Linshang Chemical
PRODUCTS
4-Bromo-2-Chlorofluorobenzene
Linshang Chemical
|
HS Code |
782161 |
| Chemical Formula | C6H3BrClF |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 186 - 188 °C |
| Density | 1.806 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 78 °C |
| Refractive Index | 1.564 |
As an accredited 4-Bromo-2-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chlorofluorobenzene packaged in a sealed glass bottle. |
| Storage | Store 4 - bromo - 2 - chlorofluorobenzene in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Avoid storing it near oxidizing agents or reactive substances. Ensure proper labeling for easy identification and follow all safety regulations regarding chemical storage. |
| Shipping | 4 - bromo - 2 - chlorofluorobenzene is shipped in properly sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, with careful handling to prevent leakage during transit. |
Competitive 4-Bromo-2-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Bromo-2-Chlorofluorobenzene in China?
As a trusted 4-Bromo-2-Chlorofluorobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Bromo-2-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-bromo-2-chlorofluorobenzene?
4-Bromo-2-chlorofluorobenzene is also an organic compound. Its chemical properties are unique, let me tell you in detail.
The first part of its substitution reaction. Because the benzene ring has an electron cloud and is rich in electrons, it is easy to be attacked by electrophilic reagents. The atoms of bromine, chlorine and fluorine are above the benzene ring, which has an impact on the electron cloud density distribution of the benzene ring. The fluorine atom has strong electronegativity and has an electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring. However, it also has the effect of electron conjugation. The two are combined, and the electron cloud density of the ortho and para-sites is relatively higher than that of the meso. Bromine and chlorine also have similar electronic effects. When the electrophilic sub For example, when co-heated with mixed acids of nitric acid and sulfuric acid, nitrification reaction can occur, and the nitro group is added to the neighbor and counterposition of bromine, chlorine, and fluorine.
On the properties of its halogen atom. Bromine, chlorine, and fluorine atoms have different activities. In the nucleophilic substitution reaction, although they can all be replaced by nucleophilic reagents, the order of activity is different. The fluorine atom has a large carbon-fluorine bond energy and is relatively difficult to be replaced; the bromine atom has a small carbon-bromine bond energy and is more likely to be attacked and left by nucleophilic reagents. If the nucleophilic reagents such as sodium alcohol react with it, the bromine atom may be preferentially replaced to form the corresponding alkoxy-containing compound.
Furthermore, 4-bromo-2-chlorofluorobenzene can participate in metal-organic reactions. If it reacts with magnesium, it can be made into Grignard reagent. This Grignard reagent is extremely active and can react with a variety of carbonyl compounds to form alcohols. If it reacts with an aldehyde, a secondary alcohol can be obtained after hydrolysis; if it reacts with a ketone, a tertiary alcohol can be obtained.
And because of its halogen-containing atoms, an elimination reaction can occur under appropriate conditions. If heated in a strong alkali alcohol solution, hydrogen halides can be removed to form unsaturated compounds containing carbon-carbon double bonds, which introduces a double bond structure for organic synthesis and broadens the synthesis path.
4-Bromo-2-chlorofluorobenzene is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It can prepare various organic compounds through various reactions.
The first part of its substitution reaction. Because the benzene ring has an electron cloud and is rich in electrons, it is easy to be attacked by electrophilic reagents. The atoms of bromine, chlorine and fluorine are above the benzene ring, which has an impact on the electron cloud density distribution of the benzene ring. The fluorine atom has strong electronegativity and has an electron-absorbing induction effect, which reduces the electron cloud density of the benzene ring. However, it also has the effect of electron conjugation. The two are combined, and the electron cloud density of the ortho and para-sites is relatively higher than that of the meso. Bromine and chlorine also have similar electronic effects. When the electrophilic sub For example, when co-heated with mixed acids of nitric acid and sulfuric acid, nitrification reaction can occur, and the nitro group is added to the neighbor and counterposition of bromine, chlorine, and fluorine.
On the properties of its halogen atom. Bromine, chlorine, and fluorine atoms have different activities. In the nucleophilic substitution reaction, although they can all be replaced by nucleophilic reagents, the order of activity is different. The fluorine atom has a large carbon-fluorine bond energy and is relatively difficult to be replaced; the bromine atom has a small carbon-bromine bond energy and is more likely to be attacked and left by nucleophilic reagents. If the nucleophilic reagents such as sodium alcohol react with it, the bromine atom may be preferentially replaced to form the corresponding alkoxy-containing compound.
Furthermore, 4-bromo-2-chlorofluorobenzene can participate in metal-organic reactions. If it reacts with magnesium, it can be made into Grignard reagent. This Grignard reagent is extremely active and can react with a variety of carbonyl compounds to form alcohols. If it reacts with an aldehyde, a secondary alcohol can be obtained after hydrolysis; if it reacts with a ketone, a tertiary alcohol can be obtained.
And because of its halogen-containing atoms, an elimination reaction can occur under appropriate conditions. If heated in a strong alkali alcohol solution, hydrogen halides can be removed to form unsaturated compounds containing carbon-carbon double bonds, which introduces a double bond structure for organic synthesis and broadens the synthesis path.
4-Bromo-2-chlorofluorobenzene is rich in chemical properties and has a wide range of uses in the field of organic synthesis. It can prepare various organic compounds through various reactions.
What are the physical properties of 4-bromo-2-chlorofluorobenzene?
4-Bromo-2-chlorofluorobenzene is one of the organic compounds. Its physical properties are particularly important, related to its application and reaction characteristics.
First of all, its appearance, under normal temperature and pressure, 4-bromo-2-chlorofluorobenzene is a colorless to light yellow transparent liquid, clear and has a special appearance. This form is easy to observe and operate.
Second and boiling point, the boiling point of this substance is about 180-190 ℃. At boiling point, the temperature limit at which a substance changes from liquid to gaseous state. Such a boiling point range indicates that within this temperature range, the intermolecular force is sufficient to maintain the liquid state. Then the temperature rises to a specific value, and the kinetic energy of the molecule increases greatly, which is enough to break free from the liquid phase and turn into a gaseous state.
Furthermore, the melting point of 4-bromo-2-chlorofluorobenzene is relatively low, about -20 ° C. The melting point reflects the transition temperature between the solid and liquid states of a substance. A lower melting point means that under normal low temperature environments, the substance can still remain in a liquid state, increasing its fluidity and processing convenience.
In terms of density, it is about 1.8 g/cm ³. Density is the mass of a unit volume of substance, and this value reflects its density compared to other substances. The higher density shows that the molecular arrangement is relatively close, and in many mixed systems, it can be separated and other operations according to this characteristic.
In terms of solubility, 4-bromo-2-chlorofluorobenzene is insoluble in water, because water is a polar solvent, and the compound has a certain degree of non-polarity. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. In the field of organic synthesis, the solubility of organic solvents is a key factor in dissolving the reactants and promoting the reaction.
The vapor pressure of 4-bromo-2-chlorofluorobenzene is lower at room temperature, and the vapor pressure is related to the difficulty of volatilization of substances. The lower vapor pressure indicates that the volatilization rate is slow and relatively stable at room temperature, which is conducive to storage and transportation, and can reduce the loss of volatile substances and potential safety risks.
In summary, the physical properties of 4-bromo-2-chlorofluorobenzene, from appearance, melting point, density, solubility to vapor pressure, have a profound impact on its application in chemical, pharmaceutical and other fields. Researchers and practitioners must consider it carefully to make good use of its characteristics.
First of all, its appearance, under normal temperature and pressure, 4-bromo-2-chlorofluorobenzene is a colorless to light yellow transparent liquid, clear and has a special appearance. This form is easy to observe and operate.
Second and boiling point, the boiling point of this substance is about 180-190 ℃. At boiling point, the temperature limit at which a substance changes from liquid to gaseous state. Such a boiling point range indicates that within this temperature range, the intermolecular force is sufficient to maintain the liquid state. Then the temperature rises to a specific value, and the kinetic energy of the molecule increases greatly, which is enough to break free from the liquid phase and turn into a gaseous state.
Furthermore, the melting point of 4-bromo-2-chlorofluorobenzene is relatively low, about -20 ° C. The melting point reflects the transition temperature between the solid and liquid states of a substance. A lower melting point means that under normal low temperature environments, the substance can still remain in a liquid state, increasing its fluidity and processing convenience.
In terms of density, it is about 1.8 g/cm ³. Density is the mass of a unit volume of substance, and this value reflects its density compared to other substances. The higher density shows that the molecular arrangement is relatively close, and in many mixed systems, it can be separated and other operations according to this characteristic.
In terms of solubility, 4-bromo-2-chlorofluorobenzene is insoluble in water, because water is a polar solvent, and the compound has a certain degree of non-polarity. According to the principle of "similar miscibility", the two are insoluble. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. In the field of organic synthesis, the solubility of organic solvents is a key factor in dissolving the reactants and promoting the reaction.
The vapor pressure of 4-bromo-2-chlorofluorobenzene is lower at room temperature, and the vapor pressure is related to the difficulty of volatilization of substances. The lower vapor pressure indicates that the volatilization rate is slow and relatively stable at room temperature, which is conducive to storage and transportation, and can reduce the loss of volatile substances and potential safety risks.
In summary, the physical properties of 4-bromo-2-chlorofluorobenzene, from appearance, melting point, density, solubility to vapor pressure, have a profound impact on its application in chemical, pharmaceutical and other fields. Researchers and practitioners must consider it carefully to make good use of its characteristics.
What are the main uses of 4-bromo-2-chlorofluorobenzene?
4-Bromo-2-chlorofluorobenzene is also an organic compound. It has a wide range of uses and is used in various fields.
First talk about the field of medicinal chemistry. With this as a raw material, a variety of drugs can be prepared. Because its molecular structure has specific activities, it can interact with specific targets in organisms. For example, it can be used to develop antibacterial drugs. By combining its structure with key enzymes or proteins in bacteria, it interferes with their normal physiological functions and achieves antibacterial effect. Or in the development of anti-tumor drugs, the structure of this compound is modified to accurately target tumor cells, inhibit tumor cell proliferation and induce apoptosis.
Looking at the field of materials science. 4-Bromo-2-chlorofluorobenzene can be used as a key monomer for the synthesis of special polymer materials. The polymer materials synthesized from this may have unique physical and chemical properties, such as high stability, corrosion resistance, etc. Such materials can be used as high-performance structural materials in the aerospace field, which can withstand extreme environments; or in the manufacture of electronic equipment, as an insulating material, because its special structure can endow the material with good insulating properties.
This compound also has potential in pesticide chemistry. It can be reasonably designed to be converted into high-efficiency pesticides. The use of its structure affects the specific physiological processes of pests, such as interfering with the transmission of the pest's nervous system, causing the pest to behave abnormally, so as to achieve the purpose of pest control, and is relatively harmless to the environment.
In conclusion, 4-bromo-2-chlorofluorobenzene is an important raw material in many fields such as medicine, materials, and pesticides. With the development of science and technology, its application prospects will be broader.
First talk about the field of medicinal chemistry. With this as a raw material, a variety of drugs can be prepared. Because its molecular structure has specific activities, it can interact with specific targets in organisms. For example, it can be used to develop antibacterial drugs. By combining its structure with key enzymes or proteins in bacteria, it interferes with their normal physiological functions and achieves antibacterial effect. Or in the development of anti-tumor drugs, the structure of this compound is modified to accurately target tumor cells, inhibit tumor cell proliferation and induce apoptosis.
Looking at the field of materials science. 4-Bromo-2-chlorofluorobenzene can be used as a key monomer for the synthesis of special polymer materials. The polymer materials synthesized from this may have unique physical and chemical properties, such as high stability, corrosion resistance, etc. Such materials can be used as high-performance structural materials in the aerospace field, which can withstand extreme environments; or in the manufacture of electronic equipment, as an insulating material, because its special structure can endow the material with good insulating properties.
This compound also has potential in pesticide chemistry. It can be reasonably designed to be converted into high-efficiency pesticides. The use of its structure affects the specific physiological processes of pests, such as interfering with the transmission of the pest's nervous system, causing the pest to behave abnormally, so as to achieve the purpose of pest control, and is relatively harmless to the environment.
In conclusion, 4-bromo-2-chlorofluorobenzene is an important raw material in many fields such as medicine, materials, and pesticides. With the development of science and technology, its application prospects will be broader.
What are 4-bromo-2-chlorofluorobenzene synthesis methods?
The synthesis method of 4-bromo-2-chlorofluorobenzene is of great importance in the field of organic synthesis. The following common synthesis methods can be used as a reference.
First, the halogenation reaction path. Fluorobenzene is used as the starting material and first halogenated. Under suitable reaction conditions, a brominating agent and a chlorinating agent act in sequence. For example, in the presence of Lewis acid catalysts such as aluminum trichloride, bromine atoms are introduced first. Due to its positioning effect, bromine atoms will selectively enter specific positions in the benzene ring, and then chlorine atoms are introduced. After fine control of reaction conditions, such as temperature, ratio of reactants, reaction time, etc., the target product 4-bromo-2-chlorofluorobenzene can be obtained. The advantage of this path is that the raw materials are relatively easy to obtain, and the reaction steps are relatively clear; however, there are also disadvantages. The selectivity of the halogenation reaction is sometimes poor, and a variety of halogenated by-products may be generated. The subsequent separation and purification work is complicated.
Second, the nucleophilic substitution reaction strategy. Select a suitable fluorobenzene derivative, and the benzene ring is connected with a group that can be replaced by a nucleophilic reagent, such as a sulfonic acid group. First, the nucleophilic reagent bromine ion is used for substitution reaction to form a bromine-containing intermediate, and then the second nucleophilic substitution is carried out with chloride ion. The reaction efficiency and product purity can be improved by optimizing the conditions such as the type The advantage of this method is that the nucleophilic substitution reaction has good selectivity and can effectively reduce side reactions; however, the requirements for starting materials are higher, and some raw materials are more difficult to synthesize, and the cost may also be higher.
Third, synthesize through aryl boric acid intermediates. First prepare fluorophenylboronic acid derivatives, and react with brominated reagents and chlorinated reagents in sequence through palladium-catalyzed coupling reaction. In this process, the activity and selectivity of palladium catalyst are crucial to the success or failure of the reaction. The reaction conditions are optimized by adjusting the ligand structure, reaction temperature, type of base and other factors. The advantage of this method is that it can achieve accurate aryl halogenation, and the product purity is high; however, palladium catalysts are expensive, and the reaction conditions are relatively harsh, which requires high reaction equipment and operation.
The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider factors such as product purity, cost, and production scale to choose the appropriate one.
First, the halogenation reaction path. Fluorobenzene is used as the starting material and first halogenated. Under suitable reaction conditions, a brominating agent and a chlorinating agent act in sequence. For example, in the presence of Lewis acid catalysts such as aluminum trichloride, bromine atoms are introduced first. Due to its positioning effect, bromine atoms will selectively enter specific positions in the benzene ring, and then chlorine atoms are introduced. After fine control of reaction conditions, such as temperature, ratio of reactants, reaction time, etc., the target product 4-bromo-2-chlorofluorobenzene can be obtained. The advantage of this path is that the raw materials are relatively easy to obtain, and the reaction steps are relatively clear; however, there are also disadvantages. The selectivity of the halogenation reaction is sometimes poor, and a variety of halogenated by-products may be generated. The subsequent separation and purification work is complicated.
Second, the nucleophilic substitution reaction strategy. Select a suitable fluorobenzene derivative, and the benzene ring is connected with a group that can be replaced by a nucleophilic reagent, such as a sulfonic acid group. First, the nucleophilic reagent bromine ion is used for substitution reaction to form a bromine-containing intermediate, and then the second nucleophilic substitution is carried out with chloride ion. The reaction efficiency and product purity can be improved by optimizing the conditions such as the type The advantage of this method is that the nucleophilic substitution reaction has good selectivity and can effectively reduce side reactions; however, the requirements for starting materials are higher, and some raw materials are more difficult to synthesize, and the cost may also be higher.
Third, synthesize through aryl boric acid intermediates. First prepare fluorophenylboronic acid derivatives, and react with brominated reagents and chlorinated reagents in sequence through palladium-catalyzed coupling reaction. In this process, the activity and selectivity of palladium catalyst are crucial to the success or failure of the reaction. The reaction conditions are optimized by adjusting the ligand structure, reaction temperature, type of base and other factors. The advantage of this method is that it can achieve accurate aryl halogenation, and the product purity is high; however, palladium catalysts are expensive, and the reaction conditions are relatively harsh, which requires high reaction equipment and operation.
The above synthesis methods have their own advantages and disadvantages. In practical applications, it is necessary to comprehensively consider factors such as product purity, cost, and production scale to choose the appropriate one.
4-bromo-2-chlorofluorobenzene what are the precautions in storage and transportation?
4-Bromo-2-chlorofluorobenzene is an organic compound. During storage and transportation, many matters must be paid attention to so that security is safe.
When storing, the first priority is to choose the environment. You should find a cool and ventilated warehouse, because the compound is prone to danger when heated. High temperature may cause it to react chemically, and even cause combustion and explosion. The temperature of the warehouse should be strictly controlled, generally not exceeding 30 ° C, and the humidity should also be kept stable to prevent moisture decomposition and other conditions.
Secondly, storage needs compliance. 4-Bromo-2-chlorofluorobenzene should be stored separately from oxidants, acids, bases, etc., and must not be mixed. The cover is chemically active, and contact with these substances is very likely to cause violent chemical reactions, resulting in serious consequences. For example, it encounters a strong oxidizing agent, or triggers a violent oxidation reaction, releasing a large amount of energy.
Furthermore, the storage container must be selected correctly. It is advisable to use a well-sealed container to prevent volatilization. It has a certain degree of volatility, and its escape not only pollutes the environment, but also may pose a threat to the health of surrounding people. And the container material needs to be compatible with 4-bromo-2-chlorofluorobenzene and does not react with it to ensure safe storage.
When transporting, packaging is crucial. The packaging material must be strong and durable, able to withstand a certain external impact, and avoid damage to the container during transportation. At the same time, the packaging should be well sealed to prevent leakage.
The transportation means should also be carefully selected. Vehicles or vessels that meet the requirements for the transportation of hazardous chemicals should be selected, and the transportation equipment should be equipped with corresponding emergency treatment facilities. In the event of an emergency such as a leak, timely response measures can be taken.
During transportation, relevant regulations and operating procedures should also be strictly adhered to. Transportation personnel must be professionally trained and familiar with the dangerous characteristics of 4-bromo-2-chlorofluorobenzene and emergency treatment methods. The route should also be carefully planned to avoid densely populated areas and important facilities to reduce transportation risks. In this way, the storage and transportation of 4-bromo-2-chlorofluorobenzene can ensure safety and avoid accidents.
When storing, the first priority is to choose the environment. You should find a cool and ventilated warehouse, because the compound is prone to danger when heated. High temperature may cause it to react chemically, and even cause combustion and explosion. The temperature of the warehouse should be strictly controlled, generally not exceeding 30 ° C, and the humidity should also be kept stable to prevent moisture decomposition and other conditions.
Secondly, storage needs compliance. 4-Bromo-2-chlorofluorobenzene should be stored separately from oxidants, acids, bases, etc., and must not be mixed. The cover is chemically active, and contact with these substances is very likely to cause violent chemical reactions, resulting in serious consequences. For example, it encounters a strong oxidizing agent, or triggers a violent oxidation reaction, releasing a large amount of energy.
Furthermore, the storage container must be selected correctly. It is advisable to use a well-sealed container to prevent volatilization. It has a certain degree of volatility, and its escape not only pollutes the environment, but also may pose a threat to the health of surrounding people. And the container material needs to be compatible with 4-bromo-2-chlorofluorobenzene and does not react with it to ensure safe storage.
When transporting, packaging is crucial. The packaging material must be strong and durable, able to withstand a certain external impact, and avoid damage to the container during transportation. At the same time, the packaging should be well sealed to prevent leakage.
The transportation means should also be carefully selected. Vehicles or vessels that meet the requirements for the transportation of hazardous chemicals should be selected, and the transportation equipment should be equipped with corresponding emergency treatment facilities. In the event of an emergency such as a leak, timely response measures can be taken.
During transportation, relevant regulations and operating procedures should also be strictly adhered to. Transportation personnel must be professionally trained and familiar with the dangerous characteristics of 4-bromo-2-chlorofluorobenzene and emergency treatment methods. The route should also be carefully planned to avoid densely populated areas and important facilities to reduce transportation risks. In this way, the storage and transportation of 4-bromo-2-chlorofluorobenzene can ensure safety and avoid accidents.
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