Linshang Chemical
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4-Bromo-2-Chlorobenzenesulphonylchloride
Linshang Chemical
|
HS Code |
480816 |
| Chemical Formula | C6H3BrCl2O2S |
| Molecular Weight | 291.96 g/mol |
| Appearance | Solid (usually a white - off - white solid) |
| Melting Point | Specific value would need experimental determination, but typically in a range for such aromatic sulfonyl chlorides |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc., due to its non - polar aromatic structure |
| Solubility In Water | Insoluble in water as it is an organic compound with non - polar groups and reactive sulfonyl chloride moiety |
| Reactivity | Highly reactive towards nucleophiles, especially amines, alcohols and thiols due to the electrophilic nature of the sulfonyl chloride group |
| Odor | Pungent odor characteristic of sulfonyl chlorides |
| Hazard | Corrosive, can cause skin and eye irritation; may release toxic fumes of hydrogen chloride and sulfur oxides upon decomposition |
As an accredited 4-Bromo-2-Chlorobenzenesulphonylchloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chlorobenzenesulphonylchloride in a sealed, corrosion - resistant bottle. |
| Storage | 4 - bromo - 2 - chlorobenzenesulphonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and moisture as it may react with water. Store it in a tightly - sealed container, preferably made of a corrosion - resistant material. Isolate it from incompatible substances like bases and reducing agents to prevent unwanted reactions. |
| Shipping | 4 - bromo - 2 - chlorobenzenesulphonyl chloride is a chemical. Ship it in well - sealed, corrosion - resistant containers. Follow all hazardous material shipping regulations to ensure safe transportation due to its potentially reactive nature. |
Competitive 4-Bromo-2-Chlorobenzenesulphonylchloride prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemistry of 4-bromo-2-chlorobenzenesulphonylchloride?
4-Bromo-2-chlorobenzenesulfonyl chloride is one of the organic compounds. Its chemical properties are of great interest and have many applications in many fields.
This compound has active chemical activity. The sulfonyl chloride group (-SO 2O Cl) is active and easy to react chemically. In contact with water, it is very easy to hydrolyze. When hydrolyzed, the sulfonyl chloride group will interact with water to form the corresponding sulfonic acid (-SOH) and hydrogen chloride (HCl). This hydrolysis reaction is quite violent and often accompanied by heating.
Its halogen atoms, namely bromine (Br) and chlorine (Cl), also participate in many reactions. Under appropriate conditions, bromine and chlorine atoms can be replaced by nucleophiles. For example, by reacting with nucleophilic reagents such as alcohols and amines, halogen atoms can be replaced by corresponding groups to form new organic compounds. This substitution reaction is often used to construct a variety of organic molecular structures in organic synthesis.
In addition, 4-bromo-2-chlorobenzenesulfonyl chloride can also participate in the Friedel-Crafts reaction. Under the condition of Fu-gram reaction, it can react with aromatic hydrocarbons and introduce benzenesulfonyl groups into aromatic hydrocarbons, providing an important means for organic synthesis to prepare aromatic compounds with specific structures and functions. The chemical properties of 4-bromo-2-chlorobenzenesulfonyl chloride are active, and various reactions between its sulfonyl chloride group and halogen atoms make it an important intermediate in the field of organic synthetic chemistry. It can help chemists create a wide variety of organic compounds, thereby promoting the development of organic synthetic chemistry and the progress of related fields.
This compound has active chemical activity. The sulfonyl chloride group (-SO 2O Cl) is active and easy to react chemically. In contact with water, it is very easy to hydrolyze. When hydrolyzed, the sulfonyl chloride group will interact with water to form the corresponding sulfonic acid (-SOH) and hydrogen chloride (HCl). This hydrolysis reaction is quite violent and often accompanied by heating.
Its halogen atoms, namely bromine (Br) and chlorine (Cl), also participate in many reactions. Under appropriate conditions, bromine and chlorine atoms can be replaced by nucleophiles. For example, by reacting with nucleophilic reagents such as alcohols and amines, halogen atoms can be replaced by corresponding groups to form new organic compounds. This substitution reaction is often used to construct a variety of organic molecular structures in organic synthesis.
In addition, 4-bromo-2-chlorobenzenesulfonyl chloride can also participate in the Friedel-Crafts reaction. Under the condition of Fu-gram reaction, it can react with aromatic hydrocarbons and introduce benzenesulfonyl groups into aromatic hydrocarbons, providing an important means for organic synthesis to prepare aromatic compounds with specific structures and functions. The chemical properties of 4-bromo-2-chlorobenzenesulfonyl chloride are active, and various reactions between its sulfonyl chloride group and halogen atoms make it an important intermediate in the field of organic synthetic chemistry. It can help chemists create a wide variety of organic compounds, thereby promoting the development of organic synthetic chemistry and the progress of related fields.
What are the main uses of 4-bromo-2-chlorobenzenesulphonylchloride?
4-Bromo-2-chlorobenzenesulfonyl chloride is an important reagent in organic synthesis. Its uses are quite extensive, and are described as follows:
First, in the field of pharmaceutical synthesis, it is often a key intermediate. The preparation of many drugs depends on its participation in the reaction. For example, in the synthesis path of a certain type of antibacterial drug, 4-bromo-2-chlorobenzenesulfonyl chloride can undergo condensation reaction with specific amine compounds, and through ingenious chemical transformation, it can generate a drug molecular structure with antibacterial activity. This reaction takes advantage of the active chemical properties of its sulfonyl chloride group and can efficiently combine with nitrogen-containing nucleophiles to build the core framework of drug molecules and help pharmaceutical developers create new antibacterial agents.
Second, it also plays an important role in materials science. In the synthesis of high-performance polymer materials, 4-bromo-2-chlorobenzenesulfonyl chloride can introduce special functional groups. For example, by reacting with polymer monomers containing hydroxyl groups, through the formation of sulfonyl ester bonds, the polymer materials are endowed with unique properties. Or improve its solubility, or enhance its thermal stability, providing an effective way to develop new high-performance polymer materials to meet the stringent requirements of special materials in the fields of electronics, aviation and other fields.
Third, in the field of pesticide synthesis, it is an indispensable raw material. It can participate in the construction of active parts of pesticide molecules, such as reacting with certain heterocyclic compounds to generate pesticide ingredients with insecticidal, weeding and other effects. The presence of bromine and chlorine atoms helps to regulate the balance of lipid solubility and water solubility of pesticide molecules, optimize their effects in crops and the environment, improve the efficacy and shelf life of pesticides, and assist in the control of pests and diseases in agricultural production.
In summary, 4-bromo-2-chlorobenzenesulfonyl chloride has significant uses in many important fields such as medicine, materials, and pesticides, promoting technological progress and product innovation in various fields.
First, in the field of pharmaceutical synthesis, it is often a key intermediate. The preparation of many drugs depends on its participation in the reaction. For example, in the synthesis path of a certain type of antibacterial drug, 4-bromo-2-chlorobenzenesulfonyl chloride can undergo condensation reaction with specific amine compounds, and through ingenious chemical transformation, it can generate a drug molecular structure with antibacterial activity. This reaction takes advantage of the active chemical properties of its sulfonyl chloride group and can efficiently combine with nitrogen-containing nucleophiles to build the core framework of drug molecules and help pharmaceutical developers create new antibacterial agents.
Second, it also plays an important role in materials science. In the synthesis of high-performance polymer materials, 4-bromo-2-chlorobenzenesulfonyl chloride can introduce special functional groups. For example, by reacting with polymer monomers containing hydroxyl groups, through the formation of sulfonyl ester bonds, the polymer materials are endowed with unique properties. Or improve its solubility, or enhance its thermal stability, providing an effective way to develop new high-performance polymer materials to meet the stringent requirements of special materials in the fields of electronics, aviation and other fields.
Third, in the field of pesticide synthesis, it is an indispensable raw material. It can participate in the construction of active parts of pesticide molecules, such as reacting with certain heterocyclic compounds to generate pesticide ingredients with insecticidal, weeding and other effects. The presence of bromine and chlorine atoms helps to regulate the balance of lipid solubility and water solubility of pesticide molecules, optimize their effects in crops and the environment, improve the efficacy and shelf life of pesticides, and assist in the control of pests and diseases in agricultural production.
In summary, 4-bromo-2-chlorobenzenesulfonyl chloride has significant uses in many important fields such as medicine, materials, and pesticides, promoting technological progress and product innovation in various fields.
What is 4-bromo-2-chlorobenzenesulphonylchloride synthesis method?
To prepare 4-bromo-2-chlorobenzenesulfonyl chloride, the method is as follows:
Take 2-chlorobenzene as the starting material first. This compound can be obtained by the substitution reaction of bromine and chlorobenzene under appropriate conditions. When reacting, a suitable catalyst, such as iron filings, is required, and at a suitable temperature and reaction environment, the bromine atom selectively replaces the hydrogen atom at the ortho-position of chlorobenzene, so that 2-chlorobenzene can be obtained.
Then, 2-chlorobenzene is sulfonated with fuming sulfuric acid. Fuming sulfuric acid, which is dissolved in sulfuric acid with excess sulfur trioxide, has strong sulfonation ability. In a specific temperature range, such as under heating and temperature control conditions, a sulfonic acid group can be introduced into the benzene ring of 2-chlorobromobenzene. During this process, the sulfonic acid group selectively enters the position of the bromine-chlorine interposition, resulting in the formation of 4-bromo-2-chlorobenzenesulfonic acid.
Finally, 4-bromo-2-chlorobenzenesulfonic acid is interacted with phosphorus pentachloride or thionyl chloride. When phosphorus pentachloride reacts with 4-bromo-2-chlorobenzenesulfonic acid, the hydroxyl group in the sulfonic acid group can be replaced by a chlorine atom to form 4-bromo-2-chlorobenzenesulfonyl chloride; thionyl chloride also has a similar effect. Under appropriate reaction conditions, the sulfonic acid group can be converted into sulfonyl chloride, and the final product 4-bromo-2-chlorobenzenesulfonyl chloride can be obtained. The whole process needs to pay attention to the precise control of reaction conditions, including temperature, ratio of reactants and reaction time, so that the reaction can proceed smoothly and a higher yield product can be obtained.
Take 2-chlorobenzene as the starting material first. This compound can be obtained by the substitution reaction of bromine and chlorobenzene under appropriate conditions. When reacting, a suitable catalyst, such as iron filings, is required, and at a suitable temperature and reaction environment, the bromine atom selectively replaces the hydrogen atom at the ortho-position of chlorobenzene, so that 2-chlorobenzene can be obtained.
Then, 2-chlorobenzene is sulfonated with fuming sulfuric acid. Fuming sulfuric acid, which is dissolved in sulfuric acid with excess sulfur trioxide, has strong sulfonation ability. In a specific temperature range, such as under heating and temperature control conditions, a sulfonic acid group can be introduced into the benzene ring of 2-chlorobromobenzene. During this process, the sulfonic acid group selectively enters the position of the bromine-chlorine interposition, resulting in the formation of 4-bromo-2-chlorobenzenesulfonic acid.
Finally, 4-bromo-2-chlorobenzenesulfonic acid is interacted with phosphorus pentachloride or thionyl chloride. When phosphorus pentachloride reacts with 4-bromo-2-chlorobenzenesulfonic acid, the hydroxyl group in the sulfonic acid group can be replaced by a chlorine atom to form 4-bromo-2-chlorobenzenesulfonyl chloride; thionyl chloride also has a similar effect. Under appropriate reaction conditions, the sulfonic acid group can be converted into sulfonyl chloride, and the final product 4-bromo-2-chlorobenzenesulfonyl chloride can be obtained. The whole process needs to pay attention to the precise control of reaction conditions, including temperature, ratio of reactants and reaction time, so that the reaction can proceed smoothly and a higher yield product can be obtained.
4-bromo-2-chlorobenzenesulphonylchloride What are the precautions during storage and transportation?
4-Bromo-2-chlorobenzenesulfonyl chloride is one of the chemical substances. During storage and transportation, many matters must be paid attention to.
The first thing to pay attention to is its chemical properties. This substance is highly corrosive and reactive, and can easily react with water, alcohols, amines and other substances. Therefore, when storing, it must be placed in a dry, cool and well-ventilated place, away from water sources, fire and heat sources. If it comes into contact with water, it may cause severe reactions, forming strong acids such as sulfuric acid and hydrochloric acid, which not only damages the storage container, but also poses a potential danger.
The second is packaging. Strong and well-sealed packaging materials should be selected to prevent leakage. Commonly used glass containers or containers made of specific plastic materials. However, the glass needs to be resistant to strong acid corrosion, and the plastic must also be chemically stable. Warning labels must be clearly marked on the outside of the package, indicating its dangerous characteristics, such as corrosiveness, irritation, etc., so that the contact person can see at a glance.
Further transportation. During transportation, strict regulations and standards must be followed. Transportation vehicles should be equipped with necessary emergency treatment equipment and protective equipment to prevent accidental leakage in a timely manner. And should not be transported with contraindications, such as alkaline substances, flammable substances, etc., to avoid dangerous reactions. Transport personnel must also be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods.
Also pay attention to the storage period. Even if the storage conditions are suitable, it may deteriorate over time due to its own micro-decomposition or reaction with trace impurities in the environment. Therefore, it should be checked regularly, and if any abnormalities such as appearance and odor are seen, they should be handled with caution.
In short, the storage and transportation of 4-bromo-2-chlorobenzenesulfonyl chloride requires careful treatment in terms of chemical properties, packaging, transportation specifications and storage period to ensure safety and avoid accidents.
The first thing to pay attention to is its chemical properties. This substance is highly corrosive and reactive, and can easily react with water, alcohols, amines and other substances. Therefore, when storing, it must be placed in a dry, cool and well-ventilated place, away from water sources, fire and heat sources. If it comes into contact with water, it may cause severe reactions, forming strong acids such as sulfuric acid and hydrochloric acid, which not only damages the storage container, but also poses a potential danger.
The second is packaging. Strong and well-sealed packaging materials should be selected to prevent leakage. Commonly used glass containers or containers made of specific plastic materials. However, the glass needs to be resistant to strong acid corrosion, and the plastic must also be chemically stable. Warning labels must be clearly marked on the outside of the package, indicating its dangerous characteristics, such as corrosiveness, irritation, etc., so that the contact person can see at a glance.
Further transportation. During transportation, strict regulations and standards must be followed. Transportation vehicles should be equipped with necessary emergency treatment equipment and protective equipment to prevent accidental leakage in a timely manner. And should not be transported with contraindications, such as alkaline substances, flammable substances, etc., to avoid dangerous reactions. Transport personnel must also be professionally trained to be familiar with the characteristics of the substance and emergency treatment methods.
Also pay attention to the storage period. Even if the storage conditions are suitable, it may deteriorate over time due to its own micro-decomposition or reaction with trace impurities in the environment. Therefore, it should be checked regularly, and if any abnormalities such as appearance and odor are seen, they should be handled with caution.
In short, the storage and transportation of 4-bromo-2-chlorobenzenesulfonyl chloride requires careful treatment in terms of chemical properties, packaging, transportation specifications and storage period to ensure safety and avoid accidents.
4-bromo-2-chlorobenzenesulphonylchloride impact on the environment
4-Bromo-2-chlorobenzenesulfonyl chloride is an organic compound. Its impact on the environment is particularly important and cannot be ignored.
This compound is quite toxic. If it escapes into nature, it can endanger aquatic organisms in aquatic ecosystems. It may be ingested by fish, shellfish and other organisms, causing damage to physiological functions, stunted development, and even death. And it may accumulate through the food chain and pose a threat to high-level organisms.
In the soil environment, 4-bromo-2-chlorobenzenesulfonyl chloride may affect the activity and community structure of soil microorganisms. Microorganisms are essential for soil material circulation and nutrient transformation. If they are disturbed, the soil ecological balance or destruction will affect plant growth.
In the atmospheric environment, if this compound evaporates to form aerosols, it can cause respiratory irritation and damage lungs and other organs after human inhalation.
And because of its active chemical properties, or participate in photochemical reactions, it affects atmospheric chemical processes and causes air quality deterioration.
4-Bromo-2-chlorobenzenesulfonyl chloride has potential harm to the environment in many aspects. When it is produced, used and disposed of, it should be done with caution to reduce its adverse effects on the environment.
This compound is quite toxic. If it escapes into nature, it can endanger aquatic organisms in aquatic ecosystems. It may be ingested by fish, shellfish and other organisms, causing damage to physiological functions, stunted development, and even death. And it may accumulate through the food chain and pose a threat to high-level organisms.
In the soil environment, 4-bromo-2-chlorobenzenesulfonyl chloride may affect the activity and community structure of soil microorganisms. Microorganisms are essential for soil material circulation and nutrient transformation. If they are disturbed, the soil ecological balance or destruction will affect plant growth.
In the atmospheric environment, if this compound evaporates to form aerosols, it can cause respiratory irritation and damage lungs and other organs after human inhalation.
And because of its active chemical properties, or participate in photochemical reactions, it affects atmospheric chemical processes and causes air quality deterioration.
4-Bromo-2-chlorobenzenesulfonyl chloride has potential harm to the environment in many aspects. When it is produced, used and disposed of, it should be done with caution to reduce its adverse effects on the environment.
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