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4-Bromo-2,6-Dichlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
552163 |
| Name | 4-Bromo-2,6-Dichlorobenzenesulfonyl Chloride |
| Chemical Formula | C6H2BrCl3O2S |
| Molar Mass | 321.31 g/mol |
| Appearance | Solid (usually a white to off - white powder) |
| Melting Point | Typically in a certain range (exact value may vary depending on purity) |
| Solubility | Soluble in some organic solvents like dichloromethane, chloroform |
| Density | Specific density value based on experimental determination |
| Stability | Stable under normal conditions, but reacts with water, alcohols |
| Hazard | Corrosive, causes skin and eye burns, harmful if inhaled or ingested |
As an accredited 4-Bromo-2,6-Dichlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 2,6 - dichlorobenzenesulfonyl Chloride in sealed chemical - grade container. |
| Storage | 4 - bromo - 2,6 - dichlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and incompatible substances like strong bases and reducing agents. Store it in a tightly - sealed container to prevent moisture ingress, which could cause hydrolysis, and ensure it is clearly labeled for easy identification and safety. |
| Shipping | 4 - bromo - 2,6 - dichlorobenzenesulfonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers, following all hazardous chemical shipping regulations to ensure safe transit. |
Competitive 4-Bromo-2,6-Dichlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Bromo-2,6-Dichlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4-bromo-2, 6-dichlorobenzenesulfonyl Chloride?
4-Bromo-2,6-dichlorobenzenesulfonyl chloride is an important reagent in organic synthesis. Its main uses are mostly in the construction and modification of organic compounds.
One is often used as a key intermediate in the field of medicinal chemistry. The design and synthesis of drug molecules often require the introduction of specific functional groups to optimize its activity, solubility, stability and many other properties. The sulfonyl chloride functional group of 4-bromo-2,6-dichlorobenzenesulfonyl chloride has high activity and can undergo nucleophilic substitution reactions with a variety of nucleophiles containing nitrogen, oxygen, sulfur, etc., so as to connect specific structural fragments for drug molecules. If reacted with amine compounds, sulfonamide derivatives can be formed. Many of these derivatives exhibit good biological activity and are of great significance in the development of antibacterial, anti-inflammatory, anti-tumor and other drugs.
Second, in the field of materials science, it also has important applications. For example, in the preparation of polymer materials, it can be used to react with polymers with active hydrogen to introduce benzenesulfonyl chloride-related structures into the polymer chain, thereby changing the surface properties, electrical properties or thermal properties of the material. In this way, functional materials with special properties can be prepared, such as adsorption materials with selective adsorption ability for specific substances, or conductive polymer materials with unique electrical responses under specific conditions.
Thirdly, at the basic research level of organic synthetic chemistry, 4-bromo-2,6-dichlorobenzenesulfonyl chloride provides an effective way to synthesize new organic compounds. Chemists can design and carry out a series of complex organic reactions based on their structural characteristics, explore new reaction mechanisms and synthesis strategies, and expand new directions for the development of organic chemistry. In short, 4-bromo-2,6-dichlorobenzenesulfonyl chloride plays an indispensable role in many chemically related fields.
One is often used as a key intermediate in the field of medicinal chemistry. The design and synthesis of drug molecules often require the introduction of specific functional groups to optimize its activity, solubility, stability and many other properties. The sulfonyl chloride functional group of 4-bromo-2,6-dichlorobenzenesulfonyl chloride has high activity and can undergo nucleophilic substitution reactions with a variety of nucleophiles containing nitrogen, oxygen, sulfur, etc., so as to connect specific structural fragments for drug molecules. If reacted with amine compounds, sulfonamide derivatives can be formed. Many of these derivatives exhibit good biological activity and are of great significance in the development of antibacterial, anti-inflammatory, anti-tumor and other drugs.
Second, in the field of materials science, it also has important applications. For example, in the preparation of polymer materials, it can be used to react with polymers with active hydrogen to introduce benzenesulfonyl chloride-related structures into the polymer chain, thereby changing the surface properties, electrical properties or thermal properties of the material. In this way, functional materials with special properties can be prepared, such as adsorption materials with selective adsorption ability for specific substances, or conductive polymer materials with unique electrical responses under specific conditions.
Thirdly, at the basic research level of organic synthetic chemistry, 4-bromo-2,6-dichlorobenzenesulfonyl chloride provides an effective way to synthesize new organic compounds. Chemists can design and carry out a series of complex organic reactions based on their structural characteristics, explore new reaction mechanisms and synthesis strategies, and expand new directions for the development of organic chemistry. In short, 4-bromo-2,6-dichlorobenzenesulfonyl chloride plays an indispensable role in many chemically related fields.
4-Bromo-2, what are the physical properties of 6-dichlorobenzenesulfonyl Chloride
4-Bromo-2,6-dichlorobenzenesulfonyl chloride is a key intermediate in organic synthesis. Looking at its physical properties, at room temperature and pressure, this substance is often in a solid state, white or white, like powder or crystal. Its melting point is in a specific range, and after precise determination, it is roughly between [X] ° C and [X] ° C. The stability of the melting point is due to the characteristics of intermolecular forces.
The density of this compound is also an important physical property, about [X] g/cm ³. The density value reflects the degree of molecular packing. Due to the specific number and arrangement of atoms in the molecule, its density shows this.
In terms of solubility, 4-bromo-2,6-dichlorobenzenesulfonyl chloride is insoluble in water. Due to the large difference between its molecular polarity and that of water, it is difficult for the two to interact. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, ether, etc. In these organic solvents, a suitable force can be formed between molecules and solvent molecules to achieve a state of dissolution.
In addition, 4-bromo-2,6-dichlorobenzenesulfonyl chloride is volatile to a certain extent and can evaporate slowly in air. Its volatilization rate is affected by factors such as temperature and air circulation. When the temperature increases and the air circulation accelerates, the volatilization rate will accelerate. And because of its volatility, it needs to be carried out in a well-ventilated environment during operation to prevent the accumulation of harmful gases.
This compound also needs attention to the stability of light and heat. Under light and high temperature, the molecular structure may change, causing its chemical properties to change. Therefore, it should be stored in a cool and dark place to maintain its physical and chemical properties, maintain quality and efficiency, and facilitate subsequent application in organic synthesis reactions.
The density of this compound is also an important physical property, about [X] g/cm ³. The density value reflects the degree of molecular packing. Due to the specific number and arrangement of atoms in the molecule, its density shows this.
In terms of solubility, 4-bromo-2,6-dichlorobenzenesulfonyl chloride is insoluble in water. Due to the large difference between its molecular polarity and that of water, it is difficult for the two to interact. However, it is soluble in some organic solvents, such as dichloromethane, chloroform, ether, etc. In these organic solvents, a suitable force can be formed between molecules and solvent molecules to achieve a state of dissolution.
In addition, 4-bromo-2,6-dichlorobenzenesulfonyl chloride is volatile to a certain extent and can evaporate slowly in air. Its volatilization rate is affected by factors such as temperature and air circulation. When the temperature increases and the air circulation accelerates, the volatilization rate will accelerate. And because of its volatility, it needs to be carried out in a well-ventilated environment during operation to prevent the accumulation of harmful gases.
This compound also needs attention to the stability of light and heat. Under light and high temperature, the molecular structure may change, causing its chemical properties to change. Therefore, it should be stored in a cool and dark place to maintain its physical and chemical properties, maintain quality and efficiency, and facilitate subsequent application in organic synthesis reactions.
Is 4-bromo-2, 6-dichlorobenzenesulfonyl Chloride chemically stable?
4-Bromo-2,6-dichlorobenzenesulfonyl chloride is unstable in nature. It has dual active groups of halogenated aromatics and sulfonyl chloride, which makes it very active.
Sulfonyl chloride (-SO ² Cl) is chemically active, and it will react violently in contact with water, resulting in corresponding sulfonic acid and hydrogen chloride. Its reaction is like Township, which is fast and intense. If it is thrown into water, the smoke rises in an instant, and the pungent hydrogen chloride gas overflows.
Furthermore, although the bromine and chlorine atoms of the halogenated aromatic hydrocarbon part are slightly more stable than the sulfonyl chloride group, they can also participate in substitution and elimination reactions under specific reaction conditions, such as strong bases, high temperatures, or when assisted by catalysts.
This compound is an important intermediate in the field of organic synthesis, and can introduce a variety of functional groups into organic molecules. However, due to its active nature, storage needs to be cautious. It should be placed in a dry, low temperature and dark environment to prevent water vapor, alkalis, etc. from contacting it, otherwise it will easily deteriorate and lose its original chemical properties and reaction functions. Therefore, looking at its properties, it can be seen that when storing and using it, it is necessary to be cautious and follow the norms to ensure complete security and effectiveness.
Sulfonyl chloride (-SO ² Cl) is chemically active, and it will react violently in contact with water, resulting in corresponding sulfonic acid and hydrogen chloride. Its reaction is like Township, which is fast and intense. If it is thrown into water, the smoke rises in an instant, and the pungent hydrogen chloride gas overflows.
Furthermore, although the bromine and chlorine atoms of the halogenated aromatic hydrocarbon part are slightly more stable than the sulfonyl chloride group, they can also participate in substitution and elimination reactions under specific reaction conditions, such as strong bases, high temperatures, or when assisted by catalysts.
This compound is an important intermediate in the field of organic synthesis, and can introduce a variety of functional groups into organic molecules. However, due to its active nature, storage needs to be cautious. It should be placed in a dry, low temperature and dark environment to prevent water vapor, alkalis, etc. from contacting it, otherwise it will easily deteriorate and lose its original chemical properties and reaction functions. Therefore, looking at its properties, it can be seen that when storing and using it, it is necessary to be cautious and follow the norms to ensure complete security and effectiveness.
What are the synthesis methods of 4-bromo-2, 6-dichlorobenzenesulfonyl Chloride
To prepare 4-bromo-2,6-dichlorobenzenesulfonyl chloride, the method is as follows.
4-bromo-2,6-dichlorobenzene is often used as the starting material. First, 4-bromo-2,6-dichlorobenzene is co-heated with fuming sulfuric acid, which is the step of sulfonation. Control its temperature and time to introduce a sulfonic acid group into the benzene ring to obtain 4-bromo-2,6-dichlorobenzenesulfonic acid.
Then, 4-bromo-2,6-dichlorobenzenesulfonic acid is co-heated with phosphorus pentachloride or dichlorosulfo If phosphorus pentachloride is used, it reacts with sulfonic acid, and the hydroxyl group in the sulfonic acid group is replaced by a chlorine atom to obtain 4-bromo-2,6-dichlorobenzenesulfonyl chloride; if dichlorosulfoxide is used, during the reaction, the chlorine atom in the dichlorosulfoxide replaces the hydroxyl group of the sulfonic acid group, and the target product can also be obtained. After the reaction, the pure 4-bromo-2,6-dichlorobenzenesulfonyl chloride can be obtained by separation and purification methods, such as distillation and recrystallization.
Or you can use 2,6-dichlorobenzene as the starting material, first sulfonate to obtain 2,6-dichlorobenzenesulfonic acid, then brominate and introduce bromine atoms to obtain 4-bromo-2,6-dichlorobenzenesulfonic acid, and finally react with phosphorus pentachloride or dichlorosulfoxide as described above to obtain 4-bromo-2,6-dichlorobenzenesulfonic chloride. When operating, pay attention to the control of reaction conditions, such as temperature, reactant ratio, etc., to increase the yield and purity of the product.
4-bromo-2,6-dichlorobenzene is often used as the starting material. First, 4-bromo-2,6-dichlorobenzene is co-heated with fuming sulfuric acid, which is the step of sulfonation. Control its temperature and time to introduce a sulfonic acid group into the benzene ring to obtain 4-bromo-2,6-dichlorobenzenesulfonic acid.
Then, 4-bromo-2,6-dichlorobenzenesulfonic acid is co-heated with phosphorus pentachloride or dichlorosulfo If phosphorus pentachloride is used, it reacts with sulfonic acid, and the hydroxyl group in the sulfonic acid group is replaced by a chlorine atom to obtain 4-bromo-2,6-dichlorobenzenesulfonyl chloride; if dichlorosulfoxide is used, during the reaction, the chlorine atom in the dichlorosulfoxide replaces the hydroxyl group of the sulfonic acid group, and the target product can also be obtained. After the reaction, the pure 4-bromo-2,6-dichlorobenzenesulfonyl chloride can be obtained by separation and purification methods, such as distillation and recrystallization.
Or you can use 2,6-dichlorobenzene as the starting material, first sulfonate to obtain 2,6-dichlorobenzenesulfonic acid, then brominate and introduce bromine atoms to obtain 4-bromo-2,6-dichlorobenzenesulfonic acid, and finally react with phosphorus pentachloride or dichlorosulfoxide as described above to obtain 4-bromo-2,6-dichlorobenzenesulfonic chloride. When operating, pay attention to the control of reaction conditions, such as temperature, reactant ratio, etc., to increase the yield and purity of the product.
4-Bromo-2, 6-dichlorobenzenesulfonyl Chloride What to pay attention to when storing and transporting
4-Bromo-2,6-dichlorobenzenesulfonyl chloride is a very important chemical substance. When storing and transporting, many aspects need to be paid attention to.
First storage, this substance may be more active, so it needs to be stored in a cool and dry place. If it is in a humid place, it may react with water vapor and cause deterioration. Because it has certain chemical activity, it should be kept away from fires and heat sources to prevent combustion or other dangerous chemical reactions. In addition, it should be stored separately from substances that can react with it, such as alkalis and alcohols, and must not be mixed to avoid interaction and accidents. The storage container must be well sealed to ensure that there is no risk of leakage and prevent it from contacting with outside air and other substances.
As for transportation, it is necessary to use suitable packaging in accordance with relevant regulations. Packaging materials should be able to resist the corrosion and reaction of the substance to ensure that no leakage occurs during transportation. During transportation, severe vibration and impact should also be avoided to prevent package damage. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. If there is a leak during transportation, it can be dealt with in time. And transportation personnel should be familiar with the characteristics of this substance and emergency treatment methods to ensure the safety of the transportation process. In this way, 4-bromo-2,6-dichlorobenzenesulfonyl chloride must be properly stored and transported to avoid accidents.
First storage, this substance may be more active, so it needs to be stored in a cool and dry place. If it is in a humid place, it may react with water vapor and cause deterioration. Because it has certain chemical activity, it should be kept away from fires and heat sources to prevent combustion or other dangerous chemical reactions. In addition, it should be stored separately from substances that can react with it, such as alkalis and alcohols, and must not be mixed to avoid interaction and accidents. The storage container must be well sealed to ensure that there is no risk of leakage and prevent it from contacting with outside air and other substances.
As for transportation, it is necessary to use suitable packaging in accordance with relevant regulations. Packaging materials should be able to resist the corrosion and reaction of the substance to ensure that no leakage occurs during transportation. During transportation, severe vibration and impact should also be avoided to prevent package damage. Transportation vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. If there is a leak during transportation, it can be dealt with in time. And transportation personnel should be familiar with the characteristics of this substance and emergency treatment methods to ensure the safety of the transportation process. In this way, 4-bromo-2,6-dichlorobenzenesulfonyl chloride must be properly stored and transported to avoid accidents.
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