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4-Amino-N-(6-Chloro-3-Pyridazinyl)Benzenesulfonamide

Linshang Chemical

Specifications

HS Code

921178

Chemical Formula C10H9ClN4O2S
Molecular Weight 284.72 g/mol
Appearance Typically a solid (color may vary depending on purity and form)
Solubility Solubility characteristics can vary; may have limited solubility in water, more soluble in some organic solvents
Melting Point Specific melting point data would require experimental determination; generally, organic sulfonamides have defined melting points
Boiling Point Boiling point also depends on structure and intermolecular forces; would need experimental measurement
Pka The sulfonamide group may have an acidic pKa value, potentially around 10 - 12 for the sulfonamide - NH proton
Density Density data would be experimentally determined, and is related to its mass - volume ratio
Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents
Odor May have a faint characteristic odor typical of organic nitrogen - sulfur - containing compounds

As an accredited 4-Amino-N-(6-Chloro-3-Pyridazinyl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - amino - N - (6 - chloro - 3 - pyridazinyl)benzenesulfonamide in sealed plastic bags.
Storage Store 4 - amino - N - (6 - chloro - 3 - pyridazinyl)benzenesulfonamide in a cool, dry place away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and contact with air. Store separately from incompatible substances to avoid potential chemical reactions. Follow local safety regulations for chemical storage.
Shipping Ship 4 - amino - N - (6 - chloro - 3 - pyridazinyl)benzenesulfonamide in well - sealed containers, following all chemical shipping regulations. Ensure proper labeling for safe transportation. Use appropriate cushioning to prevent breakage during transit.
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4-Amino-N-(6-Chloro-3-Pyridazinyl)Benzenesulfonamide 4-Amino-N-(6-Chloro-3-Pyridazinyl)Benzenesulfonamide
General Information
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Frequently Asked Questions

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What is the chemical structure of 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide?
4 - amino - N - (6 - chloro - 3 - pyridazinyl) benzenesulfonamide, this is the name of an organic compound. To clarify its chemical structure, it can be analyzed according to its name.
Looking at its name, "benzenesulfonamide" indicates that its core is a benzenesulfonamide structure. Above the benzene ring, "4-amino" is represented by an amino group (-NH ²) at position 4 of the benzene ring. This amino group has certain electron-giving properties and can affect the electron cloud distribution and reactivity of the compound.
And "N - (6 - chloro - 3 - pyridazinyl) " indicates that there is a 6 - chloro - 3 - pyridazinyl group attached to the nitrogen atom (N) of the sulfonamide group. The pyridazine ring is a six-membered heterocyclic ring containing two nitrogen atoms, with a chlorine atom (-Cl) substituted at position 6. The chlorine atom has electron-withdrawing properties, which can affect the electron cloud density of the pyridazine ring and the physical and chemical properties of the whole molecule.
In summary, the structure of this compound is based on benzenesulfonamide as the core, the benzene ring has an amino group at the 4th position, and the sulfonamide nitrogen atom has a 6-chloro-3-pyridazine group structure. This structure endows the compound with unique physical, chemical and biological activities, and may have important significance and potential application value in the fields of medicinal chemistry and organic synthesis.
What are the main uses of 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide?
4 - amino - N - (6 - chloro - 3 - pyridazinyl) benzenesulfonamide, often called chloropyrazine sulfonamide in Chinese, is an organic compound. Its main uses are as follows:
1. ** Pharmaceutical research and development **: In the field of medicine, such compounds containing sulfonamide structures are often used as potential drug molecules. Many sulfonamide drugs have antibacterial, diuretic, antihypertensive and other effects. Such as some sulfonamide antibacterial drugs, which achieve antibacterial purposes by inhibiting the synthesis of bacterial folic acid. This compound may have potential value in the development of drugs for specific diseases, such as anti-infection and cardiovascular diseases, due to its special structure, and can provide structural basis and ideas for the creation of new drugs.
2. ** Agricultural Chemistry **: In the agricultural field, some compounds containing heterocyclic and sulfonamide structures can be used as pesticides for pest control. Or have bactericidal, insecticidal, and herbicidal activities, and play a role by interfering with specific physiological processes of pests. Such as some sulfonylureas herbicides, by inhibiting the activity of weed acetyllactic acid synthase, they hinder the growth and reproduction of weeds. This compound may be modified to become a new variety of pesticides with specific target selectivity, high efficiency and low toxicity, serving agricultural production.
3. ** Organic Synthesis Intermediates **: Because its structure contains active groups such as amino groups, chlorine atoms, and sulfonamide groups, it is often used as an important intermediate in the field of organic synthesis. It can react with other organic reagents through substitution reactions, condensation reactions, etc., to build more complex organic molecular structures. It lays the foundation for the synthesis of special functional materials, new ligands or other fine chemicals, and plays a key role in the molecular design and construction of organic synthetic chemistry, expanding the structural and functional diversity of organic compounds.
What are the physical properties of 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide?
4 - amino - N - (6 - chloro - 3 - pyridazinyl) benzenesulfonamide, Chinese name or 4 - amino - N - (6 - chloro - 3 - pyridazinyl) benzenesulfonamide. The physical properties of this substance are as follows:
Viewed under light, it is often white to quasi-white crystalline powder, and its shape is fine and uniform. Viewed under light, it is slightly shiny. In terms of smell, it is almost odorless, not pungent, and has no odor.
When it comes to melting point, it is about a specific range, which is one of the important identification characteristics. Due to the interaction and arrangement of atoms in the molecular structure, the melting point is stable in this range. When heated to this temperature, the substance gradually melts from the solid state to the liquid state, and this process is orderly and measurable.
In terms of solubility, it dissolves very little in water, like a bead in water, and it is difficult to melt with water. However, in organic solvents, such as methanol and ethanol, it has a certain solubility. Due to the existence of specific forces between organic molecules and organic solvent molecules, such as van der Waals force, hydrogen bonds, etc., it can disperse and dissolve in organic solvents to form a uniform and stable system.
Its density also has characteristics, which are determined by the type of atoms, the number of atoms and the way of molecular accumulation. The density value reflects the degree of molecular compactness, which provides a basis for substance identification and separation in related research and applications.
In addition, the fluidity of its powder also needs attention. Due to its powder form, in the production and processing process, the fluidity of the powder affects the operation of material transportation and mixing. Good fluidity can ensure smooth production and uniform distribution of materials, which is essential for the preparation of high-quality products.
These physical properties are of great significance in many fields such as drug research and development, chemical production, etc., and lay the foundation for material application and treatment.
What is the synthesis of 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide?
To prepare 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide, the following ancient method can be used.
First take the appropriate starting materials, 3-chloro-6-hydrazidazine and p-acetaminobenzenesulfonamide chloride. In a suitable reaction vessel, add an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., to help the raw materials dissolve and facilitate the reaction.
Cool the reaction system to a suitable low temperature, such as about 0 ° C, and then slowly add an acid binding agent, such as triethylamine, to neutralize the acid produced by the reaction and promote the reaction to proceed forward. Then, under stirring, the p-acetaminobenzenesulfonyl chloride is slowly added to the solution containing 3-chloro-6-hydrazidazine. This process requires strict temperature control to avoid the reaction being too violent and causing more side reactions.
After the addition is completed, gradually heat up to room temperature or slightly higher temperature, and continue to stir the reaction number. During this period, the reaction progress needs to be monitored by means of thin layer chromatography. When the raw material point is almost gone and the product point is obvious, the reaction can be regarded as basically complete.
Then, the reaction mixture is treated. The reaction is quenched with an appropriate amount of water first, and then extracted with an organic solvent for many times, and the organic phases are combined. The organic phase was dried with a desiccant such as anhydrous sodium sulfate, the desiccant was filtered off, and the organic solvent was removed by reduced pressure distillation to obtain a crude product.
The crude product was purified by column chromatography, and a suitable eluent was selected. According to the difference between the adsorption and elution of the product and the impurities on the silica gel column, the pure N - (6-chloro-3-pyridazinyl) -4-acetamido benzenesulfonamide was separated.
Finally, the product is placed in an appropriate amount of acid solution, such as hydrochloric acid-ethanol solution, heated and refluxed for hydrolysis, so that the acetamide group is converted to an amino group, and then processed, such as neutralization, concentration, crystallization and other steps, and finally 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide can be obtained.
What is the market outlook for 4-amino-n- (6-chloro-3-pyridazinyl) benzenesulfonamide?
4 - amino - N - (6 - chloro - 3 - pyridazinyl) benzenesulfonamide is an organic compound. Its market prospect depends on various fields such as medicine and chemical industry.
In the field of medicine, this compound may have potential medicinal value. However, at present, although its possible activity in the treatment path of specific diseases has been studied or revealed, it still needs to go through many hurdles to develop it into a formal drug. The first to bear the brunt is rigorous pharmacological and toxicological tests to prove its safety and effectiveness. This process takes time, manpower and huge resources. If it can successfully pass the trial and be approved for marketing, it is expected to gain a share of the drug market for the treatment of corresponding diseases. If the competition of similar drugs can demonstrate unique efficacy or advantages, such as higher efficacy and fewer side effects, it can gain a favorable position in the market.
As for the chemical industry, it may be a key intermediate for the synthesis of other fine chemicals. However, the chemical market is changing, and demand often changes according to the rise and fall of downstream industries. If the downstream industry has strong demand for chemicals synthesized with this intermediate, its market prospect is bright. On the contrary, if the downstream industry is sluggish and the demand decreases sharply, its market will also be troubled.
In addition, the market for this compound is greatly affected by policies and regulations. Environmental protection policies are becoming increasingly stringent. If the production process does not meet environmental protection requirements, it will be rectified, production will be limited, and market supply will also be affected. Furthermore, intellectual property protection is also a key point. If the research and development results are protected by patents, it will have an advantage in market competition.
In summary, the market prospects of 4-amino-N - (6-chloro-3-pyazinyl) benzenesulfonamide include both opportunities and challenges, depending on the combination of factors such as research and development progress, market demand, policies and regulations.