Linshang Chemical
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4-Bromo-1-Chloro-2-Methoxybenzene
Linshang Chemical
|
HS Code |
880112 |
| Chemical Formula | C7H6BrClO |
| Molecular Weight | 221.48 |
| Appearance | Typically a colorless to light - colored liquid or solid |
| Boiling Point | Estimated around 240 - 260 °C (approximate, can vary with purity and pressure) |
| Melting Point | No widely - reported single value, but can be determined experimentally for a specific sample |
| Solubility In Water | Insoluble (organic compound, non - polar nature) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate |
| Odor | May have a characteristic organic, slightly pungent odor |
As an accredited 4-Bromo-1-Chloro-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 1 - chloro - 2 - methoxybenzene in a sealed, labeled glass bottle. |
| Storage | 4 - bromo - 1 - chloro - 2 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Label the storage container clearly with its name and relevant safety information. |
| Shipping | 4 - bromo - 1 - chloro - 2 - methoxybenzene is shipped in sealed, corrosion - resistant containers. It's transported under proper temperature control, following strict hazardous chemical shipping regulations to ensure safety during transit. |
Competitive 4-Bromo-1-Chloro-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Bromo-1-Chloro-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-bromo-1-chloro-2-methoxybenzene?
4-Bromo-1-chloro-2-methoxybenzene, an organic compound, has the characteristics of both halogenated aromatics and methoxybenzene.
In terms of its chemical properties, halogen atoms bromine and chlorine can participate in nucleophilic substitution reactions. Because the halogen atom can be used as a leaving group, under appropriate nucleophilic reagents and reaction conditions, the nucleophilic reagent can attack the carbon atom connected to the halogen atom on the benzene ring and replace the halogen atom. For example, under basic conditions, nucleophilic reagents such as sodium alcohol can replace the halogen atom with an alkoxy group to form the corresponding ether compound.
Methoxy group is the power supply radical, which can affect the electron cloud density of the benzene ring through conjugation effect and induction effect. The electron cloud density of the ortho and para-position of the benzene ring is relatively high due to its electron-supply characteristics. Therefore, in the electrophilic substitution reaction, the electrophilic reagent is more likely to attack the ortho and para-position of the methoxy group. For example, when nitration occurs, the nitro group mainly enters the ortho and para-position of the methoxy group.
In addition, the activity of bromine and chlorine in this compound is different. Generally, the ability of bromine to leave is stronger than that of chlorine, and in some nucleophilic substitution reactions, bromine is more likely to be replaced. This property makes it possible to selectively react with bromine or chlorine when designing an organic synthesis route to achieve the preparation of specific products.
At the same time, the stability of the molecular structure of 4-bromo-1-chloro-2-methoxylbenzene is also affected by the interaction of various groups. The electron supply of methoxy groups has a certain stabilization effect on the benzene ring, and although the halogen atom changes the electron cloud density distribution of the benzene ring, it also affects the overall stability of the molecule to a certain extent. Under extreme conditions such as high temperature and strong acid and base, the molecular structure may change, triggering reactions such as chemical bond breaking or rearrangement.
In terms of its chemical properties, halogen atoms bromine and chlorine can participate in nucleophilic substitution reactions. Because the halogen atom can be used as a leaving group, under appropriate nucleophilic reagents and reaction conditions, the nucleophilic reagent can attack the carbon atom connected to the halogen atom on the benzene ring and replace the halogen atom. For example, under basic conditions, nucleophilic reagents such as sodium alcohol can replace the halogen atom with an alkoxy group to form the corresponding ether compound.
Methoxy group is the power supply radical, which can affect the electron cloud density of the benzene ring through conjugation effect and induction effect. The electron cloud density of the ortho and para-position of the benzene ring is relatively high due to its electron-supply characteristics. Therefore, in the electrophilic substitution reaction, the electrophilic reagent is more likely to attack the ortho and para-position of the methoxy group. For example, when nitration occurs, the nitro group mainly enters the ortho and para-position of the methoxy group.
In addition, the activity of bromine and chlorine in this compound is different. Generally, the ability of bromine to leave is stronger than that of chlorine, and in some nucleophilic substitution reactions, bromine is more likely to be replaced. This property makes it possible to selectively react with bromine or chlorine when designing an organic synthesis route to achieve the preparation of specific products.
At the same time, the stability of the molecular structure of 4-bromo-1-chloro-2-methoxylbenzene is also affected by the interaction of various groups. The electron supply of methoxy groups has a certain stabilization effect on the benzene ring, and although the halogen atom changes the electron cloud density distribution of the benzene ring, it also affects the overall stability of the molecule to a certain extent. Under extreme conditions such as high temperature and strong acid and base, the molecular structure may change, triggering reactions such as chemical bond breaking or rearrangement.
What are the common uses of 4-bromo-1-chloro-2-methoxybenzene?
4-Bromo-1-chloro-2-methoxybenzene, this is an organic compound. Its common preparation method is multi-step chemical synthesis.
First, it can be started by phenols. First, the phenolic compound is methoxylated in an appropriate way, that is, the methoxy group is introduced at the phenolic hydroxyl group. It is common to use dimethyl sulfate or dimethyl carbonate as methoxylation reagents to react under basic conditions to generate the corresponding methoxyphenol. Subsequently, the methoxyphenol is halogenated at a specific location. Using halogenated reagents, such as brominating agents (such as liquid bromine under the action of catalysts) and chlorinating agents (such as sulfoxide chloride, etc.), through controlling the reaction conditions, the bromine atom and the chlorine atom are replaced at the target position respectively, and the final result is 4-bromo-1-chloro-2-methoxybenzene.
Second, halobenzene can also be used as a raw material. If chlorobenzene is taken as an example, methoxy is introduced first, and a suitable nucleophilic substitution reaction is also used to react with chlorobenzene with a reagent containing methoxy. After that, bromine atoms are introduced at suitable positions, and the purpose of bromination at the desired position can be achieved by selecting specific bromination reaction conditions and reagents
Or start with benzene, halogenate to obtain chlorobenzene or bromobenzene, and then gradually introduce methoxy and another halogen atom. Each step of the reaction requires fine control of the reaction conditions, such as temperature, pressure, catalyst type and dosage, to ensure the selectivity and yield of the reaction, so that 4-bromo-1-chloro-2-methoxylbenzene can be efficiently obtained.
First, it can be started by phenols. First, the phenolic compound is methoxylated in an appropriate way, that is, the methoxy group is introduced at the phenolic hydroxyl group. It is common to use dimethyl sulfate or dimethyl carbonate as methoxylation reagents to react under basic conditions to generate the corresponding methoxyphenol. Subsequently, the methoxyphenol is halogenated at a specific location. Using halogenated reagents, such as brominating agents (such as liquid bromine under the action of catalysts) and chlorinating agents (such as sulfoxide chloride, etc.), through controlling the reaction conditions, the bromine atom and the chlorine atom are replaced at the target position respectively, and the final result is 4-bromo-1-chloro-2-methoxybenzene.
Second, halobenzene can also be used as a raw material. If chlorobenzene is taken as an example, methoxy is introduced first, and a suitable nucleophilic substitution reaction is also used to react with chlorobenzene with a reagent containing methoxy. After that, bromine atoms are introduced at suitable positions, and the purpose of bromination at the desired position can be achieved by selecting specific bromination reaction conditions and reagents
Or start with benzene, halogenate to obtain chlorobenzene or bromobenzene, and then gradually introduce methoxy and another halogen atom. Each step of the reaction requires fine control of the reaction conditions, such as temperature, pressure, catalyst type and dosage, to ensure the selectivity and yield of the reaction, so that 4-bromo-1-chloro-2-methoxylbenzene can be efficiently obtained.
What are 4-bromo-1-chloro-2-methoxybenzene synthesis methods?
There are several common methods for the synthesis of 4-bromo-1-chloro-2-methoxybenzene.
First, 2-methoxy-4-bromophenol is used as the starting material. First, 2-methoxy-4-bromophenol is reacted with chlorinated reagents, such as thionyl chloride, in a suitable solvent, such as dichloromethane, at a suitable temperature. In this process, the chlorinated reagent reacts with the phenolic hydroxyl group to generate 4-bromo-1-chloro-2-methoxybenzene. When reacting, it is necessary to pay attention to the control of temperature. If the temperature is too high, it may cause more side reactions, which will affect the purity and yield of the product.
Second, starting from 2-methoxy-1-chlorobenzene. Bromination is carried out in a suitable organic solvent, such as carbon tetrachloride, in the presence of a brominating reagent, such as N-bromosuccinimide (NBS), in the presence of an initiator, such as benzoyl peroxide. This reaction uses an initiator to generate free radicals that prompt bromine atoms to replace hydrogen atoms at specific positions on the benzene ring, resulting in the target product 4-bromo-1-chloro-2-methoxybenzene. During the reaction, the amount of initiator and reaction time need to be precisely controlled, otherwise the reaction may be incomplete or too many by-products will be generated.
Third, 1,2-dimethoxybenzene is used as the raw material. First, chlorine atoms are introduced through halogenation reaction, and chlorine gas can be used to react under light or catalyst to obtain 1-chloro-2-methoxybenzene. Subsequently, 1-chloro-2-methoxybenzene is brominated. The brominating reagent can be selected from liquid bromine. Under the catalysis of iron powder or iron tribromide, bromination at a specific position on the benzene ring is achieved, and 4-bromo-1-chloro-2-methoxybenzene is finally synthesized. There are a few more steps in this route, and separation and purification are required after each step of the reaction to ensure the purity of the subsequent reaction raw materials, thereby improving the quality and yield of the final product.
First, 2-methoxy-4-bromophenol is used as the starting material. First, 2-methoxy-4-bromophenol is reacted with chlorinated reagents, such as thionyl chloride, in a suitable solvent, such as dichloromethane, at a suitable temperature. In this process, the chlorinated reagent reacts with the phenolic hydroxyl group to generate 4-bromo-1-chloro-2-methoxybenzene. When reacting, it is necessary to pay attention to the control of temperature. If the temperature is too high, it may cause more side reactions, which will affect the purity and yield of the product.
Second, starting from 2-methoxy-1-chlorobenzene. Bromination is carried out in a suitable organic solvent, such as carbon tetrachloride, in the presence of a brominating reagent, such as N-bromosuccinimide (NBS), in the presence of an initiator, such as benzoyl peroxide. This reaction uses an initiator to generate free radicals that prompt bromine atoms to replace hydrogen atoms at specific positions on the benzene ring, resulting in the target product 4-bromo-1-chloro-2-methoxybenzene. During the reaction, the amount of initiator and reaction time need to be precisely controlled, otherwise the reaction may be incomplete or too many by-products will be generated.
Third, 1,2-dimethoxybenzene is used as the raw material. First, chlorine atoms are introduced through halogenation reaction, and chlorine gas can be used to react under light or catalyst to obtain 1-chloro-2-methoxybenzene. Subsequently, 1-chloro-2-methoxybenzene is brominated. The brominating reagent can be selected from liquid bromine. Under the catalysis of iron powder or iron tribromide, bromination at a specific position on the benzene ring is achieved, and 4-bromo-1-chloro-2-methoxybenzene is finally synthesized. There are a few more steps in this route, and separation and purification are required after each step of the reaction to ensure the purity of the subsequent reaction raw materials, thereby improving the quality and yield of the final product.
4-bromo-1-chloro-2-methoxybenzene what are the precautions in storage and transportation?
4-Bromo-1-chloro-2-methoxybenzene is also an organic compound. When storing and transporting, it is necessary to pay attention to many things to ensure its safety and stability.
The first thing to do is to choose a cool, dry and well-ventilated place when storing. This compound is easily decomposed by heat, so it must be kept away from fire and heat sources to avoid danger. If it is placed in a high temperature environment, it may cause chemical reactions, resulting in the formation of harmful products, or even the risk of fire or explosion.
Secondly, the choice of storage container is also crucial. Containers made of corrosion-resistant materials such as glass or specific plastic materials should be used. Gain 4-bromo-1-chloro-2-methoxybenzene or chemical reaction with certain metal materials, causing corrosion of the container, which in turn leads to material leakage. And the container must be well sealed to prevent it from evaporating into the air, which not only pollutes the environment, but also poses a threat to human health.
Furthermore, during transportation, care should be taken. It is necessary to ensure that it is placed firmly to avoid bumps, collisions, and to prevent damage to the container. At the same time, the transportation vehicle should also have good ventilation conditions and be kept away from dangerous factors such as fire and heat sources.
In addition, regardless of storage or transportation, relevant laws and regulations and safety operating procedures must be strictly followed. Operators should be familiar with the nature and hazards of this compound, and take personal protective measures, such as wearing protective gloves, masks, goggles, etc. In the event of an accident such as leakage, emergency measures should be taken immediately, evacuate personnel, and clean up in time to prevent greater harm.
The first thing to do is to choose a cool, dry and well-ventilated place when storing. This compound is easily decomposed by heat, so it must be kept away from fire and heat sources to avoid danger. If it is placed in a high temperature environment, it may cause chemical reactions, resulting in the formation of harmful products, or even the risk of fire or explosion.
Secondly, the choice of storage container is also crucial. Containers made of corrosion-resistant materials such as glass or specific plastic materials should be used. Gain 4-bromo-1-chloro-2-methoxybenzene or chemical reaction with certain metal materials, causing corrosion of the container, which in turn leads to material leakage. And the container must be well sealed to prevent it from evaporating into the air, which not only pollutes the environment, but also poses a threat to human health.
Furthermore, during transportation, care should be taken. It is necessary to ensure that it is placed firmly to avoid bumps, collisions, and to prevent damage to the container. At the same time, the transportation vehicle should also have good ventilation conditions and be kept away from dangerous factors such as fire and heat sources.
In addition, regardless of storage or transportation, relevant laws and regulations and safety operating procedures must be strictly followed. Operators should be familiar with the nature and hazards of this compound, and take personal protective measures, such as wearing protective gloves, masks, goggles, etc. In the event of an accident such as leakage, emergency measures should be taken immediately, evacuate personnel, and clean up in time to prevent greater harm.
What are the effects of 4-bromo-1-chloro-2-methoxybenzene on the environment and human health?
4-Bromo-1-chloro-2-methoxybenzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
In the environment, if this compound is released into nature, it may contaminate water bodies, soil and atmosphere. In water bodies, it may affect the survival and reproduction of aquatic organisms. Because it has certain chemical activities, it may interfere with the physiological processes of aquatic organisms, such as hindering their respiration, feeding and reproduction functions, resulting in changes in population size. In soil, it may change the chemical properties of soil, affect the activity and types of soil microorganisms, and then affect the growth of plants. If it evaporates into the atmosphere, or participates in photochemical reactions, it will affect air quality, or even form harmful secondary pollutants.
As for personal health, if people inhale through the respiratory tract, contact with the skin or accidentally ingest substances containing this compound, there are potential hazards. Respiratory inhalation, or irritate the respiratory mucosa, causing cough, asthma and other discomfort, long-term exposure, or damage lung function. Skin contact, or cause allergic reactions, causing skin redness, swelling, itching. If ingested by mistake, or affect the digestive system, causing nausea, vomiting, abdominal pain and other diseases, and it may accumulate in the body, damage the liver, kidneys and other important organs, causing interference in the body's metabolism and detoxification mechanism.
In conclusion, 4-bromo-1-chloro-2-methoxybenzene poses latent risks to the environment and human health, and its production, use and disposal should be treated with caution to reduce its harm.
In the environment, if this compound is released into nature, it may contaminate water bodies, soil and atmosphere. In water bodies, it may affect the survival and reproduction of aquatic organisms. Because it has certain chemical activities, it may interfere with the physiological processes of aquatic organisms, such as hindering their respiration, feeding and reproduction functions, resulting in changes in population size. In soil, it may change the chemical properties of soil, affect the activity and types of soil microorganisms, and then affect the growth of plants. If it evaporates into the atmosphere, or participates in photochemical reactions, it will affect air quality, or even form harmful secondary pollutants.
As for personal health, if people inhale through the respiratory tract, contact with the skin or accidentally ingest substances containing this compound, there are potential hazards. Respiratory inhalation, or irritate the respiratory mucosa, causing cough, asthma and other discomfort, long-term exposure, or damage lung function. Skin contact, or cause allergic reactions, causing skin redness, swelling, itching. If ingested by mistake, or affect the digestive system, causing nausea, vomiting, abdominal pain and other diseases, and it may accumulate in the body, damage the liver, kidneys and other important organs, causing interference in the body's metabolism and detoxification mechanism.
In conclusion, 4-bromo-1-chloro-2-methoxybenzene poses latent risks to the environment and human health, and its production, use and disposal should be treated with caution to reduce its harm.
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