Linshang Chemical
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4-Amino-N-(5-Chloropyrazin-2-Yl)Benzenesulfonamide
Linshang Chemical
|
HS Code |
374013 |
| Chemical Formula | C11H9ClN4O2S |
| Molar Mass | 296.73 g/mol |
| Appearance | Solid (usually white or off - white powder) |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in some organic solvents like DMSO |
| Melting Point | Specific value would require experimental determination |
| Pka Value | Relevant acidic or basic groups would have specific pKa values (experimental determination needed) |
| Logp Value | Describes lipophilicity (experimental determination needed) |
| Stability | Stable under normal storage conditions, but may react with strong oxidizing or reducing agents |
As an accredited 4-Amino-N-(5-Chloropyrazin-2-Yl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - amino - N - (5 - chloropyrazin - 2 - yl)benzenesulfonamide in sealed plastic bags. |
| Storage | Store 4 - amino - N - (5 - chloropyrazin - 2 - yl)benzenesulfonamide in a cool, dry place, away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Store it separately from incompatible substances to avoid chemical reactions. |
| Shipping | 4 - amino - N - (5 - chloropyrazin - 2 - yl)benzenesulfonamide is shipped in sealed, corrosion - resistant containers. Special handling per safety regulations for chemicals is ensured during transit to prevent spills and ensure safe delivery. |
Competitive 4-Amino-N-(5-Chloropyrazin-2-Yl)Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide?
4 - amino - N - (5 - chloropyrazin - 2 - yl) benzenesulfonamide, this is the name of an organic compound. Its chemical structure can be analyzed as follows.
Looking at its name, we first focus on "benzenesulfonamide", that is, the benzenesulfonamide part. This is a core structure based on a benzene ring, which is connected with a sulfonamide group (-SO ² NH ²). This benzene ring structure, the six-membered carbon ring has a conjugated large π bond, which makes it stable and aromatic.
Looking at "4-amino" again, it can be seen that at the No. 4 position of the benzene ring, that is, the position opposite the sulfonamide group, there is an amino group (-NH -2) connected. The amino group has electron-giving properties and can affect the electron cloud density and chemical activity of the benzene ring.
As for "N- (5-chloropyrazin-2-yl) ", it means that the nitrogen atom (N) is connected to a 5-chloropyrazine-2-yl. Pyrazine is a six-membered heterocycle containing two nitrogen atoms and is aromatic. At position 5 of the pyrazine ring, there are chlorine atoms (-Cl), which are electron-absorbing and affect the electron cloud distribution and reactivity of the pyrazine ring. At position 2 of the pyrazine ring, it is connected to the nitrogen atom of benzenesulfonamide, thus building the structure of the whole molecule.
In this way, the chemical structure of 4-amino-N - (5-chloropyrazin-2-yl) benzenesulfonamide is composed of benzenesulfonamide, amino group, chloropyrazine-containing parts cleverly connected, and the interaction of each part gives this compound its unique physical and chemical properties.
Looking at its name, we first focus on "benzenesulfonamide", that is, the benzenesulfonamide part. This is a core structure based on a benzene ring, which is connected with a sulfonamide group (-SO ² NH ²). This benzene ring structure, the six-membered carbon ring has a conjugated large π bond, which makes it stable and aromatic.
Looking at "4-amino" again, it can be seen that at the No. 4 position of the benzene ring, that is, the position opposite the sulfonamide group, there is an amino group (-NH -2) connected. The amino group has electron-giving properties and can affect the electron cloud density and chemical activity of the benzene ring.
As for "N- (5-chloropyrazin-2-yl) ", it means that the nitrogen atom (N) is connected to a 5-chloropyrazine-2-yl. Pyrazine is a six-membered heterocycle containing two nitrogen atoms and is aromatic. At position 5 of the pyrazine ring, there are chlorine atoms (-Cl), which are electron-absorbing and affect the electron cloud distribution and reactivity of the pyrazine ring. At position 2 of the pyrazine ring, it is connected to the nitrogen atom of benzenesulfonamide, thus building the structure of the whole molecule.
In this way, the chemical structure of 4-amino-N - (5-chloropyrazin-2-yl) benzenesulfonamide is composed of benzenesulfonamide, amino group, chloropyrazine-containing parts cleverly connected, and the interaction of each part gives this compound its unique physical and chemical properties.
What are the main uses of 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide?
4 - amino - N - (5 - chloropyrazin - 2 - yl) benzenesulfonamide, an organic compound. It has a wide range of uses and can be used as a key drug intermediate in the field of medicine. In the process of many innovative drug development, it can participate in the construction of drug molecules, and with its unique chemical structure, endow drugs with specific pharmacological activities and curative effects. For example, in the development of antibacterial drugs, or by combining with key bacterial targets, it interferes with the normal metabolism and growth of bacteria, thereby exerting antibacterial effect.
In the field of materials science, it also has its uses. Or it can be treated by special processes to prepare functional materials with special properties. For example, by combining with other materials to improve the electrical, optical or mechanical properties of materials, it is used in electronic devices, optical instruments, etc.
In the field of chemical research, it is often used as an important reaction substrate. Chemists use it to explore and study various chemical reactions, expand organic synthesis methods and strategies, and promote the development of organic chemistry.
Due to its special structure and chemical properties, this compound has shown important value and application potential in many fields such as medicine, materials, chemical research, etc. With the progress of science and technology, more novel uses may be developed and tapped in the future.
In the field of materials science, it also has its uses. Or it can be treated by special processes to prepare functional materials with special properties. For example, by combining with other materials to improve the electrical, optical or mechanical properties of materials, it is used in electronic devices, optical instruments, etc.
In the field of chemical research, it is often used as an important reaction substrate. Chemists use it to explore and study various chemical reactions, expand organic synthesis methods and strategies, and promote the development of organic chemistry.
Due to its special structure and chemical properties, this compound has shown important value and application potential in many fields such as medicine, materials, chemical research, etc. With the progress of science and technology, more novel uses may be developed and tapped in the future.
What are the physical properties of 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide?
4 - amino - N - (5 - chloropyrazin - 2 - yl) benzenesulfonamide is an organic compound. Its physical properties are quite important and are of significance in both scientific research and practical applications.
Looking at its properties, under normal temperature and pressure, it is often in a solid state. The melting point of this compound is a key physical parameter. The melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point can be determined by experiments, but it may vary slightly depending on the experimental conditions. The determination of the melting point helps to determine the purity of the compound. If the purity is high, the melting point range is narrow; if it contains impurities, the melting point may be offset and the melting range is widened.
In addition, its solubility is also an important property. In common organic solvents, its solubility varies. In some polar organic solvents, such as ethanol and dimethyl sulfoxide (DMSO), it may have a certain solubility. The characteristics of this solubility make it possible to select suitable solvents in the field of drug research and development to prepare solutions for subsequent experiments, such as pharmacological activity testing, pharmaceutical preparation research, etc. In water, its solubility may be relatively low. Because the molecular structure of the compound contains polar groups such as amino groups, but also non-polar parts such as benzene rings and chloropyrazine groups, the overall polarity is limited, resulting in poor solubility in strong polar solvents such as water.
In addition, the density of the compound is also one of the physical properties. Density reflects the mass per unit volume of a substance. Although the exact value needs to be determined experimentally and accurately, its density characteristics are of reference value in chemical production, material storage and transportation. Understanding its density can help calculate the volume occupied by a certain mass of the compound, so as to rationally plan the size of the storage container and the space required during transportation.
As for its appearance, it often appears in a white to white powder shape. This appearance feature is convenient for preliminary identification and judgment, and can be used as a reference for quality control in the production process. If there are obvious abnormalities in the appearance color and shape, or suggest problems in the production process, further inspection and analysis are required.
Looking at its properties, under normal temperature and pressure, it is often in a solid state. The melting point of this compound is a key physical parameter. The melting point is the temperature at which a substance changes from a solid state to a liquid state. The melting point can be determined by experiments, but it may vary slightly depending on the experimental conditions. The determination of the melting point helps to determine the purity of the compound. If the purity is high, the melting point range is narrow; if it contains impurities, the melting point may be offset and the melting range is widened.
In addition, its solubility is also an important property. In common organic solvents, its solubility varies. In some polar organic solvents, such as ethanol and dimethyl sulfoxide (DMSO), it may have a certain solubility. The characteristics of this solubility make it possible to select suitable solvents in the field of drug research and development to prepare solutions for subsequent experiments, such as pharmacological activity testing, pharmaceutical preparation research, etc. In water, its solubility may be relatively low. Because the molecular structure of the compound contains polar groups such as amino groups, but also non-polar parts such as benzene rings and chloropyrazine groups, the overall polarity is limited, resulting in poor solubility in strong polar solvents such as water.
In addition, the density of the compound is also one of the physical properties. Density reflects the mass per unit volume of a substance. Although the exact value needs to be determined experimentally and accurately, its density characteristics are of reference value in chemical production, material storage and transportation. Understanding its density can help calculate the volume occupied by a certain mass of the compound, so as to rationally plan the size of the storage container and the space required during transportation.
As for its appearance, it often appears in a white to white powder shape. This appearance feature is convenient for preliminary identification and judgment, and can be used as a reference for quality control in the production process. If there are obvious abnormalities in the appearance color and shape, or suggest problems in the production process, further inspection and analysis are required.
What is the synthesis of 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide?
4-Amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide, Chinese name or 4-amino-N- (5-chloropyrazin-2-yl) benzenesulfonamide, the synthesis method is as follows:
The starting material can be 5-chloropyrazin-2-amine and benzenesulfonamide chloride derivatives. First, 5-chloropyrazine-2-amine is placed in a suitable reaction vessel and dissolved in an appropriate amount of inert organic solvent, such as dichloromethane, N, N-dimethylformamide, etc. The inert organic solvent does not chemically react with the reactants and products, but only acts as a reaction medium, so that the reactants can be uniformly mixed, which is conducive to the reaction.
The reaction system is cooled to an appropriate low temperature, usually about 0 ° C. The purpose of low temperature is to control the reaction rate and avoid too violent reactions and side reactions. Slowly drop the solution containing benzenesulfonyl chloride derivatives. This process requires continuous stirring to fully contact the reactants and promote the reaction. The molar ratio of benzenesulfonyl chloride derivatives to 5-chloropyrazine-2-amine needs to be precisely controlled. Generally, a slight excess of benzenesulfonyl chloride derivatives helps the reaction to proceed in the direction of generating the target product.
After the dropwise addition is completed, the reaction system is gradually warmed to room temperature, or raised to an appropriate temperature according to the specific reaction requirements, and the stirring reaction is maintained for a certain period of time. At this stage, the reaction process needs to be monitored by thin-layer chromatography (TLC) or other suitable analytical means. When the raw material point is basically eliminated, the reaction is basically completed.
After the reaction is completed, an appropriate amount of water is added to the reaction system to quench the unreacted benzenesulfonyl chloride derivative and the product is precipitated from the organic solvent. Extraction with a suitable organic solvent can improve the yield of the product. The organic phase is collected and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture in the organic phase.
Subsequently, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product still contains impurities and needs to be further purified. Column chromatography can be used to elute with a suitable eluent to collect fractions containing the target product. The choice of eluent is crucial, and it needs to be prepared according to the polarity difference between the product and the impurity, so that the product and the impurity can be effectively separated.
Finally, the collected fractions are concentrated and crystallized to obtain a pure 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide product. The entire synthesis process requires strict control of reaction conditions, including temperature, reactant ratio, reaction time, etc., to ensure the purity and yield of the target product.
The starting material can be 5-chloropyrazin-2-amine and benzenesulfonamide chloride derivatives. First, 5-chloropyrazine-2-amine is placed in a suitable reaction vessel and dissolved in an appropriate amount of inert organic solvent, such as dichloromethane, N, N-dimethylformamide, etc. The inert organic solvent does not chemically react with the reactants and products, but only acts as a reaction medium, so that the reactants can be uniformly mixed, which is conducive to the reaction.
The reaction system is cooled to an appropriate low temperature, usually about 0 ° C. The purpose of low temperature is to control the reaction rate and avoid too violent reactions and side reactions. Slowly drop the solution containing benzenesulfonyl chloride derivatives. This process requires continuous stirring to fully contact the reactants and promote the reaction. The molar ratio of benzenesulfonyl chloride derivatives to 5-chloropyrazine-2-amine needs to be precisely controlled. Generally, a slight excess of benzenesulfonyl chloride derivatives helps the reaction to proceed in the direction of generating the target product.
After the dropwise addition is completed, the reaction system is gradually warmed to room temperature, or raised to an appropriate temperature according to the specific reaction requirements, and the stirring reaction is maintained for a certain period of time. At this stage, the reaction process needs to be monitored by thin-layer chromatography (TLC) or other suitable analytical means. When the raw material point is basically eliminated, the reaction is basically completed.
After the reaction is completed, an appropriate amount of water is added to the reaction system to quench the unreacted benzenesulfonyl chloride derivative and the product is precipitated from the organic solvent. Extraction with a suitable organic solvent can improve the yield of the product. The organic phase is collected and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture in the organic phase.
Subsequently, the organic solvent is removed by reduced pressure distillation to obtain a crude product. The crude product still contains impurities and needs to be further purified. Column chromatography can be used to elute with a suitable eluent to collect fractions containing the target product. The choice of eluent is crucial, and it needs to be prepared according to the polarity difference between the product and the impurity, so that the product and the impurity can be effectively separated.
Finally, the collected fractions are concentrated and crystallized to obtain a pure 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide product. The entire synthesis process requires strict control of reaction conditions, including temperature, reactant ratio, reaction time, etc., to ensure the purity and yield of the target product.
What are the precautions for the use of 4-amino-n- (5-chloropyrazin-2-yl) benzenesulfonamide?
4 - amino - N - (5 - chloropyrazin - 2 - yl) benzenesulfonamide is a chemical substance. When using it, many precautions should be kept in mind.
Bear the brunt of it, and safety protection must not be ignored. This substance may be toxic and irritating to a certain extent. When contacting, protective equipment must be comprehensive. If you are wearing a lab coat, you can prevent it from being contaminated with clothing; wear protective gloves to prevent it from touching the skin; goggles are also indispensable to protect your eyes from damage. If you come into contact, you should take appropriate measures quickly according to the contact area. If you come into contact with the skin, rinse with plenty of water immediately; if you come into contact with the eyes, rinse with running water in time and seek medical attention as soon as possible.
Furthermore, the storage process is also exquisite. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its nature or affected by environmental factors, improper temperature and humidity, or deterioration, affect the use effect, or even cause danger. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc. to prevent chemical reactions.
During use, operating standards are the key. Strictly follow established operating procedures and precisely control the dosage and reaction conditions. Whether it is in laboratory research or industrial production applications, dosage deviations, improper control of temperature and pressure can cause out-of-control reactions, not only product quality is not up to expectations, but also safety accidents.
In addition, disposal cannot be ignored. Do not discard at will, and should be properly disposed of in accordance with relevant regulations and standards. Or hand it over to a professional waste treatment agency, or use specific methods to dispose of it to avoid pollution to the environment.
In short, the use of 4-amino-N - (5-chloropyrazin-2-yl) benzenesulfonamide requires careful treatment in every link from safety protection, storage, operation to disposal, and must not be taken lightly.
Bear the brunt of it, and safety protection must not be ignored. This substance may be toxic and irritating to a certain extent. When contacting, protective equipment must be comprehensive. If you are wearing a lab coat, you can prevent it from being contaminated with clothing; wear protective gloves to prevent it from touching the skin; goggles are also indispensable to protect your eyes from damage. If you come into contact, you should take appropriate measures quickly according to the contact area. If you come into contact with the skin, rinse with plenty of water immediately; if you come into contact with the eyes, rinse with running water in time and seek medical attention as soon as possible.
Furthermore, the storage process is also exquisite. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its nature or affected by environmental factors, improper temperature and humidity, or deterioration, affect the use effect, or even cause danger. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc. to prevent chemical reactions.
During use, operating standards are the key. Strictly follow established operating procedures and precisely control the dosage and reaction conditions. Whether it is in laboratory research or industrial production applications, dosage deviations, improper control of temperature and pressure can cause out-of-control reactions, not only product quality is not up to expectations, but also safety accidents.
In addition, disposal cannot be ignored. Do not discard at will, and should be properly disposed of in accordance with relevant regulations and standards. Or hand it over to a professional waste treatment agency, or use specific methods to dispose of it to avoid pollution to the environment.
In short, the use of 4-amino-N - (5-chloropyrazin-2-yl) benzenesulfonamide requires careful treatment in every link from safety protection, storage, operation to disposal, and must not be taken lightly.
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