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4-Bormo-3-Chloro-5-(Trifluoromethyl)Nitrobenzene
Linshang Chemical
|
HS Code |
670220 |
| Chemical Formula | C7H3ClF3NO2 |
| Molecular Weight | 225.55 |
| Appearance | Typically a solid |
| Physical State At Room Temperature | Solid |
| Boiling Point | Data may vary, check specific references |
| Melting Point | Data may vary, check specific references |
| Solubility In Water | Low solubility in water |
| Solubility In Organic Solvents | Soluble in some organic solvents like dichloromethane |
| Density | Data may vary, check specific references |
| Odor | Likely has a characteristic chemical odor |
| Stability | Stable under normal conditions but reactive with certain substances |
| Hazard Class | May be classified as a hazardous chemical due to nitro and halogen content |
As an accredited 4-Bormo-3-Chloro-5-(Trifluoromethyl)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 3 - chloro - 5 - (trifluoromethyl)nitrobenzene in sealed chemical - grade packaging. |
| Storage | 4 - Bromo - 3 - chloro - 5 - (trifluoromethyl)nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from incompatible substances such as oxidizing agents, reducing agents, and bases to avoid potential reactions. |
| Shipping | 4 - Bromo - 3 - chloro - 5 - (trifluoromethyl)nitrobenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage and labeled clearly with safety and handling instructions for this chemical. |
Competitive 4-Bormo-3-Chloro-5-(Trifluoromethyl)Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene?
4-Bromo-3-chloro-5- (trifluoromethyl) nitrobenzene is also an important intermediate commonly used in organic synthesis. Its main uses are roughly three-terminal.
First, it can be used as a key starting material in the synthesis of medicine. The subtlety of medicinal chemistry lies in the formation of molecules with specific pharmacological activities based on various organic compounds through multi-step reactions. This compound contains halogen atoms such as bromine, chlorine, and specific functional groups such as trifluoromethyl and nitro. It can introduce other key structural fragments through many reactions such as nucleophilic substitution and reduction, and then form drug molecules with unique biological activities. For example, when developing new antibacterial and anti-cancer drugs, or using this as a starting material, through ingeniously designed reaction routes, active ingredients with targeting and high efficiency are synthesized.
Second, in the process of pesticide creation, it is also an important cornerstone. Modern agriculture relies on pesticides to ensure crop health and increase yield. The unique structure of this compound gives it potential biological activity, which can be chemically modified to develop new insecticides, fungicides or herbicides. Because of its functional groups, it can interact with specific biological macromolecules in pests, pathogens or weeds, interfering with their physiological and biochemical processes, thus achieving the purpose of control.
Third, in the field of materials science, it has also made a name for itself. Materials science pursues the optimization and innovation of material properties. This compound can be used as a monomer to build functional materials. Due to its functional group properties, it can participate in polymerization reactions to form polymer materials with special optical, electrical or thermal properties. For example, by rationally designing the polymerization reaction, optical materials with absorption or emission properties of specific wavelengths of light can be obtained for use in optical sensors, display technologies, etc.; or materials with special electrical conductivity can be obtained for use in electronic devices.
In summary, 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene has important uses in the fields of medicine, pesticides and materials science, and plays a key role in promoting the development of related fields.
First, it can be used as a key starting material in the synthesis of medicine. The subtlety of medicinal chemistry lies in the formation of molecules with specific pharmacological activities based on various organic compounds through multi-step reactions. This compound contains halogen atoms such as bromine, chlorine, and specific functional groups such as trifluoromethyl and nitro. It can introduce other key structural fragments through many reactions such as nucleophilic substitution and reduction, and then form drug molecules with unique biological activities. For example, when developing new antibacterial and anti-cancer drugs, or using this as a starting material, through ingeniously designed reaction routes, active ingredients with targeting and high efficiency are synthesized.
Second, in the process of pesticide creation, it is also an important cornerstone. Modern agriculture relies on pesticides to ensure crop health and increase yield. The unique structure of this compound gives it potential biological activity, which can be chemically modified to develop new insecticides, fungicides or herbicides. Because of its functional groups, it can interact with specific biological macromolecules in pests, pathogens or weeds, interfering with their physiological and biochemical processes, thus achieving the purpose of control.
Third, in the field of materials science, it has also made a name for itself. Materials science pursues the optimization and innovation of material properties. This compound can be used as a monomer to build functional materials. Due to its functional group properties, it can participate in polymerization reactions to form polymer materials with special optical, electrical or thermal properties. For example, by rationally designing the polymerization reaction, optical materials with absorption or emission properties of specific wavelengths of light can be obtained for use in optical sensors, display technologies, etc.; or materials with special electrical conductivity can be obtained for use in electronic devices.
In summary, 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene has important uses in the fields of medicine, pesticides and materials science, and plays a key role in promoting the development of related fields.
What are the physical properties of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene
4-Bromo-3-chloro-5- (trifluoromethyl) nitrobenzene, the physical properties of this substance are particularly important, related to its many uses and reactions.
Its appearance is often solid, and the specific form is either crystalline, colored or yellowish, or nearly colorless, depending on the purity and preparation conditions.
The melting point is one of the important physical properties. It has been experimentally determined that its melting point falls within a specific temperature range. The value of the melting point is quite a guide in the identification, separation and purification of the substance. If compared with the standard material with known melting point, its purity can be judged.
The boiling point is also a key physical property. When it is heated to a certain temperature, the substance changes from liquid to gaseous state, and this temperature is the boiling point. The determination of boiling point is indispensable in separation operations such as distillation, which can help researchers control the separation conditions and achieve the acquisition of pure substances.
Density also belongs to the category of physical properties of this substance. The value of its density reflects the mass of the substance per unit volume. This property is of great significance in chemical production, solution preparation and other fields. For example, when preparing a solution of a specific concentration, it is necessary to measure it accurately according to its density.
In terms of solubility, 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene exhibits different solubility properties in common organic solvents. In some organic solvents such as dichloromethane and chloroform, its solubility is quite good and can form a uniform solution; in water, its solubility is very small. This difference in solubility has important applications in the extraction step of chemical synthesis, whereby the target substance can be effectively separated from the reaction system.
In addition, the refractive index of the substance is also one of the characteristics of its physical properties. The refractive index reflects the degree of refraction of light as it propagates in the substance and is related to the molecular structure and density of the substance. By measuring the refractive index, it can assist in the identification of the substance or provide valuable information when analyzing the mixture.
In summary, the various physical properties of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene have their own uses, providing key basis and guidance for chemical research, industrial production and many other fields.
Its appearance is often solid, and the specific form is either crystalline, colored or yellowish, or nearly colorless, depending on the purity and preparation conditions.
The melting point is one of the important physical properties. It has been experimentally determined that its melting point falls within a specific temperature range. The value of the melting point is quite a guide in the identification, separation and purification of the substance. If compared with the standard material with known melting point, its purity can be judged.
The boiling point is also a key physical property. When it is heated to a certain temperature, the substance changes from liquid to gaseous state, and this temperature is the boiling point. The determination of boiling point is indispensable in separation operations such as distillation, which can help researchers control the separation conditions and achieve the acquisition of pure substances.
Density also belongs to the category of physical properties of this substance. The value of its density reflects the mass of the substance per unit volume. This property is of great significance in chemical production, solution preparation and other fields. For example, when preparing a solution of a specific concentration, it is necessary to measure it accurately according to its density.
In terms of solubility, 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene exhibits different solubility properties in common organic solvents. In some organic solvents such as dichloromethane and chloroform, its solubility is quite good and can form a uniform solution; in water, its solubility is very small. This difference in solubility has important applications in the extraction step of chemical synthesis, whereby the target substance can be effectively separated from the reaction system.
In addition, the refractive index of the substance is also one of the characteristics of its physical properties. The refractive index reflects the degree of refraction of light as it propagates in the substance and is related to the molecular structure and density of the substance. By measuring the refractive index, it can assist in the identification of the substance or provide valuable information when analyzing the mixture.
In summary, the various physical properties of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene have their own uses, providing key basis and guidance for chemical research, industrial production and many other fields.
What is the chemical synthesis method of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene?
To make 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene, you can do it according to the following method.
First take 3-chloro-5- (trifluoromethyl) aniline, mix an appropriate amount of sulfuric acid with nitric acid, and slowly drop into the sulfuric acid solution of 3-chloro-5- (trifluoromethyl) aniline at low temperature (such as 0-5 ° C) to carry out nitrification reaction. This process requires strict temperature control, because the temperature is too high, it is easy to produce side reactions. After the reaction is completed, 3-chloro-5- (trifluoromethyl) nitrobenzene can be obtained after hydrolysis, separation and purification.
Then 3-chloro-5- (trifluoromethyl) nitrobenzene is placed in an appropriate solvent (such as carbon tetrachloride), an appropriate amount of bromine and a catalyst (such as iron powder) are added, and heated to reflux. During the reaction, pay close attention to the reaction process and phenomena. When the reaction is completed, after washing with water, alkali washing, drying, distillation and other steps to remove impurities, 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene is obtained.
Or 3-chloro-5- (trifluoromethyl) benzene is used as a raw material, brominated first, and then nitrified. When brominating, the appropriate brominating agent and catalyst are selected to control the reaction conditions. The brominated product can also be nitrified to obtain the target product. However, regardless of the method, the separation and purification steps after the reaction are crucial, which are related to the purity and yield of the product.
First take 3-chloro-5- (trifluoromethyl) aniline, mix an appropriate amount of sulfuric acid with nitric acid, and slowly drop into the sulfuric acid solution of 3-chloro-5- (trifluoromethyl) aniline at low temperature (such as 0-5 ° C) to carry out nitrification reaction. This process requires strict temperature control, because the temperature is too high, it is easy to produce side reactions. After the reaction is completed, 3-chloro-5- (trifluoromethyl) nitrobenzene can be obtained after hydrolysis, separation and purification.
Then 3-chloro-5- (trifluoromethyl) nitrobenzene is placed in an appropriate solvent (such as carbon tetrachloride), an appropriate amount of bromine and a catalyst (such as iron powder) are added, and heated to reflux. During the reaction, pay close attention to the reaction process and phenomena. When the reaction is completed, after washing with water, alkali washing, drying, distillation and other steps to remove impurities, 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene is obtained.
Or 3-chloro-5- (trifluoromethyl) benzene is used as a raw material, brominated first, and then nitrified. When brominating, the appropriate brominating agent and catalyst are selected to control the reaction conditions. The brominated product can also be nitrified to obtain the target product. However, regardless of the method, the separation and purification steps after the reaction are crucial, which are related to the purity and yield of the product.
What are the precautions for 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene during storage and transportation?
4-Bromo-3-chloro-5- (trifluoromethyl) nitrobenzene is an important chemical in organic synthesis. During storage and transportation, there are many key matters to be paid attention to.
First, when storing, choose a cool, dry and well-ventilated place. This compound is more sensitive to heat, and it is easy to decompose when heated, or even cause danger. If it is placed in a high temperature environment, it may lose its inherent properties due to changes in internal structure, or it may produce unstable reactions. Therefore, the warehouse temperature should be maintained at a low level, and the humidity should not be too high to prevent moisture decomposition and other conditions.
Second, because of its certain toxicity and corrosiveness, the storage container must be strong and well sealed. Special chemical storage containers should be used, and the material must be able to withstand the erosion of the compound to prevent leakage. Once leaked, it will not only cause material loss, but also pose a serious threat to the surrounding environment and personnel safety.
Third, during transportation, the relevant regulations must also be strictly followed. To ensure that the transport vehicle has appropriate protective and emergency equipment, the escort personnel should be familiar with the characteristics of the chemical and emergency treatment methods. Vibration, impact and friction should be avoided during transportation to prevent package damage.
Fourth, this compound may react violently in case of open flame or strong oxidant. Therefore, whether it is storage or transportation, it should be kept away from fire sources, heat sources and strong oxidants, and it should be stored and transported separately from other incompatible substances to avoid accidents caused by interaction.
In short, the storage and transportation of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene must be strictly operated in accordance with regulations to ensure the safety of personnel and the environment in an all-round way, and to avoid all kinds of accidents.
First, when storing, choose a cool, dry and well-ventilated place. This compound is more sensitive to heat, and it is easy to decompose when heated, or even cause danger. If it is placed in a high temperature environment, it may lose its inherent properties due to changes in internal structure, or it may produce unstable reactions. Therefore, the warehouse temperature should be maintained at a low level, and the humidity should not be too high to prevent moisture decomposition and other conditions.
Second, because of its certain toxicity and corrosiveness, the storage container must be strong and well sealed. Special chemical storage containers should be used, and the material must be able to withstand the erosion of the compound to prevent leakage. Once leaked, it will not only cause material loss, but also pose a serious threat to the surrounding environment and personnel safety.
Third, during transportation, the relevant regulations must also be strictly followed. To ensure that the transport vehicle has appropriate protective and emergency equipment, the escort personnel should be familiar with the characteristics of the chemical and emergency treatment methods. Vibration, impact and friction should be avoided during transportation to prevent package damage.
Fourth, this compound may react violently in case of open flame or strong oxidant. Therefore, whether it is storage or transportation, it should be kept away from fire sources, heat sources and strong oxidants, and it should be stored and transported separately from other incompatible substances to avoid accidents caused by interaction.
In short, the storage and transportation of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene must be strictly operated in accordance with regulations to ensure the safety of personnel and the environment in an all-round way, and to avoid all kinds of accidents.
What are the effects of 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene on the environment and human health?
4-Bromo-3-chloro-5- (trifluoromethyl) nitrobenzene, which is a chemical often involved in organic synthesis. In terms of environment and human health, its impact should not be underestimated.
First talk about the impact on the environment. It has certain chemical stability and is difficult to degrade in the natural environment. It can persist in soil and water bodies for a long time. If it is released into the soil, it may cause changes in soil properties, affect the structure and function of soil microbial communities, and interfere with the material cycle and energy flow of soil ecosystems. After entering the water body, it can cause water pollution and endanger aquatic organisms. Because of its toxicity, or cause damage to the physiological functions of aquatic organisms, growth and reproduction are inhibited, and even death, destroying the aquatic ecological balance.
Re-discussion on the harm to human health. Entering the human body through respiratory tract, skin contact or accidental ingestion. The presence of nitro and halogen atoms makes it toxic and potentially carcinogenic. Respiratory inhalation can irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure may damage lung function and increase the risk of respiratory diseases. Skin contact can cause skin allergies, redness, swelling, itching, and in severe cases, skin burns and ulceration. If ingested by mistake, it can damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea, etc., and be absorbed into the blood by the digestive system, involving organs throughout the body with blood circulation, causing damage to important organs such as the liver and kidneys, affecting their normal function.
In summary, when producing and using 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene, proper protective and handling measures must be taken to reduce its harm to the environment and human health.
First talk about the impact on the environment. It has certain chemical stability and is difficult to degrade in the natural environment. It can persist in soil and water bodies for a long time. If it is released into the soil, it may cause changes in soil properties, affect the structure and function of soil microbial communities, and interfere with the material cycle and energy flow of soil ecosystems. After entering the water body, it can cause water pollution and endanger aquatic organisms. Because of its toxicity, or cause damage to the physiological functions of aquatic organisms, growth and reproduction are inhibited, and even death, destroying the aquatic ecological balance.
Re-discussion on the harm to human health. Entering the human body through respiratory tract, skin contact or accidental ingestion. The presence of nitro and halogen atoms makes it toxic and potentially carcinogenic. Respiratory inhalation can irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure may damage lung function and increase the risk of respiratory diseases. Skin contact can cause skin allergies, redness, swelling, itching, and in severe cases, skin burns and ulceration. If ingested by mistake, it can damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea, etc., and be absorbed into the blood by the digestive system, involving organs throughout the body with blood circulation, causing damage to important organs such as the liver and kidneys, affecting their normal function.
In summary, when producing and using 4-bromo-3-chloro-5- (trifluoromethyl) nitrobenzene, proper protective and handling measures must be taken to reduce its harm to the environment and human health.
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