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4-(2-Chloroethyl)-Α,Α-Dimethyl-Benzeneacetic Acid
Linshang Chemical
|
HS Code |
870994 |
| Chemical Formula | C12H15ClO2 |
| Molar Mass | 226.7 g/mol |
| Appearance | Solid (usually) |
| Physical State At Room Temp | Solid |
| Solubility In Water | Low |
| Solubility In Organic Solvents | Moderate to high in common organic solvents |
| Odor | Typically, may have a faint, characteristic aromatic odor |
As an accredited 4-(2-Chloroethyl)-Α,Α-Dimethyl-Benzeneacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(2 - chloroethyl)-α,α - dimethyl - benzeneacetic acid in sealed plastic containers. |
| Storage | 4-(2 - chloroethyl)-α,α - dimethyl - benzeneacetic Acid should be stored in a cool, dry, well - ventilated area, away from sources of heat and ignition. Keep it in a tightly closed container to prevent exposure to air and moisture, which could potentially degrade the chemical. Store it separately from incompatible substances like oxidizing agents and bases to avoid reactions. |
| Shipping | 4-(2 - chloroethyl)-α,α - dimethyl - benzeneacetic acid is a chemical. Shipping requires compliance with strict regulations. It must be properly packaged in corrosion - resistant containers and labeled clearly for safe transport. |
Competitive 4-(2-Chloroethyl)-Α,Α-Dimethyl-Benzeneacetic Acid prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-(2-Chloroethyl)-Α,Α-Dimethyl-Benzeneacetic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4- (2 - chloro ethyl )-α,α - dimethyl - benzeneacetic Acid
4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid, which is widely used. In the field of medicine, it is often an intermediate for important drug synthesis. Because drug synthesis requires the construction of a specific chemical structure, the structural characteristics of this compound can just meet the needs of some drug molecules. For example, when developing specific anti-cancer drugs, with the help of its structural characteristics, other key groups can be introduced through a series of chemical reactions to synthesize molecules with anti-cancer activity.
In the chemical industry, it can be used as a raw material for organic synthesis. Organic synthesis aims to create various organic compounds. The unique structure of this compound can open a variety of synthesis paths. For example, when synthesizing some high-performance polymers or special functional materials, this is used as a starting material, and the clever reaction design can give the material specific properties, such as enhancing the stability and flexibility of the material.
It also plays an important role in the field of scientific research and exploration. Researchers often use it to study the mechanism of chemical reactions. Because its structure contains specific functional groups, it can present unique reaction laws when participating in various reactions, helping researchers to deeply understand the nature of the reaction, providing a basis for developing new synthesis methods and optimizing existing reactions.
In addition, in the manufacture of fine chemicals, it can be used to prepare flavors, cosmetic additives, etc. In the preparation of fragrances, its structure can be modified by specific reactions, or compounds with unique aromas can be generated; when used as cosmetic additives, some of its properties may help to improve the stability and moisturizing properties of cosmetics.
In the chemical industry, it can be used as a raw material for organic synthesis. Organic synthesis aims to create various organic compounds. The unique structure of this compound can open a variety of synthesis paths. For example, when synthesizing some high-performance polymers or special functional materials, this is used as a starting material, and the clever reaction design can give the material specific properties, such as enhancing the stability and flexibility of the material.
It also plays an important role in the field of scientific research and exploration. Researchers often use it to study the mechanism of chemical reactions. Because its structure contains specific functional groups, it can present unique reaction laws when participating in various reactions, helping researchers to deeply understand the nature of the reaction, providing a basis for developing new synthesis methods and optimizing existing reactions.
In addition, in the manufacture of fine chemicals, it can be used to prepare flavors, cosmetic additives, etc. In the preparation of fragrances, its structure can be modified by specific reactions, or compounds with unique aromas can be generated; when used as cosmetic additives, some of its properties may help to improve the stability and moisturizing properties of cosmetics.
What are the physical properties of 4- (2 - chloro ethyl )-α,α - dimethyl - benzeneacetic Acid
4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid, the physical properties of this substance are very critical, and it is related to its application in many fields.
Looking at its properties, under normal conditions, or white to white crystalline powder, this is its intuitive physical appearance, and the delicate powder morphology is also easy to follow-up processing and use.
When it comes to melting point, it is about a specific temperature range. This characteristic is of great significance for the determination of its purity and thermal stability. Accurate melting point data is like a unique "ID card" of a substance, which can help identify its quality.
In terms of solubility, it may exhibit a certain solubility in common organic solvents. For example, in organic solvents such as ethanol and acetone, it can be moderately dissolved, while the solubility in water is relatively limited. This difference in solubility provides an important basis for its separation, purification and preparation.
In terms of density, it also has specific values. Although it is not often concerned by the public, in the material balance of chemical production and specific process design, density parameters are indispensable, which are related to the accuracy and efficiency of the process.
In addition, its smell is weak, and there is almost no special pungent or strong smell. This property has obvious advantages in application scenarios involving human contact or high environmental friendly requirements.
4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid has various physical properties, and each property is interrelated to build its unique "physical property map", which has far-reaching guiding value for its production, research and development and application.
Looking at its properties, under normal conditions, or white to white crystalline powder, this is its intuitive physical appearance, and the delicate powder morphology is also easy to follow-up processing and use.
When it comes to melting point, it is about a specific temperature range. This characteristic is of great significance for the determination of its purity and thermal stability. Accurate melting point data is like a unique "ID card" of a substance, which can help identify its quality.
In terms of solubility, it may exhibit a certain solubility in common organic solvents. For example, in organic solvents such as ethanol and acetone, it can be moderately dissolved, while the solubility in water is relatively limited. This difference in solubility provides an important basis for its separation, purification and preparation.
In terms of density, it also has specific values. Although it is not often concerned by the public, in the material balance of chemical production and specific process design, density parameters are indispensable, which are related to the accuracy and efficiency of the process.
In addition, its smell is weak, and there is almost no special pungent or strong smell. This property has obvious advantages in application scenarios involving human contact or high environmental friendly requirements.
4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid has various physical properties, and each property is interrelated to build its unique "physical property map", which has far-reaching guiding value for its production, research and development and application.
What are the chemical properties of 4- (2 - chloro ethyl )-α,α - dimethyl - benzeneacetic Acid
4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid, which has unique chemical properties. It is an organic compound containing benzene ring, carboxyl group and chloroethyl group structures, which endow it with various chemical activities.
As far as acidity is concerned, due to the carboxyl group, protons can be released under suitable conditions, showing acidity, and can neutralize with bases to generate corresponding salts and water. For example, when reacted with sodium hydroxide, hydrogen in the carboxyl group combines with hydroxide to form water to generate corresponding sodium salts.
From the perspective of substitution reaction, the chlorine atom of chloroethyl group has certain activity and can be replaced by other groups under appropriate reagents and conditions. When interacting with nucleophilic reagents, chlorine atoms can be replaced by nucleophilic groups to derive different compounds.
The benzene ring in its molecule also has special properties and can undergo aromatic electrophilic substitution. Due to the high electron cloud density of the benzene ring, it is easy to attract electrophilic reagents to attack, such as halogenation, nitrification, sulfonation and other reactions, and introduce corresponding groups at specific positions of the benzene ring.
In addition ，α，α - dimethyl structure has an impact on the molecular spatial configuration and electron cloud distribution, and to a certain extent affects the physical and chemical properties of the compound, such as molecular polarity, which in turn affects its solubility in different solvents. Due to its structure containing more hydrophobic groups, its solubility in water is poor, but it is easily soluble in organic solvents, such as ethanol, ether, etc. These chemical properties make it widely used in the field of organic synthesis and can be used as an intermediate for the synthesis of complex organic compounds.
As far as acidity is concerned, due to the carboxyl group, protons can be released under suitable conditions, showing acidity, and can neutralize with bases to generate corresponding salts and water. For example, when reacted with sodium hydroxide, hydrogen in the carboxyl group combines with hydroxide to form water to generate corresponding sodium salts.
From the perspective of substitution reaction, the chlorine atom of chloroethyl group has certain activity and can be replaced by other groups under appropriate reagents and conditions. When interacting with nucleophilic reagents, chlorine atoms can be replaced by nucleophilic groups to derive different compounds.
The benzene ring in its molecule also has special properties and can undergo aromatic electrophilic substitution. Due to the high electron cloud density of the benzene ring, it is easy to attract electrophilic reagents to attack, such as halogenation, nitrification, sulfonation and other reactions, and introduce corresponding groups at specific positions of the benzene ring.
In addition ，α，α - dimethyl structure has an impact on the molecular spatial configuration and electron cloud distribution, and to a certain extent affects the physical and chemical properties of the compound, such as molecular polarity, which in turn affects its solubility in different solvents. Due to its structure containing more hydrophobic groups, its solubility in water is poor, but it is easily soluble in organic solvents, such as ethanol, ether, etc. These chemical properties make it widely used in the field of organic synthesis and can be used as an intermediate for the synthesis of complex organic compounds.
4- (2 - chloro ethyl )-α,α - dimethyl - benzeneacetic acid
There are various ways to synthesize 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid. The method of organic synthesis is often followed to deal with this matter.
One, or can be started from a suitable benzene starting material. First, the benzene ring is substituted and a specific group is introduced. If benzene is used as the starting point, after the Friedel-Crafts alkylation reaction, dimethyl can be introduced to obtain α, α-dimethylbenzene. Then, chlorinated reagents, such as thionyl chloride, phosphorus trichloride, etc., are used to chlorinate the side chain methyl of α-dimethylbenzene under appropriate conditions to obtain chlorine-containing intermediates. Subsequently, by nucleophilic substitution reaction, 2-chloroethyl is introduced. This nucleophilic substitution can select suitable nucleophilic reagents, such as nucleophilic reagents formed by the interaction of alcohol solution of halogenated alkanes with metal salts, and react with chlorine-containing intermediates under alkali catalysis to obtain key intermediates. Finally, through carboxylation reaction, 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid can be formed. The method of carboxylation can be achieved by the interaction of Grignard reagent with carbon dioxide, or the hydrolysis of nitrile.
Second, the existing phenylacetic acid derivative can also be used as the starting material. The α-position is first modified by dimethylation, which can be reacted in a suitable solvent by appropriate methylation reagents, such as the combination of iodomethane and base, to obtain α, α-dimethylphenylacetic acid derivatives. Then, the benzene ring is selectively chloroethylated. In this step, the electrophilic substitution reaction strategy can be used, and a suitable chloroethylation reagent, such as chloroethyl halide and Lewis acid catalyst, can be used to introduce 2-chloroethyl at a specific position in the benzene ring, and the final product can be obtained.
In addition, a series of reactions can be designed with the starting material of polyfunctionalization. In the same reaction system, with the regulation of different reaction conditions, continuous substitution, addition, rearrangement and other reactions occur, directly constructing the molecular structure of 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid. This series reaction requires careful consideration of the activity and selectivity of each step of the reaction to ensure that the reaction proceeds according to the expected path.
One, or can be started from a suitable benzene starting material. First, the benzene ring is substituted and a specific group is introduced. If benzene is used as the starting point, after the Friedel-Crafts alkylation reaction, dimethyl can be introduced to obtain α, α-dimethylbenzene. Then, chlorinated reagents, such as thionyl chloride, phosphorus trichloride, etc., are used to chlorinate the side chain methyl of α-dimethylbenzene under appropriate conditions to obtain chlorine-containing intermediates. Subsequently, by nucleophilic substitution reaction, 2-chloroethyl is introduced. This nucleophilic substitution can select suitable nucleophilic reagents, such as nucleophilic reagents formed by the interaction of alcohol solution of halogenated alkanes with metal salts, and react with chlorine-containing intermediates under alkali catalysis to obtain key intermediates. Finally, through carboxylation reaction, 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid can be formed. The method of carboxylation can be achieved by the interaction of Grignard reagent with carbon dioxide, or the hydrolysis of nitrile.
Second, the existing phenylacetic acid derivative can also be used as the starting material. The α-position is first modified by dimethylation, which can be reacted in a suitable solvent by appropriate methylation reagents, such as the combination of iodomethane and base, to obtain α, α-dimethylphenylacetic acid derivatives. Then, the benzene ring is selectively chloroethylated. In this step, the electrophilic substitution reaction strategy can be used, and a suitable chloroethylation reagent, such as chloroethyl halide and Lewis acid catalyst, can be used to introduce 2-chloroethyl at a specific position in the benzene ring, and the final product can be obtained.
In addition, a series of reactions can be designed with the starting material of polyfunctionalization. In the same reaction system, with the regulation of different reaction conditions, continuous substitution, addition, rearrangement and other reactions occur, directly constructing the molecular structure of 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid. This series reaction requires careful consideration of the activity and selectivity of each step of the reaction to ensure that the reaction proceeds according to the expected path.
4- (2 - chloro ethyl )-α,α - dimethyl - benzeneacetic Acid
4- (2-Chloroethyl ） - α，α - dimethyl-phenylacetic acid during use, pay attention to the following things:
First, it is related to safety protection. This is the most important, because it may have certain toxicity and irritation. During operation, be sure to wear protective clothing, such as protective gloves, goggles and masks, to prevent the substance from contacting the skin, eyes and respiratory tract. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention quickly according to the specific situation.
Second, pay attention to storage conditions. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties or causing reactions under improper conditions, it is dangerous. At the same time, it is necessary to avoid mixing with oxidizing substances, alkaline substances, etc., to prevent the interaction from causing deterioration or dangerous products.
Third, pay attention to the use specifications. Before use, it is necessary to understand its chemical properties and reaction characteristics in detail, and accurately control the dosage and reaction conditions according to the experimental purpose or production requirements. For example, the reaction temperature, reaction time and proportion of reactants, etc., a slight difference may affect the quality of the product or cause unexpected reactions. The operation process should be carried out in a place with corresponding safety facilities and ventilation equipment, such as a fume hood, to effectively discharge the harmful gases that may be generated.
Fourth, pay attention to waste disposal. After use, the remaining substances and waste must not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations. Generally speaking, it should be collected by classification and handed over to professional institutions for harmless disposal to avoid pollution to the environment.
In short, the use of 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid must be careful in all aspects to ensure the safety of personnel and the environment is not damaged, and at the same time to ensure the use effect and quality.
First, it is related to safety protection. This is the most important, because it may have certain toxicity and irritation. During operation, be sure to wear protective clothing, such as protective gloves, goggles and masks, to prevent the substance from contacting the skin, eyes and respiratory tract. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention quickly according to the specific situation.
Second, pay attention to storage conditions. Store it in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties or causing reactions under improper conditions, it is dangerous. At the same time, it is necessary to avoid mixing with oxidizing substances, alkaline substances, etc., to prevent the interaction from causing deterioration or dangerous products.
Third, pay attention to the use specifications. Before use, it is necessary to understand its chemical properties and reaction characteristics in detail, and accurately control the dosage and reaction conditions according to the experimental purpose or production requirements. For example, the reaction temperature, reaction time and proportion of reactants, etc., a slight difference may affect the quality of the product or cause unexpected reactions. The operation process should be carried out in a place with corresponding safety facilities and ventilation equipment, such as a fume hood, to effectively discharge the harmful gases that may be generated.
Fourth, pay attention to waste disposal. After use, the remaining substances and waste must not be discarded at will. It needs to be properly disposed of in accordance with relevant regulations. Generally speaking, it should be collected by classification and handed over to professional institutions for harmless disposal to avoid pollution to the environment.
In short, the use of 4- (2-chloroethyl ） - α，α - dimethyl-phenylacetic acid must be careful in all aspects to ensure the safety of personnel and the environment is not damaged, and at the same time to ensure the use effect and quality.
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