Linshang Chemical
PRODUCTS
4-(3-Chloropropoxy)-4-Fluorobenzene
Linshang Chemical
|
HS Code |
777827 |
| Chemical Formula | C9H8ClFO |
| Molecular Weight | 188.61 |
| Solubility In Water | Low solubility (due to non - polar nature of benzene ring and relatively hydrophobic groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
As an accredited 4-(3-Chloropropoxy)-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4-(3 - chloropropoxy)-4 - fluorobenzene packaged in a sealed plastic drum. |
| Storage | 4-(3 - Chloropropoxy)-4 - fluorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or unwanted reactions. Label the storage container clearly for easy identification. |
| Shipping | 4-(3 - chloropropoxy)-4 - fluorobenzene is shipped in accordance with strict chemical transport regulations. It's typically packed in well - sealed containers, safeguarded during transit to prevent spills and ensure safety. |
Competitive 4-(3-Chloropropoxy)-4-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-(3-Chloropropoxy)-4-Fluorobenzene in China?
As a trusted 4-(3-Chloropropoxy)-4-Fluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-(3-Chloropropoxy)-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4- (3-chloropropoxy) -4-fluorobenzene?
4- (3-hydroxyethylamino) -4-methoxybenzaldehyde, which has important uses in many fields.
In the field of medicine, it is a key intermediate for the synthesis of specific drugs. The presence of specific functional groups in the genome structure can be chemically modified to construct a molecular structure with biological activity, providing a basis for the development of drugs to treat specific diseases. For example, it can participate in the synthesis of drug molecules with antibacterial, anti-inflammatory or anti-tumor activities to help alleviate or cure related diseases, which is of great significance to human health.
In the dye industry, 4- (3-hydroxyethylamino) -4-methoxybenzaldehyde also plays an important role. Due to its structural properties, it can be converted into dyes with bright color and good stability through a series of reactions. Such dyes can be widely used in textile, leather and other industries to give products rich and diverse colors, enhance the aesthetics and commercial value of products.
In the field of materials science, this compound can be used as a synthetic raw material for functional materials. By reacting with other compounds, materials with special optical, electrical or mechanical properties can be prepared, such as for the preparation of organic Light Emitting Diode (OLED) materials, which enable display devices to have higher brightness, contrast and color saturation, promoting the development of display technology; or for the preparation of materials with special adsorption properties, used in environmental monitoring and pollutant treatment fields.
In summary, 4- (3-hydroxyethylamino) -4-methoxybenzaldehyde, with its unique chemical structure, has shown indispensable value in many fields such as medicine, dyes, materials science, etc., providing an important material basis for technological innovation and development in various fields.
In the field of medicine, it is a key intermediate for the synthesis of specific drugs. The presence of specific functional groups in the genome structure can be chemically modified to construct a molecular structure with biological activity, providing a basis for the development of drugs to treat specific diseases. For example, it can participate in the synthesis of drug molecules with antibacterial, anti-inflammatory or anti-tumor activities to help alleviate or cure related diseases, which is of great significance to human health.
In the dye industry, 4- (3-hydroxyethylamino) -4-methoxybenzaldehyde also plays an important role. Due to its structural properties, it can be converted into dyes with bright color and good stability through a series of reactions. Such dyes can be widely used in textile, leather and other industries to give products rich and diverse colors, enhance the aesthetics and commercial value of products.
In the field of materials science, this compound can be used as a synthetic raw material for functional materials. By reacting with other compounds, materials with special optical, electrical or mechanical properties can be prepared, such as for the preparation of organic Light Emitting Diode (OLED) materials, which enable display devices to have higher brightness, contrast and color saturation, promoting the development of display technology; or for the preparation of materials with special adsorption properties, used in environmental monitoring and pollutant treatment fields.
In summary, 4- (3-hydroxyethylamino) -4-methoxybenzaldehyde, with its unique chemical structure, has shown indispensable value in many fields such as medicine, dyes, materials science, etc., providing an important material basis for technological innovation and development in various fields.
What are the physical properties of 4- (3-chloropropoxy) -4-fluorobenzene?
The physical properties of 4- (3-hydroxyethylamino) -4-methoxybenzene generally have the following characteristics:
Its external appearance is usually solid, and the color is mostly white to white powder or crystalline. This is due to the arrangement of atoms in the molecule, which causes the absorption of light reflection to be so special.
In terms of melting, it is usually in a specific state. This is due to the interaction of molecular forces, such as Vander force, etc., a specific energy is required to break the lattice and make it solid and liquid.
In terms of solubility, it has a certain solubility in some solutions. Due to the compatibility of the solubility of its molecules, it can be dispersed in the solution of water according to the principle of similar dissolution. For example, in alcohol dissolution, the solubility of water molecules is good because of the formation of the solubility of alcohol; but the solubility in water is limited, because there are still non-soluble parts in the molecule, which affects the interaction of water molecules.
Density is also one of its physical properties, reflecting the density of molecules, and depends on the molecular weight and the size of the molecular void.
In addition, its qualitative is also a physical consideration. Under normal and special conditions, it can maintain phase stability. However, in the case of special components such as high temperature, oxidation, etc., the physical properties are also changed due to the activity of certain functionalities in the molecule, or the biochemical reaction.
Such physical properties are essential for their application in various fields. For example, in chemical engineering, their external properties, solubility, etc. determine whether they can be uniformly dispersed in the formula. In the field of chemical research, factors such as melting and qualitative factors affect the storage of the material.
Its external appearance is usually solid, and the color is mostly white to white powder or crystalline. This is due to the arrangement of atoms in the molecule, which causes the absorption of light reflection to be so special.
In terms of melting, it is usually in a specific state. This is due to the interaction of molecular forces, such as Vander force, etc., a specific energy is required to break the lattice and make it solid and liquid.
In terms of solubility, it has a certain solubility in some solutions. Due to the compatibility of the solubility of its molecules, it can be dispersed in the solution of water according to the principle of similar dissolution. For example, in alcohol dissolution, the solubility of water molecules is good because of the formation of the solubility of alcohol; but the solubility in water is limited, because there are still non-soluble parts in the molecule, which affects the interaction of water molecules.
Density is also one of its physical properties, reflecting the density of molecules, and depends on the molecular weight and the size of the molecular void.
In addition, its qualitative is also a physical consideration. Under normal and special conditions, it can maintain phase stability. However, in the case of special components such as high temperature, oxidation, etc., the physical properties are also changed due to the activity of certain functionalities in the molecule, or the biochemical reaction.
Such physical properties are essential for their application in various fields. For example, in chemical engineering, their external properties, solubility, etc. determine whether they can be uniformly dispersed in the formula. In the field of chemical research, factors such as melting and qualitative factors affect the storage of the material.
What are the chemical properties of 4- (3-chloropropoxy) -4-fluorobenzene?
The chemical properties of 4- (3-hydroxyethylamino) -4-methoxybenzene are related to the characteristics of this substance in various chemical situations. It is weakly basic, because the amino group in the molecule can accept protons. This alkalinity makes it easy to react with acids in an acidic environment to generate corresponding salts.
And the compound can participate in many nucleophilic substitution reactions because it contains specific functional groups such as methoxy and hydroxyethylamino. The oxygen atom in the methoxy group has a lone pair of electrons, which can be used as a nucleophilic reagent to attack suitable electrophilic reagents. The hydroxyethyl amino group can participate in the nucleophilic reaction due to the presence of amino groups, and the introduction of hydroxyethyl groups affects the spatial structure and electron cloud distribution of the molecule, which in turn affects the reactivity and selectivity.
In terms of solubility, the polar hydroxyethyl amino group and methoxy group should have a certain solubility in polar organic solvents such as ethanol and acetone. However, because the molecule still contains non-polar parts such as benzene ring, the solubility in water may be limited.
In the redox reaction, the compound may have certain reductivity. The methoxy group is connected to the benzene ring, which increases the electron cloud density of the benzene ring and is more susceptible to oxidation. The amino group of the hydroxyethyl amino group may also be oxidized under specific conditions, resulting in a structural transformation.
In addition, due to its benzene ring structure, typical reactions of aromatic compounds can occur, such as halogenation reactions, nitrification reactions, etc. Under suitable catalyst and reaction conditions, the hydrogen atoms on the benzene ring can be replaced by halogen atoms or nitro groups, resulting in a series of derivatives with different functions. These chemical properties provide a variety of pathways and possibilities for the preparation of more complex organic compounds in the field of organic synthesis.
And the compound can participate in many nucleophilic substitution reactions because it contains specific functional groups such as methoxy and hydroxyethylamino. The oxygen atom in the methoxy group has a lone pair of electrons, which can be used as a nucleophilic reagent to attack suitable electrophilic reagents. The hydroxyethyl amino group can participate in the nucleophilic reaction due to the presence of amino groups, and the introduction of hydroxyethyl groups affects the spatial structure and electron cloud distribution of the molecule, which in turn affects the reactivity and selectivity.
In terms of solubility, the polar hydroxyethyl amino group and methoxy group should have a certain solubility in polar organic solvents such as ethanol and acetone. However, because the molecule still contains non-polar parts such as benzene ring, the solubility in water may be limited.
In the redox reaction, the compound may have certain reductivity. The methoxy group is connected to the benzene ring, which increases the electron cloud density of the benzene ring and is more susceptible to oxidation. The amino group of the hydroxyethyl amino group may also be oxidized under specific conditions, resulting in a structural transformation.
In addition, due to its benzene ring structure, typical reactions of aromatic compounds can occur, such as halogenation reactions, nitrification reactions, etc. Under suitable catalyst and reaction conditions, the hydrogen atoms on the benzene ring can be replaced by halogen atoms or nitro groups, resulting in a series of derivatives with different functions. These chemical properties provide a variety of pathways and possibilities for the preparation of more complex organic compounds in the field of organic synthesis.
What are the synthesis methods of 4- (3-chloropropoxy) -4-fluorobenzene?
The synthesis method of 4- (3-hydroxyethylamino) -4-methoxy is as follows:
Route based on common organic reactions
1. ** Selection of starting materials **:
Suitable compounds containing methoxy groups and returnable hydroxethylamino groups can be selected as starting materials. For example, an aromatic halogen containing methoxy groups can be selected first, such as p-methoxybromobenzene. The bromine atom in this halogen is more active and prone to nucleophilic substitution reactions, laying the foundation for the subsequent introduction of hydroxyethylamino groups.
2. ** Introduction of hydroxyethylamino **:
Take p-methoxybromobenzene as an example and react it with hydroxyethylamine under basic conditions and in a suitable solvent. Commonly used basic reagents such as potassium carbonate can promote the reaction. Suitable solvents such as N, N-dimethylformamide (DMF) can dissolve the reactants and enhance the reactivity. In this reaction, the amino group in hydroxyethylamine attacks the bromine atom in p-methoxybromobenzene as a nucleophilic reagent, and a nucleophilic substitution reaction occurs, thereby introducing the hydroxyethylamino moiety to generate 4- (3-hydroxyethylamino) -4-methoxybenzene intermediates. The reaction equation is roughly as follows: p-methoxybromobenzene + hydroxyethylamine + potassium carbonate (in DMF) → 4- (3-hydroxyethylamino) -4-methoxybenzene + potassium bromide + other by-products (varies depending on the specific conditions of the reaction).
3. ** Subsequent modification and purification **: The intermediate generated by
may require further modification to meet the precise structural requirements of the target product. For example, if there are other unreacted functional groups or side reaction products, they need to be removed or converted by suitable organic reactions. The purification step can be used column chromatography, using a silica gel column to select a suitable eluent, such as a mixed solvent of petroleum ether and ethyl acetate. According to the difference in the adsorption and desorption ability of the product and impurities on the silica gel, the separation and purification of the target product can be achieved, and high-purity 4- (3-hydroxyethylamino) -4-methoxy products can be obtained.
Another possible route
1. ** Construction of the core skeleton **:
First construct the core skeleton containing methoxy groups and further reactive check points. For example, using resorcinol as the starting material, methoxy groups are introduced through methylation reaction. Using dimethyl sulfate to react with resorcinol under alkaline conditions, methoxy groups can be selectively introduced on one of the phenolic hydroxyl groups to generate 4-methoxyresorcinol. This reaction takes advantage of the nucleophilicity of phenolic hydroxyl groups. Dimethyl sulfate acts as a methylating agent. Basic conditions promote the deprotonation of phenolic hydroxyl groups and enhance their nucleophilic ability.
2. ** Introduction of hydroxyethylamino **:
Another phenolic hydroxyl group of 4-methoxyresorcinol is modified. The phenolic hydroxyl group can be first converted into a more active leaving group, such as by reacting with p-toluenesulfonyl chloride, to generate the corresponding sulfonate. This sulfonate has better exit ability, and then reacts with hydroxyethylamine to undergo nucleophilic substitution and introduce hydroxyethylamino. Finally, after appropriate post-treatment, such as acid-base neutralization, extraction, distillation and other steps, the impurities generated during the reaction process are removed to obtain the target product 4- (3-hydroxyethylamino) -4-methoxy. The specific reaction steps need to be precisely controlled according to the actual reaction conditions to ensure the smooth progress of the reaction and the high yield and purity of the product.
Route based on common organic reactions
1. ** Selection of starting materials **:
Suitable compounds containing methoxy groups and returnable hydroxethylamino groups can be selected as starting materials. For example, an aromatic halogen containing methoxy groups can be selected first, such as p-methoxybromobenzene. The bromine atom in this halogen is more active and prone to nucleophilic substitution reactions, laying the foundation for the subsequent introduction of hydroxyethylamino groups.
2. ** Introduction of hydroxyethylamino **:
Take p-methoxybromobenzene as an example and react it with hydroxyethylamine under basic conditions and in a suitable solvent. Commonly used basic reagents such as potassium carbonate can promote the reaction. Suitable solvents such as N, N-dimethylformamide (DMF) can dissolve the reactants and enhance the reactivity. In this reaction, the amino group in hydroxyethylamine attacks the bromine atom in p-methoxybromobenzene as a nucleophilic reagent, and a nucleophilic substitution reaction occurs, thereby introducing the hydroxyethylamino moiety to generate 4- (3-hydroxyethylamino) -4-methoxybenzene intermediates. The reaction equation is roughly as follows: p-methoxybromobenzene + hydroxyethylamine + potassium carbonate (in DMF) → 4- (3-hydroxyethylamino) -4-methoxybenzene + potassium bromide + other by-products (varies depending on the specific conditions of the reaction).
3. ** Subsequent modification and purification **: The intermediate generated by
may require further modification to meet the precise structural requirements of the target product. For example, if there are other unreacted functional groups or side reaction products, they need to be removed or converted by suitable organic reactions. The purification step can be used column chromatography, using a silica gel column to select a suitable eluent, such as a mixed solvent of petroleum ether and ethyl acetate. According to the difference in the adsorption and desorption ability of the product and impurities on the silica gel, the separation and purification of the target product can be achieved, and high-purity 4- (3-hydroxyethylamino) -4-methoxy products can be obtained.
Another possible route
1. ** Construction of the core skeleton **:
First construct the core skeleton containing methoxy groups and further reactive check points. For example, using resorcinol as the starting material, methoxy groups are introduced through methylation reaction. Using dimethyl sulfate to react with resorcinol under alkaline conditions, methoxy groups can be selectively introduced on one of the phenolic hydroxyl groups to generate 4-methoxyresorcinol. This reaction takes advantage of the nucleophilicity of phenolic hydroxyl groups. Dimethyl sulfate acts as a methylating agent. Basic conditions promote the deprotonation of phenolic hydroxyl groups and enhance their nucleophilic ability.
2. ** Introduction of hydroxyethylamino **:
Another phenolic hydroxyl group of 4-methoxyresorcinol is modified. The phenolic hydroxyl group can be first converted into a more active leaving group, such as by reacting with p-toluenesulfonyl chloride, to generate the corresponding sulfonate. This sulfonate has better exit ability, and then reacts with hydroxyethylamine to undergo nucleophilic substitution and introduce hydroxyethylamino. Finally, after appropriate post-treatment, such as acid-base neutralization, extraction, distillation and other steps, the impurities generated during the reaction process are removed to obtain the target product 4- (3-hydroxyethylamino) -4-methoxy. The specific reaction steps need to be precisely controlled according to the actual reaction conditions to ensure the smooth progress of the reaction and the high yield and purity of the product.
What are the precautions for using 4- (3-chloropropoxy) -4-fluorobenzene?
4- (3-hydroxyethylamino) -4-methyl ether should pay attention to the following things during use:
First, it is related to safe operation. This substance may have certain chemical activity, and it is necessary to strictly follow the established safety procedures when operating. Before starting the operation, it is necessary to fully understand its physical and chemical properties, such as melting point, boiling point, solubility, stability, etc., so as to make thorough preparations in advance. The operation site should be kept well ventilated to avoid the accumulation of volatile gases and latent risks. Operators should also wear appropriate protective equipment, such as gloves, goggles, protective clothing, etc., to prevent the substance from contacting the skin and eyes and causing unnecessary damage.
Second, pay attention to storage conditions. Store it in a dry, cool and well-ventilated place, away from fire, heat and strong oxidants. Due to its chemical structure, improper storage environment may cause chemical reactions, affecting quality and performance. At the same time, the storage container should be regularly checked to see if there is any leakage. Once detected, effective measures should be taken to deal with it in time.
Third, pay attention to the compatibility with other substances. When mixed with or in contact with other chemicals, it is necessary to know in advance whether the two will react chemically. Some reactions may lead to severe exothermic, toxic gases, or serious consequences such as product failure. If there is any doubt about compatibility, a small-scale test should be carried out first to confirm that it is safe and secure before large-scale operation.
Fourth, pay attention to waste disposal. After use, the remaining substances and related waste must not be discarded at will. It needs to be properly disposed of in accordance with local environmental regulations and relevant regulations. Generally speaking, waste should be collected by classification and handed over to a professionally qualified treatment agency for harmless treatment to avoid pollution to the environment.
First, it is related to safe operation. This substance may have certain chemical activity, and it is necessary to strictly follow the established safety procedures when operating. Before starting the operation, it is necessary to fully understand its physical and chemical properties, such as melting point, boiling point, solubility, stability, etc., so as to make thorough preparations in advance. The operation site should be kept well ventilated to avoid the accumulation of volatile gases and latent risks. Operators should also wear appropriate protective equipment, such as gloves, goggles, protective clothing, etc., to prevent the substance from contacting the skin and eyes and causing unnecessary damage.
Second, pay attention to storage conditions. Store it in a dry, cool and well-ventilated place, away from fire, heat and strong oxidants. Due to its chemical structure, improper storage environment may cause chemical reactions, affecting quality and performance. At the same time, the storage container should be regularly checked to see if there is any leakage. Once detected, effective measures should be taken to deal with it in time.
Third, pay attention to the compatibility with other substances. When mixed with or in contact with other chemicals, it is necessary to know in advance whether the two will react chemically. Some reactions may lead to severe exothermic, toxic gases, or serious consequences such as product failure. If there is any doubt about compatibility, a small-scale test should be carried out first to confirm that it is safe and secure before large-scale operation.
Fourth, pay attention to waste disposal. After use, the remaining substances and related waste must not be discarded at will. It needs to be properly disposed of in accordance with local environmental regulations and relevant regulations. Generally speaking, waste should be collected by classification and handed over to a professionally qualified treatment agency for harmless treatment to avoid pollution to the environment.
Scan to WhatsApp
