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4-Bromo-2-Chloro-1-Methylbenzene
Linshang Chemical
|
HS Code |
328288 |
| Chemical Formula | C7H6BrCl |
| Molar Mass | 207.48 g/mol |
| Appearance | Liquid (usually) |
| Boiling Point | Around 218 - 220 °C |
| Density | Approx. 1.64 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Odor | Characteristic aromatic odor |
| Vapor Pressure | Low at room temperature |
| Flash Point | Around 95 °C |
As an accredited 4-Bromo-2-Chloro-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 2 - chloro - 1 - methylbenzene packaged in a sealed glass bottle. |
| Storage | 4 - bromo - 2 - chloro - 1 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions. Ensure proper labeling for easy identification. |
| Shipping | 4 - bromo - 2 - chloro - 1 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. They are carefully packed to prevent breakage. Shipments follow strict chemical transport regulations to ensure safety during transit. |
Competitive 4-Bromo-2-Chloro-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Bromo-2-Chloro-1-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the Chinese name of 4-bromo-2-chloro-1-methylbenzene?
The Chinese name of 4-bromo-2-chloro-1-methylbenzene can be called "tetrabromodichloromethylbenzene" in terms of the ancient classical Chinese style of "Tiangong Kaiwu". This title is named after its chemical structure. "4-bromo" means that the fourth carbon on the benzene ring is connected to the bromine atom; "2-chlorine" means that the second carbon is connected to the chlorine atom; "1-methyl" means that the first carbon is connected to the methyl group.
Ancient scholars, although they did not have the precise understanding of today's chemistry, still wanted to name the substance simply and symbolically. With this name, the composition and structure of this compound can be briefly understood. Bromine, chlorine, and methyl are all common groups in organic chemistry, and their numbers are marked on the benzene ring, so that the structure is clearly distinguishable. This naming not only complies with the chemical rules, but also conforms to the ancient style of simple naming, so it is called "tetrabromodichloromethylbenzene", which is also appropriate in ancient Chinese.
Ancient scholars, although they did not have the precise understanding of today's chemistry, still wanted to name the substance simply and symbolically. With this name, the composition and structure of this compound can be briefly understood. Bromine, chlorine, and methyl are all common groups in organic chemistry, and their numbers are marked on the benzene ring, so that the structure is clearly distinguishable. This naming not only complies with the chemical rules, but also conforms to the ancient style of simple naming, so it is called "tetrabromodichloromethylbenzene", which is also appropriate in ancient Chinese.
What are the physical properties of 4-bromo-2-chloro-1-methylbenzene?
4-Bromo-2-chloro-1-methylbenzene is one of the organic compounds. Its physical properties are unique, with specific properties, melting boiling point, density and solubility.
This compound is mostly liquid at room temperature and pressure. It is clear and colorless, or has a slight light color. Its boiling point is about 200-220 ° C, which varies slightly due to experimental conditions. In the case of boiling point, the temperature at which a substance changes from liquid to gaseous state is determined at a specific pressure. The boiling point of this compound is higher, due to the existence of van der Waals forces between molecules, and the benzene ring structure increases the intermolecular force, which requires more energy to gasify it. The melting point of
is about -10-0 ° C, and the melting point is the temperature at which the substance changes from solid to liquid. The lower melting point indicates that the time division of the solid state is not extremely tight, and the intermolecular force is not extremely strong. The density of
is about 1.4-1.5 g/cm ³, which is heavier than water, so when mixed with water, it will sink to the bottom of the water. Density is the mass per unit volume of a substance and is affected by the molecular structure and composition. This compound contains elements with relatively large atomic weights such as bromine and chlorine, which cause high density.
In terms of solubility, it is extremely difficult to dissolve in water because it is a non-polar molecule, and water is a polar molecule. According to the principle of "similar miscibility", the two are insoluble. However, in organic solvents such as ethanol, ether, and dichloromethane, the solubility is quite good. Because organic solvents are mostly non-polar or weakly polar, they are similar in structure to 4-bromo-2-chloro-1-methylbenzene, and intermolecular forces can make them miscible.
In summary, 4-bromo-2-chloro-1-methylbenzene has specific physical properties, which are of great significance for its separation, purification and application in many fields of organic synthesis and chemical production.
This compound is mostly liquid at room temperature and pressure. It is clear and colorless, or has a slight light color. Its boiling point is about 200-220 ° C, which varies slightly due to experimental conditions. In the case of boiling point, the temperature at which a substance changes from liquid to gaseous state is determined at a specific pressure. The boiling point of this compound is higher, due to the existence of van der Waals forces between molecules, and the benzene ring structure increases the intermolecular force, which requires more energy to gasify it. The melting point of
is about -10-0 ° C, and the melting point is the temperature at which the substance changes from solid to liquid. The lower melting point indicates that the time division of the solid state is not extremely tight, and the intermolecular force is not extremely strong. The density of
is about 1.4-1.5 g/cm ³, which is heavier than water, so when mixed with water, it will sink to the bottom of the water. Density is the mass per unit volume of a substance and is affected by the molecular structure and composition. This compound contains elements with relatively large atomic weights such as bromine and chlorine, which cause high density.
In terms of solubility, it is extremely difficult to dissolve in water because it is a non-polar molecule, and water is a polar molecule. According to the principle of "similar miscibility", the two are insoluble. However, in organic solvents such as ethanol, ether, and dichloromethane, the solubility is quite good. Because organic solvents are mostly non-polar or weakly polar, they are similar in structure to 4-bromo-2-chloro-1-methylbenzene, and intermolecular forces can make them miscible.
In summary, 4-bromo-2-chloro-1-methylbenzene has specific physical properties, which are of great significance for its separation, purification and application in many fields of organic synthesis and chemical production.
What are the chemical properties of 4-bromo-2-chloro-1-methylbenzene?
4-Bromo-2-chloro-1-methylbenzene is also an organic compound. In its molecular structure, the bromine atom occupies four positions above the benzene ring, the chlorine atom occupies two positions, and the methyl group occupies one position. Due to this unique structure, many chemical properties are derived.
The first part describes its substitution reaction. Because the benzene ring has an electron cloud and its electron-rich properties are significant, it is vulnerable to attack by electrophilic reagents. Although the bromine and chlorine atoms are electron-absorbing groups, they can make the electron cloud density of the benzene ring o and para-position relatively increase. For example, in the bromination reaction catalyzed by iron halide, the electrophilic reagent bromine positive ion or selects the methyl ortho or para-position on the benzene ring to replace the hydrogen atom and form a new substitution product.
Furthermore, in this compound, the activities of bromine and chlorine atoms are different. Generally speaking, the carbon-bromo bond energy attached to bromine atoms is slightly lower than that of carbon-chlorine bonds, so bromine atoms are more likely to be replaced under suitable nucleophilic reagents and conditions. If sodium alcohol is used as a nucleophilic reagent, when heated, bromine atoms may be replaced by alkoxy groups to obtain corresponding products containing alkoxy groups.
Re-discussion of its oxidation reaction. Methyl is attached to the benzene ring and can be oxidized by strong oxidants. In the case of acidic potassium permanganate solution, under appropriate conditions, methyl can be oxidized to carboxyl groups to form 4-bromo-2-chlorobenzoic acid.
In addition, the halogen atom of 4-bromo-2-chloro-1-methylbenzene can participate in metal-organic reactions. For example, it reacts with magnesium to form Grignard reagents, which are extremely active and can undergo nucleophilic addition reactions with many carbonyl compounds, thereby realizing the construction of carbon-carbon bonds. It is widely used in the field of organic synthesis.
In summary, 4-bromo-2-chloro-1-methylbenzene is an important raw material and intermediate in organic synthesis due to its unique structure.
The first part describes its substitution reaction. Because the benzene ring has an electron cloud and its electron-rich properties are significant, it is vulnerable to attack by electrophilic reagents. Although the bromine and chlorine atoms are electron-absorbing groups, they can make the electron cloud density of the benzene ring o and para-position relatively increase. For example, in the bromination reaction catalyzed by iron halide, the electrophilic reagent bromine positive ion or selects the methyl ortho or para-position on the benzene ring to replace the hydrogen atom and form a new substitution product.
Furthermore, in this compound, the activities of bromine and chlorine atoms are different. Generally speaking, the carbon-bromo bond energy attached to bromine atoms is slightly lower than that of carbon-chlorine bonds, so bromine atoms are more likely to be replaced under suitable nucleophilic reagents and conditions. If sodium alcohol is used as a nucleophilic reagent, when heated, bromine atoms may be replaced by alkoxy groups to obtain corresponding products containing alkoxy groups.
Re-discussion of its oxidation reaction. Methyl is attached to the benzene ring and can be oxidized by strong oxidants. In the case of acidic potassium permanganate solution, under appropriate conditions, methyl can be oxidized to carboxyl groups to form 4-bromo-2-chlorobenzoic acid.
In addition, the halogen atom of 4-bromo-2-chloro-1-methylbenzene can participate in metal-organic reactions. For example, it reacts with magnesium to form Grignard reagents, which are extremely active and can undergo nucleophilic addition reactions with many carbonyl compounds, thereby realizing the construction of carbon-carbon bonds. It is widely used in the field of organic synthesis.
In summary, 4-bromo-2-chloro-1-methylbenzene is an important raw material and intermediate in organic synthesis due to its unique structure.
What are the main uses of 4-bromo-2-chloro-1-methylbenzene?
4-Bromo-2-chloro-1-methylbenzene is an organic compound with a wide range of uses.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the presence of bromine, chlorine and methyl on the benzene ring, these substituents give it unique reactivity. Bromine and chlorine atoms can participate in nucleophilic substitution reactions and interact with many nucleophilic reagents, thereby introducing different functional groups to lay the foundation for the synthesis of complex organic molecules. For example, under appropriate conditions, bromine atoms can be replaced by hydroxyl groups, amino groups, etc., to construct organic compounds with diverse functions for the creation of drugs, pesticides, etc.
In drug development, 4-bromo-2-chloro-1-methylbenzene also plays an important role. In the organic synthesis route, it is used as a starting material and can be converted into compounds with specific biological activities through multi-step reactions. During the modification of the molecular structure of the drug, the substituents on its benzene ring can participate in the reaction, changing the polarity and spatial structure of the drug molecule, which in turn affects the binding ability and pharmacokinetic properties of the drug and the target, and helps to develop drugs with better curative effect and fewer side effects.
It also has a place in the field of materials science. After a specific chemical reaction, it can be introduced into the structure of polymer materials. Due to its special structure, it can improve the properties of polymer materials, such as improving the thermal stability, mechanical properties, flame retardancy, etc. When synthesizing special plastics, rubbers or coatings, adding structural units containing 4-bromo-2-chloro-1-methylbenzene can give the material unique functions and application value.
4-bromo-2-chloro-1-methylbenzene has important uses in organic synthesis, drug research and development, materials science and other fields, and plays an indispensable role in promoting the development of various fields.
In the field of organic synthesis, this compound is often used as a key intermediate. Due to the presence of bromine, chlorine and methyl on the benzene ring, these substituents give it unique reactivity. Bromine and chlorine atoms can participate in nucleophilic substitution reactions and interact with many nucleophilic reagents, thereby introducing different functional groups to lay the foundation for the synthesis of complex organic molecules. For example, under appropriate conditions, bromine atoms can be replaced by hydroxyl groups, amino groups, etc., to construct organic compounds with diverse functions for the creation of drugs, pesticides, etc.
In drug development, 4-bromo-2-chloro-1-methylbenzene also plays an important role. In the organic synthesis route, it is used as a starting material and can be converted into compounds with specific biological activities through multi-step reactions. During the modification of the molecular structure of the drug, the substituents on its benzene ring can participate in the reaction, changing the polarity and spatial structure of the drug molecule, which in turn affects the binding ability and pharmacokinetic properties of the drug and the target, and helps to develop drugs with better curative effect and fewer side effects.
It also has a place in the field of materials science. After a specific chemical reaction, it can be introduced into the structure of polymer materials. Due to its special structure, it can improve the properties of polymer materials, such as improving the thermal stability, mechanical properties, flame retardancy, etc. When synthesizing special plastics, rubbers or coatings, adding structural units containing 4-bromo-2-chloro-1-methylbenzene can give the material unique functions and application value.
4-bromo-2-chloro-1-methylbenzene has important uses in organic synthesis, drug research and development, materials science and other fields, and plays an indispensable role in promoting the development of various fields.
What are 4-bromo-2-chloro-1-methylbenzene synthesis methods?
The synthesis of 4-bromo-2-chloro-1-methylbenzene has various paths to follow. First, toluene can be started. First, chlorine is used as a reagent. Under specific conditions, such as light or the presence of a catalyst, the chlorine atom can replace the hydrogen atom of the methyl ortho-position on the toluene ring to obtain 2-chloro-1-methylbenzene. Then, this product is used as a substrate, and then a brominating agent, such as liquid bromine, is used. Under the action of suitable catalysts, such as iron powder or iron tribromide, bromine atoms will selectively replace the hydrogen atoms on the benzene ring in the appropriate position with methyl and chlorine atoms, so as to obtain 4-bromo-2-chloro-1-methylbenzene.
Second, 1-methyl-2-nitrobenzene can also be used as a raw material. First, the nitro group is reduced to an amino group by a suitable reducing agent, such as iron and hydrochloric acid or catalytic hydrogenation, to obtain 2-amino-1-methylbenzene. Afterwards, through the diazotization reaction, the amino group is converted into a diazonium salt, and then reacts with cuprous bromide and hydrobromic acid to introduce bromine atoms to generate 2-bromo-1-methylbenzene. Subsequently, the product is chlorinated, and under suitable conditions, the chlorine atom replaces the hydrogen atom at a specific position on the benzene ring to achieve the purpose of synthesizing 4-bromo-2-chloro-1-methylbenzene.
Furthermore, it is also possible to use p-methylphenol as the starting material. The phenolic hydroxyl group is first protected to prevent it from interfering in the subsequent reaction. Next, chlorine atoms are introduced into the benzene ring with a chlorination reagent under appropriate conditions, and then bromine atoms are introduced with a brominating reagent. Finally, the target product 4-bromo-2-chloro-1-methylbenzene can be obtained by removing the protecting group. These methods have their own advantages and disadvantages, and need to be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.
Second, 1-methyl-2-nitrobenzene can also be used as a raw material. First, the nitro group is reduced to an amino group by a suitable reducing agent, such as iron and hydrochloric acid or catalytic hydrogenation, to obtain 2-amino-1-methylbenzene. Afterwards, through the diazotization reaction, the amino group is converted into a diazonium salt, and then reacts with cuprous bromide and hydrobromic acid to introduce bromine atoms to generate 2-bromo-1-methylbenzene. Subsequently, the product is chlorinated, and under suitable conditions, the chlorine atom replaces the hydrogen atom at a specific position on the benzene ring to achieve the purpose of synthesizing 4-bromo-2-chloro-1-methylbenzene.
Furthermore, it is also possible to use p-methylphenol as the starting material. The phenolic hydroxyl group is first protected to prevent it from interfering in the subsequent reaction. Next, chlorine atoms are introduced into the benzene ring with a chlorination reagent under appropriate conditions, and then bromine atoms are introduced with a brominating reagent. Finally, the target product 4-bromo-2-chloro-1-methylbenzene can be obtained by removing the protecting group. These methods have their own advantages and disadvantages, and need to be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity.
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