Linshang Chemical
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3-Nitro-4-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
433850 |
| Name | 3-Nitro-4-Chlorobenzenesulfonyl Chloride |
| Chemical Formula | C6H3Cl2NO4S |
| Molar Mass | 260.06 g/mol |
| Appearance | Yellow - to - light brown solid |
| Melting Point | 74 - 78 °C |
| Boiling Point | Decomposes |
| Solubility In Water | Reacts with water |
| Solubility In Organic Solvents | Soluble in many organic solvents like dichloromethane |
| Acidity Basicity | Acidic due to sulfonyl chloride group, reacts with bases |
| Hazard Class | Corrosive, harmful if swallowed, in contact with skin or if inhaled |
As an accredited 3-Nitro-4-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 3 - nitro - 4 - chlorobenzenesulfonyl chloride packaged in a sealed drum. |
| Storage | 3 - nitro - 4 - chlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent contact with moisture and air, as it may react. Store it separately from incompatible substances like reducing agents, bases, and combustibles to avoid potential hazardous reactions. |
| Shipping | 3 - nitro - 4 - chlorobenzenesulfonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, likely in sealed containers. It must be labeled clearly, and transported by carriers licensed for such hazardous substances. |
Competitive 3-Nitro-4-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 3-Nitro-4-Chlorobenzenesulfonyl Chloride in China?
As a trusted 3-Nitro-4-Chlorobenzenesulfonyl Chloride manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 3-Nitro-4-Chlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 3-nitro-4-chlorobenzenesulfonyl Chloride?
3-Nitro-4-chlorobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it is often a key raw material. It can participate in many chemical reactions to construct complex organic molecular structures.
has many applications in dye synthesis. With this as a starting material, through a series of delicate reaction steps, dyes with brilliant colors and excellent performance can be prepared. With its unique chemical structure, it can endow dyes with excellent dye fastness and color brightness, so that after dyeing the fabric, it will last for a long time and the color is still bright and dazzling.
also plays an important role in the field of medicinal chemistry. It can be used as an intermediate to help synthesize drug molecules with specific biological activities. By modifying and modifying its chemical structure, it can precisely regulate the pharmacological properties of drugs, such as enhancing the affinity of drugs to specific targets, improving drug efficacy, and reducing adverse reactions, which makes great contributions to human health.
Furthermore, in the field of materials science, it also shows extraordinary functions. After appropriate chemical reactions, it can be introduced into polymer materials to improve the properties of materials. For example, enhance the corrosion resistance and thermal stability of materials, expand the application range of materials in extreme environments, and contribute to the development of materials science.
In summary, 3-nitro-4-chlorobenzenesulfonyl chloride is indispensable in many fields such as organic synthesis, dyes, medicine and materials. Its wide range of uses and far-reaching impact make it an important member of the field of chemistry.
has many applications in dye synthesis. With this as a starting material, through a series of delicate reaction steps, dyes with brilliant colors and excellent performance can be prepared. With its unique chemical structure, it can endow dyes with excellent dye fastness and color brightness, so that after dyeing the fabric, it will last for a long time and the color is still bright and dazzling.
also plays an important role in the field of medicinal chemistry. It can be used as an intermediate to help synthesize drug molecules with specific biological activities. By modifying and modifying its chemical structure, it can precisely regulate the pharmacological properties of drugs, such as enhancing the affinity of drugs to specific targets, improving drug efficacy, and reducing adverse reactions, which makes great contributions to human health.
Furthermore, in the field of materials science, it also shows extraordinary functions. After appropriate chemical reactions, it can be introduced into polymer materials to improve the properties of materials. For example, enhance the corrosion resistance and thermal stability of materials, expand the application range of materials in extreme environments, and contribute to the development of materials science.
In summary, 3-nitro-4-chlorobenzenesulfonyl chloride is indispensable in many fields such as organic synthesis, dyes, medicine and materials. Its wide range of uses and far-reaching impact make it an important member of the field of chemistry.
What are the physical properties of 3-nitro-4-chlorobenzenesulfonyl Chloride?
3 - nitro - 4 - chlorobenzenesulfonyl Chloride is one of the organic compounds. Its physical properties are particularly important and are related to many applications in the chemical industry.
Looking at its properties, at room temperature, this substance is often in a solid state, but the specific form is either crystalline, like ice crystals, crystal clear and regular; or powdery, delicate like dust, evenly spread. Its color is usually non-solid, or light yellow, like the shimmer of morning light, soft and elegant; or light brown, like the color of autumn wood, calm and charming.
As for its melting point, it is a key physical property. The value of the melting point of this compound, according to accurate measurement, is in a specific temperature range. At this temperature limit, 3-nitro-4-chlorobenzenesulfonyl Chloride in the solid state gradually melts, from a solid state to a flowing state, just like ice in the warm sun, slowly melting. This melting point temperature can guide the purification, separation and control of specific reaction conditions in chemical operations.
When it comes to boiling point, under a specific pressure environment, 3-nitro-4-chlorobenzenesulfonyl Chloride reaches a certain high temperature, and it boils and gasifies. This boiling point data is of great significance in chemical processes such as distillation, which can help chemical workers to precisely control and achieve effective separation and purification of substances.
Its solubility cannot be underestimated. In the environment of organic solvents, such as ethanol, ether, etc., 3-nitro-4-chlorobenzenesulfonyl Chloride exhibits different dissolution patterns. In ethanol, or partially dissolved, like stars hidden in the night, the slightly soluble substance is dispersed in it; in ether, or dissolved better, like salt in a clear pool, evenly dispersed, invisible. In water, due to its chemical structure characteristics, the solubility is very small, just like stubborn stones entering water, it is difficult to blend with water.
In addition, the density of 3-nitro-4-chlorobenzenesulfonyl Chloride may be different compared with common solvents. The value of its density has a great impact on chemical storage, transportation, and mixing reactions, which is related to the choice of containers, the stratification of substances, and the process of the reaction.
And its smell is irritating, and the smell is as pungent as the nose, which is uncomfortable. This odor characteristic warns chemical practitioners to take careful protection when operating to avoid harming the body.
These physical properties are fundamental and critical elements in many fields such as chemical production and scientific research. Chemists need to know in detail in order to make good use of this compound.
Looking at its properties, at room temperature, this substance is often in a solid state, but the specific form is either crystalline, like ice crystals, crystal clear and regular; or powdery, delicate like dust, evenly spread. Its color is usually non-solid, or light yellow, like the shimmer of morning light, soft and elegant; or light brown, like the color of autumn wood, calm and charming.
As for its melting point, it is a key physical property. The value of the melting point of this compound, according to accurate measurement, is in a specific temperature range. At this temperature limit, 3-nitro-4-chlorobenzenesulfonyl Chloride in the solid state gradually melts, from a solid state to a flowing state, just like ice in the warm sun, slowly melting. This melting point temperature can guide the purification, separation and control of specific reaction conditions in chemical operations.
When it comes to boiling point, under a specific pressure environment, 3-nitro-4-chlorobenzenesulfonyl Chloride reaches a certain high temperature, and it boils and gasifies. This boiling point data is of great significance in chemical processes such as distillation, which can help chemical workers to precisely control and achieve effective separation and purification of substances.
Its solubility cannot be underestimated. In the environment of organic solvents, such as ethanol, ether, etc., 3-nitro-4-chlorobenzenesulfonyl Chloride exhibits different dissolution patterns. In ethanol, or partially dissolved, like stars hidden in the night, the slightly soluble substance is dispersed in it; in ether, or dissolved better, like salt in a clear pool, evenly dispersed, invisible. In water, due to its chemical structure characteristics, the solubility is very small, just like stubborn stones entering water, it is difficult to blend with water.
In addition, the density of 3-nitro-4-chlorobenzenesulfonyl Chloride may be different compared with common solvents. The value of its density has a great impact on chemical storage, transportation, and mixing reactions, which is related to the choice of containers, the stratification of substances, and the process of the reaction.
And its smell is irritating, and the smell is as pungent as the nose, which is uncomfortable. This odor characteristic warns chemical practitioners to take careful protection when operating to avoid harming the body.
These physical properties are fundamental and critical elements in many fields such as chemical production and scientific research. Chemists need to know in detail in order to make good use of this compound.
3-nitro-4-chlorobenzenesulfonyl the chemistry of Chloride
3 - nitro - 4 - chlorobenzenesulfonyl chloride (3 - nitro - 4 - chlorobenzenesulfonyl chloride) is a key intermediate in organic synthesis, and its chemical properties are unique and interesting.
In this compound, the nitro group and chlorine atoms are connected to the benzene ring, and the sulfonyl chloride group is also above the benzene ring. Nitro is a strong electron-absorbing group. With its induction effect and conjugation effect, the electron cloud density of the benzene ring is significantly reduced, resulting in a decrease in the electrophilic substitution activity of the benzene ring, but an increase in the nucleophilic substitution activity. Chlorine atoms also have an electron-absorbing induction effect, but their conjugation effect is weak, and in general, it also affects the electron cloud distribution of the benzene ring. The sulfonyl chloride group is active and is the carry point of many reactions of this compound.
The sulfonyl chloride group is very easy to hydrolyze and will react in contact with water to form the corresponding sulfonic acid and hydrogen chloride. This hydrolysis reaction occurs spontaneously in a humid environment and is usually an exothermic reaction. The hydrolysis reaction equation is roughly as follows: 3 - nitro - 4 - chlorobenzenesulfonyl chloride + H2O → 3 - nitro - 4 - chlorobenzenesulfonic acid + HCl.
3 - nitro - 4 - chlorobenzenesulfonyl chloride can react with alcohols to form sulfonates. This reaction generally needs to be carried out under the condition of alkali catalysis. The alkali can neutralize the hydrogen chloride generated by the reaction and promote the reaction to move in the direction of forming sulfonates. For example, when reacted with ethanol, 3-nitro-4-chloroethylbenzenesulfonate will be formed.
It can also undergo nucleophilic substitution with amine compounds, and the chlorine atoms in the sulfonyl chloride group are replaced by amine groups to form sulfonamides. This reaction is very commonly used in the preparation of various sulfonamide derivatives in organic synthesis, providing an important way to construct compounds containing sulfonamide structures.
In addition, in view of the existence of nitro and chlorine atoms on the benzene ring, under appropriate conditions, some nucleophilic substitution or electrophilic substitution reactions can also occur in the benzene ring, but the specific reactivity and selectivity will be affected by the localization effect of nitro and chlorine atoms. The nitro group is an meso-site group, which makes subsequent substitution reactions more likely to occur at the site position between the benzene ring; although the chlorine atom is an ortho-para-site group, its localization effect will be changed due to the influence of the strong electron-absorbing action of the nitro group.
3 - nitro - 4 - chlorobenzenesulfonyl chloride is chemically active and has a wide range of uses in the field of organic synthesis. However, due to its activity, care should be taken to avoid contact with water and active nucleophilic reagents when storing
In this compound, the nitro group and chlorine atoms are connected to the benzene ring, and the sulfonyl chloride group is also above the benzene ring. Nitro is a strong electron-absorbing group. With its induction effect and conjugation effect, the electron cloud density of the benzene ring is significantly reduced, resulting in a decrease in the electrophilic substitution activity of the benzene ring, but an increase in the nucleophilic substitution activity. Chlorine atoms also have an electron-absorbing induction effect, but their conjugation effect is weak, and in general, it also affects the electron cloud distribution of the benzene ring. The sulfonyl chloride group is active and is the carry point of many reactions of this compound.
The sulfonyl chloride group is very easy to hydrolyze and will react in contact with water to form the corresponding sulfonic acid and hydrogen chloride. This hydrolysis reaction occurs spontaneously in a humid environment and is usually an exothermic reaction. The hydrolysis reaction equation is roughly as follows: 3 - nitro - 4 - chlorobenzenesulfonyl chloride + H2O → 3 - nitro - 4 - chlorobenzenesulfonic acid + HCl.
3 - nitro - 4 - chlorobenzenesulfonyl chloride can react with alcohols to form sulfonates. This reaction generally needs to be carried out under the condition of alkali catalysis. The alkali can neutralize the hydrogen chloride generated by the reaction and promote the reaction to move in the direction of forming sulfonates. For example, when reacted with ethanol, 3-nitro-4-chloroethylbenzenesulfonate will be formed.
It can also undergo nucleophilic substitution with amine compounds, and the chlorine atoms in the sulfonyl chloride group are replaced by amine groups to form sulfonamides. This reaction is very commonly used in the preparation of various sulfonamide derivatives in organic synthesis, providing an important way to construct compounds containing sulfonamide structures.
In addition, in view of the existence of nitro and chlorine atoms on the benzene ring, under appropriate conditions, some nucleophilic substitution or electrophilic substitution reactions can also occur in the benzene ring, but the specific reactivity and selectivity will be affected by the localization effect of nitro and chlorine atoms. The nitro group is an meso-site group, which makes subsequent substitution reactions more likely to occur at the site position between the benzene ring; although the chlorine atom is an ortho-para-site group, its localization effect will be changed due to the influence of the strong electron-absorbing action of the nitro group.
3 - nitro - 4 - chlorobenzenesulfonyl chloride is chemically active and has a wide range of uses in the field of organic synthesis. However, due to its activity, care should be taken to avoid contact with water and active nucleophilic reagents when storing
What is the preparation method of 3-nitro-4-chlorobenzenesulfonyl Chloride?
The method for preparing 3-nitro-4-chlorobenzenesulfonyl chloride follows the following steps.
First take an appropriate amount of 4-chlorobenzenesulfonyl chloride as the starting material, which is the reaction base. Place it in a suitable reaction vessel, which needs to be clean and suitable for the reaction conditions. Then, in a specific reaction environment, slowly add nitrifying reagents to it. Commonly used nitrifying reagents, such as concentrated nitric acid and concentrated sulfuric acid mixed in an appropriate proportion. The addition process must be careful to prevent the reaction from being too violent. When adding mixed acids, the temperature conditions should be strictly controlled. Generally speaking, it is advisable to maintain the temperature within a certain range, such as 0-10 ° C. The low temperature environment helps the reaction to progress smoothly and reduce the occurrence of side reactions. If the temperature is too high, it is easy to cause the increase of by-products, which affects the purity and yield of the target product.
Add the mixed acid and continue to stir to ensure that the reactants are fully contacted and the reaction is complete. The stirring time is also exquisite, and it needs to be determined according to the specific reaction process, which varies roughly from several hours. During the reaction, pay close attention to the reaction phenomena, such as the color change of the solution and the escape of gas.
When the reaction is completed, pour the reaction mixture into an appropriate amount of ice water. This step aims to precipitate the product and stop the reaction. After that, the solid product is separated by conventional separation methods, such as filtration.
The obtained solid product still contains impurities and needs to be further The commonly used method of purification is recrystallization. Select a suitable solvent, such as ethanol, ether, etc., dissolve the solid product, heat and concentrate it, and then slowly cool it to make the product crystallize. After several recrystallization operations, the purity of the product can be significantly improved.
After this series of steps, a relatively pure 3-nitro-4-chlorobenzenesulfonyl chloride can be obtained. The whole operation process, strictly abide by safety procedures, because it involves dangerous reagents such as strong acids, it must not be slack.
First take an appropriate amount of 4-chlorobenzenesulfonyl chloride as the starting material, which is the reaction base. Place it in a suitable reaction vessel, which needs to be clean and suitable for the reaction conditions. Then, in a specific reaction environment, slowly add nitrifying reagents to it. Commonly used nitrifying reagents, such as concentrated nitric acid and concentrated sulfuric acid mixed in an appropriate proportion. The addition process must be careful to prevent the reaction from being too violent. When adding mixed acids, the temperature conditions should be strictly controlled. Generally speaking, it is advisable to maintain the temperature within a certain range, such as 0-10 ° C. The low temperature environment helps the reaction to progress smoothly and reduce the occurrence of side reactions. If the temperature is too high, it is easy to cause the increase of by-products, which affects the purity and yield of the target product.
Add the mixed acid and continue to stir to ensure that the reactants are fully contacted and the reaction is complete. The stirring time is also exquisite, and it needs to be determined according to the specific reaction process, which varies roughly from several hours. During the reaction, pay close attention to the reaction phenomena, such as the color change of the solution and the escape of gas.
When the reaction is completed, pour the reaction mixture into an appropriate amount of ice water. This step aims to precipitate the product and stop the reaction. After that, the solid product is separated by conventional separation methods, such as filtration.
The obtained solid product still contains impurities and needs to be further The commonly used method of purification is recrystallization. Select a suitable solvent, such as ethanol, ether, etc., dissolve the solid product, heat and concentrate it, and then slowly cool it to make the product crystallize. After several recrystallization operations, the purity of the product can be significantly improved.
After this series of steps, a relatively pure 3-nitro-4-chlorobenzenesulfonyl chloride can be obtained. The whole operation process, strictly abide by safety procedures, because it involves dangerous reagents such as strong acids, it must not be slack.
What are the precautions for 3-nitro-4-chlorobenzenesulfonyl Chloride during use?
3-Nitro-4-chlorobenzenesulfonyl chloride is an important reagent in organic synthesis. During use, many precautions must be kept in mind.
Those who bear the brunt must not be ignored for safety protection. This compound is corrosive and irritating, and can cause serious injury if it touches the skin, eyes or inhales its vapor. Therefore, when operating, be sure to wear complete protective equipment, such as protective gloves, goggles and gas masks, to ensure your own safety.
In addition, its chemical properties are lively and it is prone to reaction in contact with water. Therefore, when storing and using, it is necessary to ensure that the environment is dry and away from water sources to prevent it from deteriorating due to reactions such as hydrolysis, which will affect the use effect.
The precise control of the reaction conditions is also crucial. Many of the reactions it participates in have strict requirements on conditions such as temperature, pH and reaction time. If the temperature is too high or too low, side reactions may be triggered, resulting in poor product purity and yield. Therefore, during the reaction, it is necessary to closely monitor and strictly regulate the reaction conditions with the help of thermometers and other instruments to make the reaction proceed smoothly.
In addition, due to certain toxicity, after use, the disposal of related wastes should not be underestimated. It is necessary to follow relevant environmental protection regulations and laboratory regulations, and properly dispose of the waste, and must not be discarded at will to avoid polluting the environment.
At the same time, during use, ventilation conditions should not be ignored. Good ventilation can disperse volatile harmful gases in time, reduce the concentration of harmful substances in the air, and protect the health of operators.
In summary, when using 3-nitro-4-chlorobenzenesulfonyl chloride, safety protection, dry environment maintenance, reaction conditions control, waste disposal and ventilation conditions must be treated with caution to ensure the smooth and safe testing or production.
Those who bear the brunt must not be ignored for safety protection. This compound is corrosive and irritating, and can cause serious injury if it touches the skin, eyes or inhales its vapor. Therefore, when operating, be sure to wear complete protective equipment, such as protective gloves, goggles and gas masks, to ensure your own safety.
In addition, its chemical properties are lively and it is prone to reaction in contact with water. Therefore, when storing and using, it is necessary to ensure that the environment is dry and away from water sources to prevent it from deteriorating due to reactions such as hydrolysis, which will affect the use effect.
The precise control of the reaction conditions is also crucial. Many of the reactions it participates in have strict requirements on conditions such as temperature, pH and reaction time. If the temperature is too high or too low, side reactions may be triggered, resulting in poor product purity and yield. Therefore, during the reaction, it is necessary to closely monitor and strictly regulate the reaction conditions with the help of thermometers and other instruments to make the reaction proceed smoothly.
In addition, due to certain toxicity, after use, the disposal of related wastes should not be underestimated. It is necessary to follow relevant environmental protection regulations and laboratory regulations, and properly dispose of the waste, and must not be discarded at will to avoid polluting the environment.
At the same time, during use, ventilation conditions should not be ignored. Good ventilation can disperse volatile harmful gases in time, reduce the concentration of harmful substances in the air, and protect the health of operators.
In summary, when using 3-nitro-4-chlorobenzenesulfonyl chloride, safety protection, dry environment maintenance, reaction conditions control, waste disposal and ventilation conditions must be treated with caution to ensure the smooth and safe testing or production.
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