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4-Bromo-2-Chloro-1-Iodobenzene
Linshang Chemical
|
HS Code |
635998 |
| Chemical Formula | C6H3BrClI |
| Molecular Weight | 328.35 |
| Appearance | Solid |
| Color | Typically colorless to pale yellow |
| Odor | Characteristic aromatic odor |
| Melting Point | Data may vary, check specific references |
| Boiling Point | Data may vary, check specific references |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data may vary, check specific references |
| Flash Point | Data may vary, check specific references |
| Hazard Class | Harmful, irritant (general classification, check SDS for details) |
| Cas Number | Specific number would need further research |
As an accredited 4-Bromo-2-Chloro-1-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chloro - 1 - iodobenzene in a sealed glass bottle. |
| Storage | 4 - bromo - 2 - chloro - 1 - iodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly - sealed container, preferably made of glass or a chemical - resistant plastic, to prevent leakage and exposure to air or moisture, which could potentially lead to decomposition or unwanted reactions. |
| Shipping | 4 - bromo - 2 - chloro - 1 - iodobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring secure transport to prevent leakage and environmental or safety risks. |
Competitive 4-Bromo-2-Chloro-1-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the Chinese name of 4-bromo-2-chloro-1-iodobenzene?
4-Bromo-2-chloro-1-iodobenzene, this is a kind of organic compound naming. Following the naming rules of organic chemistry, the position and type of the benzene ring are calibrated in sequence with the benzene ring as the parent body and the halogen atom as the substituent.
"4-bromine" means that the fourth carbon atom on the benzene ring is connected with a bromine atom; "2-chlorine" means that the second carbon atom is connected with a chlorine atom; "1-iodine" means that the first carbon atom is connected with an iodine atom. This naming clearly defines the location of each atom in the molecular structure, which is of great significance in the fields of chemical research and synthesis.
In terms of this naming, the substituent position is first numerically calibrated, and then the substituent name is listed, which is in line with the general practice of naming halogenated aromatic hydrocarbons. With this name, chemists can accurately know the molecular structure and carry out work such as synthesis design and reaction mechanism exploration. This compound may be a key intermediate in organic synthesis. Through different reactions, it can be converted into many valuable organic compounds, which have potential uses in materials science, pharmaceutical chemistry and many other fields.
"4-bromine" means that the fourth carbon atom on the benzene ring is connected with a bromine atom; "2-chlorine" means that the second carbon atom is connected with a chlorine atom; "1-iodine" means that the first carbon atom is connected with an iodine atom. This naming clearly defines the location of each atom in the molecular structure, which is of great significance in the fields of chemical research and synthesis.
In terms of this naming, the substituent position is first numerically calibrated, and then the substituent name is listed, which is in line with the general practice of naming halogenated aromatic hydrocarbons. With this name, chemists can accurately know the molecular structure and carry out work such as synthesis design and reaction mechanism exploration. This compound may be a key intermediate in organic synthesis. Through different reactions, it can be converted into many valuable organic compounds, which have potential uses in materials science, pharmaceutical chemistry and many other fields.
What are the physical properties of 4-bromo-2-chloro-1-iodobenzene?
4-Bromo-2-chloro-1-iodobenzene is one of the organohalogenated aromatic hydrocarbons. Its physical properties are unique, so let me tell them one by one.
First, the melting point of a substance is related to its intermolecular force and lattice structure. Because the molecule contains halogen atoms such as bromine, chlorine, and iodine, the atomic weight is large, and the molecular structure regularity affects the intermolecular interaction, so the melting point is in a specific range, but the exact value needs to be determined experimentally and accurately.
The boiling point of 4-bromo-2-chloro-1-iodobenzene is also closely related to the intermolecular force. The number of halogen atoms increases, and the intermolecular dispersion force increases, causing its boiling point to rise. Its molecular polarity exists due to the difference in electronegativity of halogen atoms, and the polar force also contributes to the boiling point.
The other is solubility. In organic solvents, such as dichloromethane, chloroform, ether, etc., because it is a non-polar or weakly polar organic substance, it can be better dissolved according to the principle of similar miscibility. However, in water, because water is a strong polar solvent, it does not match the intermolecular force of 4-bromo-2-chloro-1-iodobenzene, so it is difficult to dissolve.
Looking at its appearance, at room temperature and pressure, it is mostly colorless to light yellow liquid or solid. Due to the molecular structure and electronic transition characteristics, the specific structure makes the absorption of visible light bands different, showing the corresponding color.
As for the density, because it contains heavy halogen atoms, its density is greater than that of water. When placed in water, it will sink to the bottom.
The physical properties of 4-bromo-2-chloro-1-iodobenzene are determined by the type, number and arrangement of halogen atoms in its molecular structure. It is used in organic synthesis, materials science and other fields and is closely related to its physical properties.
First, the melting point of a substance is related to its intermolecular force and lattice structure. Because the molecule contains halogen atoms such as bromine, chlorine, and iodine, the atomic weight is large, and the molecular structure regularity affects the intermolecular interaction, so the melting point is in a specific range, but the exact value needs to be determined experimentally and accurately.
The boiling point of 4-bromo-2-chloro-1-iodobenzene is also closely related to the intermolecular force. The number of halogen atoms increases, and the intermolecular dispersion force increases, causing its boiling point to rise. Its molecular polarity exists due to the difference in electronegativity of halogen atoms, and the polar force also contributes to the boiling point.
The other is solubility. In organic solvents, such as dichloromethane, chloroform, ether, etc., because it is a non-polar or weakly polar organic substance, it can be better dissolved according to the principle of similar miscibility. However, in water, because water is a strong polar solvent, it does not match the intermolecular force of 4-bromo-2-chloro-1-iodobenzene, so it is difficult to dissolve.
Looking at its appearance, at room temperature and pressure, it is mostly colorless to light yellow liquid or solid. Due to the molecular structure and electronic transition characteristics, the specific structure makes the absorption of visible light bands different, showing the corresponding color.
As for the density, because it contains heavy halogen atoms, its density is greater than that of water. When placed in water, it will sink to the bottom.
The physical properties of 4-bromo-2-chloro-1-iodobenzene are determined by the type, number and arrangement of halogen atoms in its molecular structure. It is used in organic synthesis, materials science and other fields and is closely related to its physical properties.
What are the chemical properties of 4-bromo-2-chloro-1-iodobenzene?
4-Bromo-2-chloro-1-iodobenzene is an organic halogenated aromatic compound. Its chemical properties are unique, and it is formed by connecting three halogen atoms of bromine, chlorine and iodine to the benzene ring.
As far as the electrophilic substitution reaction is concerned, the halogen atom is an ortho-para-site group. However, due to its electronegativity and electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, so the electrophilic substitution reaction activity is lower than that of benzene. Due to the largest iodine atom volume, the steric resistance effect is significant, and the electrophilic reagent is hindered in its ortho-site reaction. Moreover, the localization effects of the three halogen atoms are different, and the adjacent localization ability of bromine, chlorine and iodine is poor, which affects the distribution of the main products of the electrophilic substitution reaction.
In the nucleophilic substitution reaction, although the nucleophilic substitution of halogenated aromatics is generally difficult, it can also occur under specific conditions, such as high temperature, strong base or catalysis. Because the halogen atom absorbs electrons, the electron cloud density of the carbon atom in the adjacent position of the benzene ring is reduced, which is favorable for the attack of nucleophilic reagents. Among them, the iodine atom is more likely to leave than the bromine and chlorine atom due to the relatively small bond energy. Therefore, when the nucleophilic substitution
4-Bromo-2-chloro-1-iodobenzene is flammable and can be burned in an open flame or hot topic, decomposing to produce toxic fumes such as hydrogen halide. It can also react with strong oxidants and has certain chemical risks. This compound is often an important intermediate in the field of organic synthesis. Through the substitution reaction of halogen atoms, various functional groups can be introduced to construct complex organic molecular structures.
As far as the electrophilic substitution reaction is concerned, the halogen atom is an ortho-para-site group. However, due to its electronegativity and electron-absorbing induction effect, the electron cloud density of the benzene ring decreases, so the electrophilic substitution reaction activity is lower than that of benzene. Due to the largest iodine atom volume, the steric resistance effect is significant, and the electrophilic reagent is hindered in its ortho-site reaction. Moreover, the localization effects of the three halogen atoms are different, and the adjacent localization ability of bromine, chlorine and iodine is poor, which affects the distribution of the main products of the electrophilic substitution reaction.
In the nucleophilic substitution reaction, although the nucleophilic substitution of halogenated aromatics is generally difficult, it can also occur under specific conditions, such as high temperature, strong base or catalysis. Because the halogen atom absorbs electrons, the electron cloud density of the carbon atom in the adjacent position of the benzene ring is reduced, which is favorable for the attack of nucleophilic reagents. Among them, the iodine atom is more likely to leave than the bromine and chlorine atom due to the relatively small bond energy. Therefore, when the nucleophilic substitution
4-Bromo-2-chloro-1-iodobenzene is flammable and can be burned in an open flame or hot topic, decomposing to produce toxic fumes such as hydrogen halide. It can also react with strong oxidants and has certain chemical risks. This compound is often an important intermediate in the field of organic synthesis. Through the substitution reaction of halogen atoms, various functional groups can be introduced to construct complex organic molecular structures.
What are the main uses of 4-bromo-2-chloro-1-iodobenzene?
4-Bromo-2-chloro-1-iodobenzene is one of the organic compounds. Its main use is more common in the field of organic synthesis, and it is crucial for the preparation of intermediaries for various organic materials and drugs.
In the category of organic synthesis, the molecular structure of 4-bromo-2-chloro-1-iodobenzene contains halogen atoms such as bromine, chlorine, and iodine. It can be used by many chemical reactions, such as nucleophilic substitution reactions, metal-catalyzed cross-coupling reactions, etc., to form carbon-carbon bonds and carbon-heteroatomic bonds to prepare complex organic compounds.
Taking nucleophilic substitution as an example, halogen atoms can be replaced by nucleophilic reagents such as hydroxyl, amino, alkoxy, etc., to generate corresponding alcohols, amines, and ethers. In the metal-catalyzed cross-coupling reaction, 4-bromo-2-chloro-1-iodobenzene can react with metal-containing organic reagents, such as Grignard reagent and organolithium reagent, to form new carbon-carbon bonds. This is a common strategy for building complex organic molecular skeletons.
In the field of drug synthesis, 4-bromo-2-chloro-1-iodobenzene also plays a key role. Because it can be used as a starting material for the synthesis of specific bioactive compounds, through a series of chemical transformations, the target compounds are endowed with the required pharmacological activity, which can help the development and creation of new drugs.
In addition, 4-bromo-2-chloro-1-iodobenzene is also used in the field of materials science, which can be used to prepare organic materials with special optical and electrical properties, such as organic Light Emitting Diode (OLED) materials, conductive polymers, etc., to promote the development of related materials science.
In the category of organic synthesis, the molecular structure of 4-bromo-2-chloro-1-iodobenzene contains halogen atoms such as bromine, chlorine, and iodine. It can be used by many chemical reactions, such as nucleophilic substitution reactions, metal-catalyzed cross-coupling reactions, etc., to form carbon-carbon bonds and carbon-heteroatomic bonds to prepare complex organic compounds.
Taking nucleophilic substitution as an example, halogen atoms can be replaced by nucleophilic reagents such as hydroxyl, amino, alkoxy, etc., to generate corresponding alcohols, amines, and ethers. In the metal-catalyzed cross-coupling reaction, 4-bromo-2-chloro-1-iodobenzene can react with metal-containing organic reagents, such as Grignard reagent and organolithium reagent, to form new carbon-carbon bonds. This is a common strategy for building complex organic molecular skeletons.
In the field of drug synthesis, 4-bromo-2-chloro-1-iodobenzene also plays a key role. Because it can be used as a starting material for the synthesis of specific bioactive compounds, through a series of chemical transformations, the target compounds are endowed with the required pharmacological activity, which can help the development and creation of new drugs.
In addition, 4-bromo-2-chloro-1-iodobenzene is also used in the field of materials science, which can be used to prepare organic materials with special optical and electrical properties, such as organic Light Emitting Diode (OLED) materials, conductive polymers, etc., to promote the development of related materials science.
What are 4-bromo-2-chloro-1-iodobenzene synthesis methods?
The synthesis of 4-bromo-2-chloro-1-iodobenzene is a key issue in organic synthetic chemistry. In the past, the method was mostly based on the halogenation of aromatic hydrocarbons.
First, benzene can be started, first with a chlorinating agent, such as chlorine gas, under the action of an appropriate catalyst, such as ferric trichloride, to obtain chlorobenzene. Then a brominating agent, such as bromine, is introduced under the same catalytic conditions to produce 2-chloro-4-bromobenzene. Finally, iodizing reagents, such as potassium iodide, are used to react with oxidizing agents in suitable solvents to make iodine atoms replace hydrogen at specific positions on the benzene ring to obtain 4-bromo-2-chloro-1-iodobenzene. Although this approach can be followed, the steps are slightly complicated, and the reaction conditions of each step need to be carefully regulated, otherwise side reactions will easily occur and the product will be impure.
Second, phenol is used as the starting material. Phenol is first halogenated, and chlorine and bromine atoms are introduced. After that, a series of reactions such as diazotization and iodine generation can obtain the target product. This route requires precise control of the diazotization reaction conditions. Due to its high reactivity, it is prone to accidents if the operation is not careful. However, the advantage is that the positioning effect of phenol can be used to introduce halogen atoms into specific positions.
Third, the Grignard reagent method can also be used. After halogenated benzene is used as raw material, Grignard reagents are prepared and reacted with corresponding halogenated hydrocarbons or halogenated reagents. For example, Grignard reagents containing chlorine and bromine are prepared first, and then reacted with iodine reagents to gradually construct the target molecular structure. This method requires an anhydrous and oxygen-free environment, which requires high requirements for reaction equipment and operation. However, it can effectively control the reaction process and product structure
All these synthesis methods have advantages and disadvantages. Experimenters should choose carefully according to the actual situation, such as raw material availability, cost, equipment conditions, etc., in order to efficiently synthesize 4-bromo-2-chloro-1-iodobenzene.
First, benzene can be started, first with a chlorinating agent, such as chlorine gas, under the action of an appropriate catalyst, such as ferric trichloride, to obtain chlorobenzene. Then a brominating agent, such as bromine, is introduced under the same catalytic conditions to produce 2-chloro-4-bromobenzene. Finally, iodizing reagents, such as potassium iodide, are used to react with oxidizing agents in suitable solvents to make iodine atoms replace hydrogen at specific positions on the benzene ring to obtain 4-bromo-2-chloro-1-iodobenzene. Although this approach can be followed, the steps are slightly complicated, and the reaction conditions of each step need to be carefully regulated, otherwise side reactions will easily occur and the product will be impure.
Second, phenol is used as the starting material. Phenol is first halogenated, and chlorine and bromine atoms are introduced. After that, a series of reactions such as diazotization and iodine generation can obtain the target product. This route requires precise control of the diazotization reaction conditions. Due to its high reactivity, it is prone to accidents if the operation is not careful. However, the advantage is that the positioning effect of phenol can be used to introduce halogen atoms into specific positions.
Third, the Grignard reagent method can also be used. After halogenated benzene is used as raw material, Grignard reagents are prepared and reacted with corresponding halogenated hydrocarbons or halogenated reagents. For example, Grignard reagents containing chlorine and bromine are prepared first, and then reacted with iodine reagents to gradually construct the target molecular structure. This method requires an anhydrous and oxygen-free environment, which requires high requirements for reaction equipment and operation. However, it can effectively control the reaction process and product structure
All these synthesis methods have advantages and disadvantages. Experimenters should choose carefully according to the actual situation, such as raw material availability, cost, equipment conditions, etc., in order to efficiently synthesize 4-bromo-2-chloro-1-iodobenzene.
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