Linshang Chemical
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4-Amino-2-Chloro-Α-(4-Chlorophenyl)-5-Methylbenzeneacetonitrile
Linshang Chemical
|
HS Code |
621931 |
| Chemical Formula | C16H13Cl2N |
| Molecular Weight | 288.19 |
| Appearance | Solid (Typical appearance description) |
| Melting Point | Specific melting point value (if known) |
| Boiling Point | Specific boiling point value (if known) |
| Solubility In Water | Low/High (Indicate solubility level) |
| Solubility In Organic Solvents | Soluble in [list solvents] |
| Density | Specific density value |
| Flash Point | Specific flash point value |
| Vapor Pressure | Specific vapor pressure value |
As an accredited 4-Amino-2-Chloro-Α-(4-Chlorophenyl)-5-Methylbenzeneacetonitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - amino - 2 - chloro - α - (4 - chlorophenyl) - 5 - methylbenzeneacetonitrile in sealed chemical - grade packaging. |
| Storage | Store 4 - amino - 2 - chloro - α - (4 - chlorophenyl)-5 - methylbenzeneacetonitrile in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and degradation. Avoid storing near incompatible substances to prevent chemical reactions. |
| Shipping | 4 - amino - 2 - chloro - α - (4 - chlorophenyl)-5 - methylbenzeneacetonitrile is shipped in properly sealed, corrosion - resistant containers. Compliance with hazardous chemical shipping regulations ensures safe transport, minimizing risks during transit. |
Competitive 4-Amino-2-Chloro-Α-(4-Chlorophenyl)-5-Methylbenzeneacetonitrile prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-amino-2-chloro-α - (4-chlorophenyl) -5-methylbenzeneacetonitrile
4-Amino-2-chloro - α -（ 4-chlorophenyl) - 5-methylphenylacetonitrile, this is an organic compound. Its chemical properties are unique and have many characteristics.
In terms of its stability, under normal conditions, the structure is relatively stable. In case of high temperature, strong oxidizing agent or specific catalyst, it may trigger a chemical reaction. For example, in high temperature environment, the chemical bonds within the molecule may be broken and rearranged due to sufficient energy, causing structural changes.
From the perspective of acidity and alkalinity, the compound contains an amino group, which has a certain alkalinity and can react with acids to form corresponding salts. In this process, the lone pair of electrons on the amino nitrogen atom will combine with the hydrogen ion in the acid to form a coordination bond.
Its solubility is also an important property. Generally speaking, it has a certain solubility in organic solvents such as ethanol and dichloromethane, because these organic solvents can form van der Waals forces or hydrogen bonds between the molecules of the compound, which can help it disperse and dissolve. However, the solubility in water is not good, because the hydrophobic groups in the molecule account for a large proportion, and the force between the water molecules is weak.
In terms of chemical reactivity, cyanyl (-CN) is an active group and can undergo a variety of reactions. If under appropriate conditions, cyanyl can be hydrolyzed to form carboxyl groups, or nucleophilic addition reactions occur with nucleophiles. Although the chlorine atom on the aromatic ring is relatively stable, it can also be replaced by nucleophiles under specific conditions such as strong alkalinity and high temperature, which can change the substituents on the benzene ring.
The chemical properties of this compound make it meaningful in the field of organic synthesis. It can be used as a key intermediate to construct more complex organic molecules through various reactions, providing an important foundation for the research and practice of organic synthesis chemistry.
In terms of its stability, under normal conditions, the structure is relatively stable. In case of high temperature, strong oxidizing agent or specific catalyst, it may trigger a chemical reaction. For example, in high temperature environment, the chemical bonds within the molecule may be broken and rearranged due to sufficient energy, causing structural changes.
From the perspective of acidity and alkalinity, the compound contains an amino group, which has a certain alkalinity and can react with acids to form corresponding salts. In this process, the lone pair of electrons on the amino nitrogen atom will combine with the hydrogen ion in the acid to form a coordination bond.
Its solubility is also an important property. Generally speaking, it has a certain solubility in organic solvents such as ethanol and dichloromethane, because these organic solvents can form van der Waals forces or hydrogen bonds between the molecules of the compound, which can help it disperse and dissolve. However, the solubility in water is not good, because the hydrophobic groups in the molecule account for a large proportion, and the force between the water molecules is weak.
In terms of chemical reactivity, cyanyl (-CN) is an active group and can undergo a variety of reactions. If under appropriate conditions, cyanyl can be hydrolyzed to form carboxyl groups, or nucleophilic addition reactions occur with nucleophiles. Although the chlorine atom on the aromatic ring is relatively stable, it can also be replaced by nucleophiles under specific conditions such as strong alkalinity and high temperature, which can change the substituents on the benzene ring.
The chemical properties of this compound make it meaningful in the field of organic synthesis. It can be used as a key intermediate to construct more complex organic molecules through various reactions, providing an important foundation for the research and practice of organic synthesis chemistry.
What are the preparation methods of 4-amino-2-chloro-α - (4-chlorophenyl) -5-methylbenzeneacetonitrile
4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile is an organic compound, and there are many preparation methods. The following are the common ones:
First, the phenylacetonitrile derivative containing a specific substituent is used as the starting material. The phenylacetonitrile containing a suitable substituent can be taken first. Under suitable reaction conditions, a halogenating reagent (such as a chlorine-containing halogenating reagent) is used to halogenate the specific position of the benzene ring and introduce a chlorine atom. Subsequently, a suitable amination reagent is selected, and an amino group is introduced into the other position of the benzene ring through an amination reaction. In this process, the choice of reaction solvent is very critical, such as aprotic solvents (such as N, N-dimethylformamide, etc.), which can provide a good environment for the reaction. The reaction temperature and time also need to be finely regulated. The halogenation reaction temperature may vary depending on the activity of the reagents. The amination reaction also needs to be carried out within an appropriate temperature range and time according to the characteristics of the reagents and substrates used to ensure the high efficiency and selectivity of the reaction.
Second, the strategy of gradually constructing benzene rings and side chains is adopted. The benzene ring structure containing some substituents is first synthesized, such as the benzene ring with specific substituents (such as chlorine atoms, etc.) through the electrophilic substitution reaction of aromatics. Afterwards, a side chain structure containing cyanide groups and other substituents is introduced by a carbon-carbon bond formation reaction, such as the Grignard reaction or the Fourier-Gram reaction. In the Grignard reaction, a suitable Grignard reagent needs to be prepared first, and then reacted with the corresponding halogenate or carbonyl compound to form the desired carbon-carbon bond. During the reaction, the anhydrous and oxygen-free conditions of the reaction system are extremely important, otherwise side reactions will easily occur, affecting the yield and purity of the product.
Third, the reaction catalyzed by transition metals. For example, palladium-catalyzed cross-coupling reactions can effectively connect different organic fragments. Select benzene ring derivatives with suitable leaving groups (such as halogen atoms, etc.) and organometallic reagents (such as zinc reagents, boron reagents, etc.) containing cyanide groups and other substituents. Under the action of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as bidentate phosphine ligands, etc.), cross-coupling reactions occur to construct the target molecular structure. This method has the advantages of relatively mild reaction conditions and high selectivity, but the cost of the catalyst may be a consideration factor, and the reaction conditions need to be optimized to reduce the amount of catalyst and improve economic benefits.
The above preparation methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty in controlling reaction conditions, and the purity and yield of the product, and carefully select and optimize the appropriate preparation route.
First, the phenylacetonitrile derivative containing a specific substituent is used as the starting material. The phenylacetonitrile containing a suitable substituent can be taken first. Under suitable reaction conditions, a halogenating reagent (such as a chlorine-containing halogenating reagent) is used to halogenate the specific position of the benzene ring and introduce a chlorine atom. Subsequently, a suitable amination reagent is selected, and an amino group is introduced into the other position of the benzene ring through an amination reaction. In this process, the choice of reaction solvent is very critical, such as aprotic solvents (such as N, N-dimethylformamide, etc.), which can provide a good environment for the reaction. The reaction temperature and time also need to be finely regulated. The halogenation reaction temperature may vary depending on the activity of the reagents. The amination reaction also needs to be carried out within an appropriate temperature range and time according to the characteristics of the reagents and substrates used to ensure the high efficiency and selectivity of the reaction.
Second, the strategy of gradually constructing benzene rings and side chains is adopted. The benzene ring structure containing some substituents is first synthesized, such as the benzene ring with specific substituents (such as chlorine atoms, etc.) through the electrophilic substitution reaction of aromatics. Afterwards, a side chain structure containing cyanide groups and other substituents is introduced by a carbon-carbon bond formation reaction, such as the Grignard reaction or the Fourier-Gram reaction. In the Grignard reaction, a suitable Grignard reagent needs to be prepared first, and then reacted with the corresponding halogenate or carbonyl compound to form the desired carbon-carbon bond. During the reaction, the anhydrous and oxygen-free conditions of the reaction system are extremely important, otherwise side reactions will easily occur, affecting the yield and purity of the product.
Third, the reaction catalyzed by transition metals. For example, palladium-catalyzed cross-coupling reactions can effectively connect different organic fragments. Select benzene ring derivatives with suitable leaving groups (such as halogen atoms, etc.) and organometallic reagents (such as zinc reagents, boron reagents, etc.) containing cyanide groups and other substituents. Under the action of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.) and ligands (such as bidentate phosphine ligands, etc.), cross-coupling reactions occur to construct the target molecular structure. This method has the advantages of relatively mild reaction conditions and high selectivity, but the cost of the catalyst may be a consideration factor, and the reaction conditions need to be optimized to reduce the amount of catalyst and improve economic benefits.
The above preparation methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty in controlling reaction conditions, and the purity and yield of the product, and carefully select and optimize the appropriate preparation route.
What is the main use of 4-amino-2-chloro-alpha - (4-chlorophenyl) -5-methylbenzeneacetonitrile?
4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile, this is an organic compound with a wide range of uses and important applications in many fields.
In the field of medicinal chemistry, this compound is often used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can participate in a series of chemical reactions and can be converted into drug molecules with specific pharmacological activities through ingenious design and synthesis steps. For example, when developing new therapeutic drugs for certain specific diseases, it can serve as a starting material. With the help of chemical modification and reaction, drugs with high affinity and specificity to disease targets can be constructed, which is expected to provide new and effective means for disease treatment.
In the field of materials science, the compound may play a role in the preparation of functional materials. With appropriate modification and treatment, it can give materials certain special properties. For example, introducing it into polymer material systems may change the optical, electrical or thermal properties of materials, resulting in the preparation of new functional materials suitable for electronic devices, optical sensors and other fields.
In the field of agricultural chemistry, it may also show important value. It may be used as a key component in the synthesis of new pesticides. Due to its structural properties, or giving pesticides specific biological activities such as high-efficiency insecticides, sterilization or weeding, it can help to develop more environmentally friendly, efficient and environmentally friendly pesticide products to meet the needs of modern agriculture for pest control.
In summary, 4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile with its unique chemical structure, in medicine, materials, agriculture and many other fields have potential applications, is an important research and development value of organic compounds.
In the field of medicinal chemistry, this compound is often used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can participate in a series of chemical reactions and can be converted into drug molecules with specific pharmacological activities through ingenious design and synthesis steps. For example, when developing new therapeutic drugs for certain specific diseases, it can serve as a starting material. With the help of chemical modification and reaction, drugs with high affinity and specificity to disease targets can be constructed, which is expected to provide new and effective means for disease treatment.
In the field of materials science, the compound may play a role in the preparation of functional materials. With appropriate modification and treatment, it can give materials certain special properties. For example, introducing it into polymer material systems may change the optical, electrical or thermal properties of materials, resulting in the preparation of new functional materials suitable for electronic devices, optical sensors and other fields.
In the field of agricultural chemistry, it may also show important value. It may be used as a key component in the synthesis of new pesticides. Due to its structural properties, or giving pesticides specific biological activities such as high-efficiency insecticides, sterilization or weeding, it can help to develop more environmentally friendly, efficient and environmentally friendly pesticide products to meet the needs of modern agriculture for pest control.
In summary, 4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile with its unique chemical structure, in medicine, materials, agriculture and many other fields have potential applications, is an important research and development value of organic compounds.
What is the market outlook for 4-amino-2-chloro-alpha - (4-chlorophenyl) -5-methylbenzeneacetonitrile?
4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile is an organic compound, and its market prospect is influenced by a variety of factors.
From the demand side, in the field of medicine, because of its unique structure, or as a key intermediate for the creation of new drugs, such as the development of antibacterial and anti-inflammatory drugs, if the relevant research makes breakthroughs and the clinical demand grows, it will strongly stimulate the market. In the field of pesticides, or used to synthesize pesticides with high insecticidal and bactericidal activities, with the rising demand for green and efficient pesticides in agriculture, if it can fit this trend, the market space is considerable.
However, it also faces challenges. In terms of synthesis process, the synthesis steps of this compound may be complicated, involving many reactions and reagents, and cost control is difficult. If the research and development of new processes lags behind and the cost remains high, it will limit market expansion. At the level of regulations and policies, environmental protection supervision is becoming stricter. If a large number of pollutants are generated in the production process, enterprises need to invest huge amounts of environmental protection funds, which will affect profits and market competitiveness. Moreover, the registration and approval of medicines and pesticides is strict, and the product listing cycle is lengthened, which increases the risk of marketing activities.
The competitive situation cannot be ignored. In peer competition, if other companies take the lead in mastering better synthesis technology, reducing costs, or launching better-performing alternatives, the market share of this compound may be cannibalized. If the supply of raw materials is unstable and the price fluctuates greatly,
To sum up, 4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile market prospects Opportunities and challenges coexist. Enterprises need to focus on R & D innovation, optimize processes, reduce costs, and pay close attention to regulations and policies in order to seek development in market competition.
From the demand side, in the field of medicine, because of its unique structure, or as a key intermediate for the creation of new drugs, such as the development of antibacterial and anti-inflammatory drugs, if the relevant research makes breakthroughs and the clinical demand grows, it will strongly stimulate the market. In the field of pesticides, or used to synthesize pesticides with high insecticidal and bactericidal activities, with the rising demand for green and efficient pesticides in agriculture, if it can fit this trend, the market space is considerable.
However, it also faces challenges. In terms of synthesis process, the synthesis steps of this compound may be complicated, involving many reactions and reagents, and cost control is difficult. If the research and development of new processes lags behind and the cost remains high, it will limit market expansion. At the level of regulations and policies, environmental protection supervision is becoming stricter. If a large number of pollutants are generated in the production process, enterprises need to invest huge amounts of environmental protection funds, which will affect profits and market competitiveness. Moreover, the registration and approval of medicines and pesticides is strict, and the product listing cycle is lengthened, which increases the risk of marketing activities.
The competitive situation cannot be ignored. In peer competition, if other companies take the lead in mastering better synthesis technology, reducing costs, or launching better-performing alternatives, the market share of this compound may be cannibalized. If the supply of raw materials is unstable and the price fluctuates greatly,
To sum up, 4 - amino - 2 - chloro - α - ( 4 - chlorophenyl) -5 - methylbenzeneacetonitrile market prospects Opportunities and challenges coexist. Enterprises need to focus on R & D innovation, optimize processes, reduce costs, and pay close attention to regulations and policies in order to seek development in market competition.
What are the precautions for 4-amino-2-chloro-alpha - (4-chlorophenyl) -5-methylbenzeneacetonitrile during storage and transportation?
4-Amino-2-chloro - α -（ 4-chlorophenyl) - 5-methylphenylacetonitrile is a chemical substance, and many matters must be paid attention to during storage and transportation.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. This is due to its nature or fear of high temperature and humidity, if it is in a warm and humid place, or cause it to deteriorate. As "Tiangong Kaiwu" says, "Hide in a dry place and do not be disturbed by hot flashes", so should this chemical.
Furthermore, it must be stored separately from oxidizing agents, acids, bases, etc. This is due to the severe reaction of the substance or with such chemicals, which causes danger. Just as the old saying "water and fire are incompatible, each product has its own nature and cannot be mixed", this is also the case between chemical substances.
In terms of packaging, it is necessary to ensure that the seal is tight. Preventing leakage is the key, because once it leaks, not only the substance itself may be lost, but also it may pose a threat to the environment and personal safety. Just as the ancient packaging is rigorous, leak-proof and loss-proof, the packaging of this chemical is also indispensable.
When transporting, relevant regulations and standards should be followed. The transport vehicle must have corresponding warning labels to inform others that it is a special chemical. The escort personnel should also have professional knowledge and know how to deal with emergencies. Driving on the way, avoid vibration and impact to prevent package damage.
The loading and unloading process needs to be handled with caution. Load lightly and unload lightly, do not treat rudely, to prevent package rupture due to external impact and cause danger.
In general, the storage and transportation of 4-amino-2-chloro - α -（ 4-chlorophenyl) - 5-methylphenylacetonitrile should be based on caution, follow specifications, and ensure safety. Just like the ancients, it is rigorous and comprehensive.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. This is due to its nature or fear of high temperature and humidity, if it is in a warm and humid place, or cause it to deteriorate. As "Tiangong Kaiwu" says, "Hide in a dry place and do not be disturbed by hot flashes", so should this chemical.
Furthermore, it must be stored separately from oxidizing agents, acids, bases, etc. This is due to the severe reaction of the substance or with such chemicals, which causes danger. Just as the old saying "water and fire are incompatible, each product has its own nature and cannot be mixed", this is also the case between chemical substances.
In terms of packaging, it is necessary to ensure that the seal is tight. Preventing leakage is the key, because once it leaks, not only the substance itself may be lost, but also it may pose a threat to the environment and personal safety. Just as the ancient packaging is rigorous, leak-proof and loss-proof, the packaging of this chemical is also indispensable.
When transporting, relevant regulations and standards should be followed. The transport vehicle must have corresponding warning labels to inform others that it is a special chemical. The escort personnel should also have professional knowledge and know how to deal with emergencies. Driving on the way, avoid vibration and impact to prevent package damage.
The loading and unloading process needs to be handled with caution. Load lightly and unload lightly, do not treat rudely, to prevent package rupture due to external impact and cause danger.
In general, the storage and transportation of 4-amino-2-chloro - α -（ 4-chlorophenyl) - 5-methylphenylacetonitrile should be based on caution, follow specifications, and ensure safety. Just like the ancients, it is rigorous and comprehensive.
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