Linshang Chemical
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4-Bromo-1-Chloro-2-Fluorobenzene
Linshang Chemical
|
HS Code |
705187 |
| Chemical Formula | C6H3BrClF |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 190 - 192 °C |
| Density | 1.72 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 76 °C |
| Stability | Stable under normal conditions, avoid heat, open flame |
As an accredited 4-Bromo-1-Chloro-2-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 1 - chloro - 2 - fluorobenzene packaged in a sealed glass bottle. |
| Storage | 4 - bromo - 1 - chloro - 2 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 4 - bromo - 1 - chloro - 2 - fluorobenzene is shipped in sealed, corrosion - resistant containers. It's transported via approved carriers following strict chemical shipping regulations to ensure safety during transit. |
Competitive 4-Bromo-1-Chloro-2-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Bromo-1-Chloro-2-Fluorobenzene in China?
As a trusted 4-Bromo-1-Chloro-2-Fluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Bromo-1-Chloro-2-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-bromo-1-chloro-2-fluorobenzene?
4-Bromo-1-chloro-2-fluorobenzene is one of the organic compounds. It has a wide range of uses and plays an important role in many fields.
First in the field of medicinal chemistry. This compound can be used as a key intermediate for the synthesis of various drugs. Due to its unique chemical structure, it can endow the synthesized drugs with specific pharmacological activities. For example, when developing drugs with antibacterial and anti-inflammatory effects, 4-bromo-1-chloro-2-fluorobenzene may be an important starting material. Through a series of chemical reactions, it can be converted into drug molecules with precise therapeutic effects.
Furthermore, in the field of materials science, it also has applications. It can participate in the synthesis of special polymer materials. By polymerizing with other monomers, it imparts special properties to the material, such as enhancing the stability, corrosion resistance or optical properties of the material. The obtained materials may be applied to high-end scientific and technological products such as electronic devices and optical instruments.
In addition, in the field of pesticide chemistry, 4-bromo-1-chloro-2-fluorobenzene also has important value. It can be used to create new pesticides. With its structural characteristics, it can inhibit or kill specific pests or bacteria, providing a powerful means for pest control in agricultural production.
In conclusion, although 4-bromo-1-chloro-2-fluorobenzene is an organic small molecule, it has shown indispensable uses in many fields such as medicine, materials, and pesticides due to its unique structure. It is of great significance for promoting scientific and technological progress and industrial development in related fields.
First in the field of medicinal chemistry. This compound can be used as a key intermediate for the synthesis of various drugs. Due to its unique chemical structure, it can endow the synthesized drugs with specific pharmacological activities. For example, when developing drugs with antibacterial and anti-inflammatory effects, 4-bromo-1-chloro-2-fluorobenzene may be an important starting material. Through a series of chemical reactions, it can be converted into drug molecules with precise therapeutic effects.
Furthermore, in the field of materials science, it also has applications. It can participate in the synthesis of special polymer materials. By polymerizing with other monomers, it imparts special properties to the material, such as enhancing the stability, corrosion resistance or optical properties of the material. The obtained materials may be applied to high-end scientific and technological products such as electronic devices and optical instruments.
In addition, in the field of pesticide chemistry, 4-bromo-1-chloro-2-fluorobenzene also has important value. It can be used to create new pesticides. With its structural characteristics, it can inhibit or kill specific pests or bacteria, providing a powerful means for pest control in agricultural production.
In conclusion, although 4-bromo-1-chloro-2-fluorobenzene is an organic small molecule, it has shown indispensable uses in many fields such as medicine, materials, and pesticides due to its unique structure. It is of great significance for promoting scientific and technological progress and industrial development in related fields.
What are the physical properties of 4-bromo-1-chloro-2-fluorobenzene?
4-Bromo-1-chloro-2-fluorobenzene is one of the organic compounds. Its physical properties are unique and are described in detail by you.
Looking at its appearance, under room temperature and pressure, this substance is often in the form of a colorless to light yellow liquid, clear and has a special aromatic odor. Smell, its taste is specific, although not pungent, it is also different from ordinary odorless liquids.
When it comes to the boiling point, it is between 180-190 ° C. At this temperature, 4-bromo-1-chloro-2-fluorobenzene gradually converts from a liquid state to a gaseous state. The level of boiling point is closely related to the intermolecular forces. The intermolecular force of this compound is moderate, causing its boiling point to be in this range.
As for the melting point, it is about - 20 ° C. When the temperature drops to this value, 4-bromo-1-chloro-2-fluorobenzene converts from liquid to solid. Determination of the melting point is essential for the identification and purification of this substance.
Its density is about 1.8 g/cm ³, which is heavier than water. If it is placed in one place with water, 4-bromo-1-chloro-2-fluorobenzene will sink to the bottom of the water. This property is due to the mass and structure of its molecules, which makes its mass per unit volume greater than that of water.
In terms of solubility, 4-bromo-1-chloro-2-fluorobenzene is slightly soluble in water. Because water is a polar molecule, while the polarity of 4-bromo-1-chloro-2-fluorobenzene molecules is weak, according to the principle of "similarity and miscibility", the two are difficult to miscible. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. In organic solvents, 4-bromo-1-chloro-2-fluorobenzene can form a suitable interaction with the solvent molecules, so it can be dissolved.
In summary, the physical properties of 4-bromo-1-chloro-2-fluorobenzene, such as appearance, boiling point, melting point, density and solubility, are all important characterizations for chemical research and industrial applications.
Looking at its appearance, under room temperature and pressure, this substance is often in the form of a colorless to light yellow liquid, clear and has a special aromatic odor. Smell, its taste is specific, although not pungent, it is also different from ordinary odorless liquids.
When it comes to the boiling point, it is between 180-190 ° C. At this temperature, 4-bromo-1-chloro-2-fluorobenzene gradually converts from a liquid state to a gaseous state. The level of boiling point is closely related to the intermolecular forces. The intermolecular force of this compound is moderate, causing its boiling point to be in this range.
As for the melting point, it is about - 20 ° C. When the temperature drops to this value, 4-bromo-1-chloro-2-fluorobenzene converts from liquid to solid. Determination of the melting point is essential for the identification and purification of this substance.
Its density is about 1.8 g/cm ³, which is heavier than water. If it is placed in one place with water, 4-bromo-1-chloro-2-fluorobenzene will sink to the bottom of the water. This property is due to the mass and structure of its molecules, which makes its mass per unit volume greater than that of water.
In terms of solubility, 4-bromo-1-chloro-2-fluorobenzene is slightly soluble in water. Because water is a polar molecule, while the polarity of 4-bromo-1-chloro-2-fluorobenzene molecules is weak, according to the principle of "similarity and miscibility", the two are difficult to miscible. However, it is soluble in many organic solvents, such as ethanol, ether, dichloromethane, etc. In organic solvents, 4-bromo-1-chloro-2-fluorobenzene can form a suitable interaction with the solvent molecules, so it can be dissolved.
In summary, the physical properties of 4-bromo-1-chloro-2-fluorobenzene, such as appearance, boiling point, melting point, density and solubility, are all important characterizations for chemical research and industrial applications.
What are the chemical properties of 4-bromo-1-chloro-2-fluorobenzene?
4-Bromo-1-chloro-2-fluorobenzene is one of the organic halogenated aromatic hydrocarbons. Its chemical properties are profound, let me elaborate.
As far as the electrophilic substitution reaction is concerned, the halogen atoms above the benzene ring are all blunt groups, which can reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult than that of benzene. However, such halogen atoms are also ortho-para-sites. The electronegativity of bromine, chlorine and fluorine atoms is different, and the effect on the electron cloud density of the benzene ring is also different. The fluorine atom is extremely electronegative. Although it is an ortho-para-site group, the electron cloud density of the benzene ring is greatly reduced due to the significant electron-absorbing induction effect, and the electrophilic The electron-absorbing induction effect of bromine and chlorine atoms is slightly weaker than that of fluorine, and the inhibition of the activity of benzene ring is also slightly slower.
In the nucleophilic substitution reaction, this compound can undergo nucleophilic substitution due to the presence of halogen atoms on the benzene ring. Fluorine atoms have a small tendency to leave due to the large bond energy of C-F, but the influence of other halogen atoms and substituents on the benzene ring may change their activity. Compared with chlorine atoms, bromine and chlorine atoms have slightly stronger ability to leave, and can be replaced by nucleophilic reagents under appropriate conditions.
Furthermore, the reactivity of each halogen atom in 4-bromo-1-chloro-2-fluorobenzene is also affected by reaction conditions such as solvent, temperature, nucleophilic basicity and nucleophilicity. In polar aprotic solvents, the nucleophilicity of nucleophilic reagents is enhanced, or nucleophilic substitution reactions are more likely to occur.
In this compound, the spatial structure and chemical activity of molecules are unique due to the spatial and electronic effects of different halogen atoms. The interaction of each halogen atom may affect the difficulty and selectivity of its participation in the reaction. For example, in some reactions, due to steric hindrance, halogen atoms at specific positions may preferentially participate in the reaction, or due to the synergy of electronic effects, the reaction tends to generate specific products.
Overall, the chemical properties of 4-bromo-1-chloro-2-fluorobenzene are intertwined by the characteristics of benzene rings and halogen atoms, and have specific applications and research values in organic synthesis and other fields.
As far as the electrophilic substitution reaction is concerned, the halogen atoms above the benzene ring are all blunt groups, which can reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult than that of benzene. However, such halogen atoms are also ortho-para-sites. The electronegativity of bromine, chlorine and fluorine atoms is different, and the effect on the electron cloud density of the benzene ring is also different. The fluorine atom is extremely electronegative. Although it is an ortho-para-site group, the electron cloud density of the benzene ring is greatly reduced due to the significant electron-absorbing induction effect, and the electrophilic The electron-absorbing induction effect of bromine and chlorine atoms is slightly weaker than that of fluorine, and the inhibition of the activity of benzene ring is also slightly slower.
In the nucleophilic substitution reaction, this compound can undergo nucleophilic substitution due to the presence of halogen atoms on the benzene ring. Fluorine atoms have a small tendency to leave due to the large bond energy of C-F, but the influence of other halogen atoms and substituents on the benzene ring may change their activity. Compared with chlorine atoms, bromine and chlorine atoms have slightly stronger ability to leave, and can be replaced by nucleophilic reagents under appropriate conditions.
Furthermore, the reactivity of each halogen atom in 4-bromo-1-chloro-2-fluorobenzene is also affected by reaction conditions such as solvent, temperature, nucleophilic basicity and nucleophilicity. In polar aprotic solvents, the nucleophilicity of nucleophilic reagents is enhanced, or nucleophilic substitution reactions are more likely to occur.
In this compound, the spatial structure and chemical activity of molecules are unique due to the spatial and electronic effects of different halogen atoms. The interaction of each halogen atom may affect the difficulty and selectivity of its participation in the reaction. For example, in some reactions, due to steric hindrance, halogen atoms at specific positions may preferentially participate in the reaction, or due to the synergy of electronic effects, the reaction tends to generate specific products.
Overall, the chemical properties of 4-bromo-1-chloro-2-fluorobenzene are intertwined by the characteristics of benzene rings and halogen atoms, and have specific applications and research values in organic synthesis and other fields.
What are 4-bromo-1-chloro-2-fluorobenzene synthesis methods?
The synthesis methods of 4-bromo-1-chloro-2-fluorobenzene are different, and the advantages and disadvantages of each method are different, and it needs to be selected according to the actual situation.
First, the method of halogenation substitution. Using benzene as the starting material, chlorobenzene can be obtained by chlorination reaction first. In this process, under the action of appropriate temperature and catalyst, chlorine and benzene undergo electrophilic substitution to form chlorobenzene. Then bromination is carried out. Suitable brominating reagents and conditions need to be selected to replace bromine atoms at specific positions of chlorobenzene to form 1-chloro-4-bromobenzene. Finally, fluorination is carried out, and special fluorination reagents are used to introduce fluorine atoms under suitable reaction conditions to obtain the target product 4-bromo-1-chloro-2-fluorobenzene. Although this path step is relatively clear, the selective control of the halogenation reaction needs to be carefully considered, and the reaction conditions of each step need to be precisely adjusted.
Second, aromatics containing specific substituents are used as starting materials. If aromatics with suitable substituent positions are found, they can be achieved through a series of functional group conversions. For example, an aromatic hydrocarbon contains functional groups that can be converted into bromine, chlorine, and fluorine. After a reasonable sequence of reactions, such as nucleophilic substitution, elimination, addition, etc., the required halogen atoms are gradually introduced, and finally 4-bromo-1-chloro-2-fluorobenzene is obtained. This approach requires high starting materials, and suitable substrates need to be precisely found, but the selectivity of the reaction can be optimized by the guidance of existing substituents.
Third, the coupling reaction catalyzed by transition metals. Aromatic derivatives containing different halogen atoms can be selected, and they can be spliced by coupling reaction under the catalysis of transition metal catalysts such as palladium and nickel. For example, aromatics containing bromine and reagents containing chlorine and fluorine are reacted in suitable solvents in the presence of specific ligands and bases. With the help of transition metal catalytic activity, this method can effectively construct carbon-halogen bonds and achieve precise synthesis, but the cost of catalysts and post-treatment of reactions may pose certain challenges.
There are many methods for synthesizing 4-bromo-1-chloro-2-fluorobenzene, each with its own advantages and disadvantages. Experimenters should carefully choose the optimal synthesis path according to their own needs, such as raw material availability, cost considerations, and product purity requirements.
First, the method of halogenation substitution. Using benzene as the starting material, chlorobenzene can be obtained by chlorination reaction first. In this process, under the action of appropriate temperature and catalyst, chlorine and benzene undergo electrophilic substitution to form chlorobenzene. Then bromination is carried out. Suitable brominating reagents and conditions need to be selected to replace bromine atoms at specific positions of chlorobenzene to form 1-chloro-4-bromobenzene. Finally, fluorination is carried out, and special fluorination reagents are used to introduce fluorine atoms under suitable reaction conditions to obtain the target product 4-bromo-1-chloro-2-fluorobenzene. Although this path step is relatively clear, the selective control of the halogenation reaction needs to be carefully considered, and the reaction conditions of each step need to be precisely adjusted.
Second, aromatics containing specific substituents are used as starting materials. If aromatics with suitable substituent positions are found, they can be achieved through a series of functional group conversions. For example, an aromatic hydrocarbon contains functional groups that can be converted into bromine, chlorine, and fluorine. After a reasonable sequence of reactions, such as nucleophilic substitution, elimination, addition, etc., the required halogen atoms are gradually introduced, and finally 4-bromo-1-chloro-2-fluorobenzene is obtained. This approach requires high starting materials, and suitable substrates need to be precisely found, but the selectivity of the reaction can be optimized by the guidance of existing substituents.
Third, the coupling reaction catalyzed by transition metals. Aromatic derivatives containing different halogen atoms can be selected, and they can be spliced by coupling reaction under the catalysis of transition metal catalysts such as palladium and nickel. For example, aromatics containing bromine and reagents containing chlorine and fluorine are reacted in suitable solvents in the presence of specific ligands and bases. With the help of transition metal catalytic activity, this method can effectively construct carbon-halogen bonds and achieve precise synthesis, but the cost of catalysts and post-treatment of reactions may pose certain challenges.
There are many methods for synthesizing 4-bromo-1-chloro-2-fluorobenzene, each with its own advantages and disadvantages. Experimenters should carefully choose the optimal synthesis path according to their own needs, such as raw material availability, cost considerations, and product purity requirements.
4-bromo-1-chloro-2-fluorobenzene what are the precautions during storage and transportation?
4-Bromo-1-chloro-2-fluorobenzene is also an organic compound. When storing and transporting, several things should be taken with caution.
Safety is the first priority. This compound may be toxic, irritating, or even flammable, so it must be handled in accordance with safety procedures. The storage place should be cool, dry and well ventilated, away from fire, heat and oxidants to prevent the risk of fire and explosion.
Furthermore, the packaging must be strict. The packaging materials used should be able to withstand the erosion of this compound without leakage. When transporting, it should also ensure that the packaging is stable and protected from package damage caused by collision and vibration.
Repeat, the label must be clear. On the container, the name, characteristics, hazard warning and other information of the compound should be clearly marked, so that the contact can see at a glance, so as to take appropriate protection measures.
In addition, the operator should be professionally trained. Familiar with the properties, hazards and emergency treatment methods of this compound. When operating, be sure to wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks.
Finally, emergency measures should not be ignored. Storage and transportation sites should be equipped with corresponding emergency equipment and materials, such as fire extinguishers, eye washers, first aid medicines, etc. In case of leakage, fire and other accidents, they can respond quickly to reduce the damage.
All of these should be taken into account when storing and transporting 4-bromo-1-chloro-2-fluorobenzene, and must not be slack to ensure the safety of personnel and the environment.
Safety is the first priority. This compound may be toxic, irritating, or even flammable, so it must be handled in accordance with safety procedures. The storage place should be cool, dry and well ventilated, away from fire, heat and oxidants to prevent the risk of fire and explosion.
Furthermore, the packaging must be strict. The packaging materials used should be able to withstand the erosion of this compound without leakage. When transporting, it should also ensure that the packaging is stable and protected from package damage caused by collision and vibration.
Repeat, the label must be clear. On the container, the name, characteristics, hazard warning and other information of the compound should be clearly marked, so that the contact can see at a glance, so as to take appropriate protection measures.
In addition, the operator should be professionally trained. Familiar with the properties, hazards and emergency treatment methods of this compound. When operating, be sure to wear appropriate protective equipment, such as protective clothing, gloves, goggles and gas masks.
Finally, emergency measures should not be ignored. Storage and transportation sites should be equipped with corresponding emergency equipment and materials, such as fire extinguishers, eye washers, first aid medicines, etc. In case of leakage, fire and other accidents, they can respond quickly to reduce the damage.
All of these should be taken into account when storing and transporting 4-bromo-1-chloro-2-fluorobenzene, and must not be slack to ensure the safety of personnel and the environment.
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