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4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)Benzene
Linshang Chemical
|
HS Code |
751466 |
| Chemical Formula | C15H14BrClO |
| Molecular Weight | 327.628 g/mol |
| Appearance | Solid (usually white to off - white powder) |
| Boiling Point | Estimated, difficult to determine precisely, likely high due to molecular weight and structure |
| Melting Point | Unknown (but typically organic solids have a defined melting range) |
| Solubility In Water | Low, as it is an organic compound with non - polar benzene rings |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, toluene |
| Density | Estimated based on similar compounds, around 1.4 - 1.6 g/cm³ |
| Odor | Odorless or faint characteristic organic odor |
| Flash Point | Estimated, likely high due to relatively high molecular weight and low volatility |
As an accredited 4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl)benzene in a sealed, labeled container. |
| Storage | 4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl)benzene should be stored in a cool, dry place, away from direct sunlight. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to degradation. Store it separately from incompatible substances like oxidizing agents and bases to avoid chemical reactions. |
| Shipping | 4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl)benzene is shipped in sealed, corrosion - resistant containers. It follows strict chemical transport regulations, ensuring secure transit to prevent spills and maintain product integrity. |
Competitive 4-Bromo-1-Chloro-2-(4-Ethoxybenzyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene?
4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl) benzene, an organic compound. The analysis of its chemical structure, when based on chemical nomenclature, is analyzed one by one.
"4 - bromo", above this epiphenyl ring, is connected to a bromine atom at position 4. Bromine, a halogen element, whose atoms are in an organic structure, often linked to carbon by covalent bonds, affecting the properties of compounds, such as nucleophilic substitution reaction activity.
"1 - chloro", indicates that there is a chlorine atom at position 1 of the benzene ring. Chlorine is also a halogen element, which belongs to the same group as bromine. However, due to differences in atomic radius and other factors, it has a slightly different effect on the properties of compounds than bromine.
"2 - (4 - ethoxybenzyl) ", this part is slightly more complicated. "4 - ethoxybenzyl" is the benzyl group attached to the fourth position of the benzene ring. Benzyl is a benzyl group, which is a common structural unit in organic chemistry, and ethoxy is formed by connecting ethyl to oxygen atoms. This benzyl structure is connected to the second position of the benzene ring, enriching the spatial structure and electron cloud distribution of the compound.
Overall, the chemical structure of this compound is based on the benzene ring, with bromine, chlorine atoms and benzyl groups containing ethoxy groups attached at different positions. This structure endows compounds with unique physical and chemical properties, such as solubility, stability, reactivity, etc., which may have potential applications in organic synthesis, medicinal chemistry, and other fields.
"4 - bromo", above this epiphenyl ring, is connected to a bromine atom at position 4. Bromine, a halogen element, whose atoms are in an organic structure, often linked to carbon by covalent bonds, affecting the properties of compounds, such as nucleophilic substitution reaction activity.
"1 - chloro", indicates that there is a chlorine atom at position 1 of the benzene ring. Chlorine is also a halogen element, which belongs to the same group as bromine. However, due to differences in atomic radius and other factors, it has a slightly different effect on the properties of compounds than bromine.
"2 - (4 - ethoxybenzyl) ", this part is slightly more complicated. "4 - ethoxybenzyl" is the benzyl group attached to the fourth position of the benzene ring. Benzyl is a benzyl group, which is a common structural unit in organic chemistry, and ethoxy is formed by connecting ethyl to oxygen atoms. This benzyl structure is connected to the second position of the benzene ring, enriching the spatial structure and electron cloud distribution of the compound.
Overall, the chemical structure of this compound is based on the benzene ring, with bromine, chlorine atoms and benzyl groups containing ethoxy groups attached at different positions. This structure endows compounds with unique physical and chemical properties, such as solubility, stability, reactivity, etc., which may have potential applications in organic synthesis, medicinal chemistry, and other fields.
What are the physical properties of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene?
4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl) benzene is an organic compound with specific physical properties. In terms of its color state, it is usually white to light yellow crystalline powder at room temperature. It has a fine appearance and uniform quality. Due to the orderly arrangement of molecular structures, it has good crystallinity.
In terms of melting point, it is about 80 - 85 ° C. This characteristic is derived from the intermolecular forces, including van der Waals forces and hydrogen bonds. The bromine, chlorine atoms and benzene ring structures in the molecule stabilize the intermolecular interactions and require specific energy to overcome them. The melting point is in this range.
At the boiling point, it is roughly 350 - 370 ° C. The higher boiling point is due to the large molecular mass and complex structure, and the strong intermolecular forces. To convert the liquid state into the gaseous state, a lot of energy is required to overcome, so the boiling point is quite high.
In terms of solubility, the compound is slightly soluble in water, because water is a polar solvent, and the molecular polarity of this compound is relatively small. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is easily soluble in organic solvents, such as dichloromethane, chloroform, toluene, etc. Because these organic solvents are similar to the intermolecular forces of the compound, they can miscible with each other.
The density is about 1.3 - 1.4 g/cm ³, which is larger than water. Due to the relatively large atomic mass of bromine and chlorine atoms in the molecule, the mass per unit volume increases, and the density is higher than that of water.
In addition, the compound is volatile to a certain extent, but relatively weak. Due to the intermolecular force limiting the escape of molecules from the solid or liquid surface, the volatilization rate is slow at room temperature and pressure.
In terms of melting point, it is about 80 - 85 ° C. This characteristic is derived from the intermolecular forces, including van der Waals forces and hydrogen bonds. The bromine, chlorine atoms and benzene ring structures in the molecule stabilize the intermolecular interactions and require specific energy to overcome them. The melting point is in this range.
At the boiling point, it is roughly 350 - 370 ° C. The higher boiling point is due to the large molecular mass and complex structure, and the strong intermolecular forces. To convert the liquid state into the gaseous state, a lot of energy is required to overcome, so the boiling point is quite high.
In terms of solubility, the compound is slightly soluble in water, because water is a polar solvent, and the molecular polarity of this compound is relatively small. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is easily soluble in organic solvents, such as dichloromethane, chloroform, toluene, etc. Because these organic solvents are similar to the intermolecular forces of the compound, they can miscible with each other.
The density is about 1.3 - 1.4 g/cm ³, which is larger than water. Due to the relatively large atomic mass of bromine and chlorine atoms in the molecule, the mass per unit volume increases, and the density is higher than that of water.
In addition, the compound is volatile to a certain extent, but relatively weak. Due to the intermolecular force limiting the escape of molecules from the solid or liquid surface, the volatilization rate is slow at room temperature and pressure.
What are the main uses of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene?
4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl) benzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
Viewing the great industry of organic synthesis, this compound can be converted into other complex and special organic molecules through subtle reaction pathways. Due to its structure, functional groups such as bromine, chlorine and ethoxybenzyl each have unique reactivity. Bromine and chlorine atoms can participate in nucleophilic substitution reactions, which can combine this compound with many nucleophilic reagents to expand the structure of the molecule. The ethoxybenzyl moiety may affect the spatial configuration and electron cloud distribution of the molecule, and also have a significant impact on the selectivity and activity of the reaction in subsequent reactions.
In the field of materials science, this compound can be used as a starting material and can be prepared with special optoelectronic properties through a series of chemical transformations. For example, it can be used to synthesize organic Light Emitting Diode (OLED) materials with specific luminescent properties, because of its structural properties or can adjust the energy level structure of the material, improve luminous efficiency and color purity.
Furthermore, in the study of medicinal chemistry, this compound may serve as a structural fragment of the lead compound. After modification and modification, bioactive molecules may be obtained, which are expected to become potential drugs for the treatment of specific diseases. Structural parts such as genphenyl ring and ethoxybenzyl may interact with specific targets in organisms and exhibit pharmacological activity.
In summary, 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene has important application value in many fields such as organic synthesis, materials science and pharmaceutical chemistry, and is an important compound that cannot be ignored in organic chemistry research.
Viewing the great industry of organic synthesis, this compound can be converted into other complex and special organic molecules through subtle reaction pathways. Due to its structure, functional groups such as bromine, chlorine and ethoxybenzyl each have unique reactivity. Bromine and chlorine atoms can participate in nucleophilic substitution reactions, which can combine this compound with many nucleophilic reagents to expand the structure of the molecule. The ethoxybenzyl moiety may affect the spatial configuration and electron cloud distribution of the molecule, and also have a significant impact on the selectivity and activity of the reaction in subsequent reactions.
In the field of materials science, this compound can be used as a starting material and can be prepared with special optoelectronic properties through a series of chemical transformations. For example, it can be used to synthesize organic Light Emitting Diode (OLED) materials with specific luminescent properties, because of its structural properties or can adjust the energy level structure of the material, improve luminous efficiency and color purity.
Furthermore, in the study of medicinal chemistry, this compound may serve as a structural fragment of the lead compound. After modification and modification, bioactive molecules may be obtained, which are expected to become potential drugs for the treatment of specific diseases. Structural parts such as genphenyl ring and ethoxybenzyl may interact with specific targets in organisms and exhibit pharmacological activity.
In summary, 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene has important application value in many fields such as organic synthesis, materials science and pharmaceutical chemistry, and is an important compound that cannot be ignored in organic chemistry research.
What are the synthesis methods of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene?
The synthesis method of 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene has been known for a long time. There are many methods, and the common ones are described today.
First, the halogenated aromatic hydrocarbon is used as the starting material. First, the appropriate halogenated benzene is taken, and it is reacted with the benzyl halide containing ethoxy group in the presence of a suitable base and a catalyst. In this process, the base can help the halogen ion to leave, and the catalyst accelerates the reaction process. For example, potassium carbonate is used as a base, copper salt is used as a catalyst, and heating and stirring in an organic solvent, the halogen atom of halogenated benzene is exchanged with the halogen atom of benzyl halide, and the desired 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene is generated. This organic solvent, commonly selected dimethylformamide (DMF) or N-methylpyrrolidone (NMP), etc., has good solubility to reactants and products, and the reaction conditions are mild.
Second, it is gradually constructed from benzene derivatives. First, benzaldehyde containing ethoxy groups is prepared, which interacts with brominating agents and chlorinating agents respectively. Bromine atoms and chlorine atoms are introduced at specific positions in the benzene ring, and then the benzyl part is introduced at the designated position through a series of reactions such as reduction and substitution. For example, the benzaldehyde ring is brominated with bromine under suitable conditions. The reaction conditions can be controlled so that the bromine atom is positioned at a specific position, and then the chlorine atom is introduced through the chlorination reaction. Subsequently, the aldehyde group is reduced to alcohol, which is then converted into a halide, and then substituted with the benzene derivative containing ethoxy groups to obtain the final target product.
Third, the coupling reaction catalyzed by transition metals is used. The coupling reaction of phenylboronic acid derivatives containing bromine and chlorine and benzyl halide containing ethoxyl group occurs under the action of transition metal (such as palladium, nickel, etc.) catalysts. This kind of reaction has high selectivity and can accurately construct the target molecular structure. Palladium catalysts often cooperate with specific ligands, such as phosphine ligands, which can enhance the activity and selectivity of the catalyst. The reaction is carried out in the presence of suitable solvents and bases. Common solvents such as toluene, dichloromethane, etc. The base is preferably a strong base such as potassium tert-butanol. Under such reaction conditions, 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene can be efficiently synthesized.
The above synthesis methods have their own advantages and disadvantages. In practical application, the selection should be weighed according to factors such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.
First, the halogenated aromatic hydrocarbon is used as the starting material. First, the appropriate halogenated benzene is taken, and it is reacted with the benzyl halide containing ethoxy group in the presence of a suitable base and a catalyst. In this process, the base can help the halogen ion to leave, and the catalyst accelerates the reaction process. For example, potassium carbonate is used as a base, copper salt is used as a catalyst, and heating and stirring in an organic solvent, the halogen atom of halogenated benzene is exchanged with the halogen atom of benzyl halide, and the desired 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene is generated. This organic solvent, commonly selected dimethylformamide (DMF) or N-methylpyrrolidone (NMP), etc., has good solubility to reactants and products, and the reaction conditions are mild.
Second, it is gradually constructed from benzene derivatives. First, benzaldehyde containing ethoxy groups is prepared, which interacts with brominating agents and chlorinating agents respectively. Bromine atoms and chlorine atoms are introduced at specific positions in the benzene ring, and then the benzyl part is introduced at the designated position through a series of reactions such as reduction and substitution. For example, the benzaldehyde ring is brominated with bromine under suitable conditions. The reaction conditions can be controlled so that the bromine atom is positioned at a specific position, and then the chlorine atom is introduced through the chlorination reaction. Subsequently, the aldehyde group is reduced to alcohol, which is then converted into a halide, and then substituted with the benzene derivative containing ethoxy groups to obtain the final target product.
Third, the coupling reaction catalyzed by transition metals is used. The coupling reaction of phenylboronic acid derivatives containing bromine and chlorine and benzyl halide containing ethoxyl group occurs under the action of transition metal (such as palladium, nickel, etc.) catalysts. This kind of reaction has high selectivity and can accurately construct the target molecular structure. Palladium catalysts often cooperate with specific ligands, such as phosphine ligands, which can enhance the activity and selectivity of the catalyst. The reaction is carried out in the presence of suitable solvents and bases. Common solvents such as toluene, dichloromethane, etc. The base is preferably a strong base such as potassium tert-butanol. Under such reaction conditions, 4-bromo-1-chloro-2 - (4-ethoxybenzyl) benzene can be efficiently synthesized.
The above synthesis methods have their own advantages and disadvantages. In practical application, the selection should be weighed according to factors such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.
What are the precautions for 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene during storage and transportation?
4 - bromo - 1 - chloro - 2 - (4 - ethoxybenzyl) benzene is also an organic compound. When storing and transporting, there are several ends that need to be carefully paid attention to.
Bear the brunt first. When storing, it should be placed in a cool, dry and well-ventilated place. This compound may be quite sensitive to humidity and temperature. High temperature and humid environments can easily cause chemical reactions or deterioration. Therefore, it is necessary to avoid direct sunlight, because light may also cause luminescent chemical reactions, which can damage its chemical stability.
Furthermore, it must be tightly packed. Suitable packaging materials should be used to prevent leakage. Due to the certain toxicity and irritation of the compound, once it leaks, it will not only pollute the environment, but also endanger personal safety.
During transportation, do not take it lightly. It is necessary to strictly follow the relevant transportation regulations and transport it separately from oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with these substances is very likely to cause a violent reaction, resulting in accidents.
At the same time, transportation personnel also need to undergo professional training to be familiar with the characteristics of this compound and emergency treatment methods. Transportation tools should also ensure that they are clean and free of other chemicals to avoid cross-contamination. The safety of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene and the avoidance of potential risks can only be ensured by following strict standards and paying attention to all details during storage and transportation.
Bear the brunt first. When storing, it should be placed in a cool, dry and well-ventilated place. This compound may be quite sensitive to humidity and temperature. High temperature and humid environments can easily cause chemical reactions or deterioration. Therefore, it is necessary to avoid direct sunlight, because light may also cause luminescent chemical reactions, which can damage its chemical stability.
Furthermore, it must be tightly packed. Suitable packaging materials should be used to prevent leakage. Due to the certain toxicity and irritation of the compound, once it leaks, it will not only pollute the environment, but also endanger personal safety.
During transportation, do not take it lightly. It is necessary to strictly follow the relevant transportation regulations and transport it separately from oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with these substances is very likely to cause a violent reaction, resulting in accidents.
At the same time, transportation personnel also need to undergo professional training to be familiar with the characteristics of this compound and emergency treatment methods. Transportation tools should also ensure that they are clean and free of other chemicals to avoid cross-contamination. The safety of 4-bromo-1-chloro-2- (4-ethoxybenzyl) benzene and the avoidance of potential risks can only be ensured by following strict standards and paying attention to all details during storage and transportation.
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