Linshang Chemical
PRODUCTS
4-Amino-3-Chlorobenzenesulfonamide
Linshang Chemical
|
HS Code |
772362 |
| Chemical Formula | C6H7ClN2O2S |
| Molecular Weight | 206.65 |
| Appearance | Solid |
As an accredited 4-Amino-3-Chlorobenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - amino - 3 - chlorobenzenesulfonamide packaged in air - tight plastic bags. |
| Storage | 4 - amino - 3 - chlorobenzenesulfonamide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly closed container to prevent moisture absorption and contamination. Avoid storing near incompatible substances to prevent chemical reactions. |
| Shipping | 4 - amino - 3 - chlorobenzenesulfonamide is a chemical. For shipping, it must be packaged securely in accordance with chemical regulations. Use appropriate containers to prevent leakage and ensure safe transportation to avoid any hazards. |
Competitive 4-Amino-3-Chlorobenzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Amino-3-Chlorobenzenesulfonamide in China?
As a trusted 4-Amino-3-Chlorobenzenesulfonamide manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Amino-3-Chlorobenzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-amino-3-chlorobenzenesulfonamide?
4 - amino - 3 - chlorobenzenesulfonamide, the chemical formula is\ (C_6H_7ClN_2O_2S\), which is based on benzene. Above benzene, there is an amino group (\ (- NH_2\)) at the 4th position, which has the property of providing benzene, and can affect the density of benzene clouds. The third position has a chlorine atom (\ (-Cl\)), and the chlorine atom also has a co-effect for benzene. However, the effect is on the absorber, and the two interact, resulting in a change in the density distribution of benzene clouds.
In addition, the first position of benzene has a sulfonamide group (\ (- SO_2NH_2\)). In the sulfonamide group, the sulfur atom is an oxygen atom with a sulfonamide phase, and the sulfonamide phase is a sulfonamide phase. In this case, the sulfur atom is high in sulfonamide and has a certain degree of sulfonamide, so that the sulfonamide group is also a shadow of the benzene group.
In this way, 4-amino-3-chlorobenzenesulfonamide has a physical properties of sulfonamide. In terms of physical properties, because the molecule contains a sulfonamide group, it has a certain degree of sulfonamide and affects its solubility. In terms of chemical properties, amino groups can be acylated, alkylated, etc.; chlorine atoms can undergo nuclear substitution, etc.; sulfonamide groups can also be involved in the reaction of nitrogen and sulfur atoms. In addition, the groups in the chemical reactions interact with each other to jointly determine the general characteristics of this compound.
In addition, the first position of benzene has a sulfonamide group (\ (- SO_2NH_2\)). In the sulfonamide group, the sulfur atom is an oxygen atom with a sulfonamide phase, and the sulfonamide phase is a sulfonamide phase. In this case, the sulfur atom is high in sulfonamide and has a certain degree of sulfonamide, so that the sulfonamide group is also a shadow of the benzene group.
In this way, 4-amino-3-chlorobenzenesulfonamide has a physical properties of sulfonamide. In terms of physical properties, because the molecule contains a sulfonamide group, it has a certain degree of sulfonamide and affects its solubility. In terms of chemical properties, amino groups can be acylated, alkylated, etc.; chlorine atoms can undergo nuclear substitution, etc.; sulfonamide groups can also be involved in the reaction of nitrogen and sulfur atoms. In addition, the groups in the chemical reactions interact with each other to jointly determine the general characteristics of this compound.
What are the main uses of 4-amino-3-chlorobenzenesulfonamide?
4-Amino-3-chlorobenzenesulfonamide, also known as sulfamethoxazine, is widely used. In the field of medicine, it is an important antimicrobial raw material. It has antibacterial activity and can inhibit the growth and reproduction of bacteria. It is often used to synthesize various sulfonamide antibacterial drugs to treat a variety of bacterial infections, such as respiratory and urinary tract infections. In the field of veterinary medicine, it also has important applications. It can prevent and treat bacterial infections in livestock and poultry, improve the health level of livestock and poultry and the efficiency of breeding, and ensure the smooth development of the breeding industry. In the chemical industry, 4-amino-3-chlorobenzenesulfonamide is a key organic synthesis intermediate. With its special chemical structure, it can participate in many organic synthesis reactions and is used to prepare a variety of fine chemicals, such as dyes, pigments, etc., which makes a great contribution to the enrichment of chemical industry products and technological progress. Therefore, 4-amino-3-chlorobenzenesulfonamide plays an indispensable role in the fields of medicine, veterinary medicine and chemical industry, and has a far-reaching impact on the development of related industries.
What are the physical properties of 4-amino-3-chlorobenzenesulfonamide?
4-Amino-3-chlorobenzenesulfonamide, the Chinese name is often 4-amino-3-chlorobenzenesulfonamide. This is an organic compound and has a wide range of uses in the fields of medicine and chemical industry. Its physical properties are detailed as follows:
- ** Appearance properties **: Under normal circumstances, 4-amino-3-chlorobenzenesulfonamide is mostly white to light yellow crystalline powder. This powder is fine and visually observable. Its texture is uniform. This appearance feature is not only easy to identify, but also conducive to subsequent processing. Because of its powder shape, it is easy to mix with other substances. In the process of preparing drugs or chemical products, it can be more evenly dispersed to ensure uniform reaction or product quality.
- ** Melting point **: Melting point is between 165 - 168 ° C. Melting point is an important physical property of the substance. This temperature range indicates that 4-amino-3-chlorobenzenesulfonamide will melt from solid to liquid when heated to this temperature range. Accurate melting point is of great significance to identify its purity. If the purity is high, the melting point should be within this range. If it contains impurities, the melting point may be deviated, which can help quality control.
- ** Solubility **: Slightly soluble in water, but soluble in some organic solvents, such as ethanol, acetone, etc. Slightly soluble in water makes it limited in aqueous systems; while soluble in organic solvents, it provides convenience in organic synthesis and pharmaceutical preparation. For example, in drug research and development, it can be dissolved in organic solvents and mixed with other ingredients to make a specific dosage form.
- ** Odor **: Usually no special odor, or only a weak odor. The property of no special odor has significant advantages in practical applications, especially in the field of medicine, it will not affect the patient's medication compliance due to pungent or special odor, nor will it cause discomfort to operators in the chemical production process.
- ** Appearance properties **: Under normal circumstances, 4-amino-3-chlorobenzenesulfonamide is mostly white to light yellow crystalline powder. This powder is fine and visually observable. Its texture is uniform. This appearance feature is not only easy to identify, but also conducive to subsequent processing. Because of its powder shape, it is easy to mix with other substances. In the process of preparing drugs or chemical products, it can be more evenly dispersed to ensure uniform reaction or product quality.
- ** Melting point **: Melting point is between 165 - 168 ° C. Melting point is an important physical property of the substance. This temperature range indicates that 4-amino-3-chlorobenzenesulfonamide will melt from solid to liquid when heated to this temperature range. Accurate melting point is of great significance to identify its purity. If the purity is high, the melting point should be within this range. If it contains impurities, the melting point may be deviated, which can help quality control.
- ** Solubility **: Slightly soluble in water, but soluble in some organic solvents, such as ethanol, acetone, etc. Slightly soluble in water makes it limited in aqueous systems; while soluble in organic solvents, it provides convenience in organic synthesis and pharmaceutical preparation. For example, in drug research and development, it can be dissolved in organic solvents and mixed with other ingredients to make a specific dosage form.
- ** Odor **: Usually no special odor, or only a weak odor. The property of no special odor has significant advantages in practical applications, especially in the field of medicine, it will not affect the patient's medication compliance due to pungent or special odor, nor will it cause discomfort to operators in the chemical production process.
What are 4-amino-3-chlorobenzenesulfonamide synthesis methods?
There are various ways to synthesize 4-amino-3-chlorobenzenesulfonamide. First, it can be started from 3-chloro-4-nitrobenzenesulfonyl chloride. The 3-chloro-4-nitrobenzenesulfonyl chloride and ammonia are in a suitable solvent, such as dichloromethane or ethanol, under mild temperature conditions, often at low temperature to prevent side reactions from breeding. The two interact, and through nucleophilic substitution, the sulfonyl chloride group is replaced by the amino group to form 3-chloro-4-nitrobenzenesulfonamide. Subsequently, 3-chloro-4-nitrobenzenesulfonamide is reduced. The commonly used reducing agent is iron powder and hydrochloric acid system, or the catalytic hydrogenation method is used, with palladium carbon as the catalyst and hydrogen as the reducing agent. Under suitable reaction conditions, the nitro group is reduced to an amino group, and the final 4-amino-3-chlorobenzenesulfonamide is obtained.
Second, 4-acetaminobenzenesulfonamide can also be used as a raw material. Chloride 4-acetaminobenzenesulfonamide first. Select suitable chlorination reagents, such as chlorine gas, N-chlorosuccinimide (NCS), etc. In solvents such as chloroform and dichloroethane, the reaction temperature and time are controlled to chlorinate the benzene ring at a specific position, and chlorine atoms are introduced at the amino ortho-position to obtain 4-acetamido-3-chlorobenzenesulfonamide. Then, through hydrolysis reaction, under acidic or basic conditions, the acetamido is hydrolyzed to generate 4-amino-3-chlorobenzenesulfonamide.
Or, take p-aminobenzenesulfonamide as the starting material. After chlorination reaction, chlorine atoms can be introduced at the phenyl cycloamino ortho-position. Select suitable chlorination reagents and reaction conditions to ensure the selectivity of the reaction, avoid the formation of polychlorinated products, and finally synthesize 4-amino-3-chlorobenzenesul All the above synthesis methods have their own advantages and disadvantages, and it is necessary to make a careful choice based on actual needs, considering factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity of the product.
Second, 4-acetaminobenzenesulfonamide can also be used as a raw material. Chloride 4-acetaminobenzenesulfonamide first. Select suitable chlorination reagents, such as chlorine gas, N-chlorosuccinimide (NCS), etc. In solvents such as chloroform and dichloroethane, the reaction temperature and time are controlled to chlorinate the benzene ring at a specific position, and chlorine atoms are introduced at the amino ortho-position to obtain 4-acetamido-3-chlorobenzenesulfonamide. Then, through hydrolysis reaction, under acidic or basic conditions, the acetamido is hydrolyzed to generate 4-amino-3-chlorobenzenesulfonamide.
Or, take p-aminobenzenesulfonamide as the starting material. After chlorination reaction, chlorine atoms can be introduced at the phenyl cycloamino ortho-position. Select suitable chlorination reagents and reaction conditions to ensure the selectivity of the reaction, avoid the formation of polychlorinated products, and finally synthesize 4-amino-3-chlorobenzenesul All the above synthesis methods have their own advantages and disadvantages, and it is necessary to make a careful choice based on actual needs, considering factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity of the product.
4-amino-3-chlorobenzenesulfonamide what are the precautions during use
4-Amino-3-chlorobenzenesulfonamide is a very important chemical substance. During use, many things need to be paid attention to.
First safety protection. This substance may be harmful to the human body. When exposed, be sure to wear appropriate protective equipment. Wear protective gloves to prevent skin contact, because it may cause skin irritation or even absorption cause systemic adverse effects. Eye protection is also required. Wear goggles to avoid the substance splashing into the eyes and causing damage to the eyes, such as eye irritation, burns, etc. At the same time, it is advisable to wear a gas mask to prevent inhalation of its dust or volatile gaseous substances, which may cause respiratory irritation or even damage to the respiratory system.
Furthermore, pay attention to the operating environment. It is necessary to operate in a well-ventilated place to avoid the accumulation of the substance in the air and reduce the risk of inhalation. The operating area should be kept clean and tidy, and the substance should not be mixed with other chemicals at will to prevent accidental chemical reactions and dangerous products.
Storage should not be ignored. 4-Amino-3-chlorobenzenesulfonamide should be stored in a dry and cool place, away from fire and heat sources, to prevent it from decomposing due to heat or causing other hazards. And it should be stored separately from oxidants, acids and other substances. Due to its chemical properties, contact with these substances or cause violent reactions.
During use, strictly follow the operating procedures. Precisely weigh and measure the required amount to avoid waste and prevent adverse consequences due to improper dosage. After use, properly dispose of the remaining substances and waste, and do not discard them at will. They must be disposed of in accordance with relevant regulations to avoid pollution to the environment.
First safety protection. This substance may be harmful to the human body. When exposed, be sure to wear appropriate protective equipment. Wear protective gloves to prevent skin contact, because it may cause skin irritation or even absorption cause systemic adverse effects. Eye protection is also required. Wear goggles to avoid the substance splashing into the eyes and causing damage to the eyes, such as eye irritation, burns, etc. At the same time, it is advisable to wear a gas mask to prevent inhalation of its dust or volatile gaseous substances, which may cause respiratory irritation or even damage to the respiratory system.
Furthermore, pay attention to the operating environment. It is necessary to operate in a well-ventilated place to avoid the accumulation of the substance in the air and reduce the risk of inhalation. The operating area should be kept clean and tidy, and the substance should not be mixed with other chemicals at will to prevent accidental chemical reactions and dangerous products.
Storage should not be ignored. 4-Amino-3-chlorobenzenesulfonamide should be stored in a dry and cool place, away from fire and heat sources, to prevent it from decomposing due to heat or causing other hazards. And it should be stored separately from oxidants, acids and other substances. Due to its chemical properties, contact with these substances or cause violent reactions.
During use, strictly follow the operating procedures. Precisely weigh and measure the required amount to avoid waste and prevent adverse consequences due to improper dosage. After use, properly dispose of the remaining substances and waste, and do not discard them at will. They must be disposed of in accordance with relevant regulations to avoid pollution to the environment.
Scan to WhatsApp
