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4-Bromo-1-Chloro-2-(4-Methoxy-Benzyl)-Benzene
Linshang Chemical
|
HS Code |
787402 |
| Chemical Formula | C14H12BrClO |
| Molar Mass | 311.602 g/mol |
| Appearance | Solid (predicted) |
| Solubility In Water | Insoluble (predicted) |
| Solubility In Organic Solvents | Soluble in common organic solvents (predicted) |
| Purity | Varies by source |
As an accredited 4-Bromo-1-Chloro-2-(4-Methoxy-Benzyl)-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 1 - chloro - 2 - (4 - methoxy - benzyl) - benzene in sealed plastic bags. |
| Storage | 4 - bromo - 1 - chloro - 2 - (4 - methoxy - benzyl) - benzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to chemical degradation. Store it separately from incompatible substances, such as oxidizing agents and strong acids or bases. |
| Shipping | 4 - bromo - 1 - chloro - 2 - (4 - methoxy - benzyl) - benzene is shipped in sealed, properly labeled containers. Shipment follows strict chemical transport regulations, ensuring safe handling during transit to prevent any risks. |
Competitive 4-Bromo-1-Chloro-2-(4-Methoxy-Benzyl)-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-bromo-1-chloro-2- (4-methoxy-benzyl) benzene?
This is the name of the organic compound. According to its name "4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene", its chemical structure can be deduced. Its core is the benzene ring, which is a very common structure in organic chemistry and has special stability and chemical activity.
Above the benzene ring, there is a bromine atom at position 4. The bromine atom is a halogen element, which has strong electronegativity and can significantly affect the physical and chemical properties of the molecule. At position 1, there is a chlorine atom, which is also a halogen element. Together with the bromine atom, the electron cloud distribution of the benzene ring is changed, and the chemical activity of the benzene ring is different from that of unsubstituted benzene.
is particularly crucial, there is a substituent connected at position 2, this substituent is "4-methoxy-benzyl". Benzyl is derived from benzyl, that is, the benzene ring is connected to a methylene (-CH 2O -). At position 4 of the benzyl ring, there is a methoxy group (-OCH 🥰). Methoxy is the power supply group, which can increase the electron cloud density of the benzene ring, which in turn affects the reactivity and selectivity of the whole molecule.
In summary, the chemical structure of this compound is centered on the benzene ring, with bromine, chlorine atoms and 4-methoxy-benzyl substituents at specific positions. The interaction of each part endows the compound with unique physical and chemical properties and chemical reactivity, and may have important potential applications in organic synthesis, medicinal chemistry and other fields.
Above the benzene ring, there is a bromine atom at position 4. The bromine atom is a halogen element, which has strong electronegativity and can significantly affect the physical and chemical properties of the molecule. At position 1, there is a chlorine atom, which is also a halogen element. Together with the bromine atom, the electron cloud distribution of the benzene ring is changed, and the chemical activity of the benzene ring is different from that of unsubstituted benzene.
is particularly crucial, there is a substituent connected at position 2, this substituent is "4-methoxy-benzyl". Benzyl is derived from benzyl, that is, the benzene ring is connected to a methylene (-CH 2O -). At position 4 of the benzyl ring, there is a methoxy group (-OCH 🥰). Methoxy is the power supply group, which can increase the electron cloud density of the benzene ring, which in turn affects the reactivity and selectivity of the whole molecule.
In summary, the chemical structure of this compound is centered on the benzene ring, with bromine, chlorine atoms and 4-methoxy-benzyl substituents at specific positions. The interaction of each part endows the compound with unique physical and chemical properties and chemical reactivity, and may have important potential applications in organic synthesis, medicinal chemistry and other fields.
What are the main uses of 4-bromo-1-chloro-2- (4-methoxy-benzyl) benzene?
4-Bromo-1-chloro-2- (4-methoxy-benzyl) benzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In terms of pharmaceutical chemistry, molecular structures with specific pharmacological activities can be constructed from this compound. In the creation of many drugs, it is often used as a starting material to modify their structures through various chemical reactions to obtain the expected pharmacological properties. For example, specific functional groups can be introduced to make them show affinity and activity to specific disease targets, paving the way for the development of new drugs.
In the field of materials science, this compound also has potential uses. It can be polymerized or combined with other materials to prepare functional materials with special properties. For example, in the field of optoelectronic materials, it may endow materials with unique optical and electrical properties, and make a name for itself in the manufacture of Light Emitting Diodes, solar cells and other devices.
Furthermore, in the fine chemical industry, 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene can be used to synthesize high-end fine chemicals, such as special fragrances, pigments, etc. Through chemical transformation, fine chemical products with novel structures and excellent performance can be obtained to meet the needs of high-quality chemicals in different fields.
Overall, 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene plays an important role in many fields such as drugs, materials, and fine chemicals, providing a material basis and innovation possibilities for the development of various fields.
In terms of pharmaceutical chemistry, molecular structures with specific pharmacological activities can be constructed from this compound. In the creation of many drugs, it is often used as a starting material to modify their structures through various chemical reactions to obtain the expected pharmacological properties. For example, specific functional groups can be introduced to make them show affinity and activity to specific disease targets, paving the way for the development of new drugs.
In the field of materials science, this compound also has potential uses. It can be polymerized or combined with other materials to prepare functional materials with special properties. For example, in the field of optoelectronic materials, it may endow materials with unique optical and electrical properties, and make a name for itself in the manufacture of Light Emitting Diodes, solar cells and other devices.
Furthermore, in the fine chemical industry, 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene can be used to synthesize high-end fine chemicals, such as special fragrances, pigments, etc. Through chemical transformation, fine chemical products with novel structures and excellent performance can be obtained to meet the needs of high-quality chemicals in different fields.
Overall, 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene plays an important role in many fields such as drugs, materials, and fine chemicals, providing a material basis and innovation possibilities for the development of various fields.
What are the synthesis methods of 4-bromo-1-chloro-2- (4-methoxy-benzyl) benzene?
To prepare 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene, there are many ways to synthesize it.
First, you can start from the compound containing benzene ring. First, take a suitable benzene derivative with a modifiable group on it. If methoxybenzyl chloride is selected, the chlorine activity on the benzyl group is higher, and it can undergo nucleophilic substitution reaction with another benzene derivative containing bromine. For example, take 2-bromo-4-chlorobenzene, under suitable catalyst and reaction conditions, such as potassium carbonate as a base, in a polar aprotic solvent such as DMF, heat the reaction, benzyl chloride and hydrogen on the benzene ring are substituted, thereby introducing 4-methoxybenzyl to form the target product.
Second, it can also be halogenated from p-methoxybenzyl alcohol to obtain p-methoxybenzyl halogen, and then Suzuki coupling reaction with 2-bromo-4-chlorophenylboronic acid under palladium catalysis. Tetrakis (triphenylphosphine) palladium is used as a catalyst, and in the presence of a base (such as sodium carbonate aqueous solution), it is heated and refluxed in an organic solvent (such as toluene and ethanol mixed solvent) to achieve the construction of carbon-carbon bonds. The target compound is obtained.
Third, the benzyl ring structure can also be constructed first. For example, using m-chlorobrombenzene as a raw material, through Fu-gram alkylation reaction, under the catalyst of Lewis acid such as aluminum trichloride, it reacts with p-methoxybenzyl chloride to control the reaction conditions, so that benzyl is selectively introduced into a specific position of the benzene ring, and then 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benz Each of these methods has its own advantages and disadvantages, and it is necessary to choose the best one according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the high or low yield.
First, you can start from the compound containing benzene ring. First, take a suitable benzene derivative with a modifiable group on it. If methoxybenzyl chloride is selected, the chlorine activity on the benzyl group is higher, and it can undergo nucleophilic substitution reaction with another benzene derivative containing bromine. For example, take 2-bromo-4-chlorobenzene, under suitable catalyst and reaction conditions, such as potassium carbonate as a base, in a polar aprotic solvent such as DMF, heat the reaction, benzyl chloride and hydrogen on the benzene ring are substituted, thereby introducing 4-methoxybenzyl to form the target product.
Second, it can also be halogenated from p-methoxybenzyl alcohol to obtain p-methoxybenzyl halogen, and then Suzuki coupling reaction with 2-bromo-4-chlorophenylboronic acid under palladium catalysis. Tetrakis (triphenylphosphine) palladium is used as a catalyst, and in the presence of a base (such as sodium carbonate aqueous solution), it is heated and refluxed in an organic solvent (such as toluene and ethanol mixed solvent) to achieve the construction of carbon-carbon bonds. The target compound is obtained.
Third, the benzyl ring structure can also be constructed first. For example, using m-chlorobrombenzene as a raw material, through Fu-gram alkylation reaction, under the catalyst of Lewis acid such as aluminum trichloride, it reacts with p-methoxybenzyl chloride to control the reaction conditions, so that benzyl is selectively introduced into a specific position of the benzene ring, and then 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benz Each of these methods has its own advantages and disadvantages, and it is necessary to choose the best one according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the high or low yield.
What are the physical properties of 4-bromo-1-chloro-2- (4-methoxy-benzyl) benzene?
4 - bromo - 1 - chloro - 2 - (4 - methoxy - benzyl) benzene is an organic compound. Its physical properties are very critical and are of great significance in chemical research and industrial applications.
Looking at its appearance, under normal temperature and pressure, this compound is often in a solid state. Due to the interaction between molecules such as van der Waals force, the molecular arrangement is relatively orderly, thus forming a solid-state structure.
When it comes to the melting point, the molecular structure contains halogen atoms such as bromine and chlorine, as well as groups such as benzene ring and methoxy group. The interaction between these atoms and the groups is complex, which enhances the intermolecular force, so its melting point is relatively high. The specific value will vary slightly depending on the purity of the compound and the test conditions, but it is generally within a certain temperature range.
In terms of boiling point, due to the complex molecular structure and the large intermolecular forces, in order to make the compound change from liquid to gaseous state, more energy needs to be provided to overcome the attractive forces between molecules, so the boiling point is also high.
In terms of solubility, this compound is insoluble in water. The reason is that its molecular structure is dominated by non-polar benzene rings, and water is a polar solvent. According to the principle of "similarity and compatibility", the polar difference leads to poor miscibility between the two. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, toluene, etc. Because these organic solvents are similar to the intermolecular forces of the compound, they can be miscible with each other.
Density is also one of its important physical properties. Because the molecule contains atoms with relatively large atomic mass such as bromine and chlorine, the density is larger than that of water. In practical operation and application, this property can be used to separate and purify the compound.
In addition, the chemical properties of the compound are relatively stable at room temperature, but under certain conditions, such as high temperature, light or the presence of catalysts, the bromine atoms, chlorine atoms and benzyl groups in the molecule may undergo chemical reactions, exhibiting different chemical activities.
In conclusion, the physical properties of 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene are closely related to its molecular structure, and understanding these properties is essential for its applications in organic synthesis, materials science, and other fields.
Looking at its appearance, under normal temperature and pressure, this compound is often in a solid state. Due to the interaction between molecules such as van der Waals force, the molecular arrangement is relatively orderly, thus forming a solid-state structure.
When it comes to the melting point, the molecular structure contains halogen atoms such as bromine and chlorine, as well as groups such as benzene ring and methoxy group. The interaction between these atoms and the groups is complex, which enhances the intermolecular force, so its melting point is relatively high. The specific value will vary slightly depending on the purity of the compound and the test conditions, but it is generally within a certain temperature range.
In terms of boiling point, due to the complex molecular structure and the large intermolecular forces, in order to make the compound change from liquid to gaseous state, more energy needs to be provided to overcome the attractive forces between molecules, so the boiling point is also high.
In terms of solubility, this compound is insoluble in water. The reason is that its molecular structure is dominated by non-polar benzene rings, and water is a polar solvent. According to the principle of "similarity and compatibility", the polar difference leads to poor miscibility between the two. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, toluene, etc. Because these organic solvents are similar to the intermolecular forces of the compound, they can be miscible with each other.
Density is also one of its important physical properties. Because the molecule contains atoms with relatively large atomic mass such as bromine and chlorine, the density is larger than that of water. In practical operation and application, this property can be used to separate and purify the compound.
In addition, the chemical properties of the compound are relatively stable at room temperature, but under certain conditions, such as high temperature, light or the presence of catalysts, the bromine atoms, chlorine atoms and benzyl groups in the molecule may undergo chemical reactions, exhibiting different chemical activities.
In conclusion, the physical properties of 4-bromo-1-chloro-2 - (4-methoxy-benzyl) benzene are closely related to its molecular structure, and understanding these properties is essential for its applications in organic synthesis, materials science, and other fields.
What are the chemical properties of 4-bromo-1-chloro-2- (4-methoxy-benzyl) benzene?
4 - bromo - 1 - chloro - 2 - (4 - methoxy - benzyl) benzene, Chinese name or 4 - bromo - 1 - chloro - 2 - (4 - methoxybenzyl) benzene. This compound has unique chemical properties, is related to many organic reactions, and is very important in the field of organic synthesis.
From the structure point of view, the molecule contains bromine, chlorine atom halogen and methoxybenzyl. Bromine and chlorine atoms are highly active and can participate in nucleophilic substitution reactions. In the case of nucleophilic reagents, halogens can be replaced to form new carbon-hetero bonds. For example, under suitable conditions, cyano negative ions (CN) can replace bromine or chlorine to obtain new compounds containing cyanide groups, which introduce key functional groups for subsequent synthesis and are used to prepare nitrile derivatives, which are common in the synthesis of medicine and pesticides. The aromatic ring part of
is aromatic and can undergo electrophilic substitution reaction. Because methoxy is the power supply radical, the electron cloud density of the benzene ring can be increased, and electrophilic substitution is more likely to occur, and the electron cloud density of the methoxy group is relatively higher, and the electrophilic reagents tend to attack these positions. For example, in the reaction with bromine catalyzed by iron bromide, bromine will preferentially replace the methoxy group o and para-hydrogen atoms, generate new substitution products, enrich the molecular structure, and expand its application range. The methoxy group in the methoxybenzyl group
can participate in some special reactions. The methoxy group can be removed under specific conditions, providing a check point for subsequent modifications. For example, under the action of strong acids or specific reagents, the methoxy group can be protonated away, so that the benzyl carbon cation is formed, and then reacts with nucleophiles to realize the structural modification of the benzyl part, which is used to construct complex organic molecules. It is of great significance in the total synthesis of natural products.
The chemical properties of this compound are rich, providing a variety of reaction paths for organic synthesis chemists to prepare organic compounds with complex structures and unique functions, and promoting the development of organic synthesis chemistry, medicinal chemistry and other fields.
From the structure point of view, the molecule contains bromine, chlorine atom halogen and methoxybenzyl. Bromine and chlorine atoms are highly active and can participate in nucleophilic substitution reactions. In the case of nucleophilic reagents, halogens can be replaced to form new carbon-hetero bonds. For example, under suitable conditions, cyano negative ions (CN) can replace bromine or chlorine to obtain new compounds containing cyanide groups, which introduce key functional groups for subsequent synthesis and are used to prepare nitrile derivatives, which are common in the synthesis of medicine and pesticides. The aromatic ring part of
is aromatic and can undergo electrophilic substitution reaction. Because methoxy is the power supply radical, the electron cloud density of the benzene ring can be increased, and electrophilic substitution is more likely to occur, and the electron cloud density of the methoxy group is relatively higher, and the electrophilic reagents tend to attack these positions. For example, in the reaction with bromine catalyzed by iron bromide, bromine will preferentially replace the methoxy group o and para-hydrogen atoms, generate new substitution products, enrich the molecular structure, and expand its application range. The methoxy group in the methoxybenzyl group
can participate in some special reactions. The methoxy group can be removed under specific conditions, providing a check point for subsequent modifications. For example, under the action of strong acids or specific reagents, the methoxy group can be protonated away, so that the benzyl carbon cation is formed, and then reacts with nucleophiles to realize the structural modification of the benzyl part, which is used to construct complex organic molecules. It is of great significance in the total synthesis of natural products.
The chemical properties of this compound are rich, providing a variety of reaction paths for organic synthesis chemists to prepare organic compounds with complex structures and unique functions, and promoting the development of organic synthesis chemistry, medicinal chemistry and other fields.
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