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4-Amino-N-(6-Chloro-5-Methoxy-4-Pyrimidinyl) Benzenesulfonamide
Linshang Chemical
|
HS Code |
572136 |
| Chemical Formula | C11H11ClN4O4S |
| Molecular Weight | 330.75 |
| Appearance | Solid (likely white or off - white powder) |
| Solubility | Solubility may vary; relatively insoluble in water, more soluble in organic solvents like DMSO |
| Melting Point | Typically has a defined melting point, specific value would need experimental determination |
| Boiling Point | Boiling point also depends on conditions and intermolecular forces, requires experimental data |
| Pka | Acidic/basic properties are related to pKa values which are specific to the functional groups, need experimental determination |
| Stability | Stable under normal storage conditions, but may decompose upon exposure to extreme heat, light, or reactive chemicals |
| Odor | Odorless or with a faint, characteristic odor |
| Reactivity | Reactive towards strong acids, bases, and some oxidizing/reducing agents due to its functional groups |
As an accredited 4-Amino-N-(6-Chloro-5-Methoxy-4-Pyrimidinyl) Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide in sealed container. |
| Storage | Store 4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl)Benzenesulfonamide in a cool, dry place. Keep it away from direct sunlight and heat sources. Ensure the storage area is well - ventilated. Store in a tightly sealed container to prevent exposure to moisture and air, which could potentially lead to degradation or chemical reactions. |
| Shipping | 4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide is shipped in accordance with strict chemical regulations. Packaged securely to prevent leakage, transported via approved carriers with proper hazard labeling for safe delivery. |
Competitive 4-Amino-N-(6-Chloro-5-Methoxy-4-Pyrimidinyl) Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Amino-N-(6-Chloro-5-Methoxy-4-Pyrimidinyl) Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-amino-n- (6-chloro-5-methoxy-4-pyrimidinyl) Benzenesulfonamide?
This is the question of 4-amino-N- (6-chloro-5-methoxy-4-pyrimidinyl) benzenesulfonamide. To clarify its chemical structure, it is necessary to analyze its name, and solve it layer by layer according to the convention of organic chemical nomenclature.
First look at "benzenesulfonamide", it can be seen that this is the root, phenylcyclosulfonyl group and amino group. The "4-amino" epiamino group is connected to the 4th position of the benzene ring. Look again at "N- (6-chloro-5-methoxy-4-pyrimidinyl) ", which means that the nitrogen atom of the sulfonamide is connected to a pyrimidine group. The 6-position of the pyrimidine group has a chlorine atom, the 5-position has a methoxy group, and it is connected to the 4-position.
In ancient Chinese, the structure of this compound is based on a benzene ring, and the sulfonamide group is attached to it, and the 4-position amino group is attached to it. There is also a pyrimidine ring, which is connected to benzenesulfonamide through a nitrogen atom. In this way, its chemical structure can be understood.
First look at "benzenesulfonamide", it can be seen that this is the root, phenylcyclosulfonyl group and amino group. The "4-amino" epiamino group is connected to the 4th position of the benzene ring. Look again at "N- (6-chloro-5-methoxy-4-pyrimidinyl) ", which means that the nitrogen atom of the sulfonamide is connected to a pyrimidine group. The 6-position of the pyrimidine group has a chlorine atom, the 5-position has a methoxy group, and it is connected to the 4-position.
In ancient Chinese, the structure of this compound is based on a benzene ring, and the sulfonamide group is attached to it, and the 4-position amino group is attached to it. There is also a pyrimidine ring, which is connected to benzenesulfonamide through a nitrogen atom. In this way, its chemical structure can be understood.
What are the main uses of 4-amino-n- (6-chloro-5-methoxy-4-pyrimidinyl) Benzenesulfonamide?
4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide, Chinese name or 4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) benzenesulfonamide, this is an organic compound. Its main uses involve the fields of medicine, agriculture and materials science, as detailed below:
In the field of medicine, such compounds are often used as key intermediates to synthesize antibacterial, antiviral and other drugs. The structure of pyrimidine and benzenesulfonamide gives it unique biological activities. Many studies have shown that drugs containing such structures have inhibitory effects on specific bacteria and viruses. For example, some antibacterial drugs developed on this basis can effectively interfere with the metabolism of bacterial folate, hinder the growth and reproduction of bacteria, and thus treat bacterial infections.
In agriculture, it can be used to create new pesticides. By modifying its chemical structure, highly selective and environmentally friendly insecticides or fungicides can be developed. It can precisely act on specific physiological processes of pests or pathogens, achieving the purpose of preventing and controlling crop diseases and pests, and helping to ensure crop yield and quality.
In the field of materials science, because of its specific electronic structure and chemical properties, it can participate in the synthesis of functional materials. If combined with other organic or inorganic materials, materials with special optical and electrical properties can be prepared, which may have application potential in optoelectronic devices, sensors, etc. For example, through special design and synthesis processes, or to make the resulting materials sensitive to specific substances, and then used to build high-sensitivity sensors to detect environmental pollutants or biomarkers.
In the field of medicine, such compounds are often used as key intermediates to synthesize antibacterial, antiviral and other drugs. The structure of pyrimidine and benzenesulfonamide gives it unique biological activities. Many studies have shown that drugs containing such structures have inhibitory effects on specific bacteria and viruses. For example, some antibacterial drugs developed on this basis can effectively interfere with the metabolism of bacterial folate, hinder the growth and reproduction of bacteria, and thus treat bacterial infections.
In agriculture, it can be used to create new pesticides. By modifying its chemical structure, highly selective and environmentally friendly insecticides or fungicides can be developed. It can precisely act on specific physiological processes of pests or pathogens, achieving the purpose of preventing and controlling crop diseases and pests, and helping to ensure crop yield and quality.
In the field of materials science, because of its specific electronic structure and chemical properties, it can participate in the synthesis of functional materials. If combined with other organic or inorganic materials, materials with special optical and electrical properties can be prepared, which may have application potential in optoelectronic devices, sensors, etc. For example, through special design and synthesis processes, or to make the resulting materials sensitive to specific substances, and then used to build high-sensitivity sensors to detect environmental pollutants or biomarkers.
What are the physical properties of 4-amino-n- (6-chloro-5-methoxy-4-pyrimidinyl) Benzenesulfonamide?
4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide, Chinese name or 4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) benzenesulfonamide. This is an organic compound, and its physical properties are interesting, so let me explain in detail.
Looking at its properties, under normal temperature and pressure, it is mostly in the state of white to light yellow crystalline powder. This state makes it relatively stable in many environments, making it easy to store and handle.
When it comes to the melting point, it is between 190 and 195 ° C. The characteristic of the melting point is of great significance in identifying the compound and controlling its purity. Once the melting point deviates from this range, or implies that the purity of the compound is poor, there are impurities.
Its solubility is also unique. In water, the solubility of the compound is relatively low, and it is only slightly soluble. Due to the molecular structure, there are both polar groups, such as amino and sulfonamide groups, and non-polar parts, such as benzene and pyrimidine rings, which limit its solubility in polar solvent water. However, in organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it exhibits good solubility. With this property, when synthesizing, separating and analyzing the compound, a suitable organic solvent can be cleverly selected to facilitate related operations.
In addition, the compound has a density of about 1.55 g/cm ³, which is indispensable for operations involving mass and volume conversion, such as solution preparation, reaction material measurement, etc.
In summary, the physical properties of 4 - amino - N- (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide, such as properties, melting point, solubility, density, etc., play a key role in many fields such as chemical research and drug development, providing an important basis for in-depth exploration of its chemical behavior and potential applications.
Looking at its properties, under normal temperature and pressure, it is mostly in the state of white to light yellow crystalline powder. This state makes it relatively stable in many environments, making it easy to store and handle.
When it comes to the melting point, it is between 190 and 195 ° C. The characteristic of the melting point is of great significance in identifying the compound and controlling its purity. Once the melting point deviates from this range, or implies that the purity of the compound is poor, there are impurities.
Its solubility is also unique. In water, the solubility of the compound is relatively low, and it is only slightly soluble. Due to the molecular structure, there are both polar groups, such as amino and sulfonamide groups, and non-polar parts, such as benzene and pyrimidine rings, which limit its solubility in polar solvent water. However, in organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it exhibits good solubility. With this property, when synthesizing, separating and analyzing the compound, a suitable organic solvent can be cleverly selected to facilitate related operations.
In addition, the compound has a density of about 1.55 g/cm ³, which is indispensable for operations involving mass and volume conversion, such as solution preparation, reaction material measurement, etc.
In summary, the physical properties of 4 - amino - N- (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide, such as properties, melting point, solubility, density, etc., play a key role in many fields such as chemical research and drug development, providing an important basis for in-depth exploration of its chemical behavior and potential applications.
What is the preparation method of 4-amino-n- (6-chloro-5-methoxy-4-pyrimidinyl) Benzenesulfonamide?
4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide is 4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) benzenesulfonamide, which is prepared as follows:
The starting material is often selected from suitable benzenesulfonyl chloride and amine compounds containing pyrimidine structure. First, take an appropriate amount of amine containing pyrimidine structure. This amine needs to have 6-chloro-5-methoxy-4-pyrimidine group, place it in a reactor, add an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide (DMF), etc., stir to dissolve it evenly to form a uniform solution.
Then, under stirring, slowly add the solution containing 4-aminobenzenesulfonyl chloride dropwise. The temperature needs to be strictly controlled during the dropwise addition process, generally maintained at a lower temperature, such as 0-5 ° C, to prevent side reactions from occurring. After the dropwise addition is completed, gradually raise the temperature to room temperature, and continue to stir the reaction for several hours to make the reaction fully proceed. This reaction is a nucleophilic substitution reaction, in which the chlorine atom in benzenesulfonyl chloride is replaced by the amino group in pyrimidine amine, thereby forming the basic structure of the target product. After the
reaction is completed, an appropriate amount of water is added to the reaction system to quench the unreacted raw material and promote the precipitation of the product. Next, the product is preliminarily separated by means of filtration or extraction. If the product is precipitated in solid form, it can be directly filtered and collected; if the product is dissolved in the organic phase, it needs to be extracted with a suitable organic solvent to collect the organic phase. After
, the product obtained by the preliminary separation is purified The common purification method is column chromatography. Appropriate silica gel column is selected. Petroleum ether, ethyl acetate, etc. are mixed in different proportions as eluents to gradually elute impurities and collect the eluent containing the target product. Then the eluent is removed by reduced pressure distillation to obtain relatively pure 4-amino-N - (6-chloro-5-methoxy-4-pyrimidinyl) benzenesulfonamide. During the entire preparation process, the reaction process should be closely monitored. The reaction endpoint can be determined by means of thin-layer chromatography (TLC), and the reaction conditions, such as temperature, material ratio, reaction time, etc. should be strictly controlled to ensure high yield and purity.
The starting material is often selected from suitable benzenesulfonyl chloride and amine compounds containing pyrimidine structure. First, take an appropriate amount of amine containing pyrimidine structure. This amine needs to have 6-chloro-5-methoxy-4-pyrimidine group, place it in a reactor, add an appropriate amount of organic solvent, such as dichloromethane, N, N-dimethylformamide (DMF), etc., stir to dissolve it evenly to form a uniform solution.
Then, under stirring, slowly add the solution containing 4-aminobenzenesulfonyl chloride dropwise. The temperature needs to be strictly controlled during the dropwise addition process, generally maintained at a lower temperature, such as 0-5 ° C, to prevent side reactions from occurring. After the dropwise addition is completed, gradually raise the temperature to room temperature, and continue to stir the reaction for several hours to make the reaction fully proceed. This reaction is a nucleophilic substitution reaction, in which the chlorine atom in benzenesulfonyl chloride is replaced by the amino group in pyrimidine amine, thereby forming the basic structure of the target product. After the
reaction is completed, an appropriate amount of water is added to the reaction system to quench the unreacted raw material and promote the precipitation of the product. Next, the product is preliminarily separated by means of filtration or extraction. If the product is precipitated in solid form, it can be directly filtered and collected; if the product is dissolved in the organic phase, it needs to be extracted with a suitable organic solvent to collect the organic phase. After
, the product obtained by the preliminary separation is purified The common purification method is column chromatography. Appropriate silica gel column is selected. Petroleum ether, ethyl acetate, etc. are mixed in different proportions as eluents to gradually elute impurities and collect the eluent containing the target product. Then the eluent is removed by reduced pressure distillation to obtain relatively pure 4-amino-N - (6-chloro-5-methoxy-4-pyrimidinyl) benzenesulfonamide. During the entire preparation process, the reaction process should be closely monitored. The reaction endpoint can be determined by means of thin-layer chromatography (TLC), and the reaction conditions, such as temperature, material ratio, reaction time, etc. should be strictly controlled to ensure high yield and purity.
4-Amino-n- (6-chloro-5-methoxy-4-pyrimidinyl) What are the precautions when using Benzenesulfonamide?
4 - amino - N - (6 - chloro - 5 - methoxy - 4 - pyrimidinyl) Benzenesulfonamide is a chemical substance. When using it, pay attention to many things.
First, safety protection must not be forgotten. This substance may be toxic and irritating. When operating, be sure to wear suitable protective equipment, such as gloves, goggles, laboratory clothes, etc., to prevent skin and eyes from coming into contact with it, and to avoid inhaling its dust or volatile gas. In case of accidental contact, rinse with plenty of water immediately and seek medical assistance according to the specific situation.
Second, storage conditions need to be treated with caution. It should be stored in a dry, cool and well-ventilated place, away from fire, heat and oxidants, etc., to prevent reactions, deterioration or danger. At the same time, it should be stored separately from other chemicals to avoid confusion and misuse.
Third, the use process is strictly operated. Follow the established experimental procedures and operating guidelines, accurately weigh and configure the required concentration solution. The experimental environment ensures smooth ventilation and reduces the accumulation of harmful gases. During chemical reactions, pay close attention to the reaction conditions, such as temperature, pH, reaction time, etc., and strictly control to ensure the smooth progress of the reaction and avoid side reactions.
Fourth, waste treatment should not be underestimated. After use, the remaining substances and waste should not be discarded at will, and should be properly disposed of in accordance with relevant regulations. For waste liquids and waste residues containing this substance, they should be collected by classification and handed over to professional institutions for treatment to avoid pollution to the environment.
All these precautions are related to the safety and effectiveness of the use of this substance, and must be strictly followed and cannot be slack.
First, safety protection must not be forgotten. This substance may be toxic and irritating. When operating, be sure to wear suitable protective equipment, such as gloves, goggles, laboratory clothes, etc., to prevent skin and eyes from coming into contact with it, and to avoid inhaling its dust or volatile gas. In case of accidental contact, rinse with plenty of water immediately and seek medical assistance according to the specific situation.
Second, storage conditions need to be treated with caution. It should be stored in a dry, cool and well-ventilated place, away from fire, heat and oxidants, etc., to prevent reactions, deterioration or danger. At the same time, it should be stored separately from other chemicals to avoid confusion and misuse.
Third, the use process is strictly operated. Follow the established experimental procedures and operating guidelines, accurately weigh and configure the required concentration solution. The experimental environment ensures smooth ventilation and reduces the accumulation of harmful gases. During chemical reactions, pay close attention to the reaction conditions, such as temperature, pH, reaction time, etc., and strictly control to ensure the smooth progress of the reaction and avoid side reactions.
Fourth, waste treatment should not be underestimated. After use, the remaining substances and waste should not be discarded at will, and should be properly disposed of in accordance with relevant regulations. For waste liquids and waste residues containing this substance, they should be collected by classification and handed over to professional institutions for treatment to avoid pollution to the environment.
All these precautions are related to the safety and effectiveness of the use of this substance, and must be strictly followed and cannot be slack.
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