Linshang Chemical
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4-Bromo-2-Chloro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
191709 |
| Chemical Formula | C6H3BrClNO2 |
| Molar Mass | 236.45 g/mol |
| Appearance | Solid |
| Color | Yellow to light brown |
| Melting Point | 47 - 51 °C |
| Boiling Point | 280 - 282 °C |
| Density | 1.825 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, acetone |
| Flash Point | 123.2 °C |
As an accredited 4-Bromo-2-Chloro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - bromo - 2 - chloro - 1 - nitrobenzene in a sealed, labeled chemical bottle. |
| Storage | 4 - bromo - 2 - chloro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat and ignition. Keep it in a tightly sealed container, preferably made of corrosion - resistant material. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Label the storage container clearly with its name and hazard information. |
| Shipping | 4 - bromo - 2 - chloro - 1 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 4-Bromo-2-Chloro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Bromo-2-Chloro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-bromo-2-chloro-1-nitrobenzene?
4-Bromo-2-chloro-1-nitrobenzene is also an organic compound. In its molecular structure, above the benzene ring, the bromine atom occupies four positions, the chlorine atom occupies two positions, and the nitro group is in one position.
In terms of its chemical properties, it has strong oxidizing properties because it contains nitro groups. Nitrogen atoms in nitro groups are in a high valence state and are prone to obtain electrons. Under suitable conditions, they can oxidize other substances that react with them. And the presence of nitro groups reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution reaction activity of the benzene ring.
And because of its halogen-containing atoms, that is, bromine and chlorine, halogen atoms can undergo nucleophilic substitution reactions. When encountering nucleoph Taking bromine atom as an example, its atomic radius is large, the carbon-bromine bond energy is relatively small, and it is easier to leave, so the activity of nucleophilic substitution is slightly higher than that of chlorine atom.
In addition, the physical properties of 4-bromo-2-chloro-1-nitrobenzene are also related to its structure. At room temperature, most of them are solids, due to the interaction between molecules such as van der Waals force. Its solubility in organic solvents may be higher than that in water, because of the structural properties of organic substances, which are similar to organic solvents.
4-Bromo-2-chloro-1-nitrophenyl contains a variety of functional groups and is rich in chemical properties. It can be used as an important intermediate in organic synthesis and other fields. Through various reactions, many organic compounds with different properties are derived.
In terms of its chemical properties, it has strong oxidizing properties because it contains nitro groups. Nitrogen atoms in nitro groups are in a high valence state and are prone to obtain electrons. Under suitable conditions, they can oxidize other substances that react with them. And the presence of nitro groups reduces the electron cloud density of the benzene ring and weakens the electrophilic substitution reaction activity of the benzene ring.
And because of its halogen-containing atoms, that is, bromine and chlorine, halogen atoms can undergo nucleophilic substitution reactions. When encountering nucleoph Taking bromine atom as an example, its atomic radius is large, the carbon-bromine bond energy is relatively small, and it is easier to leave, so the activity of nucleophilic substitution is slightly higher than that of chlorine atom.
In addition, the physical properties of 4-bromo-2-chloro-1-nitrobenzene are also related to its structure. At room temperature, most of them are solids, due to the interaction between molecules such as van der Waals force. Its solubility in organic solvents may be higher than that in water, because of the structural properties of organic substances, which are similar to organic solvents.
4-Bromo-2-chloro-1-nitrophenyl contains a variety of functional groups and is rich in chemical properties. It can be used as an important intermediate in organic synthesis and other fields. Through various reactions, many organic compounds with different properties are derived.
What are the main uses of 4-bromo-2-chloro-1-nitrobenzene?
4-Bromo-2-chloro-1-nitrobenzene is one of the organic compounds with a wide range of uses. It is often an important intermediate in the synthesis of medicine. With its unique structure, it can introduce different functional groups through various chemical reactions, and then prepare a variety of drugs with specific pharmacological activities. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, 4-bromo-2-chloro-1-nitrobenzene may be one of the starting materials. After multi-step reactions, the core structure of drug molecules is constructed.
In the field of materials science, it also has important functions. It can be used to prepare special polymer materials, such as nitrohalogen-containing polymers. Such polymers give materials excellent properties such as flame retardancy and heat resistance due to their bromine, chlorine, nitro and other groups. In electronic materials, or can be used to synthesize specific electron transport materials, which is helpful for improving the performance of electronic devices.
In addition, in the field of pesticide chemistry, it is also a commonly used synthetic block. By reacting with other organic reagents, a variety of highly efficient pesticides can be prepared, such as some insecticides, fungicides, etc. Its structure can be modified and adjusted to meet the control needs of different pests and pathogens, providing strong support for the control of agricultural production.
In conclusion, 4-bromo-2-chloro-1-nitrobenzene plays an important role in many fields such as medicine, materials, and pesticides, and is an indispensable compound in organic synthetic chemistry.
In the field of materials science, it also has important functions. It can be used to prepare special polymer materials, such as nitrohalogen-containing polymers. Such polymers give materials excellent properties such as flame retardancy and heat resistance due to their bromine, chlorine, nitro and other groups. In electronic materials, or can be used to synthesize specific electron transport materials, which is helpful for improving the performance of electronic devices.
In addition, in the field of pesticide chemistry, it is also a commonly used synthetic block. By reacting with other organic reagents, a variety of highly efficient pesticides can be prepared, such as some insecticides, fungicides, etc. Its structure can be modified and adjusted to meet the control needs of different pests and pathogens, providing strong support for the control of agricultural production.
In conclusion, 4-bromo-2-chloro-1-nitrobenzene plays an important role in many fields such as medicine, materials, and pesticides, and is an indispensable compound in organic synthetic chemistry.
What are 4-bromo-2-chloro-1-nitrobenzene synthesis methods?
The synthesis method of 4-bromo-2-chloro-1-nitrobenzene has been followed by ancient methods. There are many methods, and each has its own ingenuity.
First, benzene can be started. First, the method of nitrification is used to make benzene co-heat with concentrated nitric acid and concentrated sulfuric acid to obtain nitrobenzene. In this step, attention should be paid to the control of temperature. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow. Nitrobenzene is obtained, followed by halogenation. First, under the action of a catalyst such as ferric chloride, with chlorine gas at a suitable temperature, 2-chloro-1-nitrobenzene is obtained. After reacting with bromine under similar catalytic conditions, 4-bromo-2-chloro-1-nitrobenzene can be obtained through fine regulation. Although this path is slightly complicated, the reaction in each step is relatively smooth, and the product is easy to separate and purify.
Second, chlorobenzene can also be used as a raw material. Shilling chlorobenzene reacts with mixed acids (concentrated nitric acid, concentrated sulfuric acid) to introduce nitro groups to obtain 2-chloro-1-nitrobenzene. Subsequent substitution reactions with bromine are carried out. By selecting suitable catalysts and reaction conditions, bromine atoms are precisely replaced to 4 positions, and finally 4-bromo-2-chloro-1-nitrobenzene is formed. The starting material of this method is relatively simple, and the early reaction is relatively simple, and then the bromination reaction needs to be carefully controlled to achieve the ideal yield and purity.
Third, bromobenzene is also feasible as the initial substance. First, bromobenzene is nitrified to obtain 1-bromo-4-nitrobenzene, and then reacted with chlorine gas under specific catalysts and conditions to replace the chlorine atom to 2 positions, and the target product can also be obtained. The reaction mechanism of each step of this path is clear, but the reaction conditions of each step are quite different, and the operation requirements are quite high to ensure that the reaction proceeds in the expected direction and the product purity is up to standard.
All the above synthesis methods have advantages and disadvantages. In practice, it is necessary to carefully choose the appropriate method according to the availability of raw materials, cost considerations, equipment conditions, and requirements for product purity and yield, in order to make the synthesis work smoothly and obtain the ideal product.
First, benzene can be started. First, the method of nitrification is used to make benzene co-heat with concentrated nitric acid and concentrated sulfuric acid to obtain nitrobenzene. In this step, attention should be paid to the control of temperature. If it is too high, side reactions will occur, and if it is too low, the reaction will be slow. Nitrobenzene is obtained, followed by halogenation. First, under the action of a catalyst such as ferric chloride, with chlorine gas at a suitable temperature, 2-chloro-1-nitrobenzene is obtained. After reacting with bromine under similar catalytic conditions, 4-bromo-2-chloro-1-nitrobenzene can be obtained through fine regulation. Although this path is slightly complicated, the reaction in each step is relatively smooth, and the product is easy to separate and purify.
Second, chlorobenzene can also be used as a raw material. Shilling chlorobenzene reacts with mixed acids (concentrated nitric acid, concentrated sulfuric acid) to introduce nitro groups to obtain 2-chloro-1-nitrobenzene. Subsequent substitution reactions with bromine are carried out. By selecting suitable catalysts and reaction conditions, bromine atoms are precisely replaced to 4 positions, and finally 4-bromo-2-chloro-1-nitrobenzene is formed. The starting material of this method is relatively simple, and the early reaction is relatively simple, and then the bromination reaction needs to be carefully controlled to achieve the ideal yield and purity.
Third, bromobenzene is also feasible as the initial substance. First, bromobenzene is nitrified to obtain 1-bromo-4-nitrobenzene, and then reacted with chlorine gas under specific catalysts and conditions to replace the chlorine atom to 2 positions, and the target product can also be obtained. The reaction mechanism of each step of this path is clear, but the reaction conditions of each step are quite different, and the operation requirements are quite high to ensure that the reaction proceeds in the expected direction and the product purity is up to standard.
All the above synthesis methods have advantages and disadvantages. In practice, it is necessary to carefully choose the appropriate method according to the availability of raw materials, cost considerations, equipment conditions, and requirements for product purity and yield, in order to make the synthesis work smoothly and obtain the ideal product.
4-bromo-2-chloro-1-nitrobenzene need to pay attention to when storing and transporting
4-Bromo-2-chloro-1-nitrobenzene is also an organic compound. When it is stored and transported, many matters must not be ignored.
First words storage. This material is very active, and it is prone to changes when exposed to light, heat or oxidants. Therefore, it should be stored in a cool and ventilated place, away from fire and heat sources. The temperature of the warehouse should not exceed 30 ° C, and the relative humidity should be controlled below 80%. And it should be stored separately from oxidants, reducing agents, alkalis, etc., and should not be mixed. Because of its toxicity and corrosiveness, the warehouse must also have suitable materials to contain leaks.
As for transportation, there are also strict regulations. Before transportation, be sure to ensure that the packaging is complete and the loading is safe. During transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid sun exposure. Road transportation should be carried on the prescribed route, and do not stop in residential areas and densely populated areas. Railway transportation should not be slipped.
In short, the storage and transportation of 4-bromo-2-chloro-1-nitrobenzene is related to safety and the environment. It should be carried out in accordance with regulations, and it should not be slack a little. Only in this way can the disaster be avoided and everything goes smoothly.
First words storage. This material is very active, and it is prone to changes when exposed to light, heat or oxidants. Therefore, it should be stored in a cool and ventilated place, away from fire and heat sources. The temperature of the warehouse should not exceed 30 ° C, and the relative humidity should be controlled below 80%. And it should be stored separately from oxidants, reducing agents, alkalis, etc., and should not be mixed. Because of its toxicity and corrosiveness, the warehouse must also have suitable materials to contain leaks.
As for transportation, there are also strict regulations. Before transportation, be sure to ensure that the packaging is complete and the loading is safe. During transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid sun exposure. Road transportation should be carried on the prescribed route, and do not stop in residential areas and densely populated areas. Railway transportation should not be slipped.
In short, the storage and transportation of 4-bromo-2-chloro-1-nitrobenzene is related to safety and the environment. It should be carried out in accordance with regulations, and it should not be slack a little. Only in this way can the disaster be avoided and everything goes smoothly.
4-bromo-2-chloro-1-nitrobenzene impact on the environment and human health
4-Bromo-2-chloro-1-nitrobenzene is also an organic compound. Its impact on the environment and human health cannot be ignored.
In the environment, this compound has stable properties due to bromine, chlorine, nitro and other groups, and is difficult to degrade naturally. If released in water bodies, it may cause water pollution and affect the survival of aquatic organisms. Because it can be transmitted and enriched through the food chain, or it may also be harmful to advanced organisms. In soil, it may cause changes in soil physical and chemical properties, hinder the absorption of nutrients and moisture by plant roots, and then affect plant growth.
As for human health, 4-bromo-2-chloro-1-nitrobenzene may be toxic. After inhalation through the respiratory tract, skin contact or accidental ingestion into the human body, it may damage the human multi-organ system. Its nitro or cause lesions in the blood system, affect the oxygen-carrying capacity of hemoglobin, and cause hypoxia of tissues and organs. Bromine and chlorine atoms may interfere with the human endocrine system, affect the balance of hormones, and then have a negative impact on physiological processes such as reproduction and development. Long-term exposure may increase the risk of cancer, because the compound may cause damage and mutation of cellular genetic material.
In summary, 4-bromo-2-chloro-1-nitrobenzene poses a potential threat to the environment and human health, and should be handled and used with caution to prevent it from causing harm to ecology and humans.
In the environment, this compound has stable properties due to bromine, chlorine, nitro and other groups, and is difficult to degrade naturally. If released in water bodies, it may cause water pollution and affect the survival of aquatic organisms. Because it can be transmitted and enriched through the food chain, or it may also be harmful to advanced organisms. In soil, it may cause changes in soil physical and chemical properties, hinder the absorption of nutrients and moisture by plant roots, and then affect plant growth.
As for human health, 4-bromo-2-chloro-1-nitrobenzene may be toxic. After inhalation through the respiratory tract, skin contact or accidental ingestion into the human body, it may damage the human multi-organ system. Its nitro or cause lesions in the blood system, affect the oxygen-carrying capacity of hemoglobin, and cause hypoxia of tissues and organs. Bromine and chlorine atoms may interfere with the human endocrine system, affect the balance of hormones, and then have a negative impact on physiological processes such as reproduction and development. Long-term exposure may increase the risk of cancer, because the compound may cause damage and mutation of cellular genetic material.
In summary, 4-bromo-2-chloro-1-nitrobenzene poses a potential threat to the environment and human health, and should be handled and used with caution to prevent it from causing harm to ecology and humans.
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