Linshang Chemical
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4,5-Dichloro-2-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
891944 |
| Chemical Formula | C6H2Cl2FNO2 |
| Molar Mass | 209.99 g/mol |
| Appearance | Solid |
| Color | Yellow to light brown |
| Melting Point | 48 - 52 °C |
| Boiling Point | 254 - 255 °C |
| Density | 1.624 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents |
| Flash Point | 107 °C |
| Purity | Typically high - purity grades available |
As an accredited 4,5-Dichloro-2-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4,5 - dichloro - 2 - fluoronitrobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4,5 - dichloro - 2 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be stored separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Keep containers tightly closed to avoid leakage, and label storage areas clearly to ensure proper handling and safety. |
| Shipping | 4,5 - dichloro - 2 - fluoronitrobenzene, a chemical, should be shipped in tightly sealed containers. It must be stowed away from heat, ignition sources, and incompatible substances to ensure safe transportation. |
Competitive 4,5-Dichloro-2-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4,5-Dichloro-2-Fluoronitrobenzene in China?
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As a leading 4,5-Dichloro-2-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4,5-dichloro-2-fluoronitrobenzene?
4,5-Difluoro-2-methoxybenzaldehyde, although not detailed in Tiangong Kaiji, is widely used in today's chemical and pharmaceutical industries.
In the chemical industry, it is a key intermediate in organic synthesis. It can be combined with various reagents through a series of chemical reactions to construct complex organic compounds. For example, by condensation reaction with specific amines, nitrogen-containing heterocyclic compounds can be prepared, which are often used as important raw materials in the synthesis of dyes and fragrances. Due to the special electronic effect and steric hindrance of fluorine atoms and methoxy groups in the molecule, the synthesized products are endowed with unique physical and chemical properties, such as enhancing the color brightness of dyes and enhancing the aroma durability of fragrances.
In the pharmaceutical industry, its value is particularly prominent. Many drug development uses it as a starting material. Due to its structural properties, it can be precisely modified to fit specific drug targets. Taking the development of anti-cancer drugs as an example, researchers have modified the structure of 4,5-difluoro-2-methoxybenzaldehyde to enable its derivatives to specifically bind to receptors on the surface of tumor cells, thereby blocking the growth signal transduction pathway of tumor cells and inhibiting the proliferation of tumor cells. In addition, in the development of antibacterial and antiviral drugs, it is often used as a basis to build an active molecular skeleton to improve the antibacterial and antiviral activities of the drugs through structural optimization, while reducing the toxic and side effects on normal cells.
It can be seen that although 4,5-difluoro-2-methoxybenzaldehyde is not contained in ancient books, in today's industrial development process, with its unique structure and reactivity, it plays a key role in the chemical industry, medicine and other fields, providing important support for the progress of many industries.
In the chemical industry, it is a key intermediate in organic synthesis. It can be combined with various reagents through a series of chemical reactions to construct complex organic compounds. For example, by condensation reaction with specific amines, nitrogen-containing heterocyclic compounds can be prepared, which are often used as important raw materials in the synthesis of dyes and fragrances. Due to the special electronic effect and steric hindrance of fluorine atoms and methoxy groups in the molecule, the synthesized products are endowed with unique physical and chemical properties, such as enhancing the color brightness of dyes and enhancing the aroma durability of fragrances.
In the pharmaceutical industry, its value is particularly prominent. Many drug development uses it as a starting material. Due to its structural properties, it can be precisely modified to fit specific drug targets. Taking the development of anti-cancer drugs as an example, researchers have modified the structure of 4,5-difluoro-2-methoxybenzaldehyde to enable its derivatives to specifically bind to receptors on the surface of tumor cells, thereby blocking the growth signal transduction pathway of tumor cells and inhibiting the proliferation of tumor cells. In addition, in the development of antibacterial and antiviral drugs, it is often used as a basis to build an active molecular skeleton to improve the antibacterial and antiviral activities of the drugs through structural optimization, while reducing the toxic and side effects on normal cells.
It can be seen that although 4,5-difluoro-2-methoxybenzaldehyde is not contained in ancient books, in today's industrial development process, with its unique structure and reactivity, it plays a key role in the chemical industry, medicine and other fields, providing important support for the progress of many industries.
What are the production methods of 4,5-dichloro-2-fluoronitrobenzene?
The preparation method of 4,5-dihydroxy-2-pentynylbenzyl is not detailed in "Tiangong Kaiwu", but it can be deduced from the ancient chemical process wisdom and related production methods.
In the past, alchemy, pharmaceutical and metallurgical processes were developed, and the extraction and synthesis of compounds had considerable attainments. To make this product, or follow the following ideas.
First, raw material selection and preparation. When looking for natural materials containing hydroxyl groups, alkynyl groups and benzyl groups, such as certain plants, ores, etc. Ancient Fangjia was good at identifying natural products, and it was found from various plants and trees that contained specific group components.
Second, reaction steps. Or use the method of heating, using a ceramic pot or a special cauldron as the reaction vessel. Under a suitable heat, let the raw materials interact. For example, by controlling the temperature and heating time, the groups in the raw materials will gradually react, and the hydroxyl groups, alkynyl groups and benzyl groups will be combined in the desired way. The ancient process, the control of the heat depends on experience, observe the color of the flame, listen to the sound of the fuel, and determine the degree of heating.
Third, separation and purification. After the reaction is completed, the product is mixed, and the separation technique must be used. Ancient or use the method of filtration, using a fine silk cloth or sand layer to filter out insoluble impurities. Or use the method of distillation to separate the target product by the difference in the boiling points of different substances.
Fourth, verification and adjustment. After obtaining the product, test it by sight, smell, touch, etc. Observe its color, smell its taste, and observe its texture. If it does not match expectations, adjust the ratio of raw materials and reaction conditions, and re-test.
Although the ancient production method is not as accurate and scientific as it is today, it uses the method of accumulation of experience and wisdom to lay the foundation for later chemical development and provide the source of ideas for the synthesis of 4,5-dihydroxy-2-pentynylbenzyl and other substances.
In the past, alchemy, pharmaceutical and metallurgical processes were developed, and the extraction and synthesis of compounds had considerable attainments. To make this product, or follow the following ideas.
First, raw material selection and preparation. When looking for natural materials containing hydroxyl groups, alkynyl groups and benzyl groups, such as certain plants, ores, etc. Ancient Fangjia was good at identifying natural products, and it was found from various plants and trees that contained specific group components.
Second, reaction steps. Or use the method of heating, using a ceramic pot or a special cauldron as the reaction vessel. Under a suitable heat, let the raw materials interact. For example, by controlling the temperature and heating time, the groups in the raw materials will gradually react, and the hydroxyl groups, alkynyl groups and benzyl groups will be combined in the desired way. The ancient process, the control of the heat depends on experience, observe the color of the flame, listen to the sound of the fuel, and determine the degree of heating.
Third, separation and purification. After the reaction is completed, the product is mixed, and the separation technique must be used. Ancient or use the method of filtration, using a fine silk cloth or sand layer to filter out insoluble impurities. Or use the method of distillation to separate the target product by the difference in the boiling points of different substances.
Fourth, verification and adjustment. After obtaining the product, test it by sight, smell, touch, etc. Observe its color, smell its taste, and observe its texture. If it does not match expectations, adjust the ratio of raw materials and reaction conditions, and re-test.
Although the ancient production method is not as accurate and scientific as it is today, it uses the method of accumulation of experience and wisdom to lay the foundation for later chemical development and provide the source of ideas for the synthesis of 4,5-dihydroxy-2-pentynylbenzyl and other substances.
What are the physical properties of 4,5-dichloro-2-fluoronitrobenzene?
4,5-Difluoro-2-fluoromethoxybenzophenone is an organic compound with unique physical properties and is widely used in the chemical and pharmaceutical fields.
This compound is often in a solid state at room temperature, and the melting point is within a specific range. Due to the molecular structure containing fluorine atoms and methoxy groups, it affects the intermolecular force, and the melting point has a specific value, which is of great significance to its morphology and processing under specific conditions. Its melting point is convenient for separation, purification and molding operations under corresponding temperature conditions.
The boiling point of 4,5-difluoro-2-fluoromethoxybenzophenone is also a key physical property. The boiling point reflects the energy required for the compound to change from liquid to gas state, which is closely related to the interaction between molecules. The boiling point of the substance is affected by the large electronegativity of the fluorine atom in the molecule and the formation of strong intermolecular forces. Knowing the boiling point is conducive to effective separation according to the difference between its boiling point and other substances in the process of separation and purification such as distillation.
The solubility of this compound cannot be ignored. Due to the structure of fluorine atoms and benzene rings, it has a certain solubility in organic solvents such as dichloromethane and chloroform, but poor solubility in water. This solubility characteristic provides a basis for the selection of suitable reaction solvents and drug carrier solvents in organic synthesis and drug research and development.
The density of 4,5-difluoro-2-fluoromethoxybenzophenone is one of its physical properties. The density reflects the mass of the substance per unit volume and is related to the molecular structure and accumulation mode. Accurate measurement of density is of great significance in the measurement and mixing process involving the substance, which can ensure the accurate ratio of the reaction material and affect the reaction process and product quality.
Its appearance is mostly white to light yellow crystalline powder, which provides the basis for preliminary identification. In actual production and use, its purity and quality status can be preliminarily judged by observing the appearance.
This compound is often in a solid state at room temperature, and the melting point is within a specific range. Due to the molecular structure containing fluorine atoms and methoxy groups, it affects the intermolecular force, and the melting point has a specific value, which is of great significance to its morphology and processing under specific conditions. Its melting point is convenient for separation, purification and molding operations under corresponding temperature conditions.
The boiling point of 4,5-difluoro-2-fluoromethoxybenzophenone is also a key physical property. The boiling point reflects the energy required for the compound to change from liquid to gas state, which is closely related to the interaction between molecules. The boiling point of the substance is affected by the large electronegativity of the fluorine atom in the molecule and the formation of strong intermolecular forces. Knowing the boiling point is conducive to effective separation according to the difference between its boiling point and other substances in the process of separation and purification such as distillation.
The solubility of this compound cannot be ignored. Due to the structure of fluorine atoms and benzene rings, it has a certain solubility in organic solvents such as dichloromethane and chloroform, but poor solubility in water. This solubility characteristic provides a basis for the selection of suitable reaction solvents and drug carrier solvents in organic synthesis and drug research and development.
The density of 4,5-difluoro-2-fluoromethoxybenzophenone is one of its physical properties. The density reflects the mass of the substance per unit volume and is related to the molecular structure and accumulation mode. Accurate measurement of density is of great significance in the measurement and mixing process involving the substance, which can ensure the accurate ratio of the reaction material and affect the reaction process and product quality.
Its appearance is mostly white to light yellow crystalline powder, which provides the basis for preliminary identification. In actual production and use, its purity and quality status can be preliminarily judged by observing the appearance.
What are the chemical properties of 4,5-dichloro-2-fluoronitrobenzene?
4,5-Difluoro-2-fluorobenzylpyridine, this is an organic compound. Its chemical properties are quite unique and are described in detail by you.
As far as its stability is concerned, under general conditions, the compound is still stable. However, its molecular structure contains fluorine atoms, which gives it a specific chemical activity. The electronegativity of fluorine atoms is extremely high, which increases the polarity of the chemical bonds connected to it, resulting in a change in the reactivity of the compound.
In the nucleophilic substitution reaction, the electron cloud density on the pyridine ring can be reduced due to the electron-withdrawing effect of fluorine atoms, which in turn affects the reactivity of each position on the pyridine ring to the nucleophilic reagent. The ortho-and para-sites of the pyridine ring are affected by the electron-sucking induction effect and conjugation effect of the fluorine atom, and the electron cloud density decreases significantly. Nucleophiles are more likely to attack these positions and undergo nucleophilic substitution reactions.
In addition, due to the fluorobenzyl structure, the benzyl moiety has a certain activity. The benzyl carbocation is relatively stable due to the conjugation effect of the benzene ring, which makes the benzyl moiety of the compound prone to reaction in some reactions. For example, the halogen atom on the benzyl group can be replaced by a nucleophilic reagent.
Because of the presence of fluorine atoms in the molecule, the compound can exhibit unique properties in Fluorine atoms can enhance the lipid solubility of molecules, which may affect their application in organic synthesis and medicinal chemistry. In some reactions with metal-organic reagents, fluorine atoms also affect the selectivity and activity of the reaction.
Furthermore, the chemical properties of the compound are also affected by the reaction conditions, such as reaction temperature, solvent type, catalyst, etc., which can have a significant effect on the chemical reaction process and product composition it participates in.
As far as its stability is concerned, under general conditions, the compound is still stable. However, its molecular structure contains fluorine atoms, which gives it a specific chemical activity. The electronegativity of fluorine atoms is extremely high, which increases the polarity of the chemical bonds connected to it, resulting in a change in the reactivity of the compound.
In the nucleophilic substitution reaction, the electron cloud density on the pyridine ring can be reduced due to the electron-withdrawing effect of fluorine atoms, which in turn affects the reactivity of each position on the pyridine ring to the nucleophilic reagent. The ortho-and para-sites of the pyridine ring are affected by the electron-sucking induction effect and conjugation effect of the fluorine atom, and the electron cloud density decreases significantly. Nucleophiles are more likely to attack these positions and undergo nucleophilic substitution reactions.
In addition, due to the fluorobenzyl structure, the benzyl moiety has a certain activity. The benzyl carbocation is relatively stable due to the conjugation effect of the benzene ring, which makes the benzyl moiety of the compound prone to reaction in some reactions. For example, the halogen atom on the benzyl group can be replaced by a nucleophilic reagent.
Because of the presence of fluorine atoms in the molecule, the compound can exhibit unique properties in Fluorine atoms can enhance the lipid solubility of molecules, which may affect their application in organic synthesis and medicinal chemistry. In some reactions with metal-organic reagents, fluorine atoms also affect the selectivity and activity of the reaction.
Furthermore, the chemical properties of the compound are also affected by the reaction conditions, such as reaction temperature, solvent type, catalyst, etc., which can have a significant effect on the chemical reaction process and product composition it participates in.
What should be paid attention to when storing and transporting 4,5-dichloro-2-fluoronitrobenzene?
For 4,5-difluoro-2-ethoxyphenyl ketones, when storing and transporting, be sure to pay attention to the following things:
First, the control of temperature. This material is delicate and sensitive to temperature changes. High temperature can easily cause its properties to change, or cause chemical changes that damage its quality. Therefore, it is best to store it in a cool place, and the temperature should not exceed [X] ° C. When transporting, you should also avoid hot environments. If you transport it on a hot day, you need to take cooling measures, such as using refrigerated trucks, etc., to keep it at a suitable temperature.
Second, the prevention of humidity. Moisture is often a disaster to many substances, and this is no exception. In case of moisture or moisture, or reactions such as hydrolysis, resulting in damage to the quality. The place of storage must be dry, and the humidity should be controlled below [X]%. The packaging should be strict to prevent moisture from invading. During transportation, the car box and other vehicles should also be dry, and desiccant can be placed inside. If it is rainy and wet, pay more attention to protection to prevent it from being soaked by rain.
Third, the solidification of the packaging. Packaging is related to its safety during storage and transportation. The packaging materials used must be resistant to chemical corrosion and do not react with the substance. And the packaging must be sturdy and not damaged after handling, bumping and other processes. The container should be well sealed to prevent contact with outside air, etc., to prevent volatilization, oxidation and other things.
Fourth, the importance of isolation. This substance may have incompatibility with other substances, such as strong oxidizing agents, strong acids and alkalis, etc. When storing, it must be isolated from such substances, and stored in separate warehouses or partitions to prevent danger from interaction. When transporting, it is also not allowed to be transported with mutually exclusive objects in the same car to avoid accidents.
Fifth, clear identification. Whether it is a storage place or a transportation vehicle, it is necessary to have a clear logo. Indicate the name, characteristics, danger warning and other information of the substance. Make contacts aware of its properties at a glance. Be careful when operating, and follow safety procedures to avoid accidental touch and risk.
First, the control of temperature. This material is delicate and sensitive to temperature changes. High temperature can easily cause its properties to change, or cause chemical changes that damage its quality. Therefore, it is best to store it in a cool place, and the temperature should not exceed [X] ° C. When transporting, you should also avoid hot environments. If you transport it on a hot day, you need to take cooling measures, such as using refrigerated trucks, etc., to keep it at a suitable temperature.
Second, the prevention of humidity. Moisture is often a disaster to many substances, and this is no exception. In case of moisture or moisture, or reactions such as hydrolysis, resulting in damage to the quality. The place of storage must be dry, and the humidity should be controlled below [X]%. The packaging should be strict to prevent moisture from invading. During transportation, the car box and other vehicles should also be dry, and desiccant can be placed inside. If it is rainy and wet, pay more attention to protection to prevent it from being soaked by rain.
Third, the solidification of the packaging. Packaging is related to its safety during storage and transportation. The packaging materials used must be resistant to chemical corrosion and do not react with the substance. And the packaging must be sturdy and not damaged after handling, bumping and other processes. The container should be well sealed to prevent contact with outside air, etc., to prevent volatilization, oxidation and other things.
Fourth, the importance of isolation. This substance may have incompatibility with other substances, such as strong oxidizing agents, strong acids and alkalis, etc. When storing, it must be isolated from such substances, and stored in separate warehouses or partitions to prevent danger from interaction. When transporting, it is also not allowed to be transported with mutually exclusive objects in the same car to avoid accidents.
Fifth, clear identification. Whether it is a storage place or a transportation vehicle, it is necessary to have a clear logo. Indicate the name, characteristics, danger warning and other information of the substance. Make contacts aware of its properties at a glance. Be careful when operating, and follow safety procedures to avoid accidental touch and risk.
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