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4-Bromo-2-Chlorobenzenesulfonyl Chloride
Linshang Chemical
|
HS Code |
213797 |
| Chemical Formula | C6H3BrCl2O2S |
| Molar Mass | 291.96 g/mol |
| Appearance | Typically a solid (appearance can vary based on purity and handling) |
| Physical State At Room Temperature | Solid |
| Melting Point | Data specific to this compound needs to be experimentally determined or sourced from relevant chemical databases |
| Boiling Point | Data specific to this compound needs to be experimentally determined or sourced from relevant chemical databases |
| Solubility In Water | Likely insoluble as it contains non - polar benzene ring and hydrophobic sulfonyl chloride group |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc., due to its organic nature |
| Density | Data specific to this compound needs to be experimentally determined or sourced from relevant chemical databases |
| Reactivity | Reactive towards nucleophiles due to the presence of sulfonyl chloride group which can undergo substitution reactions |
As an accredited 4-Bromo-2-Chlorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chlorobenzenesulfonyl chloride packaged in a sealed glass bottle. |
| Storage | 4 - bromo - 2 - chlorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. It must be kept away from heat, flames, and incompatible substances like strong bases and reducing agents. Store it in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air or moisture, which could lead to decomposition. |
| Shipping | 4 - bromo - 2 - chlorobenzenesulfonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers. Ensure proper labeling indicating its hazardous nature. Follow all relevant regulations for safe transportation. |
Competitive 4-Bromo-2-Chlorobenzenesulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Bromo-2-Chlorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-bromo-2-chlorobenzenesulfonyl Chloride?
4-Bromo-2-chlorobenzenesulfonyl chloride has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
The gainesulfonyl chloride group is highly active and can participate in many chemical reactions. For example, in the preparation of sulfonamides, 4-bromo-2-chlorobenzenesulfonyl chloride can react with amine compounds to form corresponding sulfonamides. Such sulfonamide compounds have important applications in the field of medicinal chemistry, some of which have unique biological activities, or can be used as potential drug molecules for the treatment of diseases.
Furthermore, it has also contributed to the field of materials science. With the help of chemical reactions, it can be introduced into the structure of polymer materials, thereby changing the physical and chemical properties of materials, such as improving the stability of materials, improving their solubility, etc., so that materials can better meet the needs of specific application scenarios.
At the same time, in the production of fine chemicals, 4-bromo-2-chlorobenzenesulfonyl chloride can be used to synthesize organic compounds with special functions, such as some substances with special optical and electrical properties. It provides raw material support for electronic devices, optical materials and other industries, and promotes technological development and product innovation in related fields.
The gainesulfonyl chloride group is highly active and can participate in many chemical reactions. For example, in the preparation of sulfonamides, 4-bromo-2-chlorobenzenesulfonyl chloride can react with amine compounds to form corresponding sulfonamides. Such sulfonamide compounds have important applications in the field of medicinal chemistry, some of which have unique biological activities, or can be used as potential drug molecules for the treatment of diseases.
Furthermore, it has also contributed to the field of materials science. With the help of chemical reactions, it can be introduced into the structure of polymer materials, thereby changing the physical and chemical properties of materials, such as improving the stability of materials, improving their solubility, etc., so that materials can better meet the needs of specific application scenarios.
At the same time, in the production of fine chemicals, 4-bromo-2-chlorobenzenesulfonyl chloride can be used to synthesize organic compounds with special functions, such as some substances with special optical and electrical properties. It provides raw material support for electronic devices, optical materials and other industries, and promotes technological development and product innovation in related fields.
What are the physical properties of 4-bromo-2-chlorobenzenesulfonyl Chloride?
4-Bromo-2-chlorobenzenesulfonyl chloride, which is an important compound in organic chemistry. Looking at its physical properties, it is mostly solid at room temperature and pressure, and the texture may be crystalline. Its color is often white to light yellow, like early morning sunlight, with a slight soft hue.
When it comes to the melting point, the melting point of this compound is quite high, because of its strong intermolecular force. Just like a solid barrier, it needs a higher temperature to break it down and turn it into a liquid state.
Its solubility is also quite characteristic, and it has a certain solubility in most organic solvents, such as ether and chloroform. Due to the characteristics of the molecular structure, a suitable interaction can be formed with the molecules of the organic solvent, which is like a puzzle that fits each other and can be blended. However, in water, its solubility is poor, and its molecular polarity does not match the polarity of the water molecule well, making it difficult to be compatible, just like the gap between oil and water.
In addition, 4-bromo-2-chlorobenzenesulfonyl chloride has low volatility and is not easy to evaporate into the air. Due to its large molecular mass and intermolecular forces, it is difficult for the molecules to break free and escape from the environment.
Furthermore, this substance has a unique or irritating odor. If inadvertently contacted, it may cause irritation to the respiratory tract, eyes and other parts of the human body. Therefore, when operating, careful protection is required, just like treating delicate and dangerous things, and it should not be taken lightly.
It can be seen from the above that the physical properties of 4-bromo-2-chlorobenzenesulfonyl chloride have an important impact on its application in many fields such as organic synthesis and chemical production, and it needs to be understood in detail before it can be used properly.
When it comes to the melting point, the melting point of this compound is quite high, because of its strong intermolecular force. Just like a solid barrier, it needs a higher temperature to break it down and turn it into a liquid state.
Its solubility is also quite characteristic, and it has a certain solubility in most organic solvents, such as ether and chloroform. Due to the characteristics of the molecular structure, a suitable interaction can be formed with the molecules of the organic solvent, which is like a puzzle that fits each other and can be blended. However, in water, its solubility is poor, and its molecular polarity does not match the polarity of the water molecule well, making it difficult to be compatible, just like the gap between oil and water.
In addition, 4-bromo-2-chlorobenzenesulfonyl chloride has low volatility and is not easy to evaporate into the air. Due to its large molecular mass and intermolecular forces, it is difficult for the molecules to break free and escape from the environment.
Furthermore, this substance has a unique or irritating odor. If inadvertently contacted, it may cause irritation to the respiratory tract, eyes and other parts of the human body. Therefore, when operating, careful protection is required, just like treating delicate and dangerous things, and it should not be taken lightly.
It can be seen from the above that the physical properties of 4-bromo-2-chlorobenzenesulfonyl chloride have an important impact on its application in many fields such as organic synthesis and chemical production, and it needs to be understood in detail before it can be used properly.
What are the chemical properties of 4-bromo-2-chlorobenzenesulfonyl Chloride?
4-Bromo-2-chlorobenzenesulfonyl chloride is an organic compound with many unique chemical properties. Its activity is quite high, among which the sulfonyl chloride group (-SO 2O Cl) is particularly active and often acts as a key intermediate in organic synthesis.
As far as nucleophilic substitution is concerned, the sulfonyl chloride group is highly susceptible to attack by nucleophilic reagents. In case of alcohols, nucleophilic substitution can occur, and the chlorine atom is replaced by an alkoxy group to form a corresponding sulfonate. This reaction is often used in organic synthesis to construct sulfonate compounds, which are important in the fields of materials science and medicinal chemistry.
In case of amines, nucleophilic substitution will also occur to form sulfonamides. Sulfonamide compounds are widely used in the pharmaceutical industry, and many drug molecular structures contain this group, which has various biological activities such as antibacterial and anti-inflammatory.
Furthermore, the halogen atoms (bromine and chlorine) in 4-bromo-2-chlorobenzenesulfonyl chloride can also participate in the reaction. Under specific conditions, bromine atoms or chlorine atoms can be replaced by other groups to modify the molecular structure and create conditions for the synthesis of complex organic compounds. For example, with the help of palladium-catalyzed coupling reactions, bromine atoms can react with arylboronic acids to achieve the introduction of aryl groups, expand the conjugation system of molecules, and change their physical and chemical properties.
Due to its chemical properties, it occupies an important position in the field of organic synthesis, laying the foundation for the creation of organic compounds with novel structures and unique functions, and playing a key role in drug development, material preparation, and other fields.
As far as nucleophilic substitution is concerned, the sulfonyl chloride group is highly susceptible to attack by nucleophilic reagents. In case of alcohols, nucleophilic substitution can occur, and the chlorine atom is replaced by an alkoxy group to form a corresponding sulfonate. This reaction is often used in organic synthesis to construct sulfonate compounds, which are important in the fields of materials science and medicinal chemistry.
In case of amines, nucleophilic substitution will also occur to form sulfonamides. Sulfonamide compounds are widely used in the pharmaceutical industry, and many drug molecular structures contain this group, which has various biological activities such as antibacterial and anti-inflammatory.
Furthermore, the halogen atoms (bromine and chlorine) in 4-bromo-2-chlorobenzenesulfonyl chloride can also participate in the reaction. Under specific conditions, bromine atoms or chlorine atoms can be replaced by other groups to modify the molecular structure and create conditions for the synthesis of complex organic compounds. For example, with the help of palladium-catalyzed coupling reactions, bromine atoms can react with arylboronic acids to achieve the introduction of aryl groups, expand the conjugation system of molecules, and change their physical and chemical properties.
Due to its chemical properties, it occupies an important position in the field of organic synthesis, laying the foundation for the creation of organic compounds with novel structures and unique functions, and playing a key role in drug development, material preparation, and other fields.
What is the preparation method of 4-bromo-2-chlorobenzenesulfonyl Chloride?
To prepare 4-bromo-2-chlorobenzenesulfonyl chloride, the following method can be used:
Take 2-chloro-4-bromobenzene as the starting material first. This compound is added to an appropriate amount of fuming sulfuric acid in an appropriate reaction vessel. The concentration of sulfur trioxide in the fuming sulfuric acid needs to be carefully prepared, generally containing 20% -30% sulfur trioxide. The reaction temperature is also a key factor, and it needs to be maintained between about 80-100 ° C. At this temperature, 2-chloro-4-bromobenzene sulfonates with sulfur trioxide in the fuming sulfuric acid.
During the reaction, sulfur trioxide attacks the benzene ring as an electrophilic reagent. Due to the localization effect of chlorine and bromine on the benzene ring, the sulfonic acid group is mainly substituted at the position of the interposition between bromine and chlorine to form 4-bromo-2-chlorobenzenesulfonic acid. This step requires constant stirring to make the reactants fully contact, and the reaction time is about 3-5 hours. During this period, the reaction process should be closely monitored. The degree of reaction can be judged by means of thin-layer chromatography.
When the reaction is basically completed, cool down to room temperature, slowly pour the reaction mixture into crushed ice, and hydrolyze it. The unreacted sulfur trioxide reacts with water, and 4-bromo-2-chlorobenzenesulfonic acid After filtration and washing, a relatively pure 4-bromo-2-chlorobenzenesulfonic acid can be obtained.
Then, 4-bromo-2-chlorobenzenesulfonic acid is placed in another reaction device, and an appropriate amount of thionyl chloride is added. Thionyl chloride is both a reactant and a solvent. The reaction temperature is controlled at 60-80 ° C for about 2-3 hours. In this process, the chlorine atom in the thionyl chloride replaces the hydroxyl group in the sulfonic acid group to form 4-bromo-2-chlorobenzenesulfonic acid chloride, and at the same time produces sulfur dioxide and hydrogen chloride gas, which can be treated separately by a condensation device and a tail gas absorption device to ensure the safety of the experimental environment After the reaction, 4-bromo-2-chlorobenzenesulfonyl chloride can be obtained by distillation, vacuum distillation and other means to collect the corresponding fractions. The whole process needs to strictly control the reaction conditions to improve the purity and yield of the product.
Take 2-chloro-4-bromobenzene as the starting material first. This compound is added to an appropriate amount of fuming sulfuric acid in an appropriate reaction vessel. The concentration of sulfur trioxide in the fuming sulfuric acid needs to be carefully prepared, generally containing 20% -30% sulfur trioxide. The reaction temperature is also a key factor, and it needs to be maintained between about 80-100 ° C. At this temperature, 2-chloro-4-bromobenzene sulfonates with sulfur trioxide in the fuming sulfuric acid.
During the reaction, sulfur trioxide attacks the benzene ring as an electrophilic reagent. Due to the localization effect of chlorine and bromine on the benzene ring, the sulfonic acid group is mainly substituted at the position of the interposition between bromine and chlorine to form 4-bromo-2-chlorobenzenesulfonic acid. This step requires constant stirring to make the reactants fully contact, and the reaction time is about 3-5 hours. During this period, the reaction process should be closely monitored. The degree of reaction can be judged by means of thin-layer chromatography.
When the reaction is basically completed, cool down to room temperature, slowly pour the reaction mixture into crushed ice, and hydrolyze it. The unreacted sulfur trioxide reacts with water, and 4-bromo-2-chlorobenzenesulfonic acid After filtration and washing, a relatively pure 4-bromo-2-chlorobenzenesulfonic acid can be obtained.
Then, 4-bromo-2-chlorobenzenesulfonic acid is placed in another reaction device, and an appropriate amount of thionyl chloride is added. Thionyl chloride is both a reactant and a solvent. The reaction temperature is controlled at 60-80 ° C for about 2-3 hours. In this process, the chlorine atom in the thionyl chloride replaces the hydroxyl group in the sulfonic acid group to form 4-bromo-2-chlorobenzenesulfonic acid chloride, and at the same time produces sulfur dioxide and hydrogen chloride gas, which can be treated separately by a condensation device and a tail gas absorption device to ensure the safety of the experimental environment After the reaction, 4-bromo-2-chlorobenzenesulfonyl chloride can be obtained by distillation, vacuum distillation and other means to collect the corresponding fractions. The whole process needs to strictly control the reaction conditions to improve the purity and yield of the product.
What are the precautions for 4-bromo-2-chlorobenzenesulfonyl Chloride in storage and transportation?
4-Bromo-2-chlorobenzenesulfonyl chloride is a chemical substance. When storing and transporting, many matters need to be paid attention to.
It is active and easily hydrolyzed in contact with water, so the storage place must be dry and protected from moisture. The storage place should be selected in a cool and ventilated place, away from fire and heat sources, to prevent the reaction or decomposition caused by the increase in temperature.
When transporting, the packaging must be tight. According to its chemical properties, suitable packaging materials should be selected, and the packaging should be strong, able to withstand certain external forces, to prevent damage and leakage.
This substance is corrosive and harmful to human body and the environment. Storage and transportation personnel should be equipped with protective equipment, such as acid and alkali-resistant gloves, protective glasses, gas masks, etc., to protect their own safety. Handling process must be handled with care, and it is strictly forbidden to drop or impact to avoid packaging damage.
In addition, relevant regulations and standards should be followed. Whether it is the layout of the storage site or the transportation process specification, it should be in compliance. At the same time, the storage and transportation place should be equipped with emergency treatment equipment and materials, such as adsorbents, neutralizers, etc. In case of leakage and other accidents, it can be responded to in time to reduce the harm. In this way, the safety of 4-bromo-2-chlorobenzenesulfonyl chloride storage and transportation is guaranteed.
It is active and easily hydrolyzed in contact with water, so the storage place must be dry and protected from moisture. The storage place should be selected in a cool and ventilated place, away from fire and heat sources, to prevent the reaction or decomposition caused by the increase in temperature.
When transporting, the packaging must be tight. According to its chemical properties, suitable packaging materials should be selected, and the packaging should be strong, able to withstand certain external forces, to prevent damage and leakage.
This substance is corrosive and harmful to human body and the environment. Storage and transportation personnel should be equipped with protective equipment, such as acid and alkali-resistant gloves, protective glasses, gas masks, etc., to protect their own safety. Handling process must be handled with care, and it is strictly forbidden to drop or impact to avoid packaging damage.
In addition, relevant regulations and standards should be followed. Whether it is the layout of the storage site or the transportation process specification, it should be in compliance. At the same time, the storage and transportation place should be equipped with emergency treatment equipment and materials, such as adsorbents, neutralizers, etc. In case of leakage and other accidents, it can be responded to in time to reduce the harm. In this way, the safety of 4-bromo-2-chlorobenzenesulfonyl chloride storage and transportation is guaranteed.
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