Linshang Chemical
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4-Bromo-2-Chloroiodobenzene
Linshang Chemical
|
HS Code |
530908 |
| Chemical Formula | C6H3BrClI |
| Molar Mass | 328.25 g/mol |
| Appearance | Solid (likely a white to off - white crystalline solid) |
| Melting Point | Data needed from literature |
| Boiling Point | Data needed from literature |
| Density | Data needed from literature |
| Solubility In Water | Insoluble (due to non - polar nature of benzene ring) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, toluene |
| Odor | Typically has a characteristic organic odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Bromo-2-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - chloroiodobenzene packaged in a sealed glass bottle. |
| Storage | 4 - bromo - 2 - chloroiodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture, which could potentially lead to decomposition. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. |
| Shipping | 4 - bromo - 2 - chloroiodobenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage and are labeled with proper hazard warnings. Shipment follows strict chemical transportation regulations. |
Competitive 4-Bromo-2-Chloroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 4-Bromo-2-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-bromo-2-chloroiodobenzene?
The chemical structure of 4-bromo-2-chloroiodobenzene is quite delicate. This compound is a halogenated aromatic hydrocarbon. Above the benzene ring, the bromine atom occupies the fourth position, the chlorine atom is located in the second position, and the iodine atom is also connected to the benzene ring. The
benzene ring is a six-membered ring structure composed of six carbon atoms connected to each other by a conjugated large π bond, which has a high degree of stability. The introduction of halogen atoms at different positions in the benzene ring makes the compound unique in properties. Bromine atoms (Br), chlorine atoms (Cl) and iodine atoms (I) are all halogen elements with different electronegativity and atomic radii.
Bromine atoms are relatively large, and their introduction will affect the electron cloud distribution of the benzene ring, change the electron density of the benzene ring, and then affect the electrophilic substitution activity of the compound. Chlorine atoms have high electronegativity, which can reduce the electron cloud density of the benzene ring, making it slightly difficult for the electrophilic substitution of the benzene ring to occur. Although iodine atoms have a large atomic radius, their electronegativity is relatively small, which also has a unique effect on the electron cloud of the benzene ring.
In this compound, the position and characteristics of each halogen atom jointly determine its physical and chemical properties. Physical properties such as its melting point, boiling point, solubility, and the activity and selectivity of participating in various chemical reactions are closely related to the type and location of halogen atoms on the benzene ring. The chemical structure of 4-bromo-2-chloroiodobenzene is composed of a benzene ring and specific bromine, chlorine and iodine atoms. Its structural characteristics profoundly affect many properties and reactivity of the compound.
benzene ring is a six-membered ring structure composed of six carbon atoms connected to each other by a conjugated large π bond, which has a high degree of stability. The introduction of halogen atoms at different positions in the benzene ring makes the compound unique in properties. Bromine atoms (Br), chlorine atoms (Cl) and iodine atoms (I) are all halogen elements with different electronegativity and atomic radii.
Bromine atoms are relatively large, and their introduction will affect the electron cloud distribution of the benzene ring, change the electron density of the benzene ring, and then affect the electrophilic substitution activity of the compound. Chlorine atoms have high electronegativity, which can reduce the electron cloud density of the benzene ring, making it slightly difficult for the electrophilic substitution of the benzene ring to occur. Although iodine atoms have a large atomic radius, their electronegativity is relatively small, which also has a unique effect on the electron cloud of the benzene ring.
In this compound, the position and characteristics of each halogen atom jointly determine its physical and chemical properties. Physical properties such as its melting point, boiling point, solubility, and the activity and selectivity of participating in various chemical reactions are closely related to the type and location of halogen atoms on the benzene ring. The chemical structure of 4-bromo-2-chloroiodobenzene is composed of a benzene ring and specific bromine, chlorine and iodine atoms. Its structural characteristics profoundly affect many properties and reactivity of the compound.
What are the physical properties of 4-bromo-2-chloroiodobenzene?
4-Bromo-2-chloroiodobenzene is also an organic compound. Its physical properties are particularly important, and it is related to the behavior of this substance in various environments.
First of all, its appearance is mostly solid at room temperature and pressure. This is due to the intermolecular force. The introduction of bromine, chlorine and iodine atoms enhances the intermolecular van der Waals force, resulting in a solid state shape. Its color is often close to colorless to light yellow, but it may be slightly different due to impurities or the environment.
When it comes to melting point, due to the presence of halogen atoms in the molecular structure, the intermolecular interaction is complex, resulting in a high melting point. It usually melts from solid to liquid within a certain temperature range. The exact value of this temperature is related to the purity of the substance. The melting point of 4-bromo-2-chloroiodobenzene with high purity is relatively stable and can be accurately determined.
In terms of boiling point, it is also quite high due to the influence of halogen atoms. When the temperature rises to the boiling point, the substance changes from liquid to gaseous state. In this process, it is necessary to overcome the strong intermolecular forces. The high boiling point makes 4-bromo-2-chloroiodobenzene not volatile at room temperature and pressure, and the stability is relatively good.
In terms of solubility, this compound has a certain solubility in organic solvents, such as benzene and dichloromethane. According to the principle of similar dissolution, van der Waals force or other weak interactions can be formed between the organic structure and the molecules of the organic solvent to help it dissolve. In water, due to the significant difference in polarity, the solubility is very small.
In terms of density, the density of 4-bromo-2-chloroiodobenzene is greater than that of water. This is because the relative atomic weight of bromine, chlorine and iodine atoms in the molecule is larger, which increases the unit volume mass. Therefore, in the coexistence system of water and 4-bromo-2-chloroiodobenzene, the latter often sinks underwater.
These physical properties are widely used in chemical industry, scientific research and other fields. In organic synthesis, its melting point, boiling point, solubility and other properties provide the basis for the control of reaction conditions, product separation and purification; density characteristics are also important in the stratification of mixtures.
First of all, its appearance is mostly solid at room temperature and pressure. This is due to the intermolecular force. The introduction of bromine, chlorine and iodine atoms enhances the intermolecular van der Waals force, resulting in a solid state shape. Its color is often close to colorless to light yellow, but it may be slightly different due to impurities or the environment.
When it comes to melting point, due to the presence of halogen atoms in the molecular structure, the intermolecular interaction is complex, resulting in a high melting point. It usually melts from solid to liquid within a certain temperature range. The exact value of this temperature is related to the purity of the substance. The melting point of 4-bromo-2-chloroiodobenzene with high purity is relatively stable and can be accurately determined.
In terms of boiling point, it is also quite high due to the influence of halogen atoms. When the temperature rises to the boiling point, the substance changes from liquid to gaseous state. In this process, it is necessary to overcome the strong intermolecular forces. The high boiling point makes 4-bromo-2-chloroiodobenzene not volatile at room temperature and pressure, and the stability is relatively good.
In terms of solubility, this compound has a certain solubility in organic solvents, such as benzene and dichloromethane. According to the principle of similar dissolution, van der Waals force or other weak interactions can be formed between the organic structure and the molecules of the organic solvent to help it dissolve. In water, due to the significant difference in polarity, the solubility is very small.
In terms of density, the density of 4-bromo-2-chloroiodobenzene is greater than that of water. This is because the relative atomic weight of bromine, chlorine and iodine atoms in the molecule is larger, which increases the unit volume mass. Therefore, in the coexistence system of water and 4-bromo-2-chloroiodobenzene, the latter often sinks underwater.
These physical properties are widely used in chemical industry, scientific research and other fields. In organic synthesis, its melting point, boiling point, solubility and other properties provide the basis for the control of reaction conditions, product separation and purification; density characteristics are also important in the stratification of mixtures.
What are the applications of 4-bromo-2-chloroiodobenzene in organic synthesis?
4-Bromo-2-chloroiodobenzene has a wide range of uses in organic synthesis. It is often a key building block when building complex organic structures.
The characteristics of the halogen atom can lead to a variety of chemical reactions. The trihalogen atoms of bromine, chlorine and iodine have different activities and each shows its own energy. The higher activity of the iodine atom is conducive to nucleophilic substitution reactions, and it is often an opportunity to introduce various functional groups. Organic synthesis craftsmen can borrow nucleophilic reagents to replace iodine with other groups, such as hydrocarbons and amino groups, so as to derive new compounds and broaden the synthesis path.
Bromine and chlorine atoms, although their activities are slightly different from iodine, still have their own uses. It can be coupled by metal catalysis, such as Suzuki coupling, Heck coupling, etc. In these reactions, 4-bromo-2-chloroiodobenzene can be coupled with boron, tin and other reagents to form carbon-carbon bonds to form more complex aromatic structures, which is of great significance in the fields of drug synthesis and materials chemistry.
In the field of drug development, this compound can create novel drug molecules with novel structures or optimize the properties of existing drugs. In material chemistry, through the reactions it participates in, materials with special optoelectronic properties can be synthesized, such as organic semiconductor materials, which have broad prospects in the manufacture of electronic devices.
Furthermore, 4-bromo-2-chloroiodobenzene can be used as a starting material for the synthesis of polyhalogenated aromatic derivatives due to its unique substituent distribution. With different reaction conditions and reagents, each halogen atom can be selectively converted, and then the target product with fine structure can be synthesized on demand to meet the diverse needs of scientific research and industrial production.
The characteristics of the halogen atom can lead to a variety of chemical reactions. The trihalogen atoms of bromine, chlorine and iodine have different activities and each shows its own energy. The higher activity of the iodine atom is conducive to nucleophilic substitution reactions, and it is often an opportunity to introduce various functional groups. Organic synthesis craftsmen can borrow nucleophilic reagents to replace iodine with other groups, such as hydrocarbons and amino groups, so as to derive new compounds and broaden the synthesis path.
Bromine and chlorine atoms, although their activities are slightly different from iodine, still have their own uses. It can be coupled by metal catalysis, such as Suzuki coupling, Heck coupling, etc. In these reactions, 4-bromo-2-chloroiodobenzene can be coupled with boron, tin and other reagents to form carbon-carbon bonds to form more complex aromatic structures, which is of great significance in the fields of drug synthesis and materials chemistry.
In the field of drug development, this compound can create novel drug molecules with novel structures or optimize the properties of existing drugs. In material chemistry, through the reactions it participates in, materials with special optoelectronic properties can be synthesized, such as organic semiconductor materials, which have broad prospects in the manufacture of electronic devices.
Furthermore, 4-bromo-2-chloroiodobenzene can be used as a starting material for the synthesis of polyhalogenated aromatic derivatives due to its unique substituent distribution. With different reaction conditions and reagents, each halogen atom can be selectively converted, and then the target product with fine structure can be synthesized on demand to meet the diverse needs of scientific research and industrial production.
What are the preparation methods of 4-bromo-2-chloroiodobenzene?
There are probably several ways to prepare 4-bromo-2-chloroiodobenzene. First, benzene derivatives can be started, and chlorine atoms are introduced through a halogenation reaction. Take an appropriate amount of benzene, place it in a reactor, add an appropriate amount of catalyst, such as ferric trichloride, introduce chlorine gas, and heat it at a controlled temperature to chlorinate the benzene to obtain chlorobenzene.
Then, brominate the chlorobenzene. Transfer the chlorobenzene into another reaction vessel, add brominating reagents, such as bromine and iron powder, and react at a suitable temperature to obtain 2-chlorobromobenzene.
Finally, react 2-chlorobromobenzene with an iodine source. Using a copper salt as a catalyst, such as cuprous iodide, in an organic solvent, 2-chlorobromobenzene is co-heated with an iodizing reagent. After substitution reaction, 4-bromo-2-chloroiodobenzene is obtained.
Second, it can also be started from another angle. First, benzene is brominated to obtain bromobenzene. Later, bromobenzene is chlorinated to obtain 2-chloro-4-bromobenzene. 4-Bromo-2-chloroiodobenzene can also be obtained by reacting with 2-chloro-4-bromobenzene under the action of a catalyst with a suitable iodine substitution reagent, such as potassium iodate and potassium iodide under acidic conditions.
Or the Grignard reagent method can be used. The Grignard reagent containing chlorine or bromine is first prepared, such as phenyl magnesium chloride from chlorobenzene, and then reacted with the reagent containing iodine and another halogen atom. After a series of complex transformations, the target product 4-bromo-2-chloroiodobenzene can also be synthesized. Each method has its own advantages and disadvantages, and it needs to be selected according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction conditions.
Then, brominate the chlorobenzene. Transfer the chlorobenzene into another reaction vessel, add brominating reagents, such as bromine and iron powder, and react at a suitable temperature to obtain 2-chlorobromobenzene.
Finally, react 2-chlorobromobenzene with an iodine source. Using a copper salt as a catalyst, such as cuprous iodide, in an organic solvent, 2-chlorobromobenzene is co-heated with an iodizing reagent. After substitution reaction, 4-bromo-2-chloroiodobenzene is obtained.
Second, it can also be started from another angle. First, benzene is brominated to obtain bromobenzene. Later, bromobenzene is chlorinated to obtain 2-chloro-4-bromobenzene. 4-Bromo-2-chloroiodobenzene can also be obtained by reacting with 2-chloro-4-bromobenzene under the action of a catalyst with a suitable iodine substitution reagent, such as potassium iodate and potassium iodide under acidic conditions.
Or the Grignard reagent method can be used. The Grignard reagent containing chlorine or bromine is first prepared, such as phenyl magnesium chloride from chlorobenzene, and then reacted with the reagent containing iodine and another halogen atom. After a series of complex transformations, the target product 4-bromo-2-chloroiodobenzene can also be synthesized. Each method has its own advantages and disadvantages, and it needs to be selected according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction conditions.
What safety precautions do 4-bromo-2-chloroiodobenzene have?
4-Bromo-2-chloroiodobenzene is an organic compound. Many safety precautions should be followed carefully during experimental operation and storage.
Bear the brunt, because of its toxicity, it can cause serious harm to human health. During operation, be fully armed, wear laboratory clothes, protective gloves and goggles to prevent the compound from coming into contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately, and then seek medical attention according to the specific situation.
Furthermore, 4-bromo-2-chloroiodobenzene is flammable. The experimental environment must be well ventilated and kept away from fire and heat sources to avoid the risk of fire or explosion. When using, appropriate heating and ignition equipment should be used, and operating procedures should be strictly followed.
In addition, the compound may be active in chemical reactions. Before use, be sure to know its chemical properties and reaction characteristics carefully, and strictly control the reaction conditions, such as temperature, pressure, reaction time, etc., to prevent accidental reactions. At the same time, properly dispose of experimental waste, and classify and dispose of it in accordance with relevant regulations to avoid pollution to the environment.
When storing, 4-bromo-2-chloroiodobenzene should be stored in a cool, dry and ventilated place, away from oxidants and other incompatible substances. It should be placed in a sealed container to prevent volatilization and leakage. Also, clearly label the information on the container, including the name of the compound, specifications, storage date, etc., for future access and management.
In short, when handling 4-bromo-2-chloroiodobenzene, the experimenter must remain highly vigilant at all times, strictly abide by the safety operating procedures, and make every effort to ensure their own safety and the smooth progress of the experiment.
Bear the brunt, because of its toxicity, it can cause serious harm to human health. During operation, be fully armed, wear laboratory clothes, protective gloves and goggles to prevent the compound from coming into contact with the skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately, and then seek medical attention according to the specific situation.
Furthermore, 4-bromo-2-chloroiodobenzene is flammable. The experimental environment must be well ventilated and kept away from fire and heat sources to avoid the risk of fire or explosion. When using, appropriate heating and ignition equipment should be used, and operating procedures should be strictly followed.
In addition, the compound may be active in chemical reactions. Before use, be sure to know its chemical properties and reaction characteristics carefully, and strictly control the reaction conditions, such as temperature, pressure, reaction time, etc., to prevent accidental reactions. At the same time, properly dispose of experimental waste, and classify and dispose of it in accordance with relevant regulations to avoid pollution to the environment.
When storing, 4-bromo-2-chloroiodobenzene should be stored in a cool, dry and ventilated place, away from oxidants and other incompatible substances. It should be placed in a sealed container to prevent volatilization and leakage. Also, clearly label the information on the container, including the name of the compound, specifications, storage date, etc., for future access and management.
In short, when handling 4-bromo-2-chloroiodobenzene, the experimenter must remain highly vigilant at all times, strictly abide by the safety operating procedures, and make every effort to ensure their own safety and the smooth progress of the experiment.
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