Linshang Chemical
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4-Bromo-1-Chloro-3,5-Difluorobenzene
|
HS Code |
220106 |
| Chemical Formula | C6H2BrClF2 |
| Appearance | Liquid (assumed, typical for such organohalides) |
| Solubility In Water | Low (organic halide, non - polar nature) |
| Solubility In Organic Solvents | Good (in common organic solvents like dichloromethane, chloroform due to non - polar nature) |
| Stability | Stable under normal conditions but may react with strong oxidizing or reducing agents |
As an accredited 4-Bromo-1-Chloro-3,5-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 1 - chloro - 3,5 - difluorobenzene packaged in a sealed glass bottle. |
| Storage | 4 - bromo - 1 - chloro - 3,5 - difluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reactive chemicals, and substances with which it may react, in accordance with local safety regulations. |
| Shipping | 4 - bromo - 1 - chloro - 3,5 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling and handling to prevent leakage and risks during transit. |
Competitive 4-Bromo-1-Chloro-3,5-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to sales01@alchemist-chem.com.
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Tel: +8615365006308
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What are the chemical properties of 4-bromo-1-chloro-3,5-difluorobenzene?
4-Bromo-1-chloro-3,5-difluorobenzene is one of the organohalogenated aromatic hydrocarbons. Its chemical properties can be inferred from the characteristics of halogen atoms.
First of all, its halogen atom activity. Bromine, chlorine and fluorotrihalogen atoms are connected to the benzene ring. The fluorine atom is extremely electronegative, which reduces the electron cloud density of the benzene ring, and the electrophilic substitution reaction is difficult to occur. However, the electron cloud density of the adjacent and para-potential is relatively higher, and electrophilic reagents may also react here. Although the electronegativity of chlorine and bromine atoms is not as good as that of fluorine, it also reduces the electron cloud density of the benzene ring, but In this trihalogen atom, the bromine atom can undergo a nucleophilic substitution reaction under appropriate conditions, such as when a strong base is heated, and the halogen atom is replaced by a nucleophilic reagent.
Re-discuss its addition reaction. Because the benzene ring has a conjugated system, it is relatively stable, but under specific conditions, such as a strong catalyst and suitable temperature and pressure, it can also undergo an addition reaction. If it is added with hydrogen, the hydrogenation product can be obtained, and the conjugated structure of the benzene ring is destroyed.
And it can undergo metal-organic reactions. Bromine atoms can interact with metal magnesium to form Grignard reagents. This Grignard reagent is extremely active and can react with many carbonyl-containing compounds to form new carbon-carbon bonds, which are widely used in the field of organic synthesis.
And the halogen atoms in this compound can participate in the elimination reaction. Under the action of a base, if the corresponding stereochemical conditions are met, the halogen atoms and the ortho-hydrogen atoms can dehalide to form compounds containing double bonds. In conclusion, the chemical properties of 4-bromo-1-chloro-3,5-difluorobenzene are jointly determined by the benzene ring and the attached halogen atom. The activity of the halogen atom and the conjugation characteristics of the benzene ring enable the compound to exhibit diverse reactive properties in organic synthesis and other fields, and complex organic molecular structures can be constructed through many reactions.
First of all, its halogen atom activity. Bromine, chlorine and fluorotrihalogen atoms are connected to the benzene ring. The fluorine atom is extremely electronegative, which reduces the electron cloud density of the benzene ring, and the electrophilic substitution reaction is difficult to occur. However, the electron cloud density of the adjacent and para-potential is relatively higher, and electrophilic reagents may also react here. Although the electronegativity of chlorine and bromine atoms is not as good as that of fluorine, it also reduces the electron cloud density of the benzene ring, but In this trihalogen atom, the bromine atom can undergo a nucleophilic substitution reaction under appropriate conditions, such as when a strong base is heated, and the halogen atom is replaced by a nucleophilic reagent.
Re-discuss its addition reaction. Because the benzene ring has a conjugated system, it is relatively stable, but under specific conditions, such as a strong catalyst and suitable temperature and pressure, it can also undergo an addition reaction. If it is added with hydrogen, the hydrogenation product can be obtained, and the conjugated structure of the benzene ring is destroyed.
And it can undergo metal-organic reactions. Bromine atoms can interact with metal magnesium to form Grignard reagents. This Grignard reagent is extremely active and can react with many carbonyl-containing compounds to form new carbon-carbon bonds, which are widely used in the field of organic synthesis.
And the halogen atoms in this compound can participate in the elimination reaction. Under the action of a base, if the corresponding stereochemical conditions are met, the halogen atoms and the ortho-hydrogen atoms can dehalide to form compounds containing double bonds. In conclusion, the chemical properties of 4-bromo-1-chloro-3,5-difluorobenzene are jointly determined by the benzene ring and the attached halogen atom. The activity of the halogen atom and the conjugation characteristics of the benzene ring enable the compound to exhibit diverse reactive properties in organic synthesis and other fields, and complex organic molecular structures can be constructed through many reactions.
What are the main uses of 4-bromo-1-chloro-3,5-difluorobenzene?
4-Bromo-1-chloro-3,5-difluorobenzene is a crucial intermediate in organic synthesis. It has a wide range of uses and is commonly found in many fields such as medicine, pesticides and materials science.
In the field of medicine, this compound is often used as a key starting material for the creation of various specific drugs. Due to its unique chemical structure, it can participate in a variety of reactions to build molecular structures with specific biological activities. For example, a series of reactions can build a core skeleton of specific pharmacological activities, and then develop new drugs for specific diseases, such as antibacterial, antiviral or antitumor drugs.
In the field of pesticides, 4-bromo-1-chloro-3,5-difluorobenzene also plays an important role. With its ingenious synthesis path, it can be converted into highly efficient pesticide components. Its structural characteristics give pesticides unique insecticidal, bactericidal or weeding properties, helping to improve crop yield and quality, and ensure the smooth progress of agricultural production.
In the field of materials science, the use of this compound should not be underestimated. With its special chemical properties, it can be used to prepare high-performance materials. For example, it can participate in polymerization reactions to prepare polymer materials with special optical, electrical or thermal properties, which can be used in electronic devices, optical components and other fields to promote the continuous development and progress of materials science.
In conclusion, 4-bromo-1-chloro-3,5-difluorobenzene is indispensable in many fields and plays a key role in promoting the development of various industries.
In the field of medicine, this compound is often used as a key starting material for the creation of various specific drugs. Due to its unique chemical structure, it can participate in a variety of reactions to build molecular structures with specific biological activities. For example, a series of reactions can build a core skeleton of specific pharmacological activities, and then develop new drugs for specific diseases, such as antibacterial, antiviral or antitumor drugs.
In the field of pesticides, 4-bromo-1-chloro-3,5-difluorobenzene also plays an important role. With its ingenious synthesis path, it can be converted into highly efficient pesticide components. Its structural characteristics give pesticides unique insecticidal, bactericidal or weeding properties, helping to improve crop yield and quality, and ensure the smooth progress of agricultural production.
In the field of materials science, the use of this compound should not be underestimated. With its special chemical properties, it can be used to prepare high-performance materials. For example, it can participate in polymerization reactions to prepare polymer materials with special optical, electrical or thermal properties, which can be used in electronic devices, optical components and other fields to promote the continuous development and progress of materials science.
In conclusion, 4-bromo-1-chloro-3,5-difluorobenzene is indispensable in many fields and plays a key role in promoting the development of various industries.
What are the synthesis methods of 4-bromo-1-chloro-3,5-difluorobenzene?
The synthesis method of 4-bromo-1-chloro-3,5-difluorobenzene is often studied in the field of organic synthesis. There are many methods, which are described in detail below.
First, the halogenation reaction method. You can first take a suitable benzene derivative as a raw material, use a brominating reagent, such as liquid bromine, under the catalysis of a catalyst such as iron powder or iron tribromide, carry out a bromination reaction, and introduce bromine atoms at specific positions in the benzene ring. Then, use a chlorination reagent, such as chlorine gas or sulfoxide chloride, to carry out a chlorination reaction under suitable conditions to introduce chlorine atoms. Finally, a fluorination reaction is carried out in the presence of a phase transfer catalyst by means of fluorinated reagents, such as potassium fluoride, etc., so that a difluorinated group is introduced at the corresponding check point of the benzene ring. In this process, the conditions of each step of the reaction need to be precisely controlled, such as reaction temperature, time, reagent dosage, etc., all of which are related to the yield and purity of the product.
Second, through the nucleophilic substitution reaction path. Active intermediates containing the desired substituents can be prepared first, such as halogenated aromatic derivatives. When this intermediate is reacted with the nucleophilic reagent, the halogen atoms in the nucleophilic reagent can be gradually replaced by bromine, chlorine and fluorine atoms. For example, in the presence of a base, a halogenated benzene derivative is used as a substrate to react with a brominated nucleophile first, then with a chlorinated and fluorinated nucleophile in sequence. After multiple steps of nucleophilic substitution, the target product 4-bromo-1-chloro-3,5-difluorobenzene is obtained. In this path, the choice of nucleophilic reagents, the type and amount of bases, and the nature of the reaction solvent all have a significant impact on the reaction process and results.
Third, metal catalytic coupling reaction method. Coupling reactions catalyzed by metal catalysts such as palladium and nickel. The aromatic hydrocarbon fragments containing different substituents can be synthesized first, and then the fragments can be connected through a coupling reaction under the action of metal catalysts. For example, the different aromatic hydrocarbon fragments containing bromine, chlorine, and fluorine are coupled in a suitable reaction system in the presence of palladium catalysts and ligands to achieve the formation of carbon-carbon bonds, and then construct the target molecular structure. This method requires strict reaction conditions. The activity of metal catalysts, the structure of ligands, and the pH of the reaction system are all key factors affecting the success or failure of the reaction.
The above synthesis methods have their own advantages and disadvantages. In practical application, the optimal synthesis strategy should be selected according to the availability of raw materials, cost, and controllability of reaction conditions.
First, the halogenation reaction method. You can first take a suitable benzene derivative as a raw material, use a brominating reagent, such as liquid bromine, under the catalysis of a catalyst such as iron powder or iron tribromide, carry out a bromination reaction, and introduce bromine atoms at specific positions in the benzene ring. Then, use a chlorination reagent, such as chlorine gas or sulfoxide chloride, to carry out a chlorination reaction under suitable conditions to introduce chlorine atoms. Finally, a fluorination reaction is carried out in the presence of a phase transfer catalyst by means of fluorinated reagents, such as potassium fluoride, etc., so that a difluorinated group is introduced at the corresponding check point of the benzene ring. In this process, the conditions of each step of the reaction need to be precisely controlled, such as reaction temperature, time, reagent dosage, etc., all of which are related to the yield and purity of the product.
Second, through the nucleophilic substitution reaction path. Active intermediates containing the desired substituents can be prepared first, such as halogenated aromatic derivatives. When this intermediate is reacted with the nucleophilic reagent, the halogen atoms in the nucleophilic reagent can be gradually replaced by bromine, chlorine and fluorine atoms. For example, in the presence of a base, a halogenated benzene derivative is used as a substrate to react with a brominated nucleophile first, then with a chlorinated and fluorinated nucleophile in sequence. After multiple steps of nucleophilic substitution, the target product 4-bromo-1-chloro-3,5-difluorobenzene is obtained. In this path, the choice of nucleophilic reagents, the type and amount of bases, and the nature of the reaction solvent all have a significant impact on the reaction process and results.
Third, metal catalytic coupling reaction method. Coupling reactions catalyzed by metal catalysts such as palladium and nickel. The aromatic hydrocarbon fragments containing different substituents can be synthesized first, and then the fragments can be connected through a coupling reaction under the action of metal catalysts. For example, the different aromatic hydrocarbon fragments containing bromine, chlorine, and fluorine are coupled in a suitable reaction system in the presence of palladium catalysts and ligands to achieve the formation of carbon-carbon bonds, and then construct the target molecular structure. This method requires strict reaction conditions. The activity of metal catalysts, the structure of ligands, and the pH of the reaction system are all key factors affecting the success or failure of the reaction.
The above synthesis methods have their own advantages and disadvantages. In practical application, the optimal synthesis strategy should be selected according to the availability of raw materials, cost, and controllability of reaction conditions.
What are the precautions for storing and transporting 4-bromo-1-chloro-3,5-difluorobenzene?
4-Bromo-1-chloro-3,5-difluorobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage. This compound should be stored in a cool, dry and well ventilated place. The cover may be more sensitive to heat, and heat can easily cause chemical reactions, damage its quality, or even cause danger, so it is important to avoid heat. And the humidity must also be controlled. If the humidity is too high, or the compound deliquescent, it will affect its chemical properties. Furthermore, the storage should be kept away from fire and heat sources. Because organic matter is flammable, in case of open flames and hot topics, it may explode into disasters. In addition, it must be stored separately from oxidizing agents, acids, alkalis, etc. These substances must come into contact with them or cause severe chemical reactions, endangering safety.
As for transportation, it should not be neglected. Before transportation, ensure that the packaging is complete to prevent leakage. Packaging materials must have good sealing and corrosion resistance to resist the influence of the external environment. During transportation, the driving should be stable to avoid severe vibration and impact, otherwise the packaging may be damaged and the compound leaks. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment, just in case. And when transportation, they must follow the specified route, and do not stop near densely populated areas and important facilities to avoid major hazards during leakage.
Therefore, when storing and transporting 4-bromo-1-chloro-3,5-difluorobenzene, adhere to the above precautions to ensure safety.
First words storage. This compound should be stored in a cool, dry and well ventilated place. The cover may be more sensitive to heat, and heat can easily cause chemical reactions, damage its quality, or even cause danger, so it is important to avoid heat. And the humidity must also be controlled. If the humidity is too high, or the compound deliquescent, it will affect its chemical properties. Furthermore, the storage should be kept away from fire and heat sources. Because organic matter is flammable, in case of open flames and hot topics, it may explode into disasters. In addition, it must be stored separately from oxidizing agents, acids, alkalis, etc. These substances must come into contact with them or cause severe chemical reactions, endangering safety.
As for transportation, it should not be neglected. Before transportation, ensure that the packaging is complete to prevent leakage. Packaging materials must have good sealing and corrosion resistance to resist the influence of the external environment. During transportation, the driving should be stable to avoid severe vibration and impact, otherwise the packaging may be damaged and the compound leaks. Transportation vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment, just in case. And when transportation, they must follow the specified route, and do not stop near densely populated areas and important facilities to avoid major hazards during leakage.
Therefore, when storing and transporting 4-bromo-1-chloro-3,5-difluorobenzene, adhere to the above precautions to ensure safety.
What are the effects of 4-bromo-1-chloro-3,5-difluorobenzene on the environment and the human body?
4-Bromo-1-chloro-3,5-difluorobenzene is also an organic compound. This article discusses its impact on the environment and the human body in detail.
In terms of the environment, such halogenated aromatics can be retained in the environment for a long time because of their stable chemical structure and difficulty in natural degradation. If released into the soil, it may penetrate into the deep layer, affecting the ecological balance of the soil microbial community, hindering the absorption of nutrients by plant roots, causing plant growth to be hindered. In water bodies, it may cause water pollution and endanger aquatic organisms. Due to biological enrichment, its concentration gradually increases in high-end organisms in the food chain, destroying the structure and function of aquatic ecosystems.
As for personal effects, this compound may be harmful to human health after respiratory tract, skin contact or dietary intake. Its halogen atom activity is high, and it is easy to react with human biological macromolecules such as proteins and nucleic acids, destroying the normal physiological functions of cells. Or damage important organs such as the liver and kidneys, because it is the key organ for detoxification and excretion, and is vulnerable to foreign toxins. Long-term exposure, or increase the risk of cancer, halogenated aromatics are potentially carcinogenic, or induce genetic mutations, which disrupt the normal growth and regulation mechanism of cells. The nervous system may also be affected by it, causing neurological symptoms such as dizziness, fatigue, and memory loss, because the nervous system is extremely sensitive to chemical toxins.
In conclusion, 4-bromo-1-chloro-3,5-difluorobenzene poses potential hazards to the environment and humans, and its production, use and discharge need to be properly controlled to protect the ecological environment and human health.
In terms of the environment, such halogenated aromatics can be retained in the environment for a long time because of their stable chemical structure and difficulty in natural degradation. If released into the soil, it may penetrate into the deep layer, affecting the ecological balance of the soil microbial community, hindering the absorption of nutrients by plant roots, causing plant growth to be hindered. In water bodies, it may cause water pollution and endanger aquatic organisms. Due to biological enrichment, its concentration gradually increases in high-end organisms in the food chain, destroying the structure and function of aquatic ecosystems.
As for personal effects, this compound may be harmful to human health after respiratory tract, skin contact or dietary intake. Its halogen atom activity is high, and it is easy to react with human biological macromolecules such as proteins and nucleic acids, destroying the normal physiological functions of cells. Or damage important organs such as the liver and kidneys, because it is the key organ for detoxification and excretion, and is vulnerable to foreign toxins. Long-term exposure, or increase the risk of cancer, halogenated aromatics are potentially carcinogenic, or induce genetic mutations, which disrupt the normal growth and regulation mechanism of cells. The nervous system may also be affected by it, causing neurological symptoms such as dizziness, fatigue, and memory loss, because the nervous system is extremely sensitive to chemical toxins.
In conclusion, 4-bromo-1-chloro-3,5-difluorobenzene poses potential hazards to the environment and humans, and its production, use and discharge need to be properly controlled to protect the ecological environment and human health.
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