Linshang Chemical
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4-Bromo-2-Chloro-1-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
270977 |
| Chemical Formula | C7H3BrClF3 |
| Molecular Weight | 273.45 |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Around 187 - 189 °C |
| Density | Approximately 1.79 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Relatively low, but increases with temperature |
| Flash Point | Around 73 °C |
As an accredited 4-Bromo-2-Chloro-1-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chloro - 1 - (trifluoromethyl)benzene in sealed chemical - grade bottle. |
| Storage | 4 - bromo - 2 - chloro - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly - sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and reactive chemicals to avoid potential chemical reactions. |
| Shipping | 4 - bromo - 2 - chloro - 1 - (trifluoromethyl)benzene is shipped in specialized, tightly - sealed containers. It adheres to strict chemical shipping regulations, ensuring safe transportation from origin to destination to prevent any spills or hazards. |
Competitive 4-Bromo-2-Chloro-1-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Bromo-2-Chloro-1-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 4-bromo-2-chloro-1- (trifluoromethyl) benzene?
The physical properties of 4-hydroxyl-2-alkane-1- (triethylmethyl) naphthalene are as follows:
In terms of quality, this compound is often in a crystalline state. When pure, the color is white, like the condensation of frost and snow, the crystal form is uniform, and the light is introverted. At room temperature, it is as stable as a virgin, and its melting point is quite specific. The melting point is about [X] ° C. When the temperature gradually rises to this point, the lattice energy gradually increases, and the lattice structure begins to be disordered. Then it gradually melts from the solid state to the liquid state, just like ice and snow melting when warm. The boiling point is around [X] ° C. At this temperature, the thermal motion of the molecules intensifies, breaking free from the shackles of the liquid phase, escaping into the gas phase, and flying in the sky like Kunpeng spreading its wings.
Its solubility is also considerable. In organic solvents, such as ethanol and ether, it is quite soluble. Ethanol is mild and organic-friendly, and it is matched with 4-hydroxyl-2-alkane-1- (triethylmethyl) naphthalene molecules, so the two are very compatible, like a duck to water, the solution is clear and transparent, without the slightest turbidity. However, in water, this compound is insoluble, and the polarity of water is different from the structure of the compound. The two are like participating in a business, and it is difficult to blend. If it is thrown into water, it will be like a stone entering water and sinking at the bottom, not being dissolved by water.
Furthermore, its density is slightly larger than that of water. If it is placed in water, it will sink down. If it sinks into the sea, it will definitely not float. And this compound has a certain stability. Under normal conditions, it is not easy to react chemically with the surrounding things. It is like a hermit, who is alone and keeps its properties. However, in severe environments such as strong acids, strong alkalis or high temperatures, its structure may change, and its chemical properties will appear lively. This will be discussed later. Its refractive index also has a specific value. When light passes through it, the light path twists and turns, just like a winding path, which is one of its characteristics.
In terms of quality, this compound is often in a crystalline state. When pure, the color is white, like the condensation of frost and snow, the crystal form is uniform, and the light is introverted. At room temperature, it is as stable as a virgin, and its melting point is quite specific. The melting point is about [X] ° C. When the temperature gradually rises to this point, the lattice energy gradually increases, and the lattice structure begins to be disordered. Then it gradually melts from the solid state to the liquid state, just like ice and snow melting when warm. The boiling point is around [X] ° C. At this temperature, the thermal motion of the molecules intensifies, breaking free from the shackles of the liquid phase, escaping into the gas phase, and flying in the sky like Kunpeng spreading its wings.
Its solubility is also considerable. In organic solvents, such as ethanol and ether, it is quite soluble. Ethanol is mild and organic-friendly, and it is matched with 4-hydroxyl-2-alkane-1- (triethylmethyl) naphthalene molecules, so the two are very compatible, like a duck to water, the solution is clear and transparent, without the slightest turbidity. However, in water, this compound is insoluble, and the polarity of water is different from the structure of the compound. The two are like participating in a business, and it is difficult to blend. If it is thrown into water, it will be like a stone entering water and sinking at the bottom, not being dissolved by water.
Furthermore, its density is slightly larger than that of water. If it is placed in water, it will sink down. If it sinks into the sea, it will definitely not float. And this compound has a certain stability. Under normal conditions, it is not easy to react chemically with the surrounding things. It is like a hermit, who is alone and keeps its properties. However, in severe environments such as strong acids, strong alkalis or high temperatures, its structure may change, and its chemical properties will appear lively. This will be discussed later. Its refractive index also has a specific value. When light passes through it, the light path twists and turns, just like a winding path, which is one of its characteristics.
What are the chemical properties of 4-bromo-2-chloro-1- (trifluoromethyl) benzene?
4-Bromo-2-chloro-1- (trifluoromethyl) benzene is one of the organic compounds. Its chemical properties are unique and worthy of detailed investigation.
In this compound, the substituents of bromine (Br), chlorine (Cl) and trifluoromethyl (CF 🥰) give it special reactivity. Bromine and chlorine, as halogen atoms, have certain electronegativity, which can change the electron cloud density distribution of the benzene ring. Due to its electron-absorbing effect, the electron cloud density of the benzene ring is reduced, so the activity of the electrophilic substitution reaction is lower than that of benzene itself. However, under appropriate conditions, the electrophilic reagent can still attack the benzene ring and cause a substitution reaction. The position of the halogen atom (4-bromo and 2-chlorine) also has a significant impact on the reaction check point and activity. The halogen atom at a specific position can selectively participate in the reaction under different reaction conditions.
Trifluoromethyl (CF 🥰) is also a strong electron-absorbing group, and its existence further reduces the electron cloud density of the benzene ring, strengthening the change of the electrophilic substitution reaction activity of the benzene ring. At the same time, the steric resistance of CF 🥰 is large, which may affect the proximity of the reagents and the configuration of the reaction products during the reaction process.
In some nucleophilic substitution reactions, bromine and chlorine atoms can be used as leaving groups and replaced by nucleophilic reagents. However, the degree of difficulty of departure varies depending on the type of halogen atom and other substituents on the benzene ring. Generally speaking, bromine atoms are more likely to leave than chlorine atoms, which provides a way to synthesize new compounds.
In addition, the physical properties of the compound are also affected by these substituents, such as melting point, boiling point, solubility, etc. Due to the introduction of CF, the polarity of the molecule changes, and the solubility in organic solvents and water is significantly different from that of benzene.
In summary, the specific substituent combination of 4-bromo-2-chloro-1- (trifluoromethyl) benzene exhibits unique chemical properties in the field of organic synthesis, providing rich materials for the study of organic chemistry and the creation of new compounds.
In this compound, the substituents of bromine (Br), chlorine (Cl) and trifluoromethyl (CF 🥰) give it special reactivity. Bromine and chlorine, as halogen atoms, have certain electronegativity, which can change the electron cloud density distribution of the benzene ring. Due to its electron-absorbing effect, the electron cloud density of the benzene ring is reduced, so the activity of the electrophilic substitution reaction is lower than that of benzene itself. However, under appropriate conditions, the electrophilic reagent can still attack the benzene ring and cause a substitution reaction. The position of the halogen atom (4-bromo and 2-chlorine) also has a significant impact on the reaction check point and activity. The halogen atom at a specific position can selectively participate in the reaction under different reaction conditions.
Trifluoromethyl (CF 🥰) is also a strong electron-absorbing group, and its existence further reduces the electron cloud density of the benzene ring, strengthening the change of the electrophilic substitution reaction activity of the benzene ring. At the same time, the steric resistance of CF 🥰 is large, which may affect the proximity of the reagents and the configuration of the reaction products during the reaction process.
In some nucleophilic substitution reactions, bromine and chlorine atoms can be used as leaving groups and replaced by nucleophilic reagents. However, the degree of difficulty of departure varies depending on the type of halogen atom and other substituents on the benzene ring. Generally speaking, bromine atoms are more likely to leave than chlorine atoms, which provides a way to synthesize new compounds.
In addition, the physical properties of the compound are also affected by these substituents, such as melting point, boiling point, solubility, etc. Due to the introduction of CF, the polarity of the molecule changes, and the solubility in organic solvents and water is significantly different from that of benzene.
In summary, the specific substituent combination of 4-bromo-2-chloro-1- (trifluoromethyl) benzene exhibits unique chemical properties in the field of organic synthesis, providing rich materials for the study of organic chemistry and the creation of new compounds.
What are the main uses of 4-bromo-2-chloro-1- (trifluoromethyl) benzene?
4-Bromo-2-chloro-1- (trifluoromethyl) benzene is a key intermediate in organic synthesis and has a wide range of uses in medicine, pesticides, materials and other fields.
In the field of medicine, this compound can be used as a key building block for the synthesis of a variety of specific drugs. For example, in the preparation of many antibacterial drugs, 4-bromo-2-chloro-1- (trifluoromethyl) benzene participates in the construction of the core skeleton of the drug, giving the drug unique antibacterial activity and pharmacokinetic properties, which can more accurately act on pathogens and improve the therapeutic effect. In the development of anti-tumor drugs, through structural modification and derivatization, compounds with targeted antitumor activity can be obtained, bringing new hope for solving cancer problems.
In the field of pesticides, it is also an important synthetic raw material. High-efficiency insecticides, fungicides and herbicides can be prepared. Taking insecticides as an example, through rational design and synthesis, pesticides containing this structure can effectively act on the nervous system or physiological and metabolic pathways of pests, achieve precise attack on pests, and are environmentally friendly, with low residues, which not only ensures a good harvest of crops, but also maintains ecological balance.
In the field of materials science, 4-bromo-2-chloro-1- (trifluoromethyl) benzene can be used to synthesize high-performance functional materials. For example, when preparing organic photoelectric materials, the introduction of this structure can adjust the electron cloud distribution and energy level structure of the material, thereby improving the photoelectric properties of the material, enhancing the luminous efficiency and stability, and showing great application potential in the fields of organic Light Emitting Diode (OLED) and solar cells.
In summary, 4-bromo-2-chloro-1- (trifluoromethyl) benzene plays an indispensable role in many important fields due to its unique structure and reactivity, promoting technological innovation and product upgrading in various fields.
In the field of medicine, this compound can be used as a key building block for the synthesis of a variety of specific drugs. For example, in the preparation of many antibacterial drugs, 4-bromo-2-chloro-1- (trifluoromethyl) benzene participates in the construction of the core skeleton of the drug, giving the drug unique antibacterial activity and pharmacokinetic properties, which can more accurately act on pathogens and improve the therapeutic effect. In the development of anti-tumor drugs, through structural modification and derivatization, compounds with targeted antitumor activity can be obtained, bringing new hope for solving cancer problems.
In the field of pesticides, it is also an important synthetic raw material. High-efficiency insecticides, fungicides and herbicides can be prepared. Taking insecticides as an example, through rational design and synthesis, pesticides containing this structure can effectively act on the nervous system or physiological and metabolic pathways of pests, achieve precise attack on pests, and are environmentally friendly, with low residues, which not only ensures a good harvest of crops, but also maintains ecological balance.
In the field of materials science, 4-bromo-2-chloro-1- (trifluoromethyl) benzene can be used to synthesize high-performance functional materials. For example, when preparing organic photoelectric materials, the introduction of this structure can adjust the electron cloud distribution and energy level structure of the material, thereby improving the photoelectric properties of the material, enhancing the luminous efficiency and stability, and showing great application potential in the fields of organic Light Emitting Diode (OLED) and solar cells.
In summary, 4-bromo-2-chloro-1- (trifluoromethyl) benzene plays an indispensable role in many important fields due to its unique structure and reactivity, promoting technological innovation and product upgrading in various fields.
What are the synthesis methods of 4-bromo-2-chloro-1- (trifluoromethyl) benzene?
To prepare 4-bromo-2-iodine-1- (trifluoromethyl) benzene, there are various methods.
First, (trifluoromethyl) benzene can be used as the starting material. Iron or iron tribromide is used as a catalyst to make it substitution reaction with bromine, and bromine atoms are introduced into the benzene ring to obtain bromo- (trifluoromethyl) benzene. In this step, because trifluoromethyl is the meta-site group, the bromine atoms mainly fall in the meta-site. Then, by means of nitration reaction, under suitable conditions, the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as a reagent to nitrate bromo- (trifluoromethyl) benzene, and nitro groups are introduced into the benzene ring. After separation and purification, the nitro group is reduced to amino group, and reducing agents such as iron and hydrochloric acid are commonly used. After that, the amino-containing compound is treated with sodium nitrite and hydrochloric acid by diazotization reaction to obtain diazonium salt. Finally, under the action of potassium iodide, the diazonium group is replaced by iodine atom, so as to prepare the target product 4-bromo-2-iodine-1 - (trifluoromethyl) benzene.
Second, (trifluoromethyl) benzene can also be used as the starting material, and the sulfonation reaction is carried out first. Using concentrated sulfuric acid as the sulfonating agent, a sulfonic acid group is introduced on the benzene ring. Because the sulfonic acid group is a strong passivation group and is an meta-localization group, when the subsequent reaction with bromine, the bromine atom will mainly enter the meta-site of the sulfonic acid group to obtain the corresponding bromide. Next, the sulfonic acid group is hydrolyzed from the benzene ring, and then the nitro group is introduced by nitrification reaction. After the above method, the nitro group is reduced to an amino group, and the diazotization reaction and the reaction with potassium iodide are used to realize the introduction of iodine atoms, and 4-bromo-2-iodine-1- (trifluoromethyl) benzene can also be obtained.
Third, from other suitable benzene-containing ring raw materials, through a series of organic reaction steps such as halogenation, substitution, oxidation, reduction, etc., the reaction route can be ingeniously designed, and the target molecular structure can be gradually constructed to achieve the purpose of synthesizing 4-bromo-2-iodine-1- (trifluoromethyl) benzene. However, when implementing it, it is necessary to consider various factors such as reaction conditions, yield, cost and difficulty of operation according to the actual situation to choose the optimal synthesis path.
First, (trifluoromethyl) benzene can be used as the starting material. Iron or iron tribromide is used as a catalyst to make it substitution reaction with bromine, and bromine atoms are introduced into the benzene ring to obtain bromo- (trifluoromethyl) benzene. In this step, because trifluoromethyl is the meta-site group, the bromine atoms mainly fall in the meta-site. Then, by means of nitration reaction, under suitable conditions, the mixed acid of concentrated sulfuric acid and concentrated nitric acid is used as a reagent to nitrate bromo- (trifluoromethyl) benzene, and nitro groups are introduced into the benzene ring. After separation and purification, the nitro group is reduced to amino group, and reducing agents such as iron and hydrochloric acid are commonly used. After that, the amino-containing compound is treated with sodium nitrite and hydrochloric acid by diazotization reaction to obtain diazonium salt. Finally, under the action of potassium iodide, the diazonium group is replaced by iodine atom, so as to prepare the target product 4-bromo-2-iodine-1 - (trifluoromethyl) benzene.
Second, (trifluoromethyl) benzene can also be used as the starting material, and the sulfonation reaction is carried out first. Using concentrated sulfuric acid as the sulfonating agent, a sulfonic acid group is introduced on the benzene ring. Because the sulfonic acid group is a strong passivation group and is an meta-localization group, when the subsequent reaction with bromine, the bromine atom will mainly enter the meta-site of the sulfonic acid group to obtain the corresponding bromide. Next, the sulfonic acid group is hydrolyzed from the benzene ring, and then the nitro group is introduced by nitrification reaction. After the above method, the nitro group is reduced to an amino group, and the diazotization reaction and the reaction with potassium iodide are used to realize the introduction of iodine atoms, and 4-bromo-2-iodine-1- (trifluoromethyl) benzene can also be obtained.
Third, from other suitable benzene-containing ring raw materials, through a series of organic reaction steps such as halogenation, substitution, oxidation, reduction, etc., the reaction route can be ingeniously designed, and the target molecular structure can be gradually constructed to achieve the purpose of synthesizing 4-bromo-2-iodine-1- (trifluoromethyl) benzene. However, when implementing it, it is necessary to consider various factors such as reaction conditions, yield, cost and difficulty of operation according to the actual situation to choose the optimal synthesis path.
What are the precautions for storing and transporting 4-bromo-2-chloro-1- (trifluoromethyl) benzene?
For 4-ether-2-alkane-1- (triethylmethyl) naphthalene, various precautions are very important during storage and transportation.
Bear the brunt, this material has specific properties and is extremely sensitive to temperature. Under high temperature, it is easy to cause its chemical structure to mutate, which in turn damages the quality. Therefore, when storing, when looking for a cool place, the temperature should be controlled within a specific range to prevent its properties from changing. And avoid direct sunlight, the energy of sunlight can cause photochemical reactions to occur, resulting in quality degradation.
In addition, 4-ether-2-alkane-1- (triethylmethyl) naphthalene may have certain volatility. It is a storage device, and it must be well sealed to prevent it from escaping into the air. One can avoid its loss, and the other can avoid the pollution of the surrounding environment caused by its volatilization, and the volatile substances may be potentially dangerous, which is related to safety and cannot be ignored.
During transportation, shock protection is also a priority. The structure of this substance may be damaged due to vibration, resulting in performance changes. The transportation vehicle should run smoothly to avoid severe bumps. The packaging material also needs to have good cushioning properties to provide stable protection.
In addition, 4-ether-2-alkane-1- (triethylmethyl) naphthalene may have certain chemical activity. Do not mix or mix with other chemicals at will to prevent chemical reactions from occurring, which can cause material deterioration in light, and cause safety accidents in severe cases. It is necessary to carefully observe its chemical properties, and store and transport them according to their nature.
And because of its potential impact on the human body and the environment, operators and transporters should prepare protective equipment, such as gloves, masks, goggles, etc., to ensure their own safety. And once there is a leak, they need to be disposed of in accordance with established methods to prevent its spread and reduce the harm to the environment.
Bear the brunt, this material has specific properties and is extremely sensitive to temperature. Under high temperature, it is easy to cause its chemical structure to mutate, which in turn damages the quality. Therefore, when storing, when looking for a cool place, the temperature should be controlled within a specific range to prevent its properties from changing. And avoid direct sunlight, the energy of sunlight can cause photochemical reactions to occur, resulting in quality degradation.
In addition, 4-ether-2-alkane-1- (triethylmethyl) naphthalene may have certain volatility. It is a storage device, and it must be well sealed to prevent it from escaping into the air. One can avoid its loss, and the other can avoid the pollution of the surrounding environment caused by its volatilization, and the volatile substances may be potentially dangerous, which is related to safety and cannot be ignored.
During transportation, shock protection is also a priority. The structure of this substance may be damaged due to vibration, resulting in performance changes. The transportation vehicle should run smoothly to avoid severe bumps. The packaging material also needs to have good cushioning properties to provide stable protection.
In addition, 4-ether-2-alkane-1- (triethylmethyl) naphthalene may have certain chemical activity. Do not mix or mix with other chemicals at will to prevent chemical reactions from occurring, which can cause material deterioration in light, and cause safety accidents in severe cases. It is necessary to carefully observe its chemical properties, and store and transport them according to their nature.
And because of its potential impact on the human body and the environment, operators and transporters should prepare protective equipment, such as gloves, masks, goggles, etc., to ensure their own safety. And once there is a leak, they need to be disposed of in accordance with established methods to prevent its spread and reduce the harm to the environment.
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