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4-[Bis(2-Chloroethyl)Amino]Benzenebutanoic Acid
Linshang Chemical
|
HS Code |
337512 |
| Chemical Formula | C14H19Cl2NO3 |
| Molar Mass | 320.21 g/mol |
| Appearance | Solid (usually white or off - white) |
| Solubility In Water | Low solubility |
| Solubility In Organic Solvents | Soluble in some organic solvents like ethanol, dichloromethane |
| Melting Point | Typically in a certain range (experimental determination required) |
| Boiling Point | High boiling point, difficult to vaporize under normal conditions |
| Density | Experimental value needed for accurate determination |
| Pka | Relevant acidic dissociation constant, specific value determined experimentally |
| Stability | Stable under normal storage conditions, but may react with strong oxidants or reducing agents |
As an accredited 4-[Bis(2-Chloroethyl)Amino]Benzenebutanoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - [bis(2 - chloroethyl)amino]benzenebutanoic Acid in sealed chemical - grade packaging. |
| Storage | 4 - [bis(2 - chloroethyl)amino]benzenebutanoic Acid should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent moisture and air exposure. Store separately from incompatible substances like oxidizing agents. Follow all safety regulations for handling and storing hazardous chemicals. |
| Shipping | 4 - [bis(2 - chloroethyl)amino]benzenebutanoic Acid is a chemical. It should be shipped in accordance with strict hazardous material regulations, using appropriate containers to prevent leakage and ensure safe transportation. |
Competitive 4-[Bis(2-Chloroethyl)Amino]Benzenebutanoic Acid prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4- [bis (2-chloroethyl) amino] benzenebutanoic Acid
4 - [bis (2 - chloroethyl) amino acid] benzenebutanoic Acid, which is the name of an organic compound. Looking at its name, it can be seen that its structure must be related to the benzene ring, butanic acid and chloroethyl-containing amino group.
To clarify its structure, first analyze "benzenebutanoic Acid", which is a benzenebutanic acid, that is, the benzene ring is connected to the butanic acid. Butanic acid is a chain-like carboxylic acid containing four carbon atoms, with a carboxyl group (-COOH) at one end. After connecting with the benzene ring, it forms the basic structure of the benzenebutanic acid.
Look again at "4 - [bis (2 - chloroethyl) amino]", the position of the "4 -" episubstituent, in the fourth position of the benzene ring; "bis (2 - chloroethyl) amino", that is, bis (2 - chloroethyl) amino. 2 - chloroethyl, which is the ethyl group containing the chlorine atom, two 2 - chloroethyl groups are connected to the nitrogen atom to form a bis (2 - chloroethyl) amino structure. This amino group is substituted in the fourth position of the benzene ring, and the structure of 4 - [bis (2 - chloroethyl) amino] benzenebutanoic Acid is obtained.
In summary, the structure of this compound is that the fourth position of the benzene ring is connected with a bis (2-chloroethyl) amino group, and the other position of the benzene ring is connected with a butanic acid structure. Its complete structure shows the complexity and particularity of organic compounds, and the parts are interconnected, giving this compound unique chemical properties and reactivity.
To clarify its structure, first analyze "benzenebutanoic Acid", which is a benzenebutanic acid, that is, the benzene ring is connected to the butanic acid. Butanic acid is a chain-like carboxylic acid containing four carbon atoms, with a carboxyl group (-COOH) at one end. After connecting with the benzene ring, it forms the basic structure of the benzenebutanic acid.
Look again at "4 - [bis (2 - chloroethyl) amino]", the position of the "4 -" episubstituent, in the fourth position of the benzene ring; "bis (2 - chloroethyl) amino", that is, bis (2 - chloroethyl) amino. 2 - chloroethyl, which is the ethyl group containing the chlorine atom, two 2 - chloroethyl groups are connected to the nitrogen atom to form a bis (2 - chloroethyl) amino structure. This amino group is substituted in the fourth position of the benzene ring, and the structure of 4 - [bis (2 - chloroethyl) amino] benzenebutanoic Acid is obtained.
In summary, the structure of this compound is that the fourth position of the benzene ring is connected with a bis (2-chloroethyl) amino group, and the other position of the benzene ring is connected with a butanic acid structure. Its complete structure shows the complexity and particularity of organic compounds, and the parts are interconnected, giving this compound unique chemical properties and reactivity.
What are the physical properties of 4- [bis (2-chloroethyl) amino] benzenebutanoic Acid
4 - [bis (2 - chloroethyl) amino] benzenebutanoic Acid, that is, 4 - [bis (2 - chloroethyl) amino] phenylbutyric acid, this material has unique physical properties.
In terms of its color state, it is mostly white to quasi-white crystalline powder at room temperature, just like the first snow in winter, pure and delicate, and it looks like a shimmering light under light, adding a bit of unique beauty to it.
The melting point range is about 108-112 ° C, which is like the boundary of a specific temperature. At this point, the lattice begins to change and the state of matter gradually changes. Just like ice melts with warmth, within this temperature range, 4- [bis (2-chloroethyl) amino] phenylbutyric acid gradually melts from the solid state.
Solubility has its own characteristics, slightly soluble in water, but easily soluble in organic solvents, such as ethanol, chloroform, etc. Water seems to be rejected, but organic solvents can be closely fused with it, as if the two have a natural fit. In ethanol, it can be slowly dispersed and uniformly fused to form a clear solution, showing unique dissolution characteristics.
In terms of stability, under conventional environmental conditions, if it exists in a cool and dry place away from light, it can be relatively stable. When exposed to high temperature, strong acid and alkali environment, its structure may change and its chemical activity looms.
The physical properties of 4- [bis (2-chloroethyl) amino] phenylbutyric acid are of great significance in chemical research, drug preparation and other fields. It helps researchers explore its characteristics, use its strengths, avoid its weaknesses, and pave the way for the development of related fields.
In terms of its color state, it is mostly white to quasi-white crystalline powder at room temperature, just like the first snow in winter, pure and delicate, and it looks like a shimmering light under light, adding a bit of unique beauty to it.
The melting point range is about 108-112 ° C, which is like the boundary of a specific temperature. At this point, the lattice begins to change and the state of matter gradually changes. Just like ice melts with warmth, within this temperature range, 4- [bis (2-chloroethyl) amino] phenylbutyric acid gradually melts from the solid state.
Solubility has its own characteristics, slightly soluble in water, but easily soluble in organic solvents, such as ethanol, chloroform, etc. Water seems to be rejected, but organic solvents can be closely fused with it, as if the two have a natural fit. In ethanol, it can be slowly dispersed and uniformly fused to form a clear solution, showing unique dissolution characteristics.
In terms of stability, under conventional environmental conditions, if it exists in a cool and dry place away from light, it can be relatively stable. When exposed to high temperature, strong acid and alkali environment, its structure may change and its chemical activity looms.
The physical properties of 4- [bis (2-chloroethyl) amino] phenylbutyric acid are of great significance in chemical research, drug preparation and other fields. It helps researchers explore its characteristics, use its strengths, avoid its weaknesses, and pave the way for the development of related fields.
What are the common uses of 4- [bis (2-chloroethyl) amino] benzenebutanoic Acids
4- [bis (2 - chloroethyl) amino] benzenebutanoic acid is 4- (bis (2 - chloroethyl) amino) phenylbutyric acid, which is commonly used in the field of medicinal chemistry, especially in the development of anti-tumor drugs.
In the past, doctors and pharmacists wanted to make anti-cancer agents, often using 4- (bis (2 - chloroethyl) amino) phenylbutyric acid as a group. Because of its structure, the part of the bis (2 - chloroethyl) amino group can closely associate with the DNA of cancer cells, preventing their replication and division, so it inhibits the growth of cancer.
In the past, many medical workers investigated cancer therapies. In the laboratory, various cancer cell lines were tested to observe the effect of 4- (bis (2-chloroethyl) amino) phenylbutyric acid. It has significant inhibitory effect on a variety of cancer cells, such as leukemia cells, lymphoma cells, etc. Therefore, it is often selected as a lead compound to develop new anti-cancer drugs.
In addition, in the pharmaceutical industry, this substance is used as a starting material, and through multiple steps of exquisite chemical synthesis, new anti-cancer drugs with higher activity, better selectivity and less side effects are prepared. For example, by modifying its benzene ring or butyric acid side chain, the affinity between the drug and the target of cancer cells is optimized, and the efficacy is improved.
In summary, although 4- (bis (2-chloroethyl) amino) phenylbutyric acid is not a drug for direct clinical application, it plays a pivotal role in the creation of anti-cancer drugs, providing a crucial foundation for the medical community to attack cancer diseases and solve the suffering of patients.
In the past, doctors and pharmacists wanted to make anti-cancer agents, often using 4- (bis (2 - chloroethyl) amino) phenylbutyric acid as a group. Because of its structure, the part of the bis (2 - chloroethyl) amino group can closely associate with the DNA of cancer cells, preventing their replication and division, so it inhibits the growth of cancer.
In the past, many medical workers investigated cancer therapies. In the laboratory, various cancer cell lines were tested to observe the effect of 4- (bis (2-chloroethyl) amino) phenylbutyric acid. It has significant inhibitory effect on a variety of cancer cells, such as leukemia cells, lymphoma cells, etc. Therefore, it is often selected as a lead compound to develop new anti-cancer drugs.
In addition, in the pharmaceutical industry, this substance is used as a starting material, and through multiple steps of exquisite chemical synthesis, new anti-cancer drugs with higher activity, better selectivity and less side effects are prepared. For example, by modifying its benzene ring or butyric acid side chain, the affinity between the drug and the target of cancer cells is optimized, and the efficacy is improved.
In summary, although 4- (bis (2-chloroethyl) amino) phenylbutyric acid is not a drug for direct clinical application, it plays a pivotal role in the creation of anti-cancer drugs, providing a crucial foundation for the medical community to attack cancer diseases and solve the suffering of patients.
4- [bis (2-chloroethyl) amino] benzenebutanoic Acid
To prepare 4 - [bis (2 - chloroethyl) amino acid] benzenebutanoic Acid, the following ancient method can be used.
Starting material, select phenylbutyric acid and appropriate halogenating agent, preferably thionyl chloride as halogenating agent. In the reaction vessel, mix phenylbutyric acid and thionyl chloride in a suitable ratio of about 1:1.2 - 1:1.5. The reaction system needs to be carried out under heating conditions, maintained at a temperature of 50 - 80 ° C, and continuously stirred for about 2 - 4 hours. This step of the reaction is a halogenation process, in which the carboxyl group of phenylbutyric acid is converted into an acid chloride.
Subsequently, bis (2 - chloroethyl) amine is prepared. Diethanolamine is used as the starting material to react with chlorinating agents such as concentrated hydrochloric acid under suitable conditions. Diethanolamine is slowly dropped into concentrated hydrochloric acid in a ratio of about 1:2-1:2.5, the reaction temperature is controlled at 40-60 ° C, and the reaction is 3-5 hours to obtain bis (2-chloroethyl) amine hydrochloride. After that, it is neutralized with a base such as sodium hydroxide to free bis (2-chloroethyl) amine.
Finally, the obtained benzoyl chloride is condensed with bis (2-chloroethyl) amine. In organic solvents such as dichloromethane, a catalyst such as triethylamine is added, the ratio of phenylbutyryl chloride to bis (2-chloroethyl) amine is about 1:1 - 1:1.2, the reaction temperature is controlled at 0-25 ° C, and the reaction is 4-6 hours. After the reaction is completed, the pure 4- [bis (2-chloroethyl) amino] benzenebutanoic Acid can be obtained by separation and purification, extraction with organic solvent, column chromatography or recrystallization.
These methods require attention to the precise control of reaction conditions, the proper allocation of material proportions, and the meticulous post-treatment of each step of the reaction to obtain satisfactory yield and purity.
Starting material, select phenylbutyric acid and appropriate halogenating agent, preferably thionyl chloride as halogenating agent. In the reaction vessel, mix phenylbutyric acid and thionyl chloride in a suitable ratio of about 1:1.2 - 1:1.5. The reaction system needs to be carried out under heating conditions, maintained at a temperature of 50 - 80 ° C, and continuously stirred for about 2 - 4 hours. This step of the reaction is a halogenation process, in which the carboxyl group of phenylbutyric acid is converted into an acid chloride.
Subsequently, bis (2 - chloroethyl) amine is prepared. Diethanolamine is used as the starting material to react with chlorinating agents such as concentrated hydrochloric acid under suitable conditions. Diethanolamine is slowly dropped into concentrated hydrochloric acid in a ratio of about 1:2-1:2.5, the reaction temperature is controlled at 40-60 ° C, and the reaction is 3-5 hours to obtain bis (2-chloroethyl) amine hydrochloride. After that, it is neutralized with a base such as sodium hydroxide to free bis (2-chloroethyl) amine.
Finally, the obtained benzoyl chloride is condensed with bis (2-chloroethyl) amine. In organic solvents such as dichloromethane, a catalyst such as triethylamine is added, the ratio of phenylbutyryl chloride to bis (2-chloroethyl) amine is about 1:1 - 1:1.2, the reaction temperature is controlled at 0-25 ° C, and the reaction is 4-6 hours. After the reaction is completed, the pure 4- [bis (2-chloroethyl) amino] benzenebutanoic Acid can be obtained by separation and purification, extraction with organic solvent, column chromatography or recrystallization.
These methods require attention to the precise control of reaction conditions, the proper allocation of material proportions, and the meticulous post-treatment of each step of the reaction to obtain satisfactory yield and purity.
4- [bis (2-chloroethyl) amino] benzenebutanoic Acid
4 - [bis (2 - chloroethyl) amino] benzenebutanoic Acid is also an organic compound. When using, all precautions should not be ignored.
First, it is related to safety protection. This compound contains chloroethyl, which is potentially toxic and irritating. When operating, it is necessary to wear suitable protective equipment, such as gloves, goggles, laboratory clothes, etc., to prevent skin contact and splashing into the eyes. If you accidentally touch it, rinse it with plenty of water as soon as possible. In severe cases, seek medical attention immediately.
Second, chemical properties. Because it contains specific functional groups, it can react chemically under specific conditions. When storing, it is best to avoid heat and moisture, and keep away from strong oxidants, strong acids and alkalis, etc., to prevent uncontrollable reactions and dangerous occurrence. During use, the reaction conditions such as temperature, pH, reaction time, etc., must be precisely controlled in order to achieve the expected reaction effect and reduce the generation of side reactions.
Third, environmental impact. Waste after use should not be discarded at will. It needs to be properly disposed of in accordance with relevant environmental regulations to prevent environmental pollution. Due to the characteristics of its chemical structure, it may persist in the environment or bioaccumulate, endangering the ecological balance.
Fourth, operating specifications. Operate in a well-ventilated place to avoid inhaling its volatile gases. The experimental instrument must be clean and dry to avoid impurities affecting its performance and reaction results. When weighing and measuring, use precise instruments to ensure accurate dosage, which not only achieves the purpose of the experiment, but also avoids waste and danger.
First, it is related to safety protection. This compound contains chloroethyl, which is potentially toxic and irritating. When operating, it is necessary to wear suitable protective equipment, such as gloves, goggles, laboratory clothes, etc., to prevent skin contact and splashing into the eyes. If you accidentally touch it, rinse it with plenty of water as soon as possible. In severe cases, seek medical attention immediately.
Second, chemical properties. Because it contains specific functional groups, it can react chemically under specific conditions. When storing, it is best to avoid heat and moisture, and keep away from strong oxidants, strong acids and alkalis, etc., to prevent uncontrollable reactions and dangerous occurrence. During use, the reaction conditions such as temperature, pH, reaction time, etc., must be precisely controlled in order to achieve the expected reaction effect and reduce the generation of side reactions.
Third, environmental impact. Waste after use should not be discarded at will. It needs to be properly disposed of in accordance with relevant environmental regulations to prevent environmental pollution. Due to the characteristics of its chemical structure, it may persist in the environment or bioaccumulate, endangering the ecological balance.
Fourth, operating specifications. Operate in a well-ventilated place to avoid inhaling its volatile gases. The experimental instrument must be clean and dry to avoid impurities affecting its performance and reaction results. When weighing and measuring, use precise instruments to ensure accurate dosage, which not only achieves the purpose of the experiment, but also avoids waste and danger.
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