Linshang Chemical
PRODUCTS
4-Acetylchlorobenzene
Linshang Chemical
|
HS Code |
871162 |
| Chemical Formula | C8H7ClO |
| Molar Mass | 156.59 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 222 - 224 °C |
| Melting Point | 15 - 17 °C |
| Density | 1.196 g/cm³ at 25 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 99 °C |
| Odor | Pungent, irritating odor |
As an accredited 4-Acetylchlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - acetylchlorobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | 4 - acetylchlorobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly closed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air or moisture, which could potentially cause decomposition or reaction. |
| Shipping | 4 - acetylchlorobenzene should be shipped in accordance with hazardous chemical regulations. Use properly labeled, sealed containers to prevent leakage. Ensure compliance with safety standards during transportation to avoid risks. |
Competitive 4-Acetylchlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-acetylchlorobenzene?
4-Acetylchlorobenzene is 4-chloroacetylbenzene. Its chemical properties are as follows:
4-chloroacetylbenzene contains a benzene ring, a carbonyl group and a chlorine atom, so it has a variety of chemical properties. As far as the benzene ring is concerned, because the benzene ring is rich in electrons, it is prone to electrophilic substitution. For example, under the action of a suitable catalyst such as ferric chloride, it can undergo a bromination reaction with bromine, and the bromine atom replaces the adjacent and para-hydrogen atoms on the benzene ring to form the corresponding brominated product.
The carbonyl group is active and can undergo a variety of reactions. It can undergo a nucleophilic addition reaction with a nucleophilic reagent, like a reaction with a Grignard reagent. The It can also be reduced. For example, with strong reducing agents such as lithium aluminum hydride, carbonyl groups can be reduced to alcohol hydroxyl groups to obtain 4-chlorophenyl ethanol; if milder reducing agents such as sodium borohydride are used, the conversion of carbonyl groups to alcohol hydroxyl groups can usually be achieved.
Chlorine atoms are affected by benzene rings and carbonyl groups and have certain reactivity. Nucleophilic substitution reactions can occur. Under basic conditions, such as co-heating with aqueous sodium hydroxide solutions, chlorine atoms can be replaced by hydroxyl groups to generate 4-hydroxyacetylbenzene; if reacted with sodium alcohol, corresponding ether compounds can be generated.
In addition, 4-chloroacetylbenzene can also participate in some reactions involving the synergistic interaction of benzene rings, carbonyl groups, and chlorine atoms, and is used as an important intermediate in the field of organic synthesis to construct more complex organic compound structures.
4-chloroacetylbenzene contains a benzene ring, a carbonyl group and a chlorine atom, so it has a variety of chemical properties. As far as the benzene ring is concerned, because the benzene ring is rich in electrons, it is prone to electrophilic substitution. For example, under the action of a suitable catalyst such as ferric chloride, it can undergo a bromination reaction with bromine, and the bromine atom replaces the adjacent and para-hydrogen atoms on the benzene ring to form the corresponding brominated product.
The carbonyl group is active and can undergo a variety of reactions. It can undergo a nucleophilic addition reaction with a nucleophilic reagent, like a reaction with a Grignard reagent. The It can also be reduced. For example, with strong reducing agents such as lithium aluminum hydride, carbonyl groups can be reduced to alcohol hydroxyl groups to obtain 4-chlorophenyl ethanol; if milder reducing agents such as sodium borohydride are used, the conversion of carbonyl groups to alcohol hydroxyl groups can usually be achieved.
Chlorine atoms are affected by benzene rings and carbonyl groups and have certain reactivity. Nucleophilic substitution reactions can occur. Under basic conditions, such as co-heating with aqueous sodium hydroxide solutions, chlorine atoms can be replaced by hydroxyl groups to generate 4-hydroxyacetylbenzene; if reacted with sodium alcohol, corresponding ether compounds can be generated.
In addition, 4-chloroacetylbenzene can also participate in some reactions involving the synergistic interaction of benzene rings, carbonyl groups, and chlorine atoms, and is used as an important intermediate in the field of organic synthesis to construct more complex organic compound structures.
What are the common uses of 4-acetylchlorobenzene?
4-Acetylchlorobenzene is a common compound in organic chemistry. Its common uses are quite extensive, and it is often used as a key intermediate in the field of organic synthesis.
In the field of pharmaceutical chemistry, 4-chloroacetenzene can be used to create a variety of drugs. Due to the special structure of the benzene ring with acetyl groups and chlorine atoms, it is endowed with specific chemical activities and pharmacological properties. Through chemical modification and reaction, molecular structures with specific physiological activities can be constructed to meet the R & D requirements of drugs. For example, it can be converted into pharmaceutical ingredients with antibacterial and anti-inflammatory effects through a series of reactions.
In the field of materials science, 4-chloroacetylbenzene is also useful. It can be used as a starting material for the synthesis of special polymer materials. By virtue of its reactivity, it can participate in polymerization reactions, etc., giving the materials unique properties, such as improving the thermal stability and mechanical properties of the materials, and can be used to make high-performance engineering plastics, fibers and other materials.
In the dye industry, 4-chloroacetylbenzene can be used as an important intermediate for the synthesis of dyes. Due to its structure, it can participate in many coupling reactions, substitution reactions, etc., to construct a variety of chromogenic groups, and synthesize dyes with rich colors and excellent properties. It is widely used in textile, printing and dye
Furthermore, in the fragrance industry, 4-chloroacetylbenzene can be appropriately derived, or a fragrance component with a special aroma can be obtained, which adds a unique flavor to the flavor preparation.
In summary, 4-chloroacetylbenzene has a unique structure and has important uses in many fields such as organic synthesis, drugs, materials, dyes, fragrances, etc. It is a class of essential compounds in the field of organic chemistry.
In the field of pharmaceutical chemistry, 4-chloroacetenzene can be used to create a variety of drugs. Due to the special structure of the benzene ring with acetyl groups and chlorine atoms, it is endowed with specific chemical activities and pharmacological properties. Through chemical modification and reaction, molecular structures with specific physiological activities can be constructed to meet the R & D requirements of drugs. For example, it can be converted into pharmaceutical ingredients with antibacterial and anti-inflammatory effects through a series of reactions.
In the field of materials science, 4-chloroacetylbenzene is also useful. It can be used as a starting material for the synthesis of special polymer materials. By virtue of its reactivity, it can participate in polymerization reactions, etc., giving the materials unique properties, such as improving the thermal stability and mechanical properties of the materials, and can be used to make high-performance engineering plastics, fibers and other materials.
In the dye industry, 4-chloroacetylbenzene can be used as an important intermediate for the synthesis of dyes. Due to its structure, it can participate in many coupling reactions, substitution reactions, etc., to construct a variety of chromogenic groups, and synthesize dyes with rich colors and excellent properties. It is widely used in textile, printing and dye
Furthermore, in the fragrance industry, 4-chloroacetylbenzene can be appropriately derived, or a fragrance component with a special aroma can be obtained, which adds a unique flavor to the flavor preparation.
In summary, 4-chloroacetylbenzene has a unique structure and has important uses in many fields such as organic synthesis, drugs, materials, dyes, fragrances, etc. It is a class of essential compounds in the field of organic chemistry.
What are 4-acetylchlorobenzene production methods?
4-Acetylchlorobenzene is 4-chloroacetophenone. The common preparation methods are as follows:
First, chlorobenzene and acetyl chloride are used as raw materials and prepared by Fu-gram acylation reaction. This reaction requires Lewis acids such as anhydrous aluminum trichloride as catalysts. At a suitable temperature, chlorobenzene interacts with acetyl chloride to generate 4-chloroacetophenone. In this process, anhydrous aluminum trichloride is very important. It can interact with acetyl chloride to enhance the positive electricity of acyl carbon and promote electrophilic substitution reactions to occur more easily. After the reaction, the product can be obtained through hydrolysis, separation and purification.
Second, using p-chlorobenzaldehyde as a raw material, p-chlorobenzoic acid is first oxidized to obtain p-chlorobenzoic acid, which is then converted into an acyl chloride, and then reacted with Grignard reagents to prepare. p-chlorobenzaldehyde is oxidized to obtain p-chlorobenzoic acid, which is commonly used as an oxidizing agent such as potassium permanganate. The p-chlorobenzoic acid is converted into an acyl chloride, which can react with reagents such as dichlorosulfoxide. The obtained acyl chloride reacts with Grignard reagents such as magnesium methylhalide, and then is post-treated to obtain 4-chloroacetophenone.
Third, using p-chlorophenyl ethanol as raw material, first oxidizing to p-chlorophenylacetaldehyde, and then further oxidizing to p-chlorophenylacetic acid. The subsequent steps are similar to those using p-chlorobenzoic acid as raw material. After conversion to acid chloride and reaction with Grignard reagents, 4-chloroacetophenone can also be prepared. Oxidation of p-chlorophenyl ethanol is commonly used as an oxidant such as potassium dichromate-sulfuric acid solution.
These various preparation methods have their own advantages and disadvantages. In actual production, the most suitable method should be selected according to factors such as raw material availability, cost, yield and product purity.
First, chlorobenzene and acetyl chloride are used as raw materials and prepared by Fu-gram acylation reaction. This reaction requires Lewis acids such as anhydrous aluminum trichloride as catalysts. At a suitable temperature, chlorobenzene interacts with acetyl chloride to generate 4-chloroacetophenone. In this process, anhydrous aluminum trichloride is very important. It can interact with acetyl chloride to enhance the positive electricity of acyl carbon and promote electrophilic substitution reactions to occur more easily. After the reaction, the product can be obtained through hydrolysis, separation and purification.
Second, using p-chlorobenzaldehyde as a raw material, p-chlorobenzoic acid is first oxidized to obtain p-chlorobenzoic acid, which is then converted into an acyl chloride, and then reacted with Grignard reagents to prepare. p-chlorobenzaldehyde is oxidized to obtain p-chlorobenzoic acid, which is commonly used as an oxidizing agent such as potassium permanganate. The p-chlorobenzoic acid is converted into an acyl chloride, which can react with reagents such as dichlorosulfoxide. The obtained acyl chloride reacts with Grignard reagents such as magnesium methylhalide, and then is post-treated to obtain 4-chloroacetophenone.
Third, using p-chlorophenyl ethanol as raw material, first oxidizing to p-chlorophenylacetaldehyde, and then further oxidizing to p-chlorophenylacetic acid. The subsequent steps are similar to those using p-chlorobenzoic acid as raw material. After conversion to acid chloride and reaction with Grignard reagents, 4-chloroacetophenone can also be prepared. Oxidation of p-chlorophenyl ethanol is commonly used as an oxidant such as potassium dichromate-sulfuric acid solution.
These various preparation methods have their own advantages and disadvantages. In actual production, the most suitable method should be selected according to factors such as raw material availability, cost, yield and product purity.
4-acetylchlorobenzene what are the precautions during storage and transportation?
4-Acetylchlorobenzene is 4-chloroacetylbenzene. When storing and transporting this substance, many matters must be paid attention to.
First, store it in a cool and well-ventilated place. Because 4-chloroacetylbenzene is prone to reaction when heated, it is dangerous. If stored in a high temperature place, it may cause combustion or explosion. In addition, it should be stored separately from oxidants and bases, and must not be mixed. When it encounters with oxidants or reacts violently, it may also change its chemical properties and affect quality.
And must be sealed and stored, because 4-chloroacetylbenzene is exposed to the air, or reacts with the ingredients in the air, causing deterioration. The storage area should also be equipped with suitable materials to contain the leakage, so as to prevent accidental leakage, it can be properly handled in time, so as not to pollute the environment and cause greater harm.
As for transportation, the transportation vehicle must ensure that it is clean and dry, and there is no residue that can react with it. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature. During summer transportation, special attention should be paid to driving in the morning and evening to avoid high temperature periods. When loading and unloading, the operation should be gentle, and it is strictly forbidden to drop, bump, or bump, so as to avoid damage to the packaging and leakage of 4-chloroacetyl
If a leak occurs during transportation, the leaked contaminated area should be immediately isolated and personnel should be restricted from entering and leaving. Emergency responders must wear a full mask and protective clothing, and do not directly contact the leak. Small leaks can be absorbed by inert materials such as sand and vermiculite; if there are large leaks, they need to build embankments or dig pits for containment, and transfer them to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal. In this way, the storage and transportation of 4-chloroacetylbenzene can be guaranteed to be safe and avoid the risk of accidents.
First, store it in a cool and well-ventilated place. Because 4-chloroacetylbenzene is prone to reaction when heated, it is dangerous. If stored in a high temperature place, it may cause combustion or explosion. In addition, it should be stored separately from oxidants and bases, and must not be mixed. When it encounters with oxidants or reacts violently, it may also change its chemical properties and affect quality.
And must be sealed and stored, because 4-chloroacetylbenzene is exposed to the air, or reacts with the ingredients in the air, causing deterioration. The storage area should also be equipped with suitable materials to contain the leakage, so as to prevent accidental leakage, it can be properly handled in time, so as not to pollute the environment and cause greater harm.
As for transportation, the transportation vehicle must ensure that it is clean and dry, and there is no residue that can react with it. During transportation, it is necessary to prevent exposure to the sun, rain, and high temperature. During summer transportation, special attention should be paid to driving in the morning and evening to avoid high temperature periods. When loading and unloading, the operation should be gentle, and it is strictly forbidden to drop, bump, or bump, so as to avoid damage to the packaging and leakage of 4-chloroacetyl
If a leak occurs during transportation, the leaked contaminated area should be immediately isolated and personnel should be restricted from entering and leaving. Emergency responders must wear a full mask and protective clothing, and do not directly contact the leak. Small leaks can be absorbed by inert materials such as sand and vermiculite; if there are large leaks, they need to build embankments or dig pits for containment, and transfer them to a tanker or a special collector for recycling or transportation to a waste treatment site for disposal. In this way, the storage and transportation of 4-chloroacetylbenzene can be guaranteed to be safe and avoid the risk of accidents.
What are the effects of 4-acetylchlorobenzene on the environment and human health?
4-Acetylchlorobenzene is 4-acetylchlorobenzene, which has an impact on both the environment and human health.
In terms of the environment, if 4-acetylchlorobenzene is released into nature, it will migrate and transform between water, soil and atmosphere. It has certain stability and is difficult to degrade rapidly. In aquatic ecosystems, it will harm aquatic organisms. If it enters water bodies or is ingested and accumulated by aquatic organisms, it will cause abnormal biological physiology and affect population size and ecological balance. It can affect soil ecology, or change the structure and function of soil microbial community, hinder normal soil material circulation and nutrient transformation, and affect plant growth. In the atmosphere, or participate in photochemical reactions, generate secondary pollutants and deteriorate air quality.
As for human health, 4-acetylchlorobenzene has potential harm to multiple systems in the human body. It enters the human body through respiratory inhalation, skin contact or accidental ingestion. It is highly irritating to the skin and eyes, and contact can cause redness, pain, and burns to the skin. If it enters the eyes, it will damage eye tissue and affect vision. After inhalation, it irritates the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties, and long-term exposure or increased risk of respiratory diseases. It may also damage the nervous system, causing neurasthenia-like symptoms such as headache, dizziness, fatigue, and insomnia, and in severe cases affect cognitive and motor functions. Moreover, studies suggest that it may have certain carcinogenicity, and long-term exposure may increase the risk of cancer.
In summary, 4-acetylchlorobenzene poses a threat to both the environment and human health. Strict prevention and control are required during production, use and disposal to reduce its harm to the environment and people.
In terms of the environment, if 4-acetylchlorobenzene is released into nature, it will migrate and transform between water, soil and atmosphere. It has certain stability and is difficult to degrade rapidly. In aquatic ecosystems, it will harm aquatic organisms. If it enters water bodies or is ingested and accumulated by aquatic organisms, it will cause abnormal biological physiology and affect population size and ecological balance. It can affect soil ecology, or change the structure and function of soil microbial community, hinder normal soil material circulation and nutrient transformation, and affect plant growth. In the atmosphere, or participate in photochemical reactions, generate secondary pollutants and deteriorate air quality.
As for human health, 4-acetylchlorobenzene has potential harm to multiple systems in the human body. It enters the human body through respiratory inhalation, skin contact or accidental ingestion. It is highly irritating to the skin and eyes, and contact can cause redness, pain, and burns to the skin. If it enters the eyes, it will damage eye tissue and affect vision. After inhalation, it irritates the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties, and long-term exposure or increased risk of respiratory diseases. It may also damage the nervous system, causing neurasthenia-like symptoms such as headache, dizziness, fatigue, and insomnia, and in severe cases affect cognitive and motor functions. Moreover, studies suggest that it may have certain carcinogenicity, and long-term exposure may increase the risk of cancer.
In summary, 4-acetylchlorobenzene poses a threat to both the environment and human health. Strict prevention and control are required during production, use and disposal to reduce its harm to the environment and people.
What are the main uses of 4-acetylchlorobenzene?
4-Acetylchlorobenzene, that is, 4-acetylchlorobenzene, is widely used. In the field of organic synthesis, it is a crucial intermediate.
can be used in the preparation of various medicines. For example, some drugs with specific curative effects, 4-acetylchlorobenzene can be converted into key structural units through a series of chemical reactions, laying the foundation for the imparting of drug activity. Doctors treat diseases and save people, using all kinds of good medicines, or relying on the synthesis of this intermediate.
In the field of materials science, it is also indispensable. It can be integrated into polymer materials by means of polymerization or modification to give materials special properties. Such as improving the stability and solubility of materials, and even affecting their optical and electrical properties. Based on this, new materials suitable for special scenarios may be prepared, such as unique materials used in electronic devices and optical instruments.
In the fine chemical industry, 4-acetylchlorobenzene is used to synthesize fine chemicals such as fragrances and dyes. In the production of fragrances, it can contribute a unique molecular structure, making fragrances have a unique flavor, either fresh and elegant, or rich. In the synthesis of dyes, it participates in the construction of chromophore groups, endowing dyes with bright colors and good dyeing properties, meeting the diverse needs of printing and dyeing industries.
In short, 4-acetylchlorobenzene plays a pivotal role in many fields, promoting the development and progress of various industries.
can be used in the preparation of various medicines. For example, some drugs with specific curative effects, 4-acetylchlorobenzene can be converted into key structural units through a series of chemical reactions, laying the foundation for the imparting of drug activity. Doctors treat diseases and save people, using all kinds of good medicines, or relying on the synthesis of this intermediate.
In the field of materials science, it is also indispensable. It can be integrated into polymer materials by means of polymerization or modification to give materials special properties. Such as improving the stability and solubility of materials, and even affecting their optical and electrical properties. Based on this, new materials suitable for special scenarios may be prepared, such as unique materials used in electronic devices and optical instruments.
In the fine chemical industry, 4-acetylchlorobenzene is used to synthesize fine chemicals such as fragrances and dyes. In the production of fragrances, it can contribute a unique molecular structure, making fragrances have a unique flavor, either fresh and elegant, or rich. In the synthesis of dyes, it participates in the construction of chromophore groups, endowing dyes with bright colors and good dyeing properties, meeting the diverse needs of printing and dyeing industries.
In short, 4-acetylchlorobenzene plays a pivotal role in many fields, promoting the development and progress of various industries.
What are the physical properties of 4-acetylchlorobenzene?
4-Acetylchlorobenzene, that is, p-acetylchlorobenzene, has the following physical properties:
p-acetylchlorobenzene, is one of the organic compounds. Looking at its appearance, it is often white to light yellow crystalline powder. When pure, the crystal shape is regular and the color is uniform. Its melting point is quite significant, about 79-81 ° C. This property allows p-acetylchlorobenzene to change from solid to liquid at a specific temperature. This phase change process has a deep impact on its processing and application.
Furthermore, its boiling point cannot be ignored, roughly in the range of 225-227 ° C. The boiling point is related to the difficulty of transforming p-acetylchlorobenzene from liquid to gaseous under heating conditions. This is a key parameter in the operation of distillation and separation in chemical production.
p-acetylchlorobenzene exhibits unique properties in terms of solubility. It is slightly soluble in water, because water is a very polar solvent, while the polarity of p-acetylchlorobenzene molecules is relatively weak. According to the principle of similar miscibility, the two are difficult to miscible. However, it has good solubility in organic solvents such as ethanol, ether, benzene, etc. In ethanol, it can quickly diffuse to form a uniform solution. This property makes it often participate in various reactions as a solute in the field of organic synthesis. With the solubility of organic solvents, the reaction can be carried out smoothly.
In addition, p-acetylchlorobenzene has a certain density, although the exact value varies depending on the measurement conditions. However, in general, under normal temperature and pressure, its density makes it exhibit a specific phase distribution and physical behavior when mixed with other substances. This is an indispensable consideration in the design of chemical process material ratio and reaction system.
p-acetylchlorobenzene, is one of the organic compounds. Looking at its appearance, it is often white to light yellow crystalline powder. When pure, the crystal shape is regular and the color is uniform. Its melting point is quite significant, about 79-81 ° C. This property allows p-acetylchlorobenzene to change from solid to liquid at a specific temperature. This phase change process has a deep impact on its processing and application.
Furthermore, its boiling point cannot be ignored, roughly in the range of 225-227 ° C. The boiling point is related to the difficulty of transforming p-acetylchlorobenzene from liquid to gaseous under heating conditions. This is a key parameter in the operation of distillation and separation in chemical production.
p-acetylchlorobenzene exhibits unique properties in terms of solubility. It is slightly soluble in water, because water is a very polar solvent, while the polarity of p-acetylchlorobenzene molecules is relatively weak. According to the principle of similar miscibility, the two are difficult to miscible. However, it has good solubility in organic solvents such as ethanol, ether, benzene, etc. In ethanol, it can quickly diffuse to form a uniform solution. This property makes it often participate in various reactions as a solute in the field of organic synthesis. With the solubility of organic solvents, the reaction can be carried out smoothly.
In addition, p-acetylchlorobenzene has a certain density, although the exact value varies depending on the measurement conditions. However, in general, under normal temperature and pressure, its density makes it exhibit a specific phase distribution and physical behavior when mixed with other substances. This is an indispensable consideration in the design of chemical process material ratio and reaction system.
What is the chemistry of 4-acetylchlorobenzene?
4-Acetylchlorobenzene is 4-chloroacetylbenzene. Its chemical properties are as follows:
This substance contains benzene ring, chlorine atom and acetyl group. The benzene ring is aromatic and can undergo electrophilic substitution reaction. Because both the chlorine atom and the acetyl group are electron-absorbing groups, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution activity is weaker than that of benzene. In electrophilic substitution, the chlorine atom and the acetyl group are ortho-para-sites, and the new substituent mainly enters its ortho-and para-sites.
The chlorine atom is active and can undergo substitution reaction. Under basic conditions, the chlorine atom is easily replaced by nucleophiles such as hydroxyl groups and amino groups to form corresponding phenols or If it is co-heated with an aqueous solution of sodium hydroxide, the chlorine atom is replaced by a hydroxyl group to obtain 4-hydroxyacetylbenzene; when reacted with ammonia under certain conditions, the chlorine atom is replaced by an amino group to obtain 4-aminoacetylbenzene.
The carbonyl group in the acetyl group is unsaturated and can undergo an addition reaction. If it reacts with Grignard's reagent, the hydrocarbon group in Grignard's reagent is added to the carbonyl carbon atom to obtain an alcohol compound after hydrolysis. In addition, acetyl α-hydrogen has a certain acidity, and under the action of a strong base, it can lose protons and form carboanions, which in turn occurs related nucleophilic The chemical properties of 4-chloroacetylbenzene make it widely used in the field of organic synthesis and can be used to prepare a variety of organic compounds.
This substance contains benzene ring, chlorine atom and acetyl group. The benzene ring is aromatic and can undergo electrophilic substitution reaction. Because both the chlorine atom and the acetyl group are electron-absorbing groups, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution activity is weaker than that of benzene. In electrophilic substitution, the chlorine atom and the acetyl group are ortho-para-sites, and the new substituent mainly enters its ortho-and para-sites.
The chlorine atom is active and can undergo substitution reaction. Under basic conditions, the chlorine atom is easily replaced by nucleophiles such as hydroxyl groups and amino groups to form corresponding phenols or If it is co-heated with an aqueous solution of sodium hydroxide, the chlorine atom is replaced by a hydroxyl group to obtain 4-hydroxyacetylbenzene; when reacted with ammonia under certain conditions, the chlorine atom is replaced by an amino group to obtain 4-aminoacetylbenzene.
The carbonyl group in the acetyl group is unsaturated and can undergo an addition reaction. If it reacts with Grignard's reagent, the hydrocarbon group in Grignard's reagent is added to the carbonyl carbon atom to obtain an alcohol compound after hydrolysis. In addition, acetyl α-hydrogen has a certain acidity, and under the action of a strong base, it can lose protons and form carboanions, which in turn occurs related nucleophilic The chemical properties of 4-chloroacetylbenzene make it widely used in the field of organic synthesis and can be used to prepare a variety of organic compounds.
What is 4-acetylchlorobenzene production method?
4-Acetylchlorobenzene is 4-chloroacetylbenzene, and its preparation method is as follows:
To prepare 4-chloroacetylbenzene, the common method is to use chlorobenzene and acetyl chloride as raw materials, through Fu-gram acylation reaction. This reaction requires anhydrous aluminum trichloride and other Lewis acids as catalysts.
In a clean and dry reaction vessel, first put an appropriate amount of chlorobenzene, and then under low temperature and stirring conditions, slowly add anhydrous aluminum trichloride to maintain a low temperature environment. This is because anhydrous aluminum trichloride is easy to decompose in contact with water, which affects the catalytic effect. After the anhydrous aluminum trichloride is uniformly dispersed, add acetyl chloride dropwise. The rate of dropwise addition of acetyl chloride needs to be carefully controlled to prevent the reaction from being too violent.
Add acetyl chloride and gradually heat up to a suitable temperature to allow the reaction to proceed fully. During the reaction process, the reaction status can be closely monitored, and the progress of the reaction can be tracked by means of thin-layer chromatography. When the reaction reaches the desired level, the reaction is terminated.
Subsequent treatment of the reaction mixture, first pour it into ice water containing an appropriate amount of hydrochloric acid. This step aims to decompose the excess anhydrous aluminum trichloride and convert it into soluble salts. After that, the organic phase is extracted with an organic solvent, collected, and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture in the organic phase. Then the organic solvent is removed by distillation and other means, and finally purified by column chromatography or recrystallization, and pure 4-chloroacetylbenzene can be obtained.
In addition, there are other preparation methods, but the Fu-Ke acylation reaction is widely used in laboratory and industrial preparation because of its easy availability of raw materials and relatively simple operation.
To prepare 4-chloroacetylbenzene, the common method is to use chlorobenzene and acetyl chloride as raw materials, through Fu-gram acylation reaction. This reaction requires anhydrous aluminum trichloride and other Lewis acids as catalysts.
In a clean and dry reaction vessel, first put an appropriate amount of chlorobenzene, and then under low temperature and stirring conditions, slowly add anhydrous aluminum trichloride to maintain a low temperature environment. This is because anhydrous aluminum trichloride is easy to decompose in contact with water, which affects the catalytic effect. After the anhydrous aluminum trichloride is uniformly dispersed, add acetyl chloride dropwise. The rate of dropwise addition of acetyl chloride needs to be carefully controlled to prevent the reaction from being too violent.
Add acetyl chloride and gradually heat up to a suitable temperature to allow the reaction to proceed fully. During the reaction process, the reaction status can be closely monitored, and the progress of the reaction can be tracked by means of thin-layer chromatography. When the reaction reaches the desired level, the reaction is terminated.
Subsequent treatment of the reaction mixture, first pour it into ice water containing an appropriate amount of hydrochloric acid. This step aims to decompose the excess anhydrous aluminum trichloride and convert it into soluble salts. After that, the organic phase is extracted with an organic solvent, collected, and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture in the organic phase. Then the organic solvent is removed by distillation and other means, and finally purified by column chromatography or recrystallization, and pure 4-chloroacetylbenzene can be obtained.
In addition, there are other preparation methods, but the Fu-Ke acylation reaction is widely used in laboratory and industrial preparation because of its easy availability of raw materials and relatively simple operation.
4-acetylchlorobenzene need to pay attention to when storing and transporting
4-Acetylchlorobenzene (4-chloroacetylbenzene) is one of the organic compounds. When storing and transporting, many matters must be paid attention to.
First words storage, this substance should be placed in a cool, dry and well ventilated place. Because it may have certain chemical activity, it is easy to deteriorate due to heat and moisture, so it is necessary to avoid high temperature and humidity. And it should be stored separately from oxidants and alkalis, because 4-acetylchlorobenzene comes into contact with them, or triggers violent chemical reactions, which may cause safety concerns. In the warehouse, the temperature and humidity also need to be strictly controlled. Usually, the temperature should be maintained at 15-30 ° C, and the relative humidity should be 40% -70%, which can ensure the stability of its chemical properties.
Times and transportation, be sure to ensure that the packaging is complete and sealed before transportation. Packaging materials need to have good corrosion resistance and sealing to prevent leakage of 4-acetylchlorobenzene. During transportation, vibration and impact should be avoided to prevent package damage. In addition, transportation vehicles need to have corresponding ventilation, sun protection and rain protection facilities to deal with different transportation environments. And transportation personnel should be familiar with the nature of this substance and emergency treatment methods. In case of leakage and other emergencies, they can be dealt with quickly and properly. In case of accidental leakage, the surrounding personnel should be evacuated immediately. It is strictly forbidden for fire to approach. Emergency responders need protective clothing and gloves, and use inert materials such as sand and vermiculite to absorb and properly dispose of waste. In short, 4-acetylchlorobenzene should be stored and transported with caution and strictly abide by safety regulations to ensure safety.
First words storage, this substance should be placed in a cool, dry and well ventilated place. Because it may have certain chemical activity, it is easy to deteriorate due to heat and moisture, so it is necessary to avoid high temperature and humidity. And it should be stored separately from oxidants and alkalis, because 4-acetylchlorobenzene comes into contact with them, or triggers violent chemical reactions, which may cause safety concerns. In the warehouse, the temperature and humidity also need to be strictly controlled. Usually, the temperature should be maintained at 15-30 ° C, and the relative humidity should be 40% -70%, which can ensure the stability of its chemical properties.
Times and transportation, be sure to ensure that the packaging is complete and sealed before transportation. Packaging materials need to have good corrosion resistance and sealing to prevent leakage of 4-acetylchlorobenzene. During transportation, vibration and impact should be avoided to prevent package damage. In addition, transportation vehicles need to have corresponding ventilation, sun protection and rain protection facilities to deal with different transportation environments. And transportation personnel should be familiar with the nature of this substance and emergency treatment methods. In case of leakage and other emergencies, they can be dealt with quickly and properly. In case of accidental leakage, the surrounding personnel should be evacuated immediately. It is strictly forbidden for fire to approach. Emergency responders need protective clothing and gloves, and use inert materials such as sand and vermiculite to absorb and properly dispose of waste. In short, 4-acetylchlorobenzene should be stored and transported with caution and strictly abide by safety regulations to ensure safety.
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