4-Bromo-2-Chloro-1-Fluorobenzene
Linshang Chemical
HS Code |
622251 |
Chemical Formula | C6H3BrClF |
Molar Mass | 211.44 g/mol |
Appearance | Colorless to light yellow liquid |
Boiling Point | Approx. 180 - 182 °C |
Density | Around 1.75 - 1.85 g/cm³ |
Solubility In Water | Insoluble |
Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, ethyl acetate |
Vapor Pressure | Low at room temperature |
As an accredited 4-Bromo-2-Chloro-1-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 4 - bromo - 2 - chloro - 1 - fluorobenzene packaged in a sealed, chemical - resistant bottle. |
Storage | 4 - bromo - 2 - chloro - 1 - fluorobenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and other reactive chemicals to prevent potential reactions. |
Shipping | 4 - bromo - 2 - chloro - 1 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. Transport follows strict chemical regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 4-Bromo-2-Chloro-1-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Bromo-2-Chloro-1-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
Let's talk about its physical rationality first. At room temperature, it is mostly liquid, has a special odor, has a higher density than water, and is insoluble in water, but can be soluble in many organic solvents, such as ethanol, ether, benzene, etc. Due to the non-polar structure of the phenyl ring, the polarity of water molecules is quite different, so it is insoluble. Organic solvents are mostly non-polar or weakly polar, similar in structure to 4-bromo-2-chloro-1-fluorobenzene, and mutually soluble according to the principle of "similarity and miscibility".
Re-discuss its chemical properties. First, nucleophilic substitution reaction. Because the electronegativity of the halogen atom is greater than that of the carbon of the benzene ring, the electron cloud of the carbon-halogen bond is biased towards the halogen atom, causing the carbon atom to be partially positively charged and vulnerable to attack by nucleophilic reagents. For example, when co-heated with an aqueous solution of sodium hydroxide, the halogen atom can be replaced by a hydroxyl group to form a corresponding phenolic compound. In this reaction, the hydroxide ion acts as a nucleophilic reagent to attack the positively charged carbon atom, and the Second, electrophilic substitution reaction. The benzene ring is electron-rich and vulnerable to electrophilic attack. Although the halogen atom is an ortho-para-localization group, the electrophilic substitution activity of 4-bromo-2-chloro-1-fluorobenzene is slightly lower than that of benzene due to the combined effect of steric hindrance and electronic effects. Common electrophilic substitution reactions, such as nitrification, sulfonation, halogenation, etc. Taking nitrification as an example, under the mixed acid of concentrated sulfuric acid and concentrated nitric acid, the nitro group can replace the hydrogen atom on the benzene ring. Third, the elimination reaction. Under certain conditions, such as heating in an alcohol solution of a strong base, 4-bromo-2-chloro-1-fluorobenzene can undergo a digestion reaction to dehalide hydrogen and form compounds containing unsaturated bonds.
In addition, 4-bromo-2-chloro-1-fluorobenzene contains a variety of halogen atoms, which can be used as an important intermediate in organic synthesis. It can be used to construct various complex organic compounds through different reaction pathways and has important uses in pharmaceutical chemistry, materials science and other fields.
Bearing the brunt, it plays a significant role in the synthesis of medicine. It can be used as a key intermediate to help create a variety of specific drugs. For example, when developing anti-cancer drugs with specific targeting properties, the unique chemical structure of 4-bromo-2-chloro-1-fluorobenzene can provide assistance for drug molecules to precisely target cancer cells, thereby improving drug efficacy and reducing damage to normal cells. The synthesis of many new antibiotics also relies on it as a raw material. By modifying and modifying its structure, antibiotics are endowed with new antibacterial properties to deal with the increasingly complex problem of bacterial resistance.
Furthermore, in the field of pesticides, 4-bromo-2-chloro-1-fluorobenzene also plays an important role. It can be chemically converted to make highly effective insecticides, fungicides or herbicides. With its structural characteristics, such pesticides can efficiently act on specific physiological processes of pests, bacteria or weeds, inhibit their growth and reproduction, and are less harmful to the environment and have a shorter residue period than traditional pesticides, which can effectively balance the relationship between agricultural production and environmental protection.
In addition, in the field of materials science, it also has a place of use. It can be used as a starting material to prepare special functional materials, such as some organic semiconductor materials with excellent photoelectric properties. Introducing it into the molecular structure of materials can regulate the energy level and charge transport properties of materials, and it can be used in cutting-edge fields such as organic Light Emitting Diode (OLED) and solar cells to promote the development and innovation of related technologies.
Although 4-bromo-2-chloro-1-fluorobenzene is a small compound, it plays an important role in many key fields such as medicine, pesticides and materials, and has made great contributions to human life and scientific and technological progress.
First of all, benzene is the one that starts with benzene. Benzene is active and can be catalyzed by bromine with iron bromide to form bromobenzene. In this reaction, bromine atoms enter the benzene ring to obtain a substituted bromobenzene. Then chlorine reagents, such as chlorine gas and ferric chloride, are used to introduce chlorine atoms at specific positions of bromobenzene to form 1-bromo-3-chlorobenzene In this case, due to the localization effect of bromine and chlorine, the chlorine atom enters the adjacent and para-position of bromine to obtain this product. After fluorination reagents, such as potassium fluoride and phase transfer catalysts, the bromine atom of 1-bromo-3-chlorobenzene is replaced by a fluorine atom, and the final product is 4-bromo-2-chloro-1-fluorobenzene.
Re-discussion on those based on halogenated benzene. You can take o-chlorobenzene first. This halogenated benzene has a dihalogen atom and has different activities. With fluorinated reagents, the bromine atom is selectively replaced by a fluorine atom to obtain 4-bromo-2-chloro-1 The key to this process is the selection of fluorination reagents and the control of reaction conditions, so that fluorination has good selectivity and high purity products.
Preparation of 4-bromo-2-chloro-1-fluorobenzene requires careful selection of raw materials and reagents, and precise control of reaction conditions, such as temperature, pressure, amount of catalyst, etc., to make the reaction go forward, and the yield and purity of the product are excellent.
First item storage. This compound should be stored in a cool, dry and well-ventilated place. Cover because of its certain chemical activity, high temperature and humid environment can easily cause it to deteriorate or promote chemical reactions. The warehouse temperature should be controlled within an appropriate range to prevent excessive temperature from exacerbating its volatilization or causing other dangers. And it must be kept away from fire and heat sources. Open flames are close, and there is a risk of combustion.
Furthermore, the storage place should be separated from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, contact with their substances, or severe chemical reactions, resulting in safety accidents. At the same time, the storage container must be tightly sealed to prevent leakage. It is advisable to use corrosion-resistant containers, because the compound may have a corrosive effect on some materials. If the container is damaged, the leaked substances or pollute the environment will also increase safety hazards.
As for transportation. Before transportation, ensure that the packaging is complete and sealed. Packaging materials should be able to withstand vibration, collision and temperature changes during transportation to prevent material leakage due to package damage. When transporting, choose a means of transportation that meets safety standards, and transporters should be familiar with the characteristics of the compound and emergency treatment methods. During transportation, avoid exposure to the sun, rain, and prevent extreme changes in temperature and humidity.
If the transportation route passes through densely populated areas or environmentally sensitive areas, it is necessary to plan in advance and drive with caution to prevent accidental leakage from causing significant harm to the public and the environment. At transportation and storage sites, corresponding emergency treatment equipment and protective equipment should be prepared, such as fire extinguishers, leakage emergency treatment tools, protective gloves, gas masks, etc., for emergencies. In this way, 4-bromo-2-chloro-1-fluorobenzene should be kept safe during storage and transportation.
At the environmental end, this compound has considerable stability and is difficult to be degraded naturally. If released into the environment, it can remain for a long time, causing soil, water, atmosphere, etc. to be polluted. It may migrate through processes such as volatilization and leaching, expanding the scope of pollution. And it can be enriched by the food chain, causing the concentration of high-end organisms to gradually increase, endangering the ecological balance, damaging biodiversity, and making the survival and reproduction of many organisms difficult.
As for human health, 4-bromo-2-chloro-1-fluorobenzene can be introduced into the body through respiratory tract, skin contact, dietary intake, etc. After entering the body, it may interfere with the endocrine system, cause hormonal imbalance, and affect the normal growth and development of the human body and physiological functions. It also has potential neurotoxicity, damaging the nervous system, causing headaches, vertigo, memory loss, etc. Long-term exposure may increase the risk of cancer due to its halogenated aromatic hydrocarbon structure or carcinogenesis. And it may have adverse effects on the reproductive system, affecting reproductive ability and fetal development.
Therefore, the production, use and treatment of 4-bromo-2-chloro-1-fluorobenzene should be handled with great care, and effective measures should be taken to control its release into the environment to protect the ecological environment and human health.

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