4-Amino-2-Chloro-5-Hydroxybenzenesulfonamide
Linshang Chemical
HS Code |
699770 |
Chemical Formula | C6H7ClN2O4S |
Molar Mass | 238.65 g/mol |
Appearance | Solid (predicted, actual may vary) |
Physical State At Room Temp | Solid |
Solubility In Water | Limited (due to polar and non - polar groups interaction) |
Melting Point | No common data found (needs experimental determination) |
Boiling Point | No common data found (needs experimental determination) |
Density | No common data found (needs experimental determination) |
Pka | No common data found (needs experimental determination for acidic - basic groups) |
Logp | No common data found (describes lipophilicity, needs experimental determination) |
As an accredited 4-Amino-2-Chloro-5-Hydroxybenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 100g of 4 - amino - 2 - chloro - 5 - hydroxybenzenesulfonamide in a sealed, labeled container. |
Storage | 4 - amino - 2 - chloro - 5 - hydroxybenzenesulfonamide should be stored in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and contact with air, which could potentially lead to chemical degradation. Store separately from incompatible substances like strong oxidizing agents to avoid dangerous reactions. |
Shipping | 4 - amino - 2 - chloro - 5 - hydroxybenzenesulfonamide should be shipped in well - sealed containers, compliant with chemical transportation regulations. It may require special handling due to its chemical nature, ensuring safe transit to prevent any leakage or degradation. |
Competitive 4-Amino-2-Chloro-5-Hydroxybenzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Amino-2-Chloro-5-Hydroxybenzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
First, because it contains amino groups (\ (- NH_ {2}\)), it is weakly basic. The nitrogen atom in the amino group has lone pair electrons, which can bind protons and react with acids to form salts. In case of hydrochloric acid, the amino group will combine with the hydrogen ion in hydrochloric acid to form the corresponding ammonium salt.
Furthermore, the hydroxyl group (\ (-OH\)) is also an important functional group. Hydroxyl groups are acidic to a certain extent. Although acidic, they can react with active metals such as sodium under certain conditions to replace hydrogen. At the same time, the hydroxyl group can participate in the esterification reaction, and under the catalysis of concentrated sulfuric acid and heating conditions with carboxylic acid, ester compounds and water are formed.
The structure of the benzene ring gives the compound special stability. The benzene ring has a large π bond, and the electron cloud is highly delocalized, so that it can undergo electrophilic substitution reaction. For example, under the action of a suitable catalyst, it can be substituted with bromine, and the bromine atom replaces the hydrogen atom on the benzene ring.
In addition, the sulfonamide group (\ (- SO_ {2} NH_ {2}\)) also affects its properties. The sulfur atom in the sulfonamide group is in a higher oxidation state and has a certain oxidation property. In addition, the sulfonamide group can be hydrolyzed to form the corresponding sulfonic acid and In conclusion, 4-amino-2-chloro-5-hydroxybenzenesulfonamide exhibits rich and diverse chemical properties due to the interaction of various functional groups, and has important applications in organic synthesis, medicinal chemistry and other fields.
In the field of medicine, it has important value. It can be used as a key intermediate for the synthesis of specific drugs. Due to its unique chemical structure, it can introduce specific active groups into drug molecules, thereby giving drugs unique pharmacological activity. If it undergoes a series of chemical transformations, it can participate in the synthesis of antibacterial drugs, and interact with key targets in microorganisms through its structure, interfering with microbial metabolic processes and achieving antibacterial effects.
In the field of agriculture, it also has extraordinary performance. Can be used as raw materials to participate in the creation of pesticides. It can develop pesticides with specific mechanisms of action on pests, such as interfering with the nervous system of pests or the growth and development process, assisting agricultural pest control, and improving crop yield and quality.
In the field of materials science, 4-amino-2-chloro-5-hydroxybenzenesulfonamide can also play a role. Because of its special functional groups, it can be used to prepare functional polymer materials. By polymerizing with other monomers, the material is endowed with special properties, such as improving the hydrophilicity and corrosion resistance of the material, expanding the application range of the material, and has great potential in the preparation of coatings, fibers and other materials.
In addition, in the dye industry, it can also be used as a raw material for the synthesis of special dyes. With its structural characteristics, dyes with high affinity and good dyeing properties for specific fibers are synthesized to meet the needs of high-quality dyes in textile and other industries. In short, 4-amino-2-chloro-5-hydroxybenzenesulfonamide has shown important uses in many industries due to its unique chemical structure, providing assistance for the development of various fields.
To synthesize this compound, the first choice of raw materials. Suitable benzene-based compounds can be selected as starting materials, such as specific substituted benzene. With benzene as the base, according to its chemical properties, the required functional groups are introduced through ingenious steps.
The introduction of chlorine groups can be achieved by chlorination. Under suitable reaction environments, such as specific solvents, temperatures and catalysts, chlorine atoms are properly attached to the benzene ring. The method requires fine control of the reaction conditions, otherwise, the chlorine atoms may be misjoined, or the reaction may be excessive, resulting in many by-products.
The addition of hydroxyl groups also requires delicate means. Or borrow a nucleophilic substitution reaction to make the reagent containing hydroxyl groups interact with the benzene ring. This step also requires careful selection of the reaction conditions. The nature of the solvent and the strength of the base are all related to the success or failure of the reaction.
The introduction of amino groups may be through nitration and reduction. First, the nitro group is added to the benzene ring with a nitrifying reagent, and then the nitro group is reduced to an amino group through a reduction step. In this process, the accuracy of nitrification and the moderation of reduction are crucial.
The formation of sulfonamide groups requires the reaction of sulfonyl chloride-containing reagents with ammonia or amine compounds. During the reaction, the proportion of materials, the temperature and time of the reaction are all the keys that affect the purity and yield of the product.
The steps are clear, and the reaction sequence needs to be properly arranged. After a reasonable combination of various reactions, step by step, 4-amino-2-chloro-5-hydroxybenzenesulfonamide can be obtained with higher yield and purity. Although this synthesis method has been explored by predecessors, it is still possible to improve in today's chemical research. Hope that future generations can gain from this method, making the synthesis more convenient and efficient.
This substance has potential chemical hazards. First, it may be irritating. If it comes into contact with the skin, rinse with plenty of water as soon as possible for at least fifteen minutes, and remove the contaminated clothing. If you still feel unwell after rinsing, seek medical attention as soon as possible. If it splashes into the eyes, you should immediately open the eyelids, rinse with flowing water or normal saline, and seek medical treatment at the same time without delay.
Second, the risk of inhalation cannot be ignored. In the place of use, air circulation should be maintained. If you inhale this substance, if you feel uncomfortable breathing, cough, etc., you should leave the scene quickly and go to a fresh air place. If the symptoms do not abate, you need to seek medical attention.
Third, ingesting by mistake is very harmful. If you accidentally eat it by mistake, do not induce vomiting. You should seek medical attention immediately and bring the relevant information of this substance to assist medical diagnosis.
Furthermore, when storing, store it in a cool, dry and well-ventilated place, away from fire and heat sources, and store it separately from oxidants, acids, and alkalis. Do not mix it to prevent dangerous reactions.
When operating, the operator must take good protection. You need to wear a self-priming filter dust mask to prevent dust inhalation; wear chemical safety glasses to protect your eyes; wear anti-poison infiltration work clothes to prevent poison from outside; wear rubber gloves to avoid hand contact.
During handling, it should be handled lightly, and do not damage the container or cause material leakage.
In short, the use of 4-amino-2-chloro-5-hydroxybenzenesulfonamide must be operated in strict accordance with safety procedures and always be vigilant to ensure safety.
Common, there are specifications by weight. If it is in powder form, it is mostly in grams, and it is commonly packaged in 5 grams, 10 grams, 25 grams, 50 grams, and 100 grams. Such small specifications are mostly suitable for experimental investigation, making it easy for researchers to access and measure accurately to observe its characteristics and reactions under different conditions.
There are also larger packages, such as 500 grams and 1 kilogram, which are suitable for slightly larger-scale R & D testing, or small-scale production, taking into account cost and dosage.
Others are distinguished by purity. High purity, up to 98%, 99% or more, this type is suitable for fields with strict requirements for impurities, such as pharmaceutical research and development, which is related to human life, purity is crucial, impurities are slightly deviated, or cause poor efficacy, or even cause adverse reactions. And industrial grade, purity or slightly lower, but it can also meet the needs of general industrial production, the cost is relatively low, and it can be used in large-scale production to reduce costs and increase efficiency.
The solution form is also available. Its concentration varies, common solutions of different concentrations such as 10%, 20%, etc. This is very convenient for some people who need to use liquid directly, which can save the tedious process of dissolution and preparation, and can be directly used in specific processes, such as some chemical synthesis processes, which can precisely control the reaction process and product quality.
Intercity specifications are designed according to the use and needs, and each is suitable to meet the needs of all parties.

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