Linshang Chemical
PRODUCTS
4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
488640 |
| Chemical Formula | C7H3BrClF3O |
| Molecular Weight | 275.45 |
As an accredited 4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chloro - 1 - (trifluoromethoxy)benzene in sealed chemical - grade bottles. |
| Storage | Store 4 - bromo - 2 - chloro - 1 - (trifluoromethoxy)benzene in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Since it is a chemical, store it separately from oxidizing agents and incompatible substances to avoid potential reactions. |
| Shipping | 4 - bromo - 2 - chloro - 1 - (trifluoromethoxy)benzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical transportation regulations, protecting against spills and environmental exposure during transit. |
Competitive 4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene in China?
As a trusted 4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Bromo-2-Chloro-1-(Trifluoromethoxy)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene
4-Bromo-2-chloro-1- (trifluoromethoxy) benzene is one of the organic compounds. Its physical properties, at room temperature or in a liquid state, have a special smell, insoluble in water, soluble in common organic solvents such as ethanol, ether and the like.
In terms of chemical properties, bromine and chlorine atoms in this compound are quite active and can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, bromine and chlorine atoms are easily replaced by nucleophilic groups. For example, when it encounters sodium alcohol, it can generate corresponding ether compounds; when it reacts with ammonia or amine substances, bromine and chlorine atoms may be replaced by amino groups, thereby deriving nitrogen-containing compounds.
The trifluoromethoxy group in the molecule has a strong electron-absorbing effect due to the extremely high electronegativity of the fluorine atom. This electronic effect not only affects the molecular polarity, but also has a significant impact on the distribution of benzene ring electron clouds, which decreases the density of benzene ring electron clouds. In the electrophilic substitution reaction, the activity of this benzene ring is lower than that of benzene, and the check point of the substitution reaction is also affected, and it is more inclined to meta-substitution.
Furthermore, the compound may participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions. In such reactions, bromine atoms can be coupled with alkenyl and aryl-containing boric acids and other reagents under the action of palladium catalysts and bases to form carbon-carbon bonds and construct more complex organic molecular structures. All these are important chemical properties of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene.
In terms of chemical properties, bromine and chlorine atoms in this compound are quite active and can participate in nucleophilic substitution reactions. When encountering nucleophilic reagents, bromine and chlorine atoms are easily replaced by nucleophilic groups. For example, when it encounters sodium alcohol, it can generate corresponding ether compounds; when it reacts with ammonia or amine substances, bromine and chlorine atoms may be replaced by amino groups, thereby deriving nitrogen-containing compounds.
The trifluoromethoxy group in the molecule has a strong electron-absorbing effect due to the extremely high electronegativity of the fluorine atom. This electronic effect not only affects the molecular polarity, but also has a significant impact on the distribution of benzene ring electron clouds, which decreases the density of benzene ring electron clouds. In the electrophilic substitution reaction, the activity of this benzene ring is lower than that of benzene, and the check point of the substitution reaction is also affected, and it is more inclined to meta-substitution.
Furthermore, the compound may participate in metal-catalyzed reactions, such as palladium-catalyzed coupling reactions. In such reactions, bromine atoms can be coupled with alkenyl and aryl-containing boric acids and other reagents under the action of palladium catalysts and bases to form carbon-carbon bonds and construct more complex organic molecular structures. All these are important chemical properties of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene.
What are the main uses of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene
4-Bromo-2-chloro-1- (trifluoromethoxy) benzene has a wide range of uses in the field of organic synthesis. Its primary use lies in the creation of medicine. Given the unique chemical structure of this compound, it can be used as a key intermediate to produce a variety of specific drugs. For example, through specific reaction steps, other functional groups can be introduced to construct a complex molecular structure with biological activity, which contributes a lot to the development of anti-viral and anti-tumor drugs.
Furthermore, in the process of pesticide synthesis, it also has its own influence. With its own structural characteristics, pesticide products with high insecticidal and bactericidal properties can be derived. By ingeniously reacting with other organic reagents, the activity and selectivity of the product can be precisely adjusted, making the pesticide more targeted and efficient, and reducing the adverse impact on the environment.
In addition, in the field of materials science, 4-bromo-2-chloro-1 - (trifluoromethoxy) benzene has also emerged. It can be used to prepare special polymer materials, whose special structure can endow the materials with properties such as excellent heat resistance and chemical stability. Using this as a raw material, through polymerization and other means, the obtained materials have potential applications in high-end fields such as aerospace, electronics and electrical appliances, such as the manufacture of high-temperature insulating materials, chemical-resistant electronic component coatings, etc.
In summary, 4-bromo-2-chloro-1- (trifluoromethoxy) benzene has shown important application value in many fields such as medicine, pesticides and materials science, and is also a key compound for promoting the development of related industries.
Furthermore, in the process of pesticide synthesis, it also has its own influence. With its own structural characteristics, pesticide products with high insecticidal and bactericidal properties can be derived. By ingeniously reacting with other organic reagents, the activity and selectivity of the product can be precisely adjusted, making the pesticide more targeted and efficient, and reducing the adverse impact on the environment.
In addition, in the field of materials science, 4-bromo-2-chloro-1 - (trifluoromethoxy) benzene has also emerged. It can be used to prepare special polymer materials, whose special structure can endow the materials with properties such as excellent heat resistance and chemical stability. Using this as a raw material, through polymerization and other means, the obtained materials have potential applications in high-end fields such as aerospace, electronics and electrical appliances, such as the manufacture of high-temperature insulating materials, chemical-resistant electronic component coatings, etc.
In summary, 4-bromo-2-chloro-1- (trifluoromethoxy) benzene has shown important application value in many fields such as medicine, pesticides and materials science, and is also a key compound for promoting the development of related industries.
What is the synthesis method of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene?
The synthesis of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene is a key skill in the field of organic synthesis. This synthesis process often requires multiple steps of reaction, carefully planning each step, in order to achieve the target product.
The choice of starting materials is crucial to the success or failure of the synthesis. Compounds containing benzene rings can usually be selected as starting materials because they have the basis for building the core structure of the target molecule. For example, 2-chloro-4-bromophenol is used as the starting material. This substance already contains chlorine and bromine atoms on the benzene ring, which have certain similarities with the structure of the target product, which is convenient for subsequent introduction of trifluoromethoxy groups.
The step of introducing trifluoromethoxy often requires special reagents and conditions. The commonly used method is to react with trifluoromethylation reagents, such as trifluoromethyl halides or trifluoromethyl sulfonyl halides, with the starting material in the presence of an appropriate base. The function of the base is to promote the deprotonation of the phenolic hydroxyl group of the starting material to form a phenoxy negative ion. This negative ion enhances the nucleophilicity and is easy to attack the trifluoromethylation reagent, thereby introducing trifluoromethoxy. This reaction needs to be carried out at a suitable temperature and reaction time to ensure a high yield. In general, the reaction temperature can be controlled in the range of low temperature to room temperature, such as between 0 ° C and 25 ° C, and the reaction time depends on the specific reaction process, which may take several hours or even tens of hours.
During the synthesis process, it is also necessary to pay attention to the selectivity of the reaction. Due to the different substituent activities at different positions on the benzene ring, it is necessary to rationally design the reaction sequence and conditions so that the trifluoromethoxy group can be precisely introduced into the target position. For example, by adjusting the proportion of reactants, reaction temperature and catalyst used, the regioselectivity of the reaction can be effectively improved.
In addition, after each step of the reaction is completed, the separation and purification of the product is also indispensable. Commonly used separation methods include extraction, distillation, column chromatography, etc. Extraction can separate the product from the reaction mixture according to the difference in solubility of the product and impurities in different solvents; distillation is suitable for separating substances with large differences in boiling points; column chromatography realizes the separation of products and impurities by means of the different adsorption capacities of adsorbents for different compounds. Through a series of careful operations, high-purity 4-bromo-2-chloro-1 - (trifluoromethoxy) benzene can be obtained.
The choice of starting materials is crucial to the success or failure of the synthesis. Compounds containing benzene rings can usually be selected as starting materials because they have the basis for building the core structure of the target molecule. For example, 2-chloro-4-bromophenol is used as the starting material. This substance already contains chlorine and bromine atoms on the benzene ring, which have certain similarities with the structure of the target product, which is convenient for subsequent introduction of trifluoromethoxy groups.
The step of introducing trifluoromethoxy often requires special reagents and conditions. The commonly used method is to react with trifluoromethylation reagents, such as trifluoromethyl halides or trifluoromethyl sulfonyl halides, with the starting material in the presence of an appropriate base. The function of the base is to promote the deprotonation of the phenolic hydroxyl group of the starting material to form a phenoxy negative ion. This negative ion enhances the nucleophilicity and is easy to attack the trifluoromethylation reagent, thereby introducing trifluoromethoxy. This reaction needs to be carried out at a suitable temperature and reaction time to ensure a high yield. In general, the reaction temperature can be controlled in the range of low temperature to room temperature, such as between 0 ° C and 25 ° C, and the reaction time depends on the specific reaction process, which may take several hours or even tens of hours.
During the synthesis process, it is also necessary to pay attention to the selectivity of the reaction. Due to the different substituent activities at different positions on the benzene ring, it is necessary to rationally design the reaction sequence and conditions so that the trifluoromethoxy group can be precisely introduced into the target position. For example, by adjusting the proportion of reactants, reaction temperature and catalyst used, the regioselectivity of the reaction can be effectively improved.
In addition, after each step of the reaction is completed, the separation and purification of the product is also indispensable. Commonly used separation methods include extraction, distillation, column chromatography, etc. Extraction can separate the product from the reaction mixture according to the difference in solubility of the product and impurities in different solvents; distillation is suitable for separating substances with large differences in boiling points; column chromatography realizes the separation of products and impurities by means of the different adsorption capacities of adsorbents for different compounds. Through a series of careful operations, high-purity 4-bromo-2-chloro-1 - (trifluoromethoxy) benzene can be obtained.
What are the precautions for storing 4-bromo-2-chloro-1- (trifluoromethoxy) benzene?
4-Bromo-2-chloro-1- (trifluoromethoxy) benzene is also an organic compound. When storing it, it is necessary to pay attention to many matters to ensure safety and quality.
Bear the brunt, and the storage place must be cool and dry. This compound is quite sensitive to temperature and humidity. In a high temperature and humid environment, it is easy to cause chemical reactions or decomposition and deterioration. Therefore, it is advisable to choose a well-ventilated place with constant temperature, away from heat sources and water sources.
Furthermore, this substance should be separated from oxidizing agents, acids, bases and other chemicals. Due to its active chemical properties, it can encounter the above objects, or react violently, even causing fire and explosion. Therefore, in the storage layout, careful planning must be made, and mixed storage is strictly prohibited.
The choice of storage containers is also crucial. When using corrosion-resistant materials, such as glass or specific plastic containers. The cover is corrosive because it contains bromine, chlorine, fluorine and other elements. If the container material is improper, it may cause leakage, which will cause serious consequences. And the container must be well sealed to prevent volatilization, avoid the escape of harmful gases, and endanger the environment and personal safety.
In addition, the storage place should be equipped with obvious warning signs, clearly indicating that this is a dangerous chemical, reminding personnel to operate with caution. At the same time, it is necessary to be equipped with corresponding emergency treatment equipment, such as fire extinguishers, adsorption materials, etc., to prepare for emergencies. The management personnel of the storage area should also be familiar with the characteristics of the compound and emergency treatment methods to ensure that in the event of an accident, they can respond quickly and properly.
Bear the brunt, and the storage place must be cool and dry. This compound is quite sensitive to temperature and humidity. In a high temperature and humid environment, it is easy to cause chemical reactions or decomposition and deterioration. Therefore, it is advisable to choose a well-ventilated place with constant temperature, away from heat sources and water sources.
Furthermore, this substance should be separated from oxidizing agents, acids, bases and other chemicals. Due to its active chemical properties, it can encounter the above objects, or react violently, even causing fire and explosion. Therefore, in the storage layout, careful planning must be made, and mixed storage is strictly prohibited.
The choice of storage containers is also crucial. When using corrosion-resistant materials, such as glass or specific plastic containers. The cover is corrosive because it contains bromine, chlorine, fluorine and other elements. If the container material is improper, it may cause leakage, which will cause serious consequences. And the container must be well sealed to prevent volatilization, avoid the escape of harmful gases, and endanger the environment and personal safety.
In addition, the storage place should be equipped with obvious warning signs, clearly indicating that this is a dangerous chemical, reminding personnel to operate with caution. At the same time, it is necessary to be equipped with corresponding emergency treatment equipment, such as fire extinguishers, adsorption materials, etc., to prepare for emergencies. The management personnel of the storage area should also be familiar with the characteristics of the compound and emergency treatment methods to ensure that in the event of an accident, they can respond quickly and properly.
What are the environmental effects of 4-bromo-2-chloro-1- (trifluoromethoxy) benzene?
4-Bromo-2-chloro-1- (trifluoromethoxy) benzene, the impact of this substance on the environment is quite important and needs to be investigated in detail.
First of all, its chemical properties, the compound contains bromine, chlorine, trifluoromethoxy and other groups, with specific chemical activity and stability. Bromine and chlorine atoms are often active check points in organic reactions, or can initiate reactions such as substitution and addition, change their chemical structure, and then affect their behavior in the environment. Trifluoromethoxy gives molecules unique physical and chemical properties, such as increasing the fat solubility of compounds, affecting their distribution in environmental media.
It is in the atmospheric environment, or triggers photochemical reactions due to conditions such as light. Bromine and chlorine atoms can be separated by photolysis, generating free radicals, participating in complex chain reactions in the atmosphere, which affect the chemical composition and oxidation capacity of the atmosphere. For example, it may interfere with the balance of ozone formation and decomposition, which is related to the protection of the ozone layer.
In the aquatic environment, due to its hydrophobicity, it may tend to adsorb on the surface of suspended particles or sediments. If it enters the aquatic ecosystem or is enriched through the food chain, it threatens aquatic organisms. After some organisms are ingested, it may be difficult to metabolize and excrete, resulting in increased concentrations in organisms and affecting their normal physiological functions, such as growth, reproduction, and immunity.
In the soil environment, it can be adsorbed on soil particles, affecting the structure and function of soil microbial communities. Microorganisms may change metabolic pathways, interfere with nutrient cycling and organic matter decomposition in soil. Long-term accumulation, or change soil chemical properties, affect vegetation growth.
4-bromo-2-chloro-1 - (trifluoromethoxy) benzene has complex behavior in environmental media, or affects the ecosystem through various pathways, which cannot be ignored. It should be carefully studied to clarify its harm and find ways to deal with it.
First of all, its chemical properties, the compound contains bromine, chlorine, trifluoromethoxy and other groups, with specific chemical activity and stability. Bromine and chlorine atoms are often active check points in organic reactions, or can initiate reactions such as substitution and addition, change their chemical structure, and then affect their behavior in the environment. Trifluoromethoxy gives molecules unique physical and chemical properties, such as increasing the fat solubility of compounds, affecting their distribution in environmental media.
It is in the atmospheric environment, or triggers photochemical reactions due to conditions such as light. Bromine and chlorine atoms can be separated by photolysis, generating free radicals, participating in complex chain reactions in the atmosphere, which affect the chemical composition and oxidation capacity of the atmosphere. For example, it may interfere with the balance of ozone formation and decomposition, which is related to the protection of the ozone layer.
In the aquatic environment, due to its hydrophobicity, it may tend to adsorb on the surface of suspended particles or sediments. If it enters the aquatic ecosystem or is enriched through the food chain, it threatens aquatic organisms. After some organisms are ingested, it may be difficult to metabolize and excrete, resulting in increased concentrations in organisms and affecting their normal physiological functions, such as growth, reproduction, and immunity.
In the soil environment, it can be adsorbed on soil particles, affecting the structure and function of soil microbial communities. Microorganisms may change metabolic pathways, interfere with nutrient cycling and organic matter decomposition in soil. Long-term accumulation, or change soil chemical properties, affect vegetation growth.
4-bromo-2-chloro-1 - (trifluoromethoxy) benzene has complex behavior in environmental media, or affects the ecosystem through various pathways, which cannot be ignored. It should be carefully studied to clarify its harm and find ways to deal with it.
Scan to WhatsApp
