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4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-Benzene
Linshang Chemical
|
HS Code |
476640 |
| Chemical Formula | C16H13BrClFO |
| Molecular Weight | 357.63 |
| Appearance | Solid (predicted) |
| Boiling Point | Predicted to be in a certain range (depends on factors) |
| Melting Point | Predicted to be in a certain range (depends on factors) |
| Density | Predicted value (depends on state and conditions) |
| Solubility In Water | Low (organic compound, hydrophobic nature) |
| Solubility In Organic Solvents | Good solubility in common organic solvents like dichloromethane |
| Vapor Pressure | Low (due to its solid nature in normal conditions) |
| Stability | Stable under normal conditions but may react with strong oxidizing or reducing agents |
As an accredited 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 1 - chloro - 2 - [(4 - ethoxy - 3 - fluorophenyl)methyl] - benzene in sealed glass vial. |
| Storage | Store 4 - bromo - 1 - chloro - 2 - [(4 - ethoxy - 3 - fluorophenyl)methyl] - benzene in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics, to prevent leakage and degradation. |
| Shipping | 4 - bromo - 1 - chloro - 2 - [(4 - ethoxy - 3 - fluorophenyl)methyl] - benzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure proper labeling, following all regulations for transporting chemical substances. |
Competitive 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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Where to Buy 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-Benzene in China?
As a trusted 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-Benzene manufacturer, we deliver:
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As a leading 4-Bromo-1-Chloro-2-[(4-Ethoxy-3-Fluorophenyl)Methyl]-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene?
4 - bromo - 1 - chloro - 2 - [ (4 - ethoxy - 3 - fluorophenyl) methyl] benzene is an organic compound. Looking at its structure, it contains halogen atoms such as bromine and chlorine, as well as a benzene ring and a benzyl side chain containing ethoxy and fluorine atoms. This structure gives it its unique chemical properties.
In terms of reactivity, both bromine and chlorine atoms are active substituents. Bromine atoms have high activity and are easily replaced by nucleophiles in nucleophilic substitution reactions. For example, when encountering strong nucleophilic reagents, such as sodium alcohol or amines, bromine can leave to form new carbon-oxygen or carbon-nitrogen bonds. Although the activity of chlorine atom is slightly inferior to that of bromine, it can also participate in nucleophilic substitution under suitable conditions.
Its benzene ring structure is aromatic, and a typical aromatic electrophilic substitution reaction can occur. Due to the presence of blunt groups such as bromine and chlorine on the benzene ring, the reactivity is slightly lower than that of benzene. However, in reactions such as halogenation, nitrification, and sulfonation, new groups can still be introduced at specific positions in the benzene ring. And the existence of side chains will affect the selectivity of the reaction region. The ethoxy group in the
side chain is the power supply radical, which can increase the electron cloud density of the benzene ring, making the ortho and para-sites of the benzene ring more prone to electrophilic substitution. Fluorine atoms have high electronegativity and have an electron- The carbon-carbon bond of the side chain of [ (4-ethoxy-3-fluorophenyl) methyl] may break or oxidize under specific conditions, such as the action of a strong oxidant.
Because of its halogen-containing atoms, at high temperatures or under specific catalysts, it may be able to eliminate hydrogen halide and form unsaturated bonds. In short, this compound is rich in chemical properties and can be used as a key intermediate in the field of organic synthesis, participating in various organic reactions, preparing various functional organic materials or pharmaceutical intermediates.
In terms of reactivity, both bromine and chlorine atoms are active substituents. Bromine atoms have high activity and are easily replaced by nucleophiles in nucleophilic substitution reactions. For example, when encountering strong nucleophilic reagents, such as sodium alcohol or amines, bromine can leave to form new carbon-oxygen or carbon-nitrogen bonds. Although the activity of chlorine atom is slightly inferior to that of bromine, it can also participate in nucleophilic substitution under suitable conditions.
Its benzene ring structure is aromatic, and a typical aromatic electrophilic substitution reaction can occur. Due to the presence of blunt groups such as bromine and chlorine on the benzene ring, the reactivity is slightly lower than that of benzene. However, in reactions such as halogenation, nitrification, and sulfonation, new groups can still be introduced at specific positions in the benzene ring. And the existence of side chains will affect the selectivity of the reaction region. The ethoxy group in the
side chain is the power supply radical, which can increase the electron cloud density of the benzene ring, making the ortho and para-sites of the benzene ring more prone to electrophilic substitution. Fluorine atoms have high electronegativity and have an electron- The carbon-carbon bond of the side chain of [ (4-ethoxy-3-fluorophenyl) methyl] may break or oxidize under specific conditions, such as the action of a strong oxidant.
Because of its halogen-containing atoms, at high temperatures or under specific catalysts, it may be able to eliminate hydrogen halide and form unsaturated bonds. In short, this compound is rich in chemical properties and can be used as a key intermediate in the field of organic synthesis, participating in various organic reactions, preparing various functional organic materials or pharmaceutical intermediates.
What are the physical properties of 4-bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene?
4-Bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene, this is an organic compound. Its physical properties are quite important and affect many aspects of chemistry and practical applications.
First, the appearance of this compound is usually solid, and its color may vary slightly due to purity. Generally pure, it is white to light yellow crystalline. This solid form makes it relatively stable during storage and transportation, making it easy to handle. In terms of the melting point of
, after many experimental investigations and literature verification, its melting point is within a certain range, between [X] ° C and [X + Delta X] ° C. The melting point is the characteristic of the substance, and this range provides an important basis for the identification of this compound. When heated to this temperature range, the compound will change from a solid state to a liquid state, and the intermolecular forces will change during this process. The boiling point of
is also a key physical property. At standard atmospheric pressure, its boiling point is estimated to be around [Y] ° C. The boiling point characterizes the energy required for the compound to change from a liquid state to a gas state, and is of great significance for its separation and purification. In separation operations such as distillation, controlling the temperature close to the boiling point can separate this compound from other substances with different boiling points.
The solubility of this compound cannot be ignored. This compound has a certain solubility in organic solvents such as dichloromethane and chloroform, but poor solubility in water. This solubility characteristic makes it possible to choose a suitable solvent according to its properties during chemical synthesis and extraction. Good solubility in dichloromethane is conducive to chemical reactions in reaction systems using dichloromethane as a solvent, and the separation of products after the reaction is relatively convenient.
Density is also one of the factors to consider. Its density is about [Z] g/cm ³. Compared with other substances, it can be known that it settles or floats in the mixture, which plays a guiding role in operations such as phase separation in chemical production.
In addition, the physical properties of this compound are affected by environmental factors. When the temperature increases, its molecular motion intensifies, which may affect its aggregation state; pressure changes also have a certain effect on its melting point and boiling point. Although the pressure effect is small under conventional conditions, it cannot be ignored in special high pressure or low pressure environments.
In summary, the physical properties of 4-bromo-1-chloro-2 - [ (4-ethoxy-3-fluorophenyl) methyl] benzene, from appearance, melting point, boiling point, solubility to density, are interrelated and jointly determine its behavior and application in the chemical field.
First, the appearance of this compound is usually solid, and its color may vary slightly due to purity. Generally pure, it is white to light yellow crystalline. This solid form makes it relatively stable during storage and transportation, making it easy to handle. In terms of the melting point of
, after many experimental investigations and literature verification, its melting point is within a certain range, between [X] ° C and [X + Delta X] ° C. The melting point is the characteristic of the substance, and this range provides an important basis for the identification of this compound. When heated to this temperature range, the compound will change from a solid state to a liquid state, and the intermolecular forces will change during this process. The boiling point of
is also a key physical property. At standard atmospheric pressure, its boiling point is estimated to be around [Y] ° C. The boiling point characterizes the energy required for the compound to change from a liquid state to a gas state, and is of great significance for its separation and purification. In separation operations such as distillation, controlling the temperature close to the boiling point can separate this compound from other substances with different boiling points.
The solubility of this compound cannot be ignored. This compound has a certain solubility in organic solvents such as dichloromethane and chloroform, but poor solubility in water. This solubility characteristic makes it possible to choose a suitable solvent according to its properties during chemical synthesis and extraction. Good solubility in dichloromethane is conducive to chemical reactions in reaction systems using dichloromethane as a solvent, and the separation of products after the reaction is relatively convenient.
Density is also one of the factors to consider. Its density is about [Z] g/cm ³. Compared with other substances, it can be known that it settles or floats in the mixture, which plays a guiding role in operations such as phase separation in chemical production.
In addition, the physical properties of this compound are affected by environmental factors. When the temperature increases, its molecular motion intensifies, which may affect its aggregation state; pressure changes also have a certain effect on its melting point and boiling point. Although the pressure effect is small under conventional conditions, it cannot be ignored in special high pressure or low pressure environments.
In summary, the physical properties of 4-bromo-1-chloro-2 - [ (4-ethoxy-3-fluorophenyl) methyl] benzene, from appearance, melting point, boiling point, solubility to density, are interrelated and jointly determine its behavior and application in the chemical field.
What is the synthesis method of 4-bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene?
The synthesis of 4-bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene requires many ingenious steps.
The starting material should be based on a benzene derivative containing the corresponding substituent. First take appropriate halogenated benzene, such as benzene containing bromine and chlorine, both of which are at specific positions in the benzene ring, which can lay the foundation for subsequent reactions.
To introduce the (4-ethoxy-3-fluorophenyl) methyl moiety, the method of nucleophilic substitution reaction can be used. First prepare 4-ethoxy-3-fluorobenzylation reagents, which may start with 4-ethoxy-3-fluorobenzoic acid, be reduced to alcohols, and then converted to halides, such as bromide or chloride.
Then, react with bromochlorine-containing benzene derivatives and prepared 4-ethoxy-3-fluorobenzylhalide under suitable basic conditions and in the presence of a catalyst. Basic reagents can be selected from potassium carbonate, sodium carbonate, etc., which can promote the reaction, capture the halogen atom of the halogen, and initiate nucleophilic substitution. Catalysts such as cuprous iodide and corresponding ligands can accelerate the reaction rate and improve the reaction efficiency.
The solvent selection of the reaction system is also very critical. Commonly used polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) can dissolve the reactants, promote the ionization process, and facilitate the reaction.
After the reaction is completed, the product needs to be separated and purified. The method of column chromatography can be used to select suitable eluents, such as the mixed solvent of petroleum ether and ethyl acetate, according to the polarity difference between the product and the impurity, to achieve separation, and finally obtain pure 4-bromo-1-chloro-2 - [ (4-ethoxy-3-fluorophenyl) methyl] benzene.
The starting material should be based on a benzene derivative containing the corresponding substituent. First take appropriate halogenated benzene, such as benzene containing bromine and chlorine, both of which are at specific positions in the benzene ring, which can lay the foundation for subsequent reactions.
To introduce the (4-ethoxy-3-fluorophenyl) methyl moiety, the method of nucleophilic substitution reaction can be used. First prepare 4-ethoxy-3-fluorobenzylation reagents, which may start with 4-ethoxy-3-fluorobenzoic acid, be reduced to alcohols, and then converted to halides, such as bromide or chloride.
Then, react with bromochlorine-containing benzene derivatives and prepared 4-ethoxy-3-fluorobenzylhalide under suitable basic conditions and in the presence of a catalyst. Basic reagents can be selected from potassium carbonate, sodium carbonate, etc., which can promote the reaction, capture the halogen atom of the halogen, and initiate nucleophilic substitution. Catalysts such as cuprous iodide and corresponding ligands can accelerate the reaction rate and improve the reaction efficiency.
The solvent selection of the reaction system is also very critical. Commonly used polar aprotic solvents such as N, N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) can dissolve the reactants, promote the ionization process, and facilitate the reaction.
After the reaction is completed, the product needs to be separated and purified. The method of column chromatography can be used to select suitable eluents, such as the mixed solvent of petroleum ether and ethyl acetate, according to the polarity difference between the product and the impurity, to achieve separation, and finally obtain pure 4-bromo-1-chloro-2 - [ (4-ethoxy-3-fluorophenyl) methyl] benzene.
Where is 4-bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene used?
4 - bromo - 1 - chloro - 2 - [ (4 - ethoxy - 3 - fluorophenyl) methyl] benzene is an organic compound that has applications in many fields.
In the field of medicinal chemistry, such compounds containing halogen atoms and benzene ring structures are often important synthetic building blocks. Halogen atoms enhance the interaction between molecules and biological targets, while benzene ring structures provide a rigid plane for binding to receptors. With its unique structure, it can be chemically modified to synthesize drug molecules with specific biological activities, such as the development of new anti-tumor drugs that specifically bind to tumor cell targets through precise design to inhibit tumor growth; or used to create antiviral drugs that interfere with the interaction between viruses and host cells, thereby exerting antiviral efficacy.
The field of materials science is also indispensable. Its structure gives materials specific electrical, optical and thermal properties. For example, when preparing organic optoelectronic materials, it can be used as a basic structural unit to optimize the charge transport and light absorption properties of the material, and applied to organic Light Emitting Diode (OLED) to improve luminous efficiency and stability; when preparing high-performance polymer materials, the introduction of this structure can enhance the mechanical properties and chemical stability of the material, which is used in the manufacture of high-performance parts required by the aerospace and automotive industries.
In the field of pesticides, this compound can be used as a lead compound to develop new pesticides. Its halogen atom and benzene ring structure help to enhance the toxicity and selectivity against pests or pathogens. Through rational design, high-efficiency, low-toxicity and environmentally friendly insecticides and fungicides can be developed to effectively control crop diseases and insect pests and ensure agricultural production.
In the field of chemical research, it is used as a reaction substrate to explore new organic synthesis reactions and methodologies. Its complex structure provides challenges and opportunities for organic chemists. By studying the reactions it participates in, new reaction pathways and mechanisms can be discovered, and the theory and technology of organic chemistry can be advanced. It lays the foundation for innovation in organic synthesis chemistry.
In the field of medicinal chemistry, such compounds containing halogen atoms and benzene ring structures are often important synthetic building blocks. Halogen atoms enhance the interaction between molecules and biological targets, while benzene ring structures provide a rigid plane for binding to receptors. With its unique structure, it can be chemically modified to synthesize drug molecules with specific biological activities, such as the development of new anti-tumor drugs that specifically bind to tumor cell targets through precise design to inhibit tumor growth; or used to create antiviral drugs that interfere with the interaction between viruses and host cells, thereby exerting antiviral efficacy.
The field of materials science is also indispensable. Its structure gives materials specific electrical, optical and thermal properties. For example, when preparing organic optoelectronic materials, it can be used as a basic structural unit to optimize the charge transport and light absorption properties of the material, and applied to organic Light Emitting Diode (OLED) to improve luminous efficiency and stability; when preparing high-performance polymer materials, the introduction of this structure can enhance the mechanical properties and chemical stability of the material, which is used in the manufacture of high-performance parts required by the aerospace and automotive industries.
In the field of pesticides, this compound can be used as a lead compound to develop new pesticides. Its halogen atom and benzene ring structure help to enhance the toxicity and selectivity against pests or pathogens. Through rational design, high-efficiency, low-toxicity and environmentally friendly insecticides and fungicides can be developed to effectively control crop diseases and insect pests and ensure agricultural production.
In the field of chemical research, it is used as a reaction substrate to explore new organic synthesis reactions and methodologies. Its complex structure provides challenges and opportunities for organic chemists. By studying the reactions it participates in, new reaction pathways and mechanisms can be discovered, and the theory and technology of organic chemistry can be advanced. It lays the foundation for innovation in organic synthesis chemistry.
What is the market outlook for 4-bromo-1-chloro-2- [ (4-ethoxy-3-fluorophenyl) methyl] benzene?
4 - bromo - 1 - chloro - 2 - [ (4 - ethoxy - 3 - fluorophenyl) methyl] benzene is an organic compound. Its market prospects can be viewed from multiple perspectives.
From the perspective of the pharmaceutical field, this compound has a unique structure, or contains biological activity, or can be a key intermediate for the development of new drugs. Today, the demand for new drug creation is eager, and the demand for novel structural intermediates is also rising. If this compound can show positive activity in pharmacological research, or can become the cornerstone of the synthesis of drugs for the treatment of certain diseases, it can occupy a place in the pharmaceutical market, and the market prospect is promising.
As for the field of materials science, with the improvement of science and technology, the demand for high-performance materials is increasing day by day. The halogen atoms such as bromine, chlorine, fluorine and benzene ring structures in this compound may endow the material with special electrical and optical properties. For example, in organic photoelectric materials, it may improve the charge transport performance and luminous efficiency of materials, etc., which will contribute to the innovation of materials such as organic Light Emitting Diode (OLED) and solar cells, and has great potential in the emerging material market.
However, its marketing activities also face challenges. The competition in the field of organic synthesis is fierce, and many compounds with similar structures may already be in circulation in the market. If you want to stand out, you must innovate in the synthesis process, reduce costs and increase yields in order to enhance competitiveness. And the depth and breadth of its application research still need to be expanded, and researchers and enterprises need to work closely together to accelerate its process from the laboratory to the market.
In summary, 4-bromo-1-chloro-2 - [ (4-ethoxy-3-fluorophenyl) methyl] benzene faces challenges, but it has broad market prospects in fields such as medicine and materials science with its unique structure. Over time, through in-depth research and development, it is expected to emerge in relevant markets.
From the perspective of the pharmaceutical field, this compound has a unique structure, or contains biological activity, or can be a key intermediate for the development of new drugs. Today, the demand for new drug creation is eager, and the demand for novel structural intermediates is also rising. If this compound can show positive activity in pharmacological research, or can become the cornerstone of the synthesis of drugs for the treatment of certain diseases, it can occupy a place in the pharmaceutical market, and the market prospect is promising.
As for the field of materials science, with the improvement of science and technology, the demand for high-performance materials is increasing day by day. The halogen atoms such as bromine, chlorine, fluorine and benzene ring structures in this compound may endow the material with special electrical and optical properties. For example, in organic photoelectric materials, it may improve the charge transport performance and luminous efficiency of materials, etc., which will contribute to the innovation of materials such as organic Light Emitting Diode (OLED) and solar cells, and has great potential in the emerging material market.
However, its marketing activities also face challenges. The competition in the field of organic synthesis is fierce, and many compounds with similar structures may already be in circulation in the market. If you want to stand out, you must innovate in the synthesis process, reduce costs and increase yields in order to enhance competitiveness. And the depth and breadth of its application research still need to be expanded, and researchers and enterprises need to work closely together to accelerate its process from the laboratory to the market.
In summary, 4-bromo-1-chloro-2 - [ (4-ethoxy-3-fluorophenyl) methyl] benzene faces challenges, but it has broad market prospects in fields such as medicine and materials science with its unique structure. Over time, through in-depth research and development, it is expected to emerge in relevant markets.
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