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4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
108523 |
| Chemical Formula | C7H3BrClF3 |
| Molar Mass | 261.45 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 180 - 190 °C |
| Density | Approx. 1.7 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
| Vapor Pressure | Low at room temperature |
| Purity | Typically sold as high - purity (e.g., 95%+ in commercial products) |
As an accredited 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 1 - chloro - 2 - (trifluoromethyl)benzene in a sealed glass bottle. |
| Storage | 4 - bromo - 1 - chloro - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents and reactive substances to prevent potential chemical reactions. |
| Shipping | 4 - bromo - 1 - chloro - 2 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transportation to prevent leakage and environmental risks. |
Competitive 4-Bromo-1-Chloro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 4-bromo-1-chloro-2- (trifluoromethyl) benzene?
4-Bromo-1-chloro-2- (trifluoromethyl) benzene is a kind of organic compound. According to its naming, according to the chemical naming convention, "4-bromo" indicates that the bromine atom is at the 4th position of the benzene ring, "1-chloro" epichlorine atom is at the 1st position of the benzene ring, and "2 - (trifluoromethyl) " indicates that the trifluoromethyl is at the 2nd position of the benzene ring.
The benzene ring is an important structure of organic compounds and has unique chemical properties. Functional groups such as bromine, chlorine and trifluoromethyl are connected to the benzene ring, which gives the compound different physical and chemical properties. Bromine atoms and chlorine atoms, because of their electronegativity and atomic radius, have an impact on the polarity and reactivity of molecules. In trifluoromethyl, fluorine atoms are extremely electronegative, and their introduction can significantly change the lipophilicity and stability of compounds.
Such compounds are often used as key intermediates in the field of organic synthesis. Due to the difference in reactivity of functional groups on the benzene ring, various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., can be used to prepare more complex organic molecules. In pharmaceutical chemistry, or due to their unique physical and chemical properties, they can participate in the construction of drug molecules, providing a basis for the development of new drugs. In the field of materials science, they may also be used in the creation of new materials due to specific chemical structures and special photoelectric properties.
The benzene ring is an important structure of organic compounds and has unique chemical properties. Functional groups such as bromine, chlorine and trifluoromethyl are connected to the benzene ring, which gives the compound different physical and chemical properties. Bromine atoms and chlorine atoms, because of their electronegativity and atomic radius, have an impact on the polarity and reactivity of molecules. In trifluoromethyl, fluorine atoms are extremely electronegative, and their introduction can significantly change the lipophilicity and stability of compounds.
Such compounds are often used as key intermediates in the field of organic synthesis. Due to the difference in reactivity of functional groups on the benzene ring, various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., can be used to prepare more complex organic molecules. In pharmaceutical chemistry, or due to their unique physical and chemical properties, they can participate in the construction of drug molecules, providing a basis for the development of new drugs. In the field of materials science, they may also be used in the creation of new materials due to specific chemical structures and special photoelectric properties.
What are the physical properties of 4-bromo-1-chloro-2- (trifluoromethyl) benzene?
4-Bromo-1-chloro-2- (trifluoromethyl) benzene is a kind of organic compound. Its physical properties are very important and relevant to its application in various fields.
First of all, its appearance is usually colorless to light yellow liquid, clear and transparent, just like a clear spring, without suspended impurities, and its color and purity are like natural jade, showing its unique appearance.
As for the boiling point, it is between 180 and 190 degrees Celsius. This boiling point characteristic is a key guide when separating operations such as distillation. When the temperature gradually rises to near the boiling point, this compound is like a feather, light from liquid to gaseous, and can be separated from other substances with different boiling points, just like the mixed pearls are sorted one by one according to their characteristics.
In terms of melting point, it is roughly -30 ° C. The solid state at this low temperature also has its application. When below the melting point, the substance solidifies stably, like a hibernating hibernation, waiting for suitable conditions to regenerate.
The density is about 1.7g/cm ³, which is thicker than the density of water. If it is placed in one place with water, it will be like a stone sinking into the sea, quietly sinking to the bottom of the water. This density characteristic has become an important basis for discrimination and operation in operations such as liquid-liquid separation.
In terms of solubility, it is difficult to dissolve in water, just like the incompatibility of oil and water, and the two are distinct. However, it shows good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., just like a fish entering water and blending leisurely. This property makes it play an important role in the construction of the reaction system of organic synthesis. It can be used as an excellent solvent for reactants and promote the smooth progress of the reaction.
In addition, this compound has a certain volatility. In the air, it is like an invisible spirit, slowly emitting. And because its molecular structure contains fluorine, chlorine, bromine and other halogen atoms, it has certain toxicity and irritation. During operation and use, it is necessary to take protective measures to ensure the safety of personnel and the tranquility of the environment.
First of all, its appearance is usually colorless to light yellow liquid, clear and transparent, just like a clear spring, without suspended impurities, and its color and purity are like natural jade, showing its unique appearance.
As for the boiling point, it is between 180 and 190 degrees Celsius. This boiling point characteristic is a key guide when separating operations such as distillation. When the temperature gradually rises to near the boiling point, this compound is like a feather, light from liquid to gaseous, and can be separated from other substances with different boiling points, just like the mixed pearls are sorted one by one according to their characteristics.
In terms of melting point, it is roughly -30 ° C. The solid state at this low temperature also has its application. When below the melting point, the substance solidifies stably, like a hibernating hibernation, waiting for suitable conditions to regenerate.
The density is about 1.7g/cm ³, which is thicker than the density of water. If it is placed in one place with water, it will be like a stone sinking into the sea, quietly sinking to the bottom of the water. This density characteristic has become an important basis for discrimination and operation in operations such as liquid-liquid separation.
In terms of solubility, it is difficult to dissolve in water, just like the incompatibility of oil and water, and the two are distinct. However, it shows good solubility in organic solvents such as ethanol, ether, dichloromethane, etc., just like a fish entering water and blending leisurely. This property makes it play an important role in the construction of the reaction system of organic synthesis. It can be used as an excellent solvent for reactants and promote the smooth progress of the reaction.
In addition, this compound has a certain volatility. In the air, it is like an invisible spirit, slowly emitting. And because its molecular structure contains fluorine, chlorine, bromine and other halogen atoms, it has certain toxicity and irritation. During operation and use, it is necessary to take protective measures to ensure the safety of personnel and the tranquility of the environment.
What are the chemical properties of 4-bromo-1-chloro-2- (trifluoromethyl) benzene?
4-Bromo-1-chloro-2- (trifluoromethyl) benzene is also an organic compound. In its molecular structure, the bromine atom occupies four positions above the benzene ring, the chlorine atom occupies one position, and the trifluoromethyl atom occupies two positions. The chemical properties of this compound are worth exploring.
The first word about its reactivity. Because it contains halogen atoms, such as bromine and chlorine, it can participate in nucleophilic substitution reactions. New compounds can be derived by adding alcohol or amine reagents to the halogen atom or being replaced by nucleophilic reagents. And the trifluoromethyl group on the benzene ring has strong electron absorption, which can cause the electron cloud density of the benzene ring to decrease, making nucleophilic substitution more likely to occur, especially the adjacent and
Furthermore, it can participate in metal-catalyzed coupling reactions. Such as palladium-catalyzed cross-coupling reactions, bromine atoms or chlorine atoms can be coupled with other organic halides, alkenyl groups, aryl groups, etc. in the presence of palladium catalysts and ligands to construct more complex organic molecular structures. This is widely used in the field of organic synthesis chemistry.
And because it contains trifluoromethyl, the group has unique physical and chemical properties, which can significantly affect the polarity and lipophilicity of compounds. This makes 4-bromo-1-chloro-2 - (trifluoromethyl) benzene show potential application value in pharmaceutical chemistry, materials science and other fields. For example, in the molecular design of drugs, the introduction of trifluoromethyl can change the biological activity, metabolic stability and membrane permeability of the compound.
In addition, its stability also needs to be considered. Although the benzene ring structure confers certain stability, the presence of halogen atoms and trifluoromethyl may cause it to chemically react under specific conditions, such as high temperature, strong base or strong acid environment, resulting in structural changes.
In summary, 4-bromo-1-chloro-2 - (trifluoromethyl) benzene has a unique molecular structure and diverse chemical properties, and has broad application prospects in organic synthesis and related fields. However, the grasp of its reaction conditions and characteristics is also the key to chemical research and application.
The first word about its reactivity. Because it contains halogen atoms, such as bromine and chlorine, it can participate in nucleophilic substitution reactions. New compounds can be derived by adding alcohol or amine reagents to the halogen atom or being replaced by nucleophilic reagents. And the trifluoromethyl group on the benzene ring has strong electron absorption, which can cause the electron cloud density of the benzene ring to decrease, making nucleophilic substitution more likely to occur, especially the adjacent and
Furthermore, it can participate in metal-catalyzed coupling reactions. Such as palladium-catalyzed cross-coupling reactions, bromine atoms or chlorine atoms can be coupled with other organic halides, alkenyl groups, aryl groups, etc. in the presence of palladium catalysts and ligands to construct more complex organic molecular structures. This is widely used in the field of organic synthesis chemistry.
And because it contains trifluoromethyl, the group has unique physical and chemical properties, which can significantly affect the polarity and lipophilicity of compounds. This makes 4-bromo-1-chloro-2 - (trifluoromethyl) benzene show potential application value in pharmaceutical chemistry, materials science and other fields. For example, in the molecular design of drugs, the introduction of trifluoromethyl can change the biological activity, metabolic stability and membrane permeability of the compound.
In addition, its stability also needs to be considered. Although the benzene ring structure confers certain stability, the presence of halogen atoms and trifluoromethyl may cause it to chemically react under specific conditions, such as high temperature, strong base or strong acid environment, resulting in structural changes.
In summary, 4-bromo-1-chloro-2 - (trifluoromethyl) benzene has a unique molecular structure and diverse chemical properties, and has broad application prospects in organic synthesis and related fields. However, the grasp of its reaction conditions and characteristics is also the key to chemical research and application.
What are the common synthesis methods of 4-bromo-1-chloro-2- (trifluoromethyl) benzene?
The common synthesis methods of 4-bromo-1-chloro-2- (trifluoromethyl) benzene are generally as follows.
One is based on halogenation reaction. You can first take the benzene derivative containing trifluoromethyl and make it react with the brominating agent and the chlorinating agent in turn. For example, using 2- (trifluoromethyl) aniline as the starting material, first through the diazotization reaction, and then reacting with cuprous bromide to introduce bromine atoms to obtain bromine-containing intermediates; then on the basis of this intermediate, select suitable chlorination conditions and introduce chlorine atoms to obtain the target product. In this path, the diazotization reaction requires precise control of the reaction temperature and the amount of reagent to prevent side reactions from breeding and affecting the purity and yield of the product.
Second, through the electrophilic substitution reaction of aromatics. Select 2 - (trifluoromethyl) benzoic acid as the raw material, first convert it into the corresponding acid chloride, and then introduce an acyl group at a specific position in the benzene ring through the Fu-gram acylation reaction, and then introduce bromine and chlorine atoms in turn through the halogenation reaction. After the reaction is completed, the target product can be obtained through the steps of reducing and decarbonylation. In this process, the choice and dosage of the catalyst for the Fu-Ke acylation reaction, as well as the control of the halogenation reaction conditions, are all crucial, which are related to whether the reaction can proceed smoothly and the structure and purity of the product.
Third, the coupling reaction with the help of metal catalysts. For example, the coupling reaction between a suitable halogenated aromatic hydrocarbon and a halide or trifluoromethylation reagent containing trifluoromethyl groups is catalyzed by metal catalysts such as palladium and nickel. Such methods have relatively mild conditions and good selectivity, but the cost of metal catalysts is high, and the reaction system is more sensitive to impurities. Strict control of the reaction environment and the purity of raw materials is required to obtain the product with ideal yield and purity.
All synthetic methods have their own advantages and disadvantages. In practical application, the appropriate synthetic path should be carefully selected according to factors such as the availability of raw materials, cost considerations, and product purity requirements.
One is based on halogenation reaction. You can first take the benzene derivative containing trifluoromethyl and make it react with the brominating agent and the chlorinating agent in turn. For example, using 2- (trifluoromethyl) aniline as the starting material, first through the diazotization reaction, and then reacting with cuprous bromide to introduce bromine atoms to obtain bromine-containing intermediates; then on the basis of this intermediate, select suitable chlorination conditions and introduce chlorine atoms to obtain the target product. In this path, the diazotization reaction requires precise control of the reaction temperature and the amount of reagent to prevent side reactions from breeding and affecting the purity and yield of the product.
Second, through the electrophilic substitution reaction of aromatics. Select 2 - (trifluoromethyl) benzoic acid as the raw material, first convert it into the corresponding acid chloride, and then introduce an acyl group at a specific position in the benzene ring through the Fu-gram acylation reaction, and then introduce bromine and chlorine atoms in turn through the halogenation reaction. After the reaction is completed, the target product can be obtained through the steps of reducing and decarbonylation. In this process, the choice and dosage of the catalyst for the Fu-Ke acylation reaction, as well as the control of the halogenation reaction conditions, are all crucial, which are related to whether the reaction can proceed smoothly and the structure and purity of the product.
Third, the coupling reaction with the help of metal catalysts. For example, the coupling reaction between a suitable halogenated aromatic hydrocarbon and a halide or trifluoromethylation reagent containing trifluoromethyl groups is catalyzed by metal catalysts such as palladium and nickel. Such methods have relatively mild conditions and good selectivity, but the cost of metal catalysts is high, and the reaction system is more sensitive to impurities. Strict control of the reaction environment and the purity of raw materials is required to obtain the product with ideal yield and purity.
All synthetic methods have their own advantages and disadvantages. In practical application, the appropriate synthetic path should be carefully selected according to factors such as the availability of raw materials, cost considerations, and product purity requirements.
What are the main application fields of 4-bromo-1-chloro-2- (trifluoromethyl) benzene?
4 - bromo - 1 - chloro - 2 - (trifluoromethyl) benzene, this is an organic compound with a wide range of main application fields.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. Because of its unique chemical structure, it can construct molecular structures with specific biological activities through various chemical reactions. For example, when developing new antimicrobial drugs, its structure can be modified by introducing other functional groups to obtain compounds with high inhibitory activity against specific bacteria. Through carefully designed reaction routes, this compound is reacted with other reagents containing specific functional groups to gradually build a complex drug molecular structure, providing an important material basis for pharmaceutical innovation.
In the field of materials science, it also shows important value. It can be used to prepare functional polymer materials. For example, when it is polymerized as a monomer with other monomers with complementary reactivity, the resulting polymer material may have unique electrical, optical or thermal properties. Due to the bromine, chlorine and trifluoromethyl groups contained in the molecule, it can significantly affect the electron cloud distribution and intermolecular forces of the material, thereby imparting properties such as good electrical conductivity, high refractive index or excellent thermal stability to the material, making it suitable for the manufacture of high-end materials such as electronic devices and optical lenses.
also plays an important role in the research and development of pesticides. As a starting material, pesticide ingredients with high insecticidal, bactericidal or herbicidal activities can be derived. The halogen atom and trifluoromethyl in its structure can enhance the interaction between the compound and specific receptors or enzymes in the target organism, and enhance the biological activity and selectivity of the pesticide. Through reasonable structural optimization and modification, new pesticides with high control effect on specific crop diseases and insect pests and environmental friendliness can be developed, providing strong support for the sustainable development of agricultural production.
In the field of pharmaceutical synthesis, it is often used as a key intermediate. Because of its unique chemical structure, it can construct molecular structures with specific biological activities through various chemical reactions. For example, when developing new antimicrobial drugs, its structure can be modified by introducing other functional groups to obtain compounds with high inhibitory activity against specific bacteria. Through carefully designed reaction routes, this compound is reacted with other reagents containing specific functional groups to gradually build a complex drug molecular structure, providing an important material basis for pharmaceutical innovation.
In the field of materials science, it also shows important value. It can be used to prepare functional polymer materials. For example, when it is polymerized as a monomer with other monomers with complementary reactivity, the resulting polymer material may have unique electrical, optical or thermal properties. Due to the bromine, chlorine and trifluoromethyl groups contained in the molecule, it can significantly affect the electron cloud distribution and intermolecular forces of the material, thereby imparting properties such as good electrical conductivity, high refractive index or excellent thermal stability to the material, making it suitable for the manufacture of high-end materials such as electronic devices and optical lenses.
also plays an important role in the research and development of pesticides. As a starting material, pesticide ingredients with high insecticidal, bactericidal or herbicidal activities can be derived. The halogen atom and trifluoromethyl in its structure can enhance the interaction between the compound and specific receptors or enzymes in the target organism, and enhance the biological activity and selectivity of the pesticide. Through reasonable structural optimization and modification, new pesticides with high control effect on specific crop diseases and insect pests and environmental friendliness can be developed, providing strong support for the sustainable development of agricultural production.
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