Linshang Chemical
PRODUCTS
4-Amino-N-(6-Chloropyridazin-3-Yl)Benzenesulfonamide
Linshang Chemical
|
HS Code |
206529 |
| Chemical Formula | C11H9ClN4O2S |
| Molecular Weight | 296.73 g/mol |
| Appearance | Solid (usually powder) |
| Physical State At Room Temp | Solid |
| Odor | Odorless (usually) |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like DMSO |
| Melting Point | Specific value would need experimental determination |
| Boiling Point | Decomposes before boiling (usually) |
| Pka | Value depends on the environment and specific functional groups |
| Stability | Stable under normal conditions, may react with strong oxidizing agents |
As an accredited 4-Amino-N-(6-Chloropyridazin-3-Yl)Benzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - amino - N - (6 - chloropyridazin - 3 - yl)benzenesulfonamide in sealed plastic bags. |
| Storage | Store 4 - amino - N - (6 - chloropyridazin - 3 - yl)benzenesulfonamide in a cool, dry place away from direct sunlight. Keep it in a well - sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Avoid storing near heat sources or incompatible substances to maintain its chemical integrity. |
| Shipping | Ship 4 - amino - N - (6 - chloropyridazin - 3 - yl)benzenesulfonamide in sealed, corrosion - resistant containers. Ensure compliance with chemical shipping regulations, and use appropriate cushioning to prevent damage during transit. |
Competitive 4-Amino-N-(6-Chloropyridazin-3-Yl)Benzenesulfonamide prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Amino-N-(6-Chloropyridazin-3-Yl)Benzenesulfonamide in China?
As a trusted 4-Amino-N-(6-Chloropyridazin-3-Yl)Benzenesulfonamide manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Amino-N-(6-Chloropyridazin-3-Yl)Benzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4-amino-n- (6-chloropyridazin-3-yl) benzenesulfonamide
4-Amino-N- (6-chloropyridazin-3-yl) benzenesulfonamide, often referred to as 6-chloropyridazin-3-yl-4-aminobenzenesulfonamide in Chinese, has many applications in the field of medicine and is a key pharmaceutical chemical intermediate.
The domain of Guanfu Pharmaceutical's creation, this compound is often the cornerstone of the development of new antibacterial and anti-inflammatory drugs. In the process of antibacterial drug development, its unique chemical structure can be closely bound to specific targets in bacteria. Because the growth and reproduction of bacteria require the participation of specific proteins and enzymes, the compound can precisely act on these key components, or inhibit the activity of enzymes, or interfere with protein synthesis, causing bacterial growth to be hindered and reproduction to be unsustainable, and eventually the bacteria die, thus achieving antibacterial effect.
In the development of anti-inflammatory drugs, it can regulate the body's immune response and the release of inflammatory mediators. When inflammation occurs, many inflammatory mediators such as cytokines and prostaglandins in the body will be produced in large quantities, causing symptoms such as redness, swelling and pain. This compound can act on inflammation-related signaling pathways, reduce the generation and release of inflammatory mediators, thereby relieving inflammatory responses and relieving patient pain.
Furthermore, in pharmaceutical chemistry research, 4-amino-N - (6-chloropyridazin-3-yl) benzenesulfonamide is often used as a lead compound. Based on it, researchers have modified and modified its structure, such as introducing different substituents on the benzene ring or the pyridazine ring, changing its electron cloud density and spatial structure, etc., to optimize the activity, selectivity and pharmacokinetic properties of the compound, hoping to obtain new drugs with better efficacy and less side effects. Therefore, it plays a pivotal role in the field of modern drug development.
The domain of Guanfu Pharmaceutical's creation, this compound is often the cornerstone of the development of new antibacterial and anti-inflammatory drugs. In the process of antibacterial drug development, its unique chemical structure can be closely bound to specific targets in bacteria. Because the growth and reproduction of bacteria require the participation of specific proteins and enzymes, the compound can precisely act on these key components, or inhibit the activity of enzymes, or interfere with protein synthesis, causing bacterial growth to be hindered and reproduction to be unsustainable, and eventually the bacteria die, thus achieving antibacterial effect.
In the development of anti-inflammatory drugs, it can regulate the body's immune response and the release of inflammatory mediators. When inflammation occurs, many inflammatory mediators such as cytokines and prostaglandins in the body will be produced in large quantities, causing symptoms such as redness, swelling and pain. This compound can act on inflammation-related signaling pathways, reduce the generation and release of inflammatory mediators, thereby relieving inflammatory responses and relieving patient pain.
Furthermore, in pharmaceutical chemistry research, 4-amino-N - (6-chloropyridazin-3-yl) benzenesulfonamide is often used as a lead compound. Based on it, researchers have modified and modified its structure, such as introducing different substituents on the benzene ring or the pyridazine ring, changing its electron cloud density and spatial structure, etc., to optimize the activity, selectivity and pharmacokinetic properties of the compound, hoping to obtain new drugs with better efficacy and less side effects. Therefore, it plays a pivotal role in the field of modern drug development.
What are the chemical properties of 4-amino-n- (6-chloropyridazin-3-yl) benzenesulfonamide
4 - amino - N - (6 - chloropyridazin - 3 - yl) benzenesulfonamide, this is an organic compound. Its chemical properties are unique, let me explain in detail.
From the structural point of view, the compound contains benzenesulfonamide structure and pyrazine structure, and the 6th position of the pyrazine ring has chlorine atom substitution, and the 4th position of the benzene ring has amino group. This structure gives it a variety of chemical activities.
It has a certain acid-base nature. The amino group is weakly basic, and in an appropriate acid-base environment, it can react with the acid to form a corresponding salt. For example, in the case of strong acids, the amino nitrogen atom can accept protons, making the compound positively charged.
The sulfonyl group of the benzenesulfonamide part has a certain electron-absorbing property, which affects the distribution of molecular electron clouds. This not only affects the acidity and alkalinity of the compound, but also plays a role in its chemical reactivity. For example, in the nucleophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the electron-absorbing of the sulfonyl group, and the difficulty of the nucleophilic reagent to attack the benzene ring increases; but the electron cloud density on the ring also changes due to the electron-absorbing of the pyrazine ring due to the chlorine atom. Under certain conditions, a nucleophilic substitution reaction can occur, and the chlorine atom can be replaced by a suitable nucleophilic reagent.
In addition, the compound has certain optical properties due to the conjugated system. Under ultraviolet light irradiation, Due to the existence of various functional groups in its structure, it can participate in many organic reactions, such as the reaction with acyl chloride to form amide derivatives, providing an important intermediate for organic synthesis and has potential application value in pharmaceutical chemistry, materials science and other fields.
From the structural point of view, the compound contains benzenesulfonamide structure and pyrazine structure, and the 6th position of the pyrazine ring has chlorine atom substitution, and the 4th position of the benzene ring has amino group. This structure gives it a variety of chemical activities.
It has a certain acid-base nature. The amino group is weakly basic, and in an appropriate acid-base environment, it can react with the acid to form a corresponding salt. For example, in the case of strong acids, the amino nitrogen atom can accept protons, making the compound positively charged.
The sulfonyl group of the benzenesulfonamide part has a certain electron-absorbing property, which affects the distribution of molecular electron clouds. This not only affects the acidity and alkalinity of the compound, but also plays a role in its chemical reactivity. For example, in the nucleophilic substitution reaction, the electron cloud density of the benzene ring decreases due to the electron-absorbing of the sulfonyl group, and the difficulty of the nucleophilic reagent to attack the benzene ring increases; but the electron cloud density on the ring also changes due to the electron-absorbing of the pyrazine ring due to the chlorine atom. Under certain conditions, a nucleophilic substitution reaction can occur, and the chlorine atom can be replaced by a suitable nucleophilic reagent.
In addition, the compound has certain optical properties due to the conjugated system. Under ultraviolet light irradiation, Due to the existence of various functional groups in its structure, it can participate in many organic reactions, such as the reaction with acyl chloride to form amide derivatives, providing an important intermediate for organic synthesis and has potential application value in pharmaceutical chemistry, materials science and other fields.
What is the synthesis method of 4-amino-n- (6-chloropyridazin-3-yl) benzenesulfonamide
4 - amino - N - (6 - chloropyridazin - 3 - yl) benzenesulfonamide is an organic compound, and its synthesis method is complicated, so let me explain in detail.
The first step is often the selection and preparation of raw materials. 6 - chloropyridazine - 3 - amine and p-aminobenzenesulfonyl chloride can be selected as the main raw materials. The key reaction can only occur under specific reaction conditions.
The second time is the reaction progress. 6-Chloropyridazine-3-amine and p-aminobenzenesulfonyl chloride are placed in a suitable reaction solvent, such as dichloromethane, N, N-dimethylformamide, etc. The reaction system needs to be stable at the appropriate temperature and pH. Alkali substances such as triethylamine and pyridine are often used as catalysts to promote the reaction. Alkali can assist in the activation of p-aminobenzenesulfonyl chloride, making it easier to undergo nucleophilic substitution with 6-chloropyridazine-3-amine.
The reaction process needs to be closely monitored. The reaction progress can be tracked by thin layer chromatography (TLC). When the raw material point is significantly reduced and the product point appears clearly and no longer changes, the reaction can be preliminarily determined to be completed.
After the reaction is completed, it needs to go through the steps of separation and purification. Column chromatography is commonly used, using silica gel as the fixed phase, selecting a suitable eluent, such as a mixed solvent of petroleum ether and ethyl acetate, and eluting it in different proportions to effectively separate the product from impurities. Or using recrystallization method, according to the solubility difference of the product in different solvents, select a suitable solvent, heat to dissolve the product, slowly cool it, and allow the product to crystallize and precipitate, so as to achieve the purpose of purification.
At the end, the structure of the obtained product needs to be confirmed. Analysis methods such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and infrared spectroscopy (IR) can be used. NMR can reveal the chemical environment and connection mode of hydrogen and carbon atoms in molecules; MS can determine the relative molecular mass and fragment information of molecules; IR can confirm the existence of specific functional groups in molecules. After these steps, pure and structurally confirmed 4-amino-N - (6-chloropyridazin-3-yl) benzenesulfonamide products can be obtained.
The first step is often the selection and preparation of raw materials. 6 - chloropyridazine - 3 - amine and p-aminobenzenesulfonyl chloride can be selected as the main raw materials. The key reaction can only occur under specific reaction conditions.
The second time is the reaction progress. 6-Chloropyridazine-3-amine and p-aminobenzenesulfonyl chloride are placed in a suitable reaction solvent, such as dichloromethane, N, N-dimethylformamide, etc. The reaction system needs to be stable at the appropriate temperature and pH. Alkali substances such as triethylamine and pyridine are often used as catalysts to promote the reaction. Alkali can assist in the activation of p-aminobenzenesulfonyl chloride, making it easier to undergo nucleophilic substitution with 6-chloropyridazine-3-amine.
The reaction process needs to be closely monitored. The reaction progress can be tracked by thin layer chromatography (TLC). When the raw material point is significantly reduced and the product point appears clearly and no longer changes, the reaction can be preliminarily determined to be completed.
After the reaction is completed, it needs to go through the steps of separation and purification. Column chromatography is commonly used, using silica gel as the fixed phase, selecting a suitable eluent, such as a mixed solvent of petroleum ether and ethyl acetate, and eluting it in different proportions to effectively separate the product from impurities. Or using recrystallization method, according to the solubility difference of the product in different solvents, select a suitable solvent, heat to dissolve the product, slowly cool it, and allow the product to crystallize and precipitate, so as to achieve the purpose of purification.
At the end, the structure of the obtained product needs to be confirmed. Analysis methods such as nuclear magnetic resonance (NMR), mass spectrometry (MS), and infrared spectroscopy (IR) can be used. NMR can reveal the chemical environment and connection mode of hydrogen and carbon atoms in molecules; MS can determine the relative molecular mass and fragment information of molecules; IR can confirm the existence of specific functional groups in molecules. After these steps, pure and structurally confirmed 4-amino-N - (6-chloropyridazin-3-yl) benzenesulfonamide products can be obtained.
What is the price of 4-amino-n- (6-chloropyridazin-3-yl) benzenesulfonamide in the market?
4 - amino - n - (6 - chloropyridazin - 3 - yl) benzenesulfonamide is also a chemical substance. It is not easy to know its market price. The price of this compound often changes for a variety of reasons.
First, the simplicity of the production process is related to the cost. If the preparation of this compound requires complex steps, special raw materials or harsh reaction conditions, the cost will be high, and the price will rise accordingly. Second, the market supply and demand shape the price. If demand is strong and supply is limited, the price will rise; conversely, if supply is abundant and demand is insufficient, the price will fall. Third, the purity of the product affects the price. High purity 4 - amino - n - (6 - chloropyridazin - 3 - yl) benzenesulfonamide, because of its high quality, often get higher prices.
In addition, different suppliers have different pricing due to their own cost structures and market strategies. Some suppliers sell at lower prices because they have a market share; while some suppliers have slightly higher prices due to their advantages such as brands and services. And the market price is not static, and will change accordingly over time due to fluctuations in raw material prices, technological innovation, policy adjustments, etc. Therefore, to determine the exact market price of 4 - amino - n - (6 - chloropyridazin - 3 - yl) benzenesulfonamide, it is necessary to consult the chemical product trading platform, consult relevant suppliers or industry insiders to obtain the latest and accurate price information.
First, the simplicity of the production process is related to the cost. If the preparation of this compound requires complex steps, special raw materials or harsh reaction conditions, the cost will be high, and the price will rise accordingly. Second, the market supply and demand shape the price. If demand is strong and supply is limited, the price will rise; conversely, if supply is abundant and demand is insufficient, the price will fall. Third, the purity of the product affects the price. High purity 4 - amino - n - (6 - chloropyridazin - 3 - yl) benzenesulfonamide, because of its high quality, often get higher prices.
In addition, different suppliers have different pricing due to their own cost structures and market strategies. Some suppliers sell at lower prices because they have a market share; while some suppliers have slightly higher prices due to their advantages such as brands and services. And the market price is not static, and will change accordingly over time due to fluctuations in raw material prices, technological innovation, policy adjustments, etc. Therefore, to determine the exact market price of 4 - amino - n - (6 - chloropyridazin - 3 - yl) benzenesulfonamide, it is necessary to consult the chemical product trading platform, consult relevant suppliers or industry insiders to obtain the latest and accurate price information.
How safe is 4-amino-n- (6-chloropyridazin-3-yl) benzenesulfonamide
4 - amino - N - (6 - chloropyridazin - 3 - yl) benzenesulfonamide, this is an organic compound. Its safety is related to many aspects and needs to be investigated in detail with caution.
In terms of toxicity, it needs to be carefully investigated by experiments. Animal experiments may reveal its effects on various systems of the body, such as liver, kidney and other organ functions. If this compound enters the body, it may interact with biological macromolecules and interfere with normal physiological and biochemical processes. If it is toxic to cells, it may affect cell proliferation, differentiation and apoptosis, and then cause adverse consequences for the growth and development of organisms.
In terms of environmental safety, it should not be underestimated. How stable it is in the environment, if the stability is quite high, it may persist in the environment for a long time. Its migration and transformation laws in soil and water bodies need to be studied in depth to understand whether it will accumulate in the environment and whether it will affect soil microbial communities, aquatic organisms and other ecosystem components. For example, if it is toxic to aquatic organisms, it may destroy the aquatic ecological balance and affect the survival and reproduction of fish, plankton and other organisms.
In terms of its chemical properties, because it contains amino groups, chlorine atoms, sulfonamide groups and other functional groups, these functional groups may endow it with certain chemical activities. Under certain conditions, chemical reactions may occur to generate new substances, and the safety of these new substances also needs to be considered. If you come into contact with other chemical substances during storage or use, whether it will cause dangerous chemical reactions, such as violent redox reactions, toxic gases, etc., all need to be taken seriously.
The safety of this compound needs to be explored in depth from multiple dimensions, including toxicity studies, environmental behavior studies, and chemical property analysis. Only in this way can its safety be fully recognized, so that appropriate measures can be taken during use and disposal to protect human health and the safety of the ecological environment.
In terms of toxicity, it needs to be carefully investigated by experiments. Animal experiments may reveal its effects on various systems of the body, such as liver, kidney and other organ functions. If this compound enters the body, it may interact with biological macromolecules and interfere with normal physiological and biochemical processes. If it is toxic to cells, it may affect cell proliferation, differentiation and apoptosis, and then cause adverse consequences for the growth and development of organisms.
In terms of environmental safety, it should not be underestimated. How stable it is in the environment, if the stability is quite high, it may persist in the environment for a long time. Its migration and transformation laws in soil and water bodies need to be studied in depth to understand whether it will accumulate in the environment and whether it will affect soil microbial communities, aquatic organisms and other ecosystem components. For example, if it is toxic to aquatic organisms, it may destroy the aquatic ecological balance and affect the survival and reproduction of fish, plankton and other organisms.
In terms of its chemical properties, because it contains amino groups, chlorine atoms, sulfonamide groups and other functional groups, these functional groups may endow it with certain chemical activities. Under certain conditions, chemical reactions may occur to generate new substances, and the safety of these new substances also needs to be considered. If you come into contact with other chemical substances during storage or use, whether it will cause dangerous chemical reactions, such as violent redox reactions, toxic gases, etc., all need to be taken seriously.
The safety of this compound needs to be explored in depth from multiple dimensions, including toxicity studies, environmental behavior studies, and chemical property analysis. Only in this way can its safety be fully recognized, so that appropriate measures can be taken during use and disposal to protect human health and the safety of the ecological environment.
Scan to WhatsApp
