesticides have better effectiveness.
plays a key role in the field of pharmaceutical synthesis. The properties of halogen atoms can be introduced into the molecular structure of drugs through specific chemical reactions. The electronic and spatial effects of halogen atoms can significantly affect the interaction between drugs and targets. For example, it can change the lipophilicity of drug molecules, thereby enhancing their ability to penetrate biofilms and enhancing the bioavailability of drugs. And it can improve the activity and selectivity of drugs through special interactions such as halogen bonds with protein targets.
It is also of great value in the field of materials science. In the field of organic optoelectronic materials, 3-fluoro-5-bromochlorobenzene can be used as a building block for the synthesis of conjugated polymers or small molecules with specific optoelectronic properties. The presence of halogen atoms can adjust the electron cloud distribution of the material, affect its energy level structure, and then change the material's luminescence, conductivity and other properties. For example, in organic Light Emitting Diode (OLED) materials, the luminous efficiency and color purity can be optimized by rationally designing the structure containing this compound.
has also many applications in pesticide chemistry. Halogenated aromatics often exhibit good biological activity and can be used as lead compounds for structural modification and optimization. 3-Fluoro-5-bromochlorobenzene may be introduced into pesticide molecules to endow pesticides with biological activities such as insecticidal and bactericidal. Due to its unique chemical structure, it may be able to act against specific pests or pathogens, and the stability of halogen atoms may make pesticides have better effectiveness.
What are the physical properties of 3-fluoro-5-bromochlorobenzene?
3-Fluoro-5-bromochlorobenzene is also an organic compound. Its physical properties are particularly important, related to its application and characteristics.
When it comes to appearance, it is usually a colorless to light yellow liquid, which is relatively stable at room temperature and pressure. Looking at its color, the yellowish state is like the first blooming of autumn chrysanthemum, and it is slightly dyed by morning light. This is one of the external characteristics of the substance, which is easy to identify intuitively.
The value of its boiling point is within a certain range. If the boiling point is covered, the critical temperature at which the substance changes from liquid to gaseous state is also. The boiling point of 3-fluoro-5-bromochlorobenzene causes it to undergo a phase change at a specific temperature, which is crucial for separation, purification and storage. If the temperature approaches the boiling point, the substance will gradually vaporize, such as clouds rising and dissipating in space.
Melting point is also an important physical property. At the melting point, the substance changes from solid to liquid state, which is like melting ice in spring and occurs quietly. The melting point of 3-fluoro-5-bromochlorobenzene determines the low temperature environment at which it remains solid and above which temperature it turns into a flowing liquid.
In terms of solubility, it often has a certain solubility in organic solvents. Organic solvents such as alcohols and ethers are like gentle embraces, accepting 3-fluoro-5-bromochlorobenzene molecules to disperse them evenly. In water, its solubility is quite limited, and water and the compound are like two different faces, making it difficult to blend.
Density is also not negligible. Its density is different from that of water or other common substances. The difference in density makes 3-fluoro-5-bromochlorobenzene in the mixed system either float on the top or sink on the bottom, just like a boat traveling in water, each according to its weight.
These various physical properties are interrelated and together outline the characteristics of 3-fluoro-5-bromochlorobenzene, which is an indispensable consideration in many fields such as chemical synthesis and materials science.
When it comes to appearance, it is usually a colorless to light yellow liquid, which is relatively stable at room temperature and pressure. Looking at its color, the yellowish state is like the first blooming of autumn chrysanthemum, and it is slightly dyed by morning light. This is one of the external characteristics of the substance, which is easy to identify intuitively.
The value of its boiling point is within a certain range. If the boiling point is covered, the critical temperature at which the substance changes from liquid to gaseous state is also. The boiling point of 3-fluoro-5-bromochlorobenzene causes it to undergo a phase change at a specific temperature, which is crucial for separation, purification and storage. If the temperature approaches the boiling point, the substance will gradually vaporize, such as clouds rising and dissipating in space.
Melting point is also an important physical property. At the melting point, the substance changes from solid to liquid state, which is like melting ice in spring and occurs quietly. The melting point of 3-fluoro-5-bromochlorobenzene determines the low temperature environment at which it remains solid and above which temperature it turns into a flowing liquid.
In terms of solubility, it often has a certain solubility in organic solvents. Organic solvents such as alcohols and ethers are like gentle embraces, accepting 3-fluoro-5-bromochlorobenzene molecules to disperse them evenly. In water, its solubility is quite limited, and water and the compound are like two different faces, making it difficult to blend.
Density is also not negligible. Its density is different from that of water or other common substances. The difference in density makes 3-fluoro-5-bromochlorobenzene in the mixed system either float on the top or sink on the bottom, just like a boat traveling in water, each according to its weight.
These various physical properties are interrelated and together outline the characteristics of 3-fluoro-5-bromochlorobenzene, which is an indispensable consideration in many fields such as chemical synthesis and materials science.
What is the market price of 3-fluoro-5-bromochlorobenzene?
3-Fluoro-5-bromochlorobenzene is a fine chemical in organic chemistry. Its market price often fluctuates due to a variety of factors, and it is difficult to determine accurately.
First, the price of raw materials has a great impact on it. If the price of various basic chemical raw materials required for the preparation of 3-fluoro-5-bromochlorobenzene rises or falls, the cost of 3-fluoro-5-bromochlorobenzene will change, which will affect the selling price. If raw materials are scarce, prices will also rise.
Second, the complexity of the production process is closely related to the cost. If complex processes, high-end equipment and professional and technical personnel are required, the production cost will be high, and the product price will also rise. On the contrary, if the process is simple and efficient, the cost may be reduced, and the price will be more affordable.
Third, the market supply and demand relationship is the key factor. If the market has strong demand for 3-fluoro-5-bromochlorobenzene and limited supply, its price will go up; if the market demand is weak and the supply is excessive, the price will easily fall. For example, if the chemical is widely used in the pharmaceutical, pesticide and other industries and the demand increases, the price may rise; if the development of related industries is blocked and the demand decreases, the price will also be affected.
Fourth, the purity requirement also affects the price. 3-Fluoro-5-bromochlorobenzene with high purity is difficult to prepare and expensive, and the price is naturally higher than that of ordinary purity products. In some high-end scientific research or special industrial application fields, the purity requirements are strict, and the price of such high-purity products is high.
According to past market conditions and related similar chemical price fluctuations, the price of ordinary purity 3-fluoro-5-bromochlorobenzene may range from tens of yuan to 100 yuan per gram; if it is high purity and used in special fields, the price per gram may exceed 100 yuan, or even higher. However, this is only a rough estimate. The actual price can only be determined by paying attention to market dynamics in real time, consulting professional chemical product suppliers, or consulting the chemical product trading platform.
First, the price of raw materials has a great impact on it. If the price of various basic chemical raw materials required for the preparation of 3-fluoro-5-bromochlorobenzene rises or falls, the cost of 3-fluoro-5-bromochlorobenzene will change, which will affect the selling price. If raw materials are scarce, prices will also rise.
Second, the complexity of the production process is closely related to the cost. If complex processes, high-end equipment and professional and technical personnel are required, the production cost will be high, and the product price will also rise. On the contrary, if the process is simple and efficient, the cost may be reduced, and the price will be more affordable.
Third, the market supply and demand relationship is the key factor. If the market has strong demand for 3-fluoro-5-bromochlorobenzene and limited supply, its price will go up; if the market demand is weak and the supply is excessive, the price will easily fall. For example, if the chemical is widely used in the pharmaceutical, pesticide and other industries and the demand increases, the price may rise; if the development of related industries is blocked and the demand decreases, the price will also be affected.
Fourth, the purity requirement also affects the price. 3-Fluoro-5-bromochlorobenzene with high purity is difficult to prepare and expensive, and the price is naturally higher than that of ordinary purity products. In some high-end scientific research or special industrial application fields, the purity requirements are strict, and the price of such high-purity products is high.
According to past market conditions and related similar chemical price fluctuations, the price of ordinary purity 3-fluoro-5-bromochlorobenzene may range from tens of yuan to 100 yuan per gram; if it is high purity and used in special fields, the price per gram may exceed 100 yuan, or even higher. However, this is only a rough estimate. The actual price can only be determined by paying attention to market dynamics in real time, consulting professional chemical product suppliers, or consulting the chemical product trading platform.
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