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4-Benzyloxy-3-Chlorobromobenzene
Linshang Chemical
|
HS Code |
926293 |
| Chemical Formula | C13H10BrClO |
| Molecular Weight | 283.58 |
| Appearance | Solid (Typical description, actual may vary) |
| Solubility In Water | Low (Aromatic halides generally have low water solubility) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low (Based on its physical state and structure) |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Benzyloxy-3-Chlorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - benzyloxy - 3 - chlorobromobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - benzyloxy - 3 - chlorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of heat, ignition, and oxidizing agents. Store in a tightly closed container to prevent moisture and air exposure, which could potentially lead to chemical degradation. Label the storage container clearly to avoid misidentification. |
| Shipping | 4 - benzyloxy - 3 - chlorobromobenzene is shipped in accordance with chemical transport regulations. It's carefully packaged in suitable containers to prevent leakage, transported under controlled conditions to maintain stability. |
Competitive 4-Benzyloxy-3-Chlorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Benzyloxy-3-Chlorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 4-benzyloxy-3-chlorobromobenzene?
4-Benzyloxy-3-chlorobrombenzene is also an organic compound. Its physical properties are worth exploring.
Looking at its properties, under normal circumstances, it is mostly white to pale yellow solids. Due to the characteristics of its molecular structure, the intermolecular forces make the substance appear like this. Its melting point is also an important physical property. It has been measured by many experiments that it is about a specific temperature range. The definition of this temperature range depends on precise instruments and rigorous experimental procedures. Due to the arrangement and interaction between molecules, specific energy is required to destroy the lattice structure, resulting in this melting point characteristic.
When it comes to solubility, it shows a certain solubility in common organic solvents, such as ether and dichloromethane. This is because the molecule of the compound has both lipophilic parts, and interactions such as van der Waals forces can be formed with organic solvent molecules, so it can be dissolved in it. However, in water, the solubility is very small, because the overall polarity of the molecule does not match the strong polar environment of water, it is difficult to form an effective interaction between water molecules and the compound molecules to promote dissolution.
Its density is also a key physical property, and its density value can be obtained by precise measurement. This value reflects the mass of the substance per unit volume, which is closely related to the relative mass of the molecule and the degree of molecular accumulation. Due to the molecular structure including benzyloxy, chlorine and bromine atoms, the relative mass and spatial arrangement of the compound affect the overall density.
In addition, the boiling point of the compound is also affected by intermolecular forces. Due to the existence of various forces between molecules, such as dispersion forces, dipole-dipole forces, etc., in order to transform the substance from a liquid state to a gas state, it is necessary to provide enough energy to overcome these forces, so as to exhibit a specific boiling point.
All these physical properties are of great significance in many fields such as organic synthesis and drug development. In organic synthesis, separation and purification methods can be designed according to their solubility, melting point, and other properties. During drug development, physical properties are closely related to pharmacokinetic properties such as drug absorption and distribution, which is crucial for the development of efficient and safe drugs.
Looking at its properties, under normal circumstances, it is mostly white to pale yellow solids. Due to the characteristics of its molecular structure, the intermolecular forces make the substance appear like this. Its melting point is also an important physical property. It has been measured by many experiments that it is about a specific temperature range. The definition of this temperature range depends on precise instruments and rigorous experimental procedures. Due to the arrangement and interaction between molecules, specific energy is required to destroy the lattice structure, resulting in this melting point characteristic.
When it comes to solubility, it shows a certain solubility in common organic solvents, such as ether and dichloromethane. This is because the molecule of the compound has both lipophilic parts, and interactions such as van der Waals forces can be formed with organic solvent molecules, so it can be dissolved in it. However, in water, the solubility is very small, because the overall polarity of the molecule does not match the strong polar environment of water, it is difficult to form an effective interaction between water molecules and the compound molecules to promote dissolution.
Its density is also a key physical property, and its density value can be obtained by precise measurement. This value reflects the mass of the substance per unit volume, which is closely related to the relative mass of the molecule and the degree of molecular accumulation. Due to the molecular structure including benzyloxy, chlorine and bromine atoms, the relative mass and spatial arrangement of the compound affect the overall density.
In addition, the boiling point of the compound is also affected by intermolecular forces. Due to the existence of various forces between molecules, such as dispersion forces, dipole-dipole forces, etc., in order to transform the substance from a liquid state to a gas state, it is necessary to provide enough energy to overcome these forces, so as to exhibit a specific boiling point.
All these physical properties are of great significance in many fields such as organic synthesis and drug development. In organic synthesis, separation and purification methods can be designed according to their solubility, melting point, and other properties. During drug development, physical properties are closely related to pharmacokinetic properties such as drug absorption and distribution, which is crucial for the development of efficient and safe drugs.
What are the chemical properties of 4-benzyloxy-3-chlorobromobenzene?
4-Benzyloxy-3-chlorobrombenzene, an organic compound, has unique chemical properties and is widely used in the field of organic synthesis.
First of all, its structure contains two halogen atoms, bromine and chlorine. Halogen atoms are highly active and can participate in many reactions. For example, in nucleophilic substitution reactions, bromine atoms are more active. Under suitable nucleophilic reagents and reaction conditions, they are easily replaced by nucleophilic reagents. For example, when reacted with sodium alcohol, bromine atoms can be replaced by alkoxy groups to form ether compounds; when reacted with amines, nitrogen-containing derivatives can be formed.
Furthermore, the benzyloxy moiety also has certain reactivity. Benzyl carbon-oxygen bonds can be broken under specific conditions. For example, in a strongly acidic environment or under the action of some metal catalysts, benzyl groups may leave to form phenolic derivatives, which may participate in subsequent reactions.
In addition, there are chlorine atoms, bromine atoms and benzyloxy groups on the benzene ring of the compound, which affect the electron cloud density and reactivity of the benzene ring. Due to the combined action of chlorine and bromine as electron-withdrawing groups and benzyloxy groups as power-supplying sub-groups, the density distribution of the electron cloud of the benzene ring is changed, which affects the location and activity of the electrophilic substitution reaction. Generally speaking, the power-supplying sub-groups increase the density of the electron clouds of the benzene ring, and the electrophilic reagents are more likely to attack In conclusion, 4-benzyloxy-3-chlorobromobenzene can participate in many reactions such as nucleophilic substitution, benzyl departure and electrophilic substitution due to the characteristics of halogen atom, benzyloxy group and benzene ring. It can be used as a key intermediate in organic synthesis to construct complex organic molecular structures.
First of all, its structure contains two halogen atoms, bromine and chlorine. Halogen atoms are highly active and can participate in many reactions. For example, in nucleophilic substitution reactions, bromine atoms are more active. Under suitable nucleophilic reagents and reaction conditions, they are easily replaced by nucleophilic reagents. For example, when reacted with sodium alcohol, bromine atoms can be replaced by alkoxy groups to form ether compounds; when reacted with amines, nitrogen-containing derivatives can be formed.
Furthermore, the benzyloxy moiety also has certain reactivity. Benzyl carbon-oxygen bonds can be broken under specific conditions. For example, in a strongly acidic environment or under the action of some metal catalysts, benzyl groups may leave to form phenolic derivatives, which may participate in subsequent reactions.
In addition, there are chlorine atoms, bromine atoms and benzyloxy groups on the benzene ring of the compound, which affect the electron cloud density and reactivity of the benzene ring. Due to the combined action of chlorine and bromine as electron-withdrawing groups and benzyloxy groups as power-supplying sub-groups, the density distribution of the electron cloud of the benzene ring is changed, which affects the location and activity of the electrophilic substitution reaction. Generally speaking, the power-supplying sub-groups increase the density of the electron clouds of the benzene ring, and the electrophilic reagents are more likely to attack In conclusion, 4-benzyloxy-3-chlorobromobenzene can participate in many reactions such as nucleophilic substitution, benzyl departure and electrophilic substitution due to the characteristics of halogen atom, benzyloxy group and benzene ring. It can be used as a key intermediate in organic synthesis to construct complex organic molecular structures.
What are the main uses of 4-benzyloxy-3-chlorobromobenzene?
4-Benzyloxy-3-chlorobrombenzene is one of the organic compounds. Its main use is more common in the field of organic synthesis.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its molecular structure, both bromine and chlorine atoms have high reactivity, and other functional groups can be introduced through many chemical reactions, such as nucleophilic substitution reactions, to build more complex organic molecular structures.
Take nucleophilic substitution reactions as an example, bromine atoms or chlorine atoms can be replaced by nucleophilic reagents such as hydroxyl groups and amino groups. In this way, chemists can precisely design the reaction path according to the structure of the desired synthetic target product, and gradually build the target molecule with 4-benzyloxy-3-chlorobromobenzene as the starting material.
In addition, the presence of benzyloxy groups also contributes to the selectivity and controllability of the reaction. Under specific reaction conditions, benzyloxy groups can selectively react, or play a protective role on other parts of the molecule, ensuring that the synthesis reaction proceeds in the desired direction.
Furthermore, in the field of pharmaceutical chemistry, such halogen-containing compounds with benzyloxy structures may exhibit unique biological activities after modification and transformation, providing potential lead compounds for the development of new drugs. Chemists can optimize and modify their structures to explore their interactions with biological targets, in order to discover novel molecular entities with medicinal value.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to its molecular structure, both bromine and chlorine atoms have high reactivity, and other functional groups can be introduced through many chemical reactions, such as nucleophilic substitution reactions, to build more complex organic molecular structures.
Take nucleophilic substitution reactions as an example, bromine atoms or chlorine atoms can be replaced by nucleophilic reagents such as hydroxyl groups and amino groups. In this way, chemists can precisely design the reaction path according to the structure of the desired synthetic target product, and gradually build the target molecule with 4-benzyloxy-3-chlorobromobenzene as the starting material.
In addition, the presence of benzyloxy groups also contributes to the selectivity and controllability of the reaction. Under specific reaction conditions, benzyloxy groups can selectively react, or play a protective role on other parts of the molecule, ensuring that the synthesis reaction proceeds in the desired direction.
Furthermore, in the field of pharmaceutical chemistry, such halogen-containing compounds with benzyloxy structures may exhibit unique biological activities after modification and transformation, providing potential lead compounds for the development of new drugs. Chemists can optimize and modify their structures to explore their interactions with biological targets, in order to discover novel molecular entities with medicinal value.
What are 4-benzyloxy-3-chlorobromobenzene synthesis methods?
To prepare 4-benzyloxy-3-chlorobromobenzene, there are two common methods. One is to use 3-chloro-4-hydroxybromobenzene as the starting material to react with benzyl halide in an alkaline environment. In this reaction, the basic substance can take the hydrogen of the phenolic hydroxyl group to form a phenoxy anion, which has strong nucleophilicity and can undergo nucleophilic substitution reaction with benzyl halide to obtain the target product. Commonly used bases include potassium carbonate, sodium hydroxide, etc. The reaction solvent can be selected from polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), which can increase the solubility of the reactants and facilitate the reaction.
The second method is to use 4-benzyloxy bromobenzene as raw material and introduce chlorine atoms through halogenation reaction. This process usually uses chlorine gas or chlorine-containing reagents as halogenating agents, such as N-chlorosuccinimide (NCS). During the reaction, suitable catalysts and reaction conditions need to be selected. When NCS is used as halogenating agent, benzoyl peroxide (BPO) is often used as initiator. Under light or heating conditions, a free radical reaction is initiated, so that the chlorine atom replaces the hydrogen at a specific position on the benzene ring to achieve the synthesis of 4-benzyloxy-3-chlorobromobenzene.
These two methods have their own advantages and disadvantages. The phenol-hydroxyl selective modification of the starting material of the first method is easy to control, but the selection of benzyl halide may have an impact on the reaction; the secondary method is easy to obtain, but the regional selectivity of the halogenation reaction needs to be carefully controlled to obtain high-purity target products. In actual synthesis, the appropriate synthesis path should be carefully selected according to factors such as the availability of raw materials, reaction conditions and product purity requirements.
The second method is to use 4-benzyloxy bromobenzene as raw material and introduce chlorine atoms through halogenation reaction. This process usually uses chlorine gas or chlorine-containing reagents as halogenating agents, such as N-chlorosuccinimide (NCS). During the reaction, suitable catalysts and reaction conditions need to be selected. When NCS is used as halogenating agent, benzoyl peroxide (BPO) is often used as initiator. Under light or heating conditions, a free radical reaction is initiated, so that the chlorine atom replaces the hydrogen at a specific position on the benzene ring to achieve the synthesis of 4-benzyloxy-3-chlorobromobenzene.
These two methods have their own advantages and disadvantages. The phenol-hydroxyl selective modification of the starting material of the first method is easy to control, but the selection of benzyl halide may have an impact on the reaction; the secondary method is easy to obtain, but the regional selectivity of the halogenation reaction needs to be carefully controlled to obtain high-purity target products. In actual synthesis, the appropriate synthesis path should be carefully selected according to factors such as the availability of raw materials, reaction conditions and product purity requirements.
4-benzyloxy-3-chlorobromobenzene need to pay attention to when storing and transporting
4-Benzyloxy-3-chlorobromobenzene is one of the organic compounds. During storage and transportation, many matters need to be paid attention to.
First words storage. This compound should be placed in a cool and dry place, away from fire and heat sources. Due to its flammability, it may be dangerous to fire in case of heat or open flame. And should be stored in a well-ventilated place to prevent the accumulation of volatile gases, resulting in excessive concentration in the space and endangering safety.
Furthermore, it needs to be stored separately from oxidants, acids, bases and other substances. The chemical properties of 4-benzyloxy-3-chlorobromobenzene make it easy to cause chemical reactions, or cause material deterioration, and even cause serious consequences such as explosion.
Packaging is also crucial. Appropriate packaging materials must be used to ensure a good seal to prevent leakage. If the packaging is damaged, the compound is not only susceptible to deterioration due to the influence of the external environment, but also the leakage may cause harm to the environment and people.
As for transportation, it is necessary to follow relevant regulations and standards. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. During transportation, the traffic should be stable to avoid bumps and collisions to prevent compound leakage due to package damage. And transportation personnel should be familiar with the properties of the compound and emergency treatment methods, and can quickly and properly dispose of it in case of emergencies.
In short, the storage and transportation of 4-benzyloxy-3-chlorobromobenzene must be treated with caution and operated in strict accordance with regulations to ensure safety and avoid accidents.
First words storage. This compound should be placed in a cool and dry place, away from fire and heat sources. Due to its flammability, it may be dangerous to fire in case of heat or open flame. And should be stored in a well-ventilated place to prevent the accumulation of volatile gases, resulting in excessive concentration in the space and endangering safety.
Furthermore, it needs to be stored separately from oxidants, acids, bases and other substances. The chemical properties of 4-benzyloxy-3-chlorobromobenzene make it easy to cause chemical reactions, or cause material deterioration, and even cause serious consequences such as explosion.
Packaging is also crucial. Appropriate packaging materials must be used to ensure a good seal to prevent leakage. If the packaging is damaged, the compound is not only susceptible to deterioration due to the influence of the external environment, but also the leakage may cause harm to the environment and people.
As for transportation, it is necessary to follow relevant regulations and standards. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. During transportation, the traffic should be stable to avoid bumps and collisions to prevent compound leakage due to package damage. And transportation personnel should be familiar with the properties of the compound and emergency treatment methods, and can quickly and properly dispose of it in case of emergencies.
In short, the storage and transportation of 4-benzyloxy-3-chlorobromobenzene must be treated with caution and operated in strict accordance with regulations to ensure safety and avoid accidents.
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